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Volumn 13, Issue 12, 2014, Pages 1958-1969

Urokinase-type plasminogen activator receptor signaling is critical in nasopharyngeal carcinoma cell growth and metastasis

Author keywords

Genome wide expression profiling; JAK; Metastasis; Nasopharyngeal carcinoma; STAT; Tumor growth; uPAR

Indexed keywords

JANUS KINASE 2; JANUS KINASE 3; NERVE CELL ADHESION MOLECULE; PLASMIN; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; UROKINASE RECEPTOR; UVOMORULIN; VIMENTIN; ENZYME INHIBITOR; JANUS KINASE; PYRAZOLE DERIVATIVE; RUXOLITINIB; STAT PROTEIN;

EID: 84902440808     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.28921     Document Type: Article
Times cited : (52)

References (52)
  • 1
    • 79954529928 scopus 로고    scopus 로고
    • The prevalence and prevention of nasopharyngeal carcinoma in China
    • PMID:21272443
    • Cao SM, Simons MJ, Qian CN. The prevalence and prevention of nasopharyngeal carcinoma in China. Chin J Cancer 2011; 30:114-9; PMID:21272443; http://dx.doi.org/10.5732/cjc.010.10377
    • (2011) Chin J Cancer , vol.30 , pp. 114-119
    • Cao, S.M.1    Simons, M.J.2    Qian, C.N.3
  • 2
    • 79954506032 scopus 로고    scopus 로고
    • Nasopharyngeal carcinoma in the Northeastern states of India
    • PMID:21272442
    • Kataki AC, Simons MJ, Das AK, Sharma K, Mehra NK. Nasopharyngeal carcinoma in the Northeastern states of India. Chin J Cancer 2011; 30:106-13; PMID:21272442; http://dx.doi.org/10.5732/cjc.010.10607
    • (2011) Chin J Cancer , vol.30 , pp. 106-113
    • Kataki, A.C.1    Simons, M.J.2    Das, A.K.3    Sharma, K.4    Mehra, N.K.5
  • 4
    • 84896483685 scopus 로고    scopus 로고
    • Preliminary assessment of nasopharyngeal carcinoma incidence in the Philippines: A second look at published data from four centers
    • PMID:23958058
    • Sarmiento MP, Mejia MB. Preliminary assessment of nasopharyngeal carcinoma incidence in the Philippines: a second look at published data from four centers. Chin J Cancer 2014; 33:159-64; PMID:23958058
    • (2014) Chin J Cancer , vol.33 , pp. 159-164
    • Sarmiento, M.P.1    Mejia, M.B.2
  • 5
    • 0023037120 scopus 로고
    • Distant metastases of nasopharyngeal carcinoma: A study of 256 male patients
    • PMID:3773537
    • Ahmad A, Stefani S. Distant metastases of nasopharyngeal carcinoma: a study of 256 male patients. J Surg Oncol 1986; 33:194-7; PMID:3773537; http://dx.doi.org/10.1002/jso.2930330310
    • (1986) J Surg Oncol , vol.33 , pp. 194-197
    • Ahmad, A.1    Stefani, S.2
  • 6
    • 0026720425 scopus 로고
    • Retrospective analysis of 5037 patients with nasopharyngeal carcinoma treated during 1976-1985: Overall survival and patterns of failure
    • PMID:1587745
    • Lee AW, Poon YF, Foo W, Law SC, Cheung FK, Chan DK, Tung SY, Thaw M, Ho JH. Retrospective analysis of 5037 patients with nasopharyngeal carcinoma treated during 1976-1985: overall survival and patterns of failure. Int J Radiat Oncol Biol Phys 1992; 23:261-70; PMID:1587745; http://dx.doi.org/10.1016/0360- 3016(92)90740-9
    • (1992) Int J Radiat Oncol Biol Phys , vol.23 , pp. 261-270
