SCOPUS 정보 검색 플랫폼

Volumn 22, Issue 14, 2014, Pages 3620-3628

Novel 3-arylfuran-2(5H)-one-fluoroquinolone hybrid: Design, synthesis and evaluation as antibacterial agent

(12) Wang, Xu Dong a Wei, Wei a Wang, Peng Fei b Tang, Yun Tao a Deng, Rui Cheng a Li, Biao a Zhou, Sha Sha a Zhang, Jing Wen a Zhang, Lei a Xiao, Zhu Ping a Ouyang, Hui a Zhu, Hai Liang a,b

a JISHOU UNIVERSITY (China)

b NANJING UNIVERSITY (China)

Author keywords

3 Arylfuran 2(5H) one; DNA gyrase; Fluoroquinolone; Hybrid; Multi target; TyrRS

Indexed keywords

7 (4 (2 (3 (2 CHLOROPHENYL)FURAN 2(5H) ONE 4 YLOXY)ETHYL)PIPERAZIN 1 YL) 1 (4 FLUOROPHENYL) 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 (4 (2 (3 (2 CHLOROPHENYL)FURAN 2(5H) ONE 4 YLOXY)ETHYL)PIPERAZIN 1 YL) 1 ETHYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 (4 (2 (3 (2 FLUOROPHENYL)FURAN 2(5H) ONE 4 YLOXY)ETHYL)PIPERAZIN 1 YL) 1 (4 FLUOROPHENYL) 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 (4 (2 (3 (2 FLUOROPHENYL)FURAN 2(5H) ONE 4 YLOXY)ETHYL)PIPERAZIN 1 YL) 1 CYCLOPROPYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 (4 (2 (3 (2 FLUOROPHENYL)FURAN 2(5H) ONE 4 YLOXY)ETHYL)PIPERAZIN 1 YL) 1 ETHYL 6 FLUORO 4 OXO 1,4 DIHYDRO 1,8 NAPHTHYRIDINE 3 CARBOXYLIC ACID; 7 (4 (2 (3 (2 FLUOROPHENYL)FURAN 2(5H) ONE 4 YLOXY)ETHYL)PIPERAZIN 1 YL) 1 ETHYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 (4 (2 (3 (3 BROMOPHENYL)FURAN 2(5H) ONE 4 YLOXY)ETHYL)PIPERAZIN 1 YL) 1 (4 FLUOROPHENYL) 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 (4 (2 (3 (3 BROMOPHENYL)FURAN 2(5H) ONE 4 YLOXY)ETHYL)PIPERAZIN 1 YL) 1 ETHYL 6 FLUORO 4 OXO 1,4 DIHYDRO 1,8 NAPHTHYRIDINE 3 CARBOXYLIC ACID; 7 (4 (2 (3 (3 CHLOROPHENYL)FURAN 2(5H) ONE 4 YLOXY)ETHYL)PIPERAZIN 1 YL) 1 (4 FLUOROPHENYL) 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 (4 (2 (3 (3 CHLOROPHENYL)FURAN 2(5H) ONE 4 YLOXY)ETHYL)PIPERAZIN 1 YL) 1 ETHYL 6 FLUORO 4 OXO 1,4 DIHYDRO 1,8 NAPHTHYRIDINE 3 CARBOXYLIC ACID; 7 (4 (2 (3 (4 BROMOPHENYL)FURAN 2(5H) ONE 4 YLOXY)ETHYL)PIPERAZIN 1 YL) 1 (4 FLUOROPHENYL) 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 (4 (2 (3 (4 BROMOPHENYL)FURAN 2(5H) ONE 4 YLOXY)ETHYL)PIPERAZIN 1 YL) 1 CYCLOPROPYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 (4 (2 (3 (4 BROMOPHENYL)FURAN 2(5H) ONE 4 YLOXY)ETHYL)PIPERAZIN 1 YL) 1 ETHYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 (4 (2 (3 (4 CHLOROPHENYL)FURAN 2(5H) ONE 4 YLOXY)ETHYL)PIPERAZIN 1 YL) 1 (4 FLUOROPHENYL) 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 (4 (2 (3 (4 CHLOROPHENYL)FURAN 2(5H) ONE 4 YLOXY)ETHYL)PIPERAZIN 1 YL) 1 CYCLOPROPYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 (4 (2 (3 (4 CHLOROPHENYL)FURAN 2(5H) ONE 4 YLOXY)ETHYL)PIPERAZIN 1 YL) 1 ETHYL 6 FLUORO 4 OXO 1,4 DIHYDRO 1,8 NAPHTHYRIDINE 3 CARBOXYLIC ACID; 7 (4 (2 (3 (4 CHLOROPHENYL)FURAN 2(5H) ONE 4 YLOXY)ETHYL)PIPERAZIN 1 YL) 1 ETHYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 (4 (2 (3 (4 FLUOROPHENYL)FURAN 2(5H) ONE 4 YLOXY)ETHYL)PIPERAZIN 1 YL) 1 (4 FLUOROPHENYL) 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 (4 (2 (3 (4 FLUOROPHENYL)FURAN 2(5H) ONE 4 YLOXY)ETHYL)PIPERAZIN 1 YL) 1 CYCLOPROPYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 (4 (2 (3 (4 METHOXYPHENYL)FURAN 2(5H) ONE 4 YLOXY)ETHYL)PIPERAZIN 1 YL) 1 CYCLOPROPYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 (4 (2 (3 (4 METHYLPHENYL)FURAN 2(5H) ONE 4 YLOXY)ETHYL)PIPERAZIN 1 YL) 1 (4 FLUOROPHENYL) 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 (4 (2 (3 (4 METHYLPHENYL)FURAN 2(5H) ONE 4 YLOXY)ETHYL)PIPERAZIN 1 YL) 1 CYCLOPROPYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 (4 (2 (3 PHENYLFURAN 2(5H) ONE 4 YLOXY)ETHYL)PIPERAZIN 1 YL) 1 (4 FLUOROPHENYL) 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 (4 (2 (3 PHENYLFURAN 2(5H) ONE 4 YLOXY)ETHYL)PIPERAZIN 1 YL) 1 CYCLOPROPYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 7 (4 (2 (3 PHENYLFURAN 2(5H) ONE 4 YLOXY)ETHYL)PIPERAZIN 1 YL) 1 ETHYL 6 FLUORO 4 OXO 1,4 DIHYDRO 1,8 NAPHTHYRIDINE 3 CARBOXYLIC ACID; 7 (4 (2 (3 PHENYLFURAN 2(5H) ONE 4 YLOXY)ETHYL)PIPERAZIN 1 YL) 1 ETHYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; CIPROFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG; ANTIINFECTIVE AGENT; FURAN DERIVATIVE; QUINOLONE DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL STRAIN; CONTROLLED STUDY; DRUG DESIGN; DRUG DETERMINATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ASSAY; ESCHERICHIA COLI; IC 50; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; STRUCTURE ANALYSIS; BACTERIA; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; MICROBIAL SENSITIVITY TEST; MULTIDRUG RESISTANCE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ESCHERICHIA COLI; NEGIBACTERIA; POSIBACTERIA;

ANTI-BACTERIAL AGENTS; BACTERIA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, MULTIPLE, BACTERIAL; FLUOROQUINOLONES; FURANS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84902540245 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2014.05.018 Document Type: Article

Times cited : (49)

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