Toll-like receptor 4 plays a central role in cardiac dysfunction during trauma hemorrhage shock

Shock

Volumn 42, Issue 1, 2014, Pages 31-37

  Zhang, Xia ^a   Lu, Chen ^a   Gao, Ming ^a   Cao, Xinyun ^a   Ha, Tuanzhu ^a   Kalbfleisch, John H ^a   Williams, David L ^a   Li, Chuanfu ^a   Kao, Race L ^a  

^a East Tennessee State University   (United States)

Author keywords

Cardiac function; eritoran; injury; innate immune; NF B; TLRs

Indexed keywords

ERITORAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MYELOPEROXIDASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; LIPID A; TLR4 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; HEART DISEASE; HEART FUNCTION; HEART MUSCLE; HEMORRHAGIC SHOCK; JUGULAR VEIN; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SOFT TISSUE INJURY; TRAUMATIC SHOCK; TRAUMATOLOGY; WESTERN BLOTTING; WILD TYPE; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; COMPLICATION; DEFICIENCY; DOSE RESPONSE; DRUG EFFECTS; HEART; HEMODYNAMICS; KNOCKOUT MOUSE; MALE; METABOLISM; NEUTROPHIL CHEMOTAXIS; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; SHOCK, HEMORRHAGIC;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART; HEMODYNAMICS; LIPID A; MALE; MICE, KNOCKOUT; NEUTROPHIL INFILTRATION; NF-KAPPA B; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SHOCK, HEMORRHAGIC; SOFT TISSUE INJURIES; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84902546280     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000155     Document Type: Article

References (34)