    • Lee, A.W.1    Poon, Y.F.2    Foo, W.3    Law, S.C.4    Cheung, F.K.5    Chan, D.K.6    Tung, S.Y.7    Thaw, M.8    Ho, J.H.9
  • 7
    • 0020527731 scopus 로고
    • Nasopharyngeal carcinoma in Taiwan. Clinical manifestations and results of therapy
    • PMID:6190547
    • Hsu MM, Tu SM. Nasopharyngeal carcinoma in Taiwan. Clinical manifestations and results of therapy. Cancer 1983; 52:362-8; PMID:6190547; http://dx.doi.org/10.1002/1097-0142(19830715)52:2〈362:: AIDCNCR2820520230〉3.0.CO;2-V
    • (1983) Cancer , vol.52 , pp. 362-368
    • Hsu, M.M.1    Tu, S.M.2
  • 9
    • 34247126476 scopus 로고    scopus 로고
    • The management of neck metastases in nasopharyngeal cancer
    • PMID:17413410
    • Wei WI, Mok VW. The management of neck metastases in nasopharyngeal cancer. Curr Opin Otolaryngol Head Neck Surg 2007; 15:99-102; PMID:17413410; http://dx.doi.org/10.1097/MOO.0b013e3280148a06
    • (2007) Curr Opin Otolaryngol Head Neck Surg , vol.15 , pp. 99-102
    • Wei, W.I.1    Mok, V.W.2
  • 11
    • 0026063532 scopus 로고
    • Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol
    • PMID:1846368
    • Ploug M, Rønne E, Behrendt N, Jensen AL, Blasi F, Danø K. Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol. J Biol Chem 1991; 266:1926-33; PMID:1846368
    • (1991) J Biol Chem , vol.266 , pp. 1926-1933
    • Ploug, M.1    Rønne, E.2    Behrendt, N.3    Jensen, A.L.4    Blasi, F.5    Danø, K.6
  • 12
    • 0028064814 scopus 로고
    • Structure-function relationships in the receptor for urokinase-type plasminogen activator. Comparison to other members of the Ly-6 family and snake venom alpha-neurotoxins
    • PMID:8050560
    • Ploug M, Ellis V. Structure-function relationships in the receptor for urokinase-type plasminogen activator. Comparison to other members of the Ly-6 family and snake venom alpha-neurotoxins. FEBS Lett 1994; 349:163-8; PMID:8050560; http://dx.doi.org/10.1016/0014-5793(94)00674-1
    • (1994) FEBS Lett , vol.349 , pp. 163-168
    • Ploug, M.1    Ellis, V.2
  • 13
    • 52049086879 scopus 로고    scopus 로고
    • Structure and ligand interactions of the urokinase receptor (uPAR)
    • PMID:18508598
    • Kjaergaard M, Hansen LV, Jacobsen B, Gardsvoll H, Ploug M. Structure and ligand interactions of the urokinase receptor (uPAR). Front Biosci 2008; 13:5441-61; PMID:18508598; http://dx.doi.org/10.2741/3092
    • (2008) Front Biosci , vol.13 , pp. 5441-5461
    • Kjaergaard, M.1    Hansen, L.V.2    Jacobsen, B.3    Gardsvoll, H.4    Ploug, M.5
  • 14
    • 0027076170 scopus 로고
    • The urokinase receptor: Involvement in cell surface proteolysis and cancer invasion
    • PMID:1339241
    • Ellis V, Pyke C, Eriksen J, Solberg H, Danø K. The urokinase receptor: involvement in cell surface proteolysis and cancer invasion. Ann N Y Acad Sci 1992; 667:13-31; PMID:1339241; http://dx.doi.org/10.1111/j.1749-6632. 1992.tb51591.x
    • (1992) Ann N Y Acad Sci , vol.667 , pp. 13-31
    • Ellis, V.1    Pyke, C.2    Eriksen, J.3    Solberg, H.4    Danø, K.5
  • 16
    • 0036906177 scopus 로고    scopus 로고
