Cytochrome P450 2B6 and 2C9 genotype polymorphism - A possible cause of prasugrel low responsiveness

Thrombosis and Haemostasis

Volumn 110, Issue 1, 2013, Pages 131-140

  Franken, Cora C ^a   Kaiser, Andreas F C ^a   Krüger, Jan C ^a   Overbeck, Kristina ^a   Mügge, Andreas ^a   Neubauer, Horst ^a  

^a ST JOSEF HOSPITAL   (Germany)

Author keywords

Clopidogrel; Cytochrome P450; Low responder; Platelet aggregation; Prasugrel

Indexed keywords

ACETYLSALICYLIC ACID; C REACTIVE PROTEIN; CALCIUM CHANNEL BLOCKING AGENT; CLOPIDOGREL; CYTOCHROME P450 2B6; CYTOCHROME P450 2C9; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; NITRATE; PRASUGREL; PROTON PUMP INHIBITOR; THIENOPYRIDINE DERIVATIVE; TICAGRELOR;

ACUTE CORONARY SYNDROME; ADULT; AGED; ARTICLE; BODY MASS; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORONARY STENT; DNA POLYMORPHISM; DRUG DOSE INCREASE; DRUG RESPONSE; FEMALE; GENETIC SCREENING; GENETIC VARIABILITY; HUMAN; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; PERCUTANEOUS CORONARY INTERVENTION; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK FACTOR; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE FUNCTION;

ARYL HYDROCARBON HYDROXYLASES; ASPIRIN; BIOMARKERS, PHARMACOLOGICAL; BLOOD PLATELETS; CORONARY ARTERY DISEASE; DRUG RESISTANCE; DRUG THERAPY, COMBINATION; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENOTYPE; HUMANS; MALE; MIDDLE AGED; PIPERAZINES; POLYMORPHISM, GENETIC; PURINERGIC P2Y RECEPTOR ANTAGONISTS; THIOPHENES; TICLOPIDINE;

EID: 84879624900     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH13-01-0021     Document Type: Article

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