A rapid and sensitive determination of aucubin in rat plasma by liquid chromatography-tandem mass spectrometry and its pharmacokinetic application

Biomedical Chromatography

Volumn 26, Issue 9, 2012, Pages 1066-1070

  Xu, Wei ^a,b   Deng, Zhipeng ^c   Guo, Hong ^d   Ling, Peixue ^a  

^a SHANDONG UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF SHANDONG FIRST MEDICAL UNIVERSITY   (China)

^c SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY   (China)

^d Jinan Stomatologic Hospital Shungeng Branch   (China)

Author keywords

Aucubin; LC MS MS; Protein precipitation; Rat plasma

Indexed keywords

BODY FLUIDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; RATS;

AUCUBIN; BIOACTIVES; LC-MS-MS; LC.MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; PHARMACOKINETIC STUDIES; PLASMA SAMPLES; PROTEIN PRECIPITATION; RAT PLASMA;

METHANOL;

AMMONIUM ACETATE; AUCUBIN; CATALPOL; METHANOL; WATER;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CALIBRATION; CHEMICAL COMPOSITION; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; DRUG SCREENING; DRUG STABILITY; FREEZE THAWING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY; MALE; MAXIMUM PLASMA CONCENTRATION; MEDICINAL PLANT; MONITORING; MULTIPLE REACTION MONITORING; NONHUMAN; PHARMACOLOGICAL PARAMETERS; PHASE TRANSITION; RAT; REACTION TIME; SENSITIVITY AND SPECIFICITY; SINGLE DRUG DOSE; SUPERNATANT; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

AUCUBA JAPONICA; EUCOMMIA ULMOIDES; PLANTAGO ASIATICA; RATTUS;

EID: 84864812991     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1748     Document Type: Article

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