    • uPAR: A versatile signalling orchestrator
    • PMID:12461559
    • Blasi F, Carmeliet P. uPAR: a versatile signalling orchestrator. Nat Rev Mol Cell Biol 2002; 3:932-43; PMID:12461559; http://dx.doi.org/10.1038/nrm977
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 932-943
    • Blasi, F.1    Carmeliet, P.2
  • 17
    • 72949116366 scopus 로고    scopus 로고
    • Regulation of cell signalling by uPAR
    • PMID:20027185
    • Smith HW, Marshall CJ. Regulation of cell signalling by uPAR. Nat Rev Mol Cell Biol 2010; 11:23-36; PMID:20027185; http://dx.doi.org/10.1038/nrm2821
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 23-36
    • Smith, H.W.1    Marshall, C.J.2
  • 18
    • 58149269633 scopus 로고    scopus 로고
    • The urokinase receptor and its structural homologue C4.4A in human cancer: Expression, prognosis and pharmacological inhibition
    • PMID:18855679
    • Jacobsen B, Ploug M. The urokinase receptor and its structural homologue C4.4A in human cancer: expression, prognosis and pharmacological inhibition. Curr Med Chem 2008; 15:2559-73; PMID:18855679; http://dx.doi.org/10.2174/ 092986708785909012
    • (2008) Curr Med Chem , vol.15 , pp. 2559-2573
    • Jacobsen, B.1    Ploug, M.2
  • 19
    • 52049092484 scopus 로고    scopus 로고
    • Intact and cleaved uPAR forms: Diagnostic and prognostic value in cancer
    • PMID:18508692
    • Rasch MG, Lund IK, Almasi CE, Hoyer-Hansen G. Intact and cleaved uPAR forms: diagnostic and prognostic value in cancer. Front Biosci 2008; 13:6752-62; PMID:18508692; http://dx.doi.org/10.2741/3186
    • (2008) Front Biosci , vol.13 , pp. 6752-6762
    • Rasch, M.G.1    Lund, I.K.2    Almasi, C.E.3    Hoyer-Hansen, G.4
  • 20
    • 84859992161 scopus 로고    scopus 로고
    • The JAK-STAT pathway at twenty
    • PMID:22520844
    • Stark GR, Darnell JE Jr. The JAK-STAT pathway at twenty. Immunity 2012; 36:503-14; PMID:22520844; http://dx.doi.org/10.1016/j.immuni.2012.03.013
    • (2012) Immunity , vol.36 , pp. 503-514
    • Stark, G.R.1    Darnell Jr., J.E.2
  • 21
    • 84862658179 scopus 로고    scopus 로고
    • The Jak/STAT pathway
    • PMID:22383755
    • Harrison DA. The Jak/STAT pathway. Cold Spring Harb Perspect Biol 2012; 4; PMID:22383755; http://dx.doi.org/10.1101/cshperspect.a011205
    • (2012) Cold Spring Harb Perspect Biol , vol.4
    • Harrison, D.A.1
  • 22
    • 80051672211 scopus 로고    scopus 로고
    • Systems biology of JAK-STAT signalling in human malignancies
    • PMID:21762720
    • Vera J, Rateitschak K, Lange F, Kossow C, Wolkenhauer O, Jaster R. Systems biology of JAK-STAT signalling in human malignancies. Prog Biophys Mol Biol 2011; 106:426-34; PMID:21762720; http://dx.doi.org/10.1016/j.pbiomolbio. 2011.06.013
    • (2011) Prog Biophys Mol Biol , vol.106 , pp. 426-434
    • Vera, J.1    Rateitschak, K.2    Lange, F.3    Kossow, C.4    Wolkenhauer, O.5    Jaster, R.6
  • 23
    • 0031983177 scopus 로고    scopus 로고
    • The Jak/Stat pathway and urokinase receptor signaling in human aortic vascular smooth muscle cells
    • PMID:9417082
