Caffeic acid phenethyl ester promotes anti-inflammatory effects by inhibiting MAPK and NF-κB signaling in activated HMC-1 human mast cells

Pharmaceutical Biology

Volumn 52, Issue 7, 2014, Pages 926-932

  Cho, Mi Suk ^a   Park, Won Sun ^b   Jung, Won Kyo ^c   Qian, Zhong Ji ^c   Lee, Dae Sung ^d   Choi, Jung Sik ^e   Lee, Da Young ^f   Park, Sae Gwang ^f   Seo, Su Kil ^f   Kim, Hak Ju ^g   Won, Jun Yeon ^b   Yu, Byeng Chul ^h   Choi, Il Whan ^f  

^a Choonhae College of Health Science   (South Korea)

^b Kangwon National University   (South Korea)

^c Pukyong National University   (South Korea)

^d Pohang University of Science and Technology (POSTECH)   (South Korea)

^e Inje University College of Medicine   (South Korea)

^f Inje University   (South Korea)

^g Seojin Biotech Co Ltd   (South Korea)

^h Kosin University   (South Korea)

Author keywords

Allergy; Cytokine; Histamine; Immunoglobulin E; Passive cutaneous anaphylaxis

Indexed keywords

CAFFEIC ACID PHENETHYL ESTER; CALCIMYCIN; CALCIUM; HISTAMINE; I KAPPA B ALPHA; IMMUNOGLOBULIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; PHORBOL 13 ACETATE 12 MYRISTATE; STRESS ACTIVATED PROTEIN KINASE; CAFFEIC ACID DERIVATIVE; CYTOKINE; NONSTEROID ANTIINFLAMMATORY AGENT; PHENETHYL ALCOHOL;

ALLERGIC REACTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CALCIUM CELL LEVEL; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG STRUCTURE; HISTAMINE RELEASE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; MAST CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PASSIVE SKIN ANAPHYLAXIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; HYPERSENSITIVITY; METABOLISM; PHOSPHORYLATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CAFFEIC ACIDS; CALCIUM; CELL SURVIVAL; CELLS, CULTURED; CYTOKINES; HISTAMINE; HISTAMINE RELEASE; HUMANS; HYPERSENSITIVITY; IMMUNOGLOBULIN E; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MAP KINASE SIGNALING SYSTEM; MAST CELLS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PHENYLETHYL ALCOHOL; PHOSPHORYLATION;

EID: 84902458209     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2013.865243     Document Type: Article

References (33)

