Mycobacterium tuberculosis expressing phospholipase C subverts PGE 2 synthesis and induces necrosis in alveolar macrophages

BMC Microbiology

Volumn 14, Issue 1, 2014, Pages

  Assis, Patricia A ^a   Espíndola, Milena S ^a   Paula Silva, Francisco Wg ^a   Rios, Wendy M ^a   Pereira, Priscilla At ^a   Leão, Sylvia C ^b   Silva, Célio L ^a   Faccioli, Lúcia H ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Cell death; Lipid mediator; Macrophage necrosis; Mycobacterium; Phospholipase C; Prostaglandins

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; CYCLOOXYGENASE 2; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEUKOTRIENE B4 RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PHOSPHOLIPASE C; PROSTAGLANDIN E2; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; BACTERIAL PROTEIN; MPCA PROTEIN, MYCOBACTERIUM TUBERCULOSIS; MPCB PROTEIN, MYCOBACTERIUM TUBERCULOSIS; VIRULENCE FACTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENETIC VARIABILITY; IN VITRO STUDY; LUNG ALVEOLUS MACROPHAGE; NONHUMAN; PROSTAGLANDIN SYNTHESIS; RAT; TUBERCULOSIS; ANTAGONISTS AND INHIBITORS; ENZYMOLOGY; GENETICS; HUMAN; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; MYCOBACTERIUM TUBERCULOSIS; PHYSIOLOGY;

BACTERIAL PROTEINS; CELL DEATH; DINOPROSTONE; HUMANS; MACROPHAGES, ALVEOLAR; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS; TYPE C PHOSPHOLIPASES; VIRULENCE FACTORS;

EID: 84902537545     PISSN: None     EISSN: 14712180     Source Type: Journal    
DOI: 10.1186/1471-2180-14-128     Document Type: Article

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