    • Dumler I, Weis A, Mayboroda OA, Maasch C, Jerke U, Haller H, Gulba DC. The Jak/Stat pathway and urokinase receptor signaling in human aortic vascular smooth muscle cells. J Biol Chem 1998; 273:315-21; PMID:9417082; http://dx.doi.org/10.1074/jbc.273.1.315
    • (1998) J Biol Chem , vol.273 , pp. 315-321
    • Dumler, I.1    Weis, A.2    Mayboroda, O.A.3    Maasch, C.4    Jerke, U.5    Haller, H.6    Gulba, D.C.7
  • 24
    • 0030716909 scopus 로고    scopus 로고
    • Urokinase receptor is associated with the components of the JAK1/STAT1 signaling pathway and leads to activation of this pathway upon receptor clustering in the human kidney epithelial tumor cell line TCL-598
    • PMID:9353320
    • Koshelnick Y, Ehart M, Hufnagl P, Heinrich PC, Binder BR. Urokinase receptor is associated with the components of the JAK1/STAT1 signaling pathway and leads to activation of this pathway upon receptor clustering in the human kidney epithelial tumor cell line TCL-598. J Biol Chem 1997; 272:28563-7; PMID:9353320; http://dx.doi.org/10.1074/jbc.272.45.28563
    • (1997) J Biol Chem , vol.272 , pp. 28563-28567
    • Koshelnick, Y.1    Ehart, M.2    Hufnagl, P.3    Heinrich, P.C.4    Binder, B.R.5
  • 25
    • 0025882214 scopus 로고
    • An autocrine role for urokinase in phorbol ester-mediated differentiation of myeloid cell lines
    • PMID:1847936
    • Nusrat AR, Chapman HA Jr. An autocrine role for urokinase in phorbol ester-mediated differentiation of myeloid cell lines. J Clin Invest 1991; 87:1091-7; PMID:1847936; http://dx.doi.org/10.1172/JCI115070
    • (1991) J Clin Invest , vol.87 , pp. 1091-1097
    • Nusrat, A.R.1    Chapman Jr., H.A.2
  • 26
    • 0028569183 scopus 로고
    • Identification of the urokinase receptor as an adhesion receptor for vitronectin
    • PMID:7528215
    • Wei Y, Waltz DA, Rao N, Drummond RJ, Rosenberg S, Chapman HA. Identification of the urokinase receptor as an adhesion receptor for vitronectin. J Biol Chem 1994; 269:32380-8; PMID:7528215
    • (1994) J Biol Chem , vol.269 , pp. 32380-32388
    • Wei, Y.1    Waltz, D.A.2    Rao, N.3    Drummond, R.J.4    Rosenberg, S.5    Chapman, H.A.6
  • 27
    • 0035911966 scopus 로고    scopus 로고
    • Rac mediates cytoskeletal rearrangements and increased cell motility induced by urokinase-type plasminogen activator receptor binding to vitronectin
    • PMID:11257116
    • Kjøller L, Hall A. Rac mediates cytoskeletal rearrangements and increased cell motility induced by urokinase-type plasminogen activator receptor binding to vitronectin. J Cell Biol 2001; 152:1145-57; PMID:11257116; http://dx.doi.org/10.1083/jcb.152.6.1145
    • (2001) J Cell Biol , vol.152 , pp. 1145-1157
    • Kjøller, L.1    Hall, A.2
  • 28
    • 34249870363 scopus 로고    scopus 로고
    • uPAR-induced cell adhesion and migration: Vitronectin provides the key
    • PMID:17548516
    • Madsen CD, Ferraris GM, Andolfo A, Cunningham O, Sidenius N. uPAR-induced cell adhesion and migration: vitronectin provides the key. J Cell Biol 2007; 177:927-39; PMID:17548516; http://dx.doi.org/10.1083/jcb.200612058
    • (2007) J Cell Biol , vol.177 , pp. 927-939
    • Madsen, C.D.1    Ferraris, G.M.2    Andolfo, A.3    Cunningham, O.4    Sidenius, N.5
