Development and validation of high liquid performance chromatography-tandem mass spectrometry method for simultaneous determination of geniposidic acid and aucubin in rat plasma for pharmacokinetic study after oral administration of Du-zhong tea extract

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 963, Issue , 2014, Pages 62-69

  Zhang, Lin ^a   Ma, Yu Liang ^b   Liu, Yang ^a   Zu, Yuan Gang ^a  

^a NORTHEAST FORESTRY UNIVERSITY   (China)

^b HEILONGJIANG UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Aucubin; Du zhong tea; Geniposidic acid; HPLC MS MS; Pharmacokinetics; Rat plasma

Indexed keywords

CHROMATOGRAPHY; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHANOL; PHARMACOKINETICS;

AUCUBIN; CHROMATOGRAPHIC SEPARATIONS; DU-ZHONG TEA; HPLC-MS/MS; MULTIPLE REACTION MONITORING; RAT PLASMA; SIMULTANEOUS DETERMINATIONS; TANDEM MASS SPECTROMETRIC;

BODY FLUIDS;

ACETONITRILE; AUCUBIN; EUCOMMIA ULMOIDES EXTRACT; FORMIC ACID; GENIPOSIDIC ACID; METHANOL; PLANT GLYCOSIDE; UNCLASSIFIED DRUG; WATER; HERBACEOUS AGENT; IRIDOID;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG ABSORPTION; DRUG DETERMINATION; DRUG DISPOSITION; DRUG HALF LIFE; ELECTRIC POTENTIAL; ELECTROSPRAY; ENTEROHEPATIC CIRCULATION; EXTRACTION; FLOW RATE; FREEZE THAWING; GAS FLOW; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONIZATION; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PLASMA; PLASMA CONCENTRATION-TIME CURVE; PRECIPITATION; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY; TEMPERATURE; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; BLOOD; CHEMISTRY; EUCOMMIACEAE; ORAL DRUG ADMINISTRATION; PROCEDURES; VALIDATION STUDY; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; EUCOMMIACEAE; IRIDOID GLUCOSIDES; MALE; RATS, WISTAR; TANDEM MASS SPECTROMETRY;

EID: 84902511222     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2014.04.033     Document Type: Article

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