KIR2DS4 promotes HIV-1 pathogenesis: New evidence from analyses of immunogenetic data and natural killer cell function

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Merino, Aimee M ^a,b   Dugast, Anne Sophie ^c   Wilson, Craig M ^d   Goepfert, Paul A ^a,b   Alter, Galit ^c   Kaslow, Richard A ^a,e   Tang, Jianming ^a,b  

^a University of Alabama at Birmingham   (United States)

^b University of Alabama at Birmingham   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^e DEPARTMENT OF VETERANS AFFAIRS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; HLA ANTIGEN; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; KIR2DS4 PROTEIN, HUMAN;

ADOLESCENT; ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; CELL SURFACE; CONTROLLED STUDY; CYTOKINE RELEASE; DEGRANULATION; FEMALE; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNOGENETICS; KIR2DS4 GENE; MAJOR CLINICAL STUDY; MALE; NATURAL KILLER CELL; OUTCOME ASSESSMENT; VIRUS GENE; VIRUS LOAD; VIRUS PATHOGENESIS; YOUNG ADULT; CD4+ T LYMPHOCYTE; CELL LINE; CHRONIC DISEASE; CROSS-SECTIONAL STUDY; CYTOLOGY; GENETICS; GENOTYPE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; LONGITUDINAL STUDY; METABOLISM; PATHOGENICITY; PATHOLOGY; STATISTICAL MODEL; VIROLOGY;

ADOLESCENT; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; CHRONIC DISEASE; CROSS-SECTIONAL STUDIES; FEMALE; GENOTYPE; HIV INFECTIONS; HIV-1; HLA ANTIGENS; HUMANS; KILLER CELLS, NATURAL; LINEAR MODELS; LONGITUDINAL STUDIES; MALE; RECEPTORS, KIR; VIRAL LOAD; YOUNG ADULT;

EID: 84902436694     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0099353     Document Type: Article

References (32)