  • 29
    • 77951883821 scopus 로고    scopus 로고
    • The urokinase receptor: Focused cell surface proteolysis, cell adhesion and signaling
    • PMID:20036661
    • Blasi F, Sidenius N. The urokinase receptor: focused cell surface proteolysis, cell adhesion and signaling. FEBS Lett 2010; 584:1923-30; PMID:20036661; http://dx.doi.org/10.1016/j.febslet.2009.12.039
    • (2010) FEBS Lett , vol.584 , pp. 1923-1930
    • Blasi, F.1    Sidenius, N.2
  • 30
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • PMID:19945376
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009; 139:871-90; PMID:19945376; http://dx.doi.org/10.1016/j.cell.2009.11.007
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 31
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • PMID:19487818
    • Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 2009; 119:1420-8; PMID:19487818; http://dx.doi.org/10.1172/ JCI39104
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 32
    • 67650996754 scopus 로고    scopus 로고
    • Biomarkers for epithelial-mesenchymal transitions
    • PMID:19487819
    • Zeisberg M, Neilson EG. Biomarkers for epithelial-mesenchymal transitions. J Clin Invest 2009; 119:1429-37; PMID:19487819; http://dx.doi.org/10.1172/JCI36183
    • (2009) J Clin Invest , vol.119 , pp. 1429-1437
    • Zeisberg, M.1    Neilson, E.G.2
  • 33
    • 0033824172 scopus 로고    scopus 로고
    • Urokinase receptor and integrin partnership: Coordination of signaling for cell adhesion, migration and growth
    • PMID:10978898
    • Ossowski L, Aguirre-Ghiso JA. Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth. Curr Opin Cell Biol 2000; 12:613-20; PMID:10978898; http://dx.doi.org/10.1016/ S0955-0674(00)00140-X
    • (2000) Curr Opin Cell Biol , vol.12 , pp. 613-620
    • Ossowski, L.1    Aguirre-Ghiso, J.A.2
  • 34
    • 0036596352 scopus 로고    scopus 로고
    • EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma
    • PMID:12124174
    • Liu D, Aguirre Ghiso J, Estrada Y, Ossowski L. EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma. Cancer Cell 2002; 1:445-57; PMID:12124174; http://dx.doi.org/10.1016/S1535-6108(02)00072-7
    • (2002) Cancer Cell , vol.1 , pp. 445-457
    • Liu, D.1    Aguirre Ghiso, J.2    Estrada, Y.3    Ossowski, L.4
  • 35
    • 34548569983 scopus 로고    scopus 로고
    • Down-regulation of uPAR and uPA activates caspase-mediated apoptosis and inhibits the PI3K/AKT pathway
    • PMID:17549401
    • Gondi CS, Kandhukuri N, Dinh DH, Gujrati M, Rao JS. Down-regulation of uPAR and uPA activates caspase-mediated apoptosis and inhibits the PI3K/AKT pathway. Int J Oncol 2007; 31:19-27; PMID:17549401
    • (2007) Int J Oncol , vol.31 , pp. 19-27
    • Gondi, C.S.1    Kandhukuri, N.2    Dinh, D.H.3    Gujrati, M.4    Rao, J.S.5
  • 36
    • 34547610957 scopus 로고    scopus 로고
    • uPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells
    • PMID:17664334
    • Lester RD, Jo M, Montel V, Takimoto S, Gonias SL. uPAR induces epithelial-mesenchymal transition in hypoxic breast cancer cells. J Cell Biol 2007; 178:425-36; PMID:17664334; http://dx.doi.org/10.1083/jcb.200701092