1. Barnes PJ, Karin M. (1997). Nuclear factor-kappa B: A pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336:1066-71.
2. Fesen MR, Kohn KW, Leteurtre F, Pommier Y. (1993). Inhibitors of human immunodeficiency virus integrase. Proc Natl Acad Sci USA 90:2399-403.
3. Galli SJ, Maurer M, Lantz CS. (1999). Mast cells as sentinels of innate immunity. Curr Opin Immunol 11:53-9.
4. Grémy O, Benderitter M, Linard C. (2006). Caffeic acid phenethyl ester modifies the Th1/Th2 balance in ileal mucosa after gamma-irradiation in the rat by modulating the cytokine pattern. World J Gastroenterol 12:4996-5004.
5. Hepsen IF, Er H, Cekic O. (1999). Topically applied water extract of propolis of to suppress corneal neovascularization in rabbits. Ophtalmic Res 31:426-31.
6. Hishikawa K, Nakaki T, Fujita T. (2005). Oral flavonoid supplementation attenuates atherosclerosis development in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 25:442-6.
7. Ilhan A, Iraz M, Gurel A, et al. (2004). Caffeic acid phenethyl ester exerts a neuroprotective effect on CNS against pentylenetetrazolinduced seizures in mice. Neurochem Res 29:2287-92.
8. Jung WK, Lee DY, Choi YH, et al. (2008). Caffeic acid phenethyl ester attenuates allergic airway inflammation and hyperresponsiveness in murine model of ovalbumin-induced asthma. Life Sci 82:797-805.
9. Kalesnikoff J, Galli SJ. (2008). New developments in mast cell biology. Nat Immunol 9:1215-23.
10. Kawakami T, Galli SJ. (2002). Regulation of mast-cell and basophil function and survival by IgE. Nat Rev Immunol 2:773-86.
11. Kemp SF, Lockey RF. (2002). Anaphylaxis: A review of causes and mechanisms. J Allergy Clin Immunol 110:341-8.
12. Kim EK, Kim EY, Moon PD, et al. (2007). Lithospermi radix extract inhibits histamine release and production of inflammatory cytokine in mast cells. Biosci Biotechnol Biochem 71:2886-92.
13. Koshihara Y, Neichi T, Murota S, et al. (1984). Caffeic acid is a selective inhibitor for leukotriene biosynthesis. Biochem Biophys Acta 792: 92-7.
14. Liao HF, Chen YY, Liu JJ, et al. (2003). Inhibitory effect of caffeic acid phenethyl ester on angiogenesis, tumor invasion, and metastasis. J Agric Food Chem 51:7907-12.
15. Ma HT, Beaven MA. (2009). Regulation of Ca2+ signaling with particular focus on mast cells. Crit Rev Immunol 29:155-86.
16. Márquez N, Sancho R, Macho A, et al. (2004). Caffeic acid phenethyl ester inhibits T-cell activation by targeting both nuclear factor of activated T-cells and NF-kappa B transcription factors. J Pharmacol Exp Ther 308:993-1001.
17. Marshall JS. (2004). Mast-cell responses to pathogens. Nat Rev Immunol 4:787-99.
18. Metz M, Maurer M. (2007). Mast cells-key effector cells in immune responses. Trends Immunol 28:234-41.
19. Metzger H, Alcaraz G, Hohman R, et al. (1986). The receptor with high affinity for immunoglobulin E. Annu Rev Immunol 4:419-70.
20. Michaluart P, Masferrer JL, Carothers AM, et al. (1999). Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation. Cancer Res 59:2347-52.
21. Nader MA. (2013). Caffeic acid phenethyl ester attenuates IgE-induced immediate allergic reaction. Inflammopharmacology 21:169-76.
22. Natarajan K, Singh S, Burke Jr TR, et al. (1996). Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc Natl Acad Sci USA 93:9090-5.
23. Orban Z, Mitsiades N, Burke Jr TR, et al. (2000). Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation. Neuroimmunomodulation 7: 99-105.
24. Orsolić N, Terzić S, Mihaljević Z, et al. (2005). Effects of local administration of propolis and its polyphenolic compounds on tumor formation and growth. Biol Pharm Bull 28:1928-33.
25. Park EH, Kang JH. (1999). Suppressive effects of propolis in rat adjuvant arthritis. Arch Pharm Res 22:554-8.
26. Park JH, Lee JK, Kim HS, et al. (2004). Immunomodulatory effect of caffeic acid phenethyl ester in Balb/c mice. Int Immunopharmacol 4: 429-36.
27. Park SG, Lee DY, Seo SK, et al. (2008). Evaluation of anti-allergic properties of caffeic acid phenethyl ester in a murine model of systemic anaphylaxis. Toxicol Appl Pharmacol 226:22-9.
28. Royer B, Varadaradjalou S, Saas P, et al. (2001). Autocrine regulation of cord blood-derived human mast cell activation by IL-10. J Allergy Clin Immunol 108:80-6.
29. Stassen M, Müller C, Arnold M, et al. (2001). IL-9 and IL-13 production by activated mast cells is strongly enhanced in the presence of lipopolysaccharide: NF-kappa B is decisively involved in the expression of IL-9. J Immunol 166:4391-8.
30. Suzuki Y, Inoue T, Ra C. (2010). L-type Ca2+ channels: A new player in the regulation of Ca2+ signaling, cell activation and cell survival in immune cells. Mol Immunol 47:640-8.
31. Yang YH. (2011). Caffeic Acid phenethyl ester possessing various immunomodulatory effects is a potentially effective therapy for asthma. Pediatr Neonatol 52:307-8.
32. Yoshimaru T, Suzuki Y, Inoue T, Ra C. (2009). L-type Ca2+ channels in mast cells: Activation by membrane depolarization and distinct roles in regulating mediator release from store-operated Ca2+ channels. Mol Immunol 46:1267-77.
33. Zhu Z, Homer RJ, Wang Z, et al. (1999). Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 103:779-88.