Tyrosyl-tRNA synthetase inhibitors as antibacterial agents: Synthesis, molecular docking and structure-activity relationship analysis of 3-aryl-4-arylaminofuran-2(5H)-ones

European Journal of Medicinal Chemistry

Volumn 46, Issue 10, 2011, Pages 4904-4914

  Xiao, Zhu Ping ^a,b   Ma, Tao Wu ^a   Liao, Mei Lin ^a   Feng, Yu Ting ^a   Peng, Xiao Chun ^a   Li, Jia Liang ^a   Li, Zhi Ping ^a   Wu, Ying ^a   Luo, Qun ^a   Deng, Yang ^a   Liang, Xiao ^a   Zhu, Hai Liang ^a,b  

^a JISHOU UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

3 Aryl 4 arylaminofuran 2(5H) one; Antibacterial agent; Molecular docking; Structure activity relationship; Tyrosyl tRNA synthetase

Indexed keywords

3 (3 BROMOPHENYL) 4 (3,5 DICHLOROPHENYLAMINO)FURAN 2 (5H)ONE; 3 (4 BROMOPHENYL) 4 (2 CHLOROPHENYLAMINO)FURAN 2(5H)ONE; 3 (4 BROMOPHENYL) 4 (2 METHOXYPHENYLAMINO)FURAN 2(5H)ONE; 3 (4 BROMOPHENYL) 4 (2 NITROPHENYLAMINO)FURAN 2(5H)ONE; 3 (4 BROMOPHENYL) 4 (3 CHLOROPHENYLAMINO)FURAN 2(5H)ONE; 3 (4 BROMOPHENYL) 4 (3 HYDROXYPHENYLAMINO)FURAN 2(5H)ONE; 3 (4 BROMOPHENYL) 4 (3 NITROPHENYLAMINO)FURAN 2(5H)ONE; 3 (4 BROMOPHENYL) 4 (3,5 DIBROMOPHENYLAMINO)FURAN 2(5H)ONE; 3 (4 BROMOPHENYL) 4 (3,5 DICHLOROPHENYLAMINO)FURAN 2(5H)ONE; 3 (4 BROMOPHENYL) 4 (3,5 DIFLUOROPHENYLAMINO)FURAN 2(5H)ONE; 3 (4 BROMOPHENYL) 4 (3,5 DIMETHOXYPHENYLAMINO)FURAN 2(5H)ONE; 3 (4 BROMOPHENYL) 4 (4 BROMOPHENYLAMINO)FURAN 2(5H)ONE; 3 (4 BROMOPHENYL) 4 (4 CHLOROPHENYLAMINO)FURAN 2(5H)ONE; 3 (4 BROMOPHENYL) 4 (4 HYDROXYPHENYLAMINO)FURAN 2(5H)ONE; 3 (4 BROMOPHENYL) 4 (4 METHOXYPHENYLAMINO)FURAN 2(5H)ONE; 3 (4 BROMOPHENYL) 4 (4 METHYLPHENYLAMINO)FURAN 2(5H)ONE; 3 (4 BROMOPHENYL) 4 (4 NITROPHENYLAMINO)FURAN 2(5H)ONE; 3 (4 BROMOPHENYL) 4 (PHENYLAMINO)FURAN 2(5H)ONE; 3 (4 BROMOPHENYL) 4 (PYRIDIN 2 YLAMINO)FURAN 2(5H)ONE; 3 (4 BROMOPHENYL) 4 [METHYL(PHENYL)AMINO]FURAN 2(5H)ONE; 3 (4 CHLOROPHENYL) 4 (3 CHLOROPHENYLAMINO)FURAN 2(5H)ONE; 4 (2 NITROPHENYLAMINO) 3 PHENYLFURAN 2(5H)ONE; 4 (3 CHLOROPHENYLAMINO) 3 PHENYLFURAN 2(5H)ONE; 4 (3 NITROPHENYLAMINO) 3 PHENYLFURAN 2(5H)ONE; 4 (3,5 DIBROMOPHENYLAMINO) 3 (4 FLUOROPHENYL)FURAN 2(5H)ONE; ANTIBIOTIC AGENT; FURAN DERIVATIVE; LIGASE INHIBITOR; TYROSINE TRANSFER RNA LIGASE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG BINDING SITE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; HYDROGEN BOND; IC 50; IN VITRO STUDY; METHYLATION; MOLECULAR DOCKING; NONHUMAN; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANTI-BACTERIAL AGENTS; ENZYME INHIBITORS; FURANS; GRAM-POSITIVE BACTERIA; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; MODELS, MOLECULAR; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE-TRNA LIGASE;

EID: 80053179826     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.07.047     Document Type: Article

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