    • (2007) J Cell Biol , vol.178 , pp. 425-436
    • Lester, R.D.1    Jo, M.2    Montel, V.3    Takimoto, S.4    Gonias, S.L.5
  • 37
    • 0034705424 scopus 로고    scopus 로고
    • Urokinase-type plasminogen activator stimulates the Ras/Extracellular signal-regulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requires focal adhesion kinase, Src, and Shc. Rapid dissociation of GRB2/Sps-Shc complex is associated with the transient phosphorylation of ERK in urokinase-treated cells
    • PMID:10777511
    • Nguyen DH, Webb DJ, Catling AD, Song Q, Dhakephalkar A, Weber MJ, Ravichandran KS, Gonias SL. Urokinase-type plasminogen activator stimulates the Ras/Extracellular signal-regulated kinase (ERK) signaling pathway and MCF-7 cell migration by a mechanism that requires focal adhesion kinase, Src, and Shc. Rapid dissociation of GRB2/Sps-Shc complex is associated with the transient phosphorylation of ERK in urokinase-treated cells. J Biol Chem 2000; 275:19382-8; PMID:10777511; http://dx.doi.org/10.1074/jbc.M909575199
    • (2000) J Biol Chem , vol.275 , pp. 19382-19388
    • Nguyen, D.H.1    Webb, D.J.2    Catling, A.D.3    Song, Q.4    Dhakephalkar, A.5    Weber, M.J.6    Ravichandran, K.S.7    Gonias, S.L.8
  • 38
    • 50249145697 scopus 로고    scopus 로고
    • uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180
    • PMID:18725541
    • Smith HW, Marra P, Marshall CJ. uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180. J Cell Biol 2008; 182:777-90; PMID:18725541; http://dx.doi.org/10.1083/jcb.200712050
    • (2008) J Cell Biol , vol.182 , pp. 777-790
    • Smith, H.W.1    Marra, P.2    Marshall, C.J.3
  • 39
    • 69249111313 scopus 로고    scopus 로고
    • Reversibility of epithelial-mesenchymal transition (EMT) induced in breast cancer cells by activation of urokinase receptor-dependent cell signaling
    • PMID:19546228
    • Jo M, Lester RD, Montel V, Eastman B, Takimoto S, Gonias SL. Reversibility of epithelial-mesenchymal transition (EMT) induced in breast cancer cells by activation of urokinase receptor-dependent cell signaling. J Biol Chem 2009; 284:22825-33; PMID:19546228; http://dx.doi.org/10.1074/jbc.M109. 023960
    • (2009) J Biol Chem , vol.284 , pp. 22825-22833
    • Jo, M.1    Lester, R.D.2    Montel, V.3    Eastman, B.4    Takimoto, S.5    Gonias, S.L.6
  • 40
    • 79952020999 scopus 로고    scopus 로고
    • Downregulation of uPA/uPAR inhibits intermittent hypoxia-induced epithelialmesenchymal transition (EMT) in DAOY and D283 medulloblastoma cells
    • PMID:21181094
    • Gupta R, Chetty C, Bhoopathi P, Lakka S, Mohanam S, Rao JS, Dinh DE. Downregulation of uPA/uPAR inhibits intermittent hypoxia-induced epithelialmesenchymal transition (EMT) in DAOY and D283 medulloblastoma cells. Int J Oncol 2011; 38:733-44; PMID:21181094
    • (2011) Int J Oncol , vol.38 , pp. 733-744
    • Gupta, R.1    Chetty, C.2    Bhoopathi, P.3    Lakka, S.4    Mohanam, S.5    Rao, J.S.6    Dinh, D.E.7
  • 41
    • 0034933664 scopus 로고    scopus 로고
    • The urokinase plasminogen activator receptor (uPAR) as a target for the diagnosis and therapy of cancer
