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Volumn 10, Issue 10, 2009, Pages 1103-1110

Hidden talents of natural killers: NK cells in innate and adaptive immunity

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 22;

EID: 70449703309     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2009.203     Document Type: Review
Times cited : (96)

References (74)
  • 1
    • 52649116495 scopus 로고    scopus 로고
    • Human natural killer cells exposed to IL-2, IL-12, IL-18, or IL-4 differently modulate priming of naive T cells by monocyte-derived dendritic cells
    • Agaugue S, Marcenaro E, Ferranti B, Moretta L, Moretta A (2008) Human natural killer cells exposed to IL-2, IL-12, IL-18, or IL-4 differently modulate priming of naive T cells by monocyte-derived dendritic cells. Blood 112: 1776-1783
    • (2008) Blood , vol.112 , pp. 1776-1783
    • Agaugue, S.1    Marcenaro, E.2    Ferranti, B.3    Moretta, L.4    Moretta, A.5
  • 3
    • 0037123607 scopus 로고    scopus 로고
    • Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors
    • Arase H, Mocarski ES, Campbell AE, Hill AB, Lanier LL (2002) Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors. Science 296:1 323-1326
    • (2002) Science , vol.296 , Issue.1 , pp. 323-1326
    • Arase, H.1    Mocarski, E.S.2    Campbell, A.E.3    Hill, A.B.4    Lanier, L.L.5
  • 4
    • 67349275024 scopus 로고    scopus 로고
    • IL-22: A critical mediator in mucosal host defense
    • Aujla SJ, Kolls JK (2009) IL-22: A critical mediator in mucosal host defense. J Mol Med 87: 451-454
    • (2009) J Mol Med , vol.87 , pp. 451-454
    • Aujla, S.J.1    Kolls, J.K.2
  • 5
    • 0024315206 scopus 로고
    • Severe herpesvirus infections in an adolescent without natural killer cells
    • Biron CA, Byron KS, Sullivan JL (1989) Severe herpesvirus infections in an adolescent without natural killer cells. N Engl J Med 320 1731-1735
    • (1989) N Engl J Med , vol.320 , pp. 1731-1735
    • Biron, C.A.1    Byron, K.S.2    Sullivan, J.L.3
  • 6
    • 0035424543 scopus 로고    scopus 로고
    • NK cells and NKT cells in innate defense against viral infections
    • Biron CA, Brossay L (2001) NK cells and NKT cells in innate defense against viral infections. Curr Opin Immunol 13: 458-464
    • (2001) Curr Opin Immunol , vol.13 , pp. 458-464
    • Biron, C.A.1    Brossay, L.2
  • 8
    • 45449115527 scopus 로고    scopus 로고
    • Line of attack: NK cell specificity and integration of signals
    • Bryceson YT, Long EO (2008) Line of attack: NK cell specificity and integration of signals. Curr Opin Immunol 20: 344-352
    • (2008) Curr Opin Immunol , vol.20 , pp. 344-352
    • Bryceson, Y.T.1    Long, E.O.2
  • 13
    • 33748500234 scopus 로고    scopus 로고
    • Hydrodynamic-based delivery of an interleukin-22-Ig fusion gene ameliorates experimental autoimmune myocarditis in rats
    • Chang H et al (2006) Hydrodynamic-based delivery of an interleukin-22-Ig fusion gene ameliorates experimental autoimmune myocarditis in rats. J Immunol 177: 3635-3643
    • (2006) J Immunol , vol.177 , pp. 3635-3643
    • Chang, H.1
  • 18
    • 0035796469 scopus 로고    scopus 로고
    • Murine cytomegalovirus is regulated by a discrete subset of natural killer cells reactive with monoclonal antibody to Ly49