3-Aryl-4-acyloxyethoxyfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: Synthesis, molecular docking and antibacterial evaluation

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 17, 2013, Pages 4914-4922

  Wang, Xu Dong ^a   Deng, Rui Cheng ^a   Dong, Jing Jun ^b   Peng, Zhi Yun ^a   Gao, Xiao Ming ^a   Li, Shu Ting ^a   Lin, Wan Qiang ^a   Lu, Chun Lei ^a   Xiao, Zhu Ping ^a   Zhu, Hai Liang ^a,b  

^a JISHOU UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

3 Aryl 4 acyloxyethoxyfuran 2(5H) ones; Antibacterial; Molecular docking; Structure activity relationship; Tyrosyl tRNA synthetase

Indexed keywords

4 (2 BUTYRYLOXYETHOXY) 3 PHENYLFURAN 2(5H) ONE; 4 (2 HEXANOYLOXYETHOXY) 3 PHENYLFURAN 2(5H) ONE; 4 (2 OCTANOYLOXYETHOXY) 3 PHENYLFURAN 2(5H) ONE; 4 (2 PHENYLACETYLOXYLETHOXY) 3 PHENYLFURAN 2(5H) ONE; 4 [2 (2 CHLOROPHENYLFORMYLOXYL)ETHOXY] 3 PHENYLFURAN 2(5H) ONE; 4 [2 (2 HYDROXYPHENYLFORMYLOXYL)ETHOXY] 3 PHENYLFURAN 2(5H) ONE; 4 [2 (2 METHOXYPHENYLFORMYLOXY)ETHOXY] 3 PHENYLFURAN 2(5H) ONE; 4 [2 (2 METHYLPHENYLFORMYLOXYL)ETHOXY] 3 PHENYLFURAN 2(5H) ONE; 4 [2 (2 NITROPHENYLFORMYLOXYL)ETHOXY] 3 PHENYLFURAN 2(5H) ONE; 4 [2 (2,4 DICHLOROPHENYLFORMYLOXYL)ETHOXY] 3 PHENYLFURAN 2(5H) ONE; 4 [2 (2,4 DIHYDROXYPHENYLFORMYLOXYL)ETHOXY] 3 PHENYLFURAN 2(5H) ONE; 4 [2 (2,5 DICHLOROPHENYLFORMYLOXYL)ETHOXY] 3 PHENYLFURAN 2(5H) ONE; 4 [2 (3 CHLOROPHENYLFORMYLOXY)ETHOXY] 3 (4 CHLOROPHENYL)FURAN 2(5H) ONE; 4 [2 (3 METHYLPHENYLFORMYLOXY)ETHOXY] 3 PHENYLFURAN 2(5H) ONE; 4 [2 (3 NITROPHENYLFORMYLOXY)ETHOXY] 3 PHENYLFURAN 2(5H) ONE; 4 [2 (3 PYRIDYLFORMYLOXY)ETHOXY] 3 PHENYLFURAN 2(5H) ONE; 4 [2 (3 TRIFLUOROMETHYLPHENYLFORMYOXYL)ETHOXY] 3 PHENYLFURAN 2(5H) ONE; 4 [2 (3,4 DICHLOROPHENYLFORMYLOXYL)ETHOXY] 3 PHENYLFURAN 2(5H) ONE; 4 [2 (3,4 DIHYDROXYPHENYLFORMYLOXYL)ETHOXY] 3 PHENYLFURAN 2(5H) ONE; 4 [2 (4 CHLOROPHENYLFORMYLOXYL)ETHOXY] 3 PHENYLFURAN 2(5H) ONE; 4 [2 (4 FLUOROPHENYLFORMYLOXYL)ETHOXY] 3 PHENYLFURAN 2(5H) ONE; 4 [2 (4 HYDROXYPHENYLFORMYLOXYL)ETHOXY] 3 PHENYLFURAN 2(5H) ONE; 4 [2 (4 METHYLPHENYLFORMYLOXYL)ETHOXY] 3 PHENYLFURAN 2(5H) ONE; 4 [2 (4 NITROPHENYLFORMYLOXYL)ETHOXY] 3 PHENYLFURAN 2(5H) ONE; 4 [2 (6 HYDROXYNAPHTHALEN 2 YLFORMYLOXYL)ETHOXY] 3 PHENYLFURAN 2(5H) ONE; 4 [2 (NAPHTHALEN 2 YLFORMYLOXYL)ETHOXY] 3 PHENYLFURAN 2(5H) ONE; ANTIINFECTIVE AGENT; ENZYME INHIBITOR; TYROSINE TRANSFER RNA LIGASE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL CELL; CANDIDA ALBICANS; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ESCHERICHIA COLI; FUNGUS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; WHOLE CELL;

CANDIDA ALBICANS; ESCHERICHIA COLI; FUNGI; NEGIBACTERIA; POSIBACTERIA; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

3-ARYL-4-ACYLOXYETHOXYFURAN-2(5H)-ONES; ANTIBACTERIAL; MOLECULAR DOCKING; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSYL-TRNA SYNTHETASE;

ANTI-INFECTIVE AGENTS; BINDING SITES; CATALYTIC DOMAIN; ENZYME INHIBITORS; FUNGI; FURANS; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; MOLECULAR DOCKING SIMULATION; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; TYROSINE-TRNA LIGASE;

EID: 84881374886     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.06.066     Document Type: Article

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