    • PMID:11395568
    • Mazar AP. The urokinase plasminogen activator receptor (uPAR) as a target for the diagnosis and therapy of cancer. Anticancer Drugs 2001; 12:387-400; PMID:11395568; http://dx.doi.org/10.1097/00001813-200106000-00001
    • (2001) Anticancer Drugs , vol.12 , pp. 387-400
    • Mazar, A.P.1
  • 42
    • 0038364216 scopus 로고    scopus 로고
    • The urokinase plasminogen activator system in cancer: Recent advances and implication for prognosis and therapy
    • PMID:12784997
    • Sidenius N, Blasi F. The urokinase plasminogen activator system in cancer: recent advances and implication for prognosis and therapy. Cancer Metastasis Rev 2003; 22:205-22; PMID:12784997; http://dx.doi.org/10.1023/A: 1023099415940
    • (2003) Cancer Metastasis Rev , vol.22 , pp. 205-222
    • Sidenius, N.1    Blasi, F.2
  • 43
    • 34548414532 scopus 로고    scopus 로고
    • Targeting uPA/uPAR in prostate cancer
    • PMID:17658220
    • Li Y, Cozzi PJ. Targeting uPA/uPAR in prostate cancer. Cancer Treat Rev 2007; 33:521-7; PMID:17658220; http://dx.doi.org/10.1016/j.ctrv.2007.06.003
    • (2007) Cancer Treat Rev , vol.33 , pp. 521-527
    • Li, Y.1    Cozzi, P.J.2
  • 44
    • 84875048566 scopus 로고    scopus 로고
    • The urokinase plasminogen activating system in thyroid cancer: Clinical implications
    • PMID:23095556
    • Baldini E, Sorrenti S, D'Armiento E, Di Matteo FM, Catania A, Ulisse S. The urokinase plasminogen activating system in thyroid cancer: clinical implications. G Chir 2012; 33:305-10; PMID:23095556
    • (2012) G Chir , vol.33 , pp. 305-310
    • Baldini, E.1    Sorrenti, S.2    D'Armiento, E.3    Di Matteo, F.M.4    Catania, A.5    Ulisse, S.6
  • 45
    • 84875971261 scopus 로고    scopus 로고
    • Targeting uPAR with antagonistic recombinant human antibodies in aggressive breast cancer
    • PMID:23400595
    • LeBeau AM, Duriseti S, Murphy ST, Pepin F, Hann B, Gray JW, VanBrocklin HF, Craik CS. Targeting uPAR with antagonistic recombinant human antibodies in aggressive breast cancer. Cancer Res 2013; 73:2070-81; PMID:23400595; http://dx.doi.org/10.1158/0008-5472.CAN-12-3526
    • (2013) Cancer Res , vol.73 , pp. 2070-2081
    • LeBeau, A.M.1    Duriseti, S.2    Murphy, S.T.3    Pepin, F.4    Hann, B.5    Gray, J.W.6    VanBrocklin, H.F.7    Craik, C.S.8
  • 46
    • 33751275549 scopus 로고    scopus 로고
    • Preparing the "soil": The primary tumor induces vasculature reorganization in the sentinel lymph node before the arrival of metastatic cancer cells
    • PMID:17062557
    • Qian CN, Berghuis B, Tsarfaty G, Bruch M, Kort EJ, Ditlev J, Tsarfaty I, Hudson E, Jackson DG, Petillo D, et al. Preparing the "soil": the primary tumor induces vasculature reorganization in the sentinel lymph node before the arrival of metastatic cancer cells. Cancer Res 2006; 66:10365-76; PMID:17062557; http://dx.doi.org/10.1158/0008-5472.CAN-06-2977
    • (2006) Cancer Res , vol.66 , pp. 10365-10376
    • Qian, C.N.1    Berghuis, B.2    Tsarfaty, G.3    Bruch, M.4    Kort, E.J.5    Ditlev, J.6    Tsarfaty, I.7    Hudson, E.8    Jackson, D.G.9    Petillo, D.10