1. Curry N, Hopewell S, Doree C, Hyde C, Brohi K, Stanworth S: The acute management of trauma hemorrhage: a systematic review of randomized controlled trials. Crit Care 15:R92, 2011.
2. Haut ER, Kalish BT, Cotton BA, Efron DT, Haider AH, Stevens KA, Kieninger AN, Cornwell EE III, Chang DC: Prehospital intravenous fluid administration is associated with higher mortality in trauma patients: a National Trauma Data Bank analysis. Ann Surg 253:371-377, 2011.
3. Angele MK, Schneider CP, Chaudry IH: Bench-to-bedside review: latest results in hemorrhagic shock. Crit Care 12:218, 2008.
4. Lenz A, Franklin GA, Cheadle WG: Systemic inflammation after trauma. Injury 38:1336-1345, 2007.
5. Benhamou Y, Favre J, Musette P, Renet S, Thuillez C, Richard V, Tamion F: Toll-like receptors 4 contribute to endothelial injury and inflammation in hemorrhagic shock in mice. Crit Care Med 37:1724-1728, 2009.
6. Mollen KP, Levy RM, Prince JM, Hoffman RA, Scott MJ, Kaczorowski DJ, Vallabhaneni R, Vodovotz Y, Billiar TR: Systemic inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrowYderived cells and parenchymal cells. J Leukoc Biol 83: 80-88, 2008.
7. McGhan LJ, Jaroszewski DE: The role of Toll-like receptor-4 in the development of multi-organ failure following traumatic haemorrhagic shock and resuscitation. Injury 43:129-136, 2012.
8. Chow JC, Young DW, Golenbock DT, Christ WJ, Gusovsky F: Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem 274:10689-10692, 1999.
9. Meldrum DR, Shenkar R, Sheridan BC, Cain BS, Abraham E, Harken AH: Hemorrhage activates myocardial NFkappaB and increases TNF-alpha in the heart. J Mol Cell Cardiol 29:2849-2854, 1997.
10. Meng X, Ao L, Song Y, Raeburn CD, Fullerton DA, Harken AH: Signaling for myocardial depression in hemorrhagic shock: roles of Toll-like receptor 4 and p55 TNF-alpha receptor. Am J Physiol Regul Integr Comp Physiol 288:R600-R606, 2005.
11. McDonald MC, Mota-Filipe H, Paul A, Cuzzocrea S, Abdelrahman M, Harwood S, Plevin R, Chatterjee PK, Yaqoob MM, Thiemermann C: Calpain inhibitor I reduces the activation of nuclear factor-kappaB and organ injury/dysfunction in hemorrhagic shock. FASEB J 15:171-186, 2001.
12. Cantley LC: The phosphoinositide 3-kinase pathway. Science 296:1655-1657, 2002.
13. Condorelli G, Drusco A, Stassi G, Bellacosa A, Roncarati R, Iaccarino G, Russo MA, Gu Y, Dalton N, Chung C, et al. Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice. Proc Natl Acad Sci U S A 99:12333-12338, 2002.
14. Gude N, Muraski J, Rubio M, Kajstura J, Schaefer E, Anversa P, Sussman MA: Akt promotes increased cardiomyocyte cycling and expansion of the cardiac progenitor cell population. Circ Res 99:381-388, 2006.
15. Williams DL, Ozment-Skelton T, Li C: Modulation of the phosphoinositide 3-kinase signaling pathway alters host response to sepsis, inflammation, and ischemia/reperfusion injury. Shock 25:432-439, 2006.
16. Fukao T, Koyasu S: PI3K and negative regulation of TLR signaling. Trends Immunol 24:358-363, 2003.
17. Hsu JT, Kan WH, Hsieh CH, Choudhry MA, Bland KI, Chaudry IH: Mechanism of salutary effects of estrogen on cardiac function following trauma-hemorrhage: Akt-dependent HO-1 up-regulation. Crit Care Med 37: 2338-2344, 2009.
18. Li C, Hua F, Ha T, Singh K, Lu C, Kalbfleisch J, Breuel KF, Ford T, Kao RL, Gao M, et al. Activation of myocardial phosphoinositide-3-kinase p110alpha ameliorates cardiac dysfunction and improves survival in polymicrobial sepsis. PLoS One 7:e44712, 2012.
19. Hua F, Ha T, Ma J, Li Y, Kelley J, Gao X, Browder IW, Kao RL,Williams DL, Li C: Protection against myocardial ischemia/reperfusion injury in TLR4-deficient mice is mediated through a phosphoinositide 3-kinaseYdependent mechanism. J Immunol 178:7317-7324, 2007.
20. Zhang X, Gao M, Ha T, Kalbfleisch JH, Williams DL, Li C, Kao RL: The Tolllike receptor 9 agonist, CpG-oligodeoxynucleotide 1826, ameliorates cardiac dysfunction after trauma-hemorrhage. Shock 38:146-152, 2012.
21. Li C, Browder W, Kao RL: Early activation of transcription factor NF-kappaB during ischemia in perfused rat heart. Am J Physiol 276:H543YH552, 1999.
22. Gao M, THa T, Zhang X, Liu L, Wang X, Kelley J, Singh K, Kao RL, Gao X, Williams DL, et al. Toll-like receptor 3 plays a central role in cardiac dysfunction during polymicrobial sepsis. Crit Care Med 40:2390-2399, 2012.
23. Mullane KM, Kraemer R, Smith B: Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium. J Pharmacol Methods 14(3):157-167, 1985.
24. Yang S, Zheng R, Hu S, Ma Y, Choudhry MA, Messina JL, Rue LW III, Bland KI, Chaudry IH: Mechanism of cardiac depression after traumahemorrhage: increased cardiomyocyte IL-6 and effect of sex steroids on IL- 6 regulation and cardiac function. Am J Physiol Heart Circ Physiol 287: H2183YH2191, 2004.
25. Reino DC, Palange D, Feketeova E, Bonitz RP, Xu DZ, Lu Q, Sheth SU, Pena G, Ulloa L, De MA, et al. Activation of Toll-like receptor 4 is necessary for trauma hemorrhagic shockYinduced gut injury and polymorphonuclear neutrophil priming. Shock 38:107-114, 2012.
26. Czarniecki M: Small molecule modulators of Toll-like receptors. J Med Chem 51:6621-6626, 2008.
27. Kim HM, Park BS, Kim JI, Kim SE, Lee J, Oh SC, Enkhbayar P, Matsushima N, Lee H, Yoo OJ, et al. Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell 130:906-917, 2007.
28. Roach J, Glusman G, Rowen L, Kaur A, Purcell M, Smith K, et al. The evolution of vertebrate Toll-like receptors. Proc Natl Acad Sci USA 102(27): 9577-9582, 2005.
29. Barochia A, Solomon S, Cui X, Natanson C, Eichacker PQ: Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies. Expert Opin Drug Metab Toxicol 16:479-494, 2011.
30. Shimamoto A, Chong AJ, Yada M, Shomura S, Takayama H, Fleisig AJ, Agnew ML, Hampton CR, Rothnie CL, Spring DJ, et al. Inhibition of Toll-like receptor 4 with eritoran attenuates myocardial ischemia-reperfusion injury. Circulation 114:I-270-I-274, 2006.
31. Laird MH, Rhee SH, Perkins DJ, Medvedev AE, Piao W, Fenton MJ, Vogel SN: TLR4/MyD88/PI3K interactions regulate TLR4 signaling. J Leukoc Biol 85:966-977, 2009.
32. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME: Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-241, 1997.
33. Zhang X, Tang N, Hadden TJ, Rishi AK: Akt, FoxO and regulation of apoptosis. Biochim Biophys Acta 1813:1978-1986, 2011.
34. Catalucci D, Zhang DH, DeSantiago J, Aimond F, Barbara G, Chemin J, Bonci D, Picht E, Rusconi F, Dalton ND, et al. Akt regulates L-type Ca2+ channel activity by modulating Cavalpha1 protein stability. J Cell Biol 184:923-933, 2009.