1. Cooper MA, Colonna M, Yokoyama WM (2009) Hidden talents of natural killers: NK cells in innate and adaptive immunity. EMBO Rep 10: 1103-1110.
2. Alter G, Heckerman D, Schneidewind A, Fadda L, Kadie CM, et al. (2011) HIV-1 adaptation to NK-cell-mediated immune pressure. Nature 476: 96-100.
3. Alter G, Rihn S, Walter K, Nolting A, Martin M, et al. (2009) HLA class I subtype-dependent expansion of KIR3DS1+ and KIR3DL1 + NK cells during acute human immunodeficiency virus type 1 infection. J Virol 83: 6798-6805.
4. Alter G, Martin MP, Teigen N, Carr WH, Suscovich TJ, et al. (2007) Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes. J Exp Med 204: 3027-3036. (Pubitemid 350179568)
5. Merino A, Malhotra R, Morton M, Mulenga J, Allen S, et al. (2011) Impact of a functional KIR2DS4 allele on heterosexual HIV-1 transmission among discordant Zambian couples. J Infect Dis 203: 487-495.
6. Katz G, Markel G, Mizrahi S, Arnon TI, Mandelboim O (2001) Recognition of HLA-Cw4 but not HLA-Cw6 by the NK cell receptor killer cell Ig-like receptor two-domain short tail number 4. J Immunol 166: 7260-7267. (Pubitemid 32525600)
7. Christensen MD, Geisler C (2000) Recruitment of SHP-1 protein tyrosine phosphatase and signalling by a chimeric T-cell receptor-killer inhibitory receptor. Scand J Immunol 51: 557-564. (Pubitemid 30353364)
8. Chwae YJ, Chang MJ, Park SM, Yoon H, Park HJ, et al. (2002) Molecular mechanism of the activation-induced cell death inhibition mediated by a p70 inhibitory killer cell Ig-like receptor in Jurkat T cells. J Immunol 169: 3726-3735.
9. Biassoni R, Cantoni C, Falco M, Verdiani S, Bottino C, et al. (1996) The human leukocyte antigen (HLA)-C-specific "activatory" or "inhibitory" natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions. J Exp Med 183: 645-650.
10. Schellekens J, Rozemuller EH, Petersen EJ, van den Tweel JG, Verdonck LF, et al. (2008) Patients benefit from the addition of KIR repertoire data to the donor selection procedure for unrelated haematopoietic stem cell transplantation. Mol Immunol 45: 981-989. (Pubitemid 350016341)
11. Martin MP, Gao X, Lee JH, Nelson GW, Detels R, et al. (2002) Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat Genet 31: 429-434. (Pubitemid 35154456)
12. Long BR, Ndhlovu LC, Oksenberg JR, Lanier LL, Hecht FM, et al. (2008) Conferral of enhanced natural killer cell function by KIR3DS1 in early human immunodeficiency virus type 1 infection. J Virol 82: 4785-4792. (Pubitemid 351657040)
13. Maxwell LD, Wallace A, Middleton D, Curran MD (2002) A common KIR2DS4 deletion variant in the human that predicts a soluble KIR molecule analogous to the KIR1D molecule observed in the rhesus monkey. Tissue Antigens 60: 254-258. (Pubitemid 35398828)
14. Graef T, Moesta AK, Norman PJ, Abi-Rached L, Vago L, et al. (2009) KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C. J Exp Med 206: 2557-2572.
15. Long EO (1999) Regulation of immune responses through inhibitory receptors. Annu Rev Immunol 17: 875-904.
16. Cooper MA, Fehniger TA, Caligiuri MA (2001) The biology of human natural killer-cell subsets. Trends Immunol 22: 633-640. (Pubitemid 33043908)
17. Eller MA, Koehler RN, Kijak GH, Eller LA, Guwatudde D, et al. (2011) Human immunodeficiency virus type 1 infection is associated with increased NK cell polyfunctionality and higher levels of KIR3DL1+ NK cells in ugandans carrying the HLA-B Bw4 motif. J Virol 85: 4802-4811.
18. Kamya P, Boulet S, Tsoukas CM, Routy JP, Thomas R, et al. (2011) Receptorligand requirements for increased NK cell polyfunctional potential in slow progressors infected with HIV-1 coexpressing KIR3DL1*h/*y and HLA-B*57. J Virol 85: 5949-5960.
19. Naranbhai V, Abdool Karim SS, Altfeld M, Samsunder N, Durgiah R, et al. (2012) Innate immune activation enhances hiv acquisition in women, diminishing the effectiveness of tenofovir microbicide gel. J Infect Dis 206: 993-1001.
20. McErlean C, Gonzalez AA, Cunningham R, Meenagh A, Shovlin T, et al. (2010) Differential RNA expression of KIR alleles. Immunogenetics 62: 431-440.
21. Liu H, Ge N, Yu KT, Krolikowski D, Zilberstein A, et al. (2004) Prediction of IFN-gamma regulated gene transcription. In Silico Biol 4: 489-505. (Pubitemid 40372385)
22. Yao H, Bethel-Brown C, Li CZ, Buch SJ (2010) HIV neuropathogenesis: a tight rope walk of innate immunity. J Neuroimmune Pharmacol 5: 489-495.
23. Liovat AS, Rey-Cuille MA, Lecuroux C, Jacquelin B, Girault I, et al. (2012) Acute plasma biomarkers of T cell activation set-point levels and of disease progression in HIV-1 infection. PLoS One 7: e46143.
24. McGowan I, Elliott J, Fuerst M, Taing P, Boscardin J, et al. (2004) Increased HIV-1 mucosal replication is associated with generalized mucosal cytokine activation. J Acquir Immune Defic Syndr 37: 1228-1236. (Pubitemid 39281503)
25. Jiang Y, Zhou F, Tian Y, Zhang Z, Kuang R, et al. (2013) Higher NK cell IFN-gamma production is associated with delayed HIV disease progression in LTNPs. J Clin Immunol 33: 1376-1385.
26. Katz G, Gazit R, Arnon TI, Gonen-Gross T, Tarcic G, et al. (2004) MHC class I-independent recognition of NK-activating receptor KIR2DS4. J Immunol 173: 1819-1825. (Pubitemid 38971615)
27. Horowitz A, Strauss-Albee DM, Leipold M, Kubo J, Nemat-Gorgani N, et al. (2013) Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry. Sci Transl Med 5: 208ra145.
28. Wilson CM, Houser J, Partlow C, Rudy BJ, Futterman DC, et al. (2001) The REACH (Reaching for Excellence in Adolescent Care and Health) project: study design, methods, and population profile. J Adolesc Health 29: 8-18. (Pubitemid 32799155)
29. Shao W, Lazaryan A, Dorak MT, Penman-Aguilar A, Wilson CM, et al. (2006) Cohort- and time-specific associations of CTLA4 genotypes with HIV-1 disease progression. AIDS 20: 1583-1590. (Pubitemid 44162399)
30. Holland CA, Ellenberg JH, Wilson CM, Douglas SD, Futterman DC, et al. (2000) Relationship of CD4+ T cell counts and HIV type 1 viral loads in untreated, infected adolescents. Adolescent Medicine HIV/AIDS Research Network. AIDS Res Hum Retroviruses 16: 959-963. (Pubitemid 30436494)
31. + NK cells are activated mature NK cells with impaired effector function during HIV-1 infection. Retrovirology 10: 158.
32. Roederer M, Nozzi JL, Nason MC (2011) SPICE: exploration and analysis of post-cytometric complex multivariate datasets. Cytometry A 79: 167-174.