  • 47
    • 79954613658 scopus 로고    scopus 로고
    • Serglycin is a theranostic target in nasopharyngeal carcinoma that promotes metastasis
    • PMID:21289131
    • Li XJ, Ong CK, Cao Y, Xiang YQ, Shao JY, Ooi A, Peng LX, Lu WH, Zhang Z, Petillo D, et al. Serglycin is a theranostic target in nasopharyngeal carcinoma that promotes metastasis. Cancer Res 2011; 71:3162-72; PMID:21289131; http://dx.doi.org/10.1158/0008-5472.CAN-10-3557
    • (2011) Cancer Res , vol.71 , pp. 3162-3172
    • Li, X.J.1    Ong, C.K.2    Cao, Y.3    Xiang, Y.Q.4    Shao, J.Y.5    Ooi, A.6    Peng, L.X.7    Lu, W.H.8    Zhang, Z.9    Petillo, D.10
  • 48
    • 0036463895 scopus 로고    scopus 로고
    • Molecular mechanisms of tumorgenesis and metastasis in nasopharyngeal carcinoma cell sublines
    • PMID:12479066
    • Song LB, Yan J, Jian SW, Zhang L, Li MZ, Li D, Wang HM. [Molecular mechanisms of tumorgenesis and metastasis in nasopharyngeal carcinoma cell sublines]. Ai Zheng 2002; 21:158-62; PMID:12479066
    • (2002) Ai Zheng , vol.21 , pp. 158-162
    • Song, L.B.1    Yan, J.2    Jian, S.W.3    Zhang, L.4    Li, M.Z.5    Li, D.6    Wang, H.M.7
  • 49
    • 84865185941 scopus 로고    scopus 로고
    • As an independent unfavorable prognostic factor, IL-8 promotes metastasis of nasopharyngeal carcinoma through induction of epithelial-mesenchymal transition and activation of AKT signaling
    • PMID:22610073
    • Li XJ, Peng LX, Shao JY, Lu WH, Zhang JX, Chen S, Chen ZY, Xiang YQ, Bao YN, Zheng FJ, et al. As an independent unfavorable prognostic factor, IL-8 promotes metastasis of nasopharyngeal carcinoma through induction of epithelial-mesenchymal transition and activation of AKT signaling. Carcinogenesis 2012; 33:1302-9; PMID:22610073; http://dx.doi.org/10.1093/carcin/ bgs181
    • (2012) Carcinogenesis , vol.33 , pp. 1302-1309
    • Li, X.J.1    Peng, L.X.2    Shao, J.Y.3    Lu, W.H.4    Zhang, J.X.5    Chen, S.6    Chen, Z.Y.7    Xiang, Y.Q.8    Bao, Y.N.9    Zheng, F.J.10
  • 50
    • 77951192102 scopus 로고    scopus 로고
    • Stem-like cancer cells are inducible by increasing genomic instability in cancer cells
    • PMID:20007324
    • Liang Y, Zhong Z, Huang Y, Deng W, Cao J, Tsao G, Liu Q, Pei D, Kang T, Zeng YX. Stem-like cancer cells are inducible by increasing genomic instability in cancer cells. J Biol Chem 2010; 285:4931-40; PMID:20007324; http://dx.doi.org/10.1074/jbc.M109.048397
    • (2010) J Biol Chem , vol.285 , pp. 4931-4940
    • Liang, Y.1    Zhong, Z.2    Huang, Y.3    Deng, W.4    Cao, J.5    Tsao, G.6    Liu, Q.7    Pei, D.8    Kang, T.9    Zeng, Y.X.10
  • 51
    • 0024354304 scopus 로고
    • Determination of subcutaneous tumor size in athymic (nude) mice
    • PMID:2544306
    • Tomayko MM, Reynolds CP. Determination of subcutaneous tumor size in athymic (nude) mice. Cancer Chemother Pharmacol 1989; 24:148-54; PMID:2544306; http://dx.doi.org/10.1007/BF00300234
    • (1989) Cancer Chemother Pharmacol , vol.24 , pp. 148-154
    • Tomayko, M.M.1    Reynolds, C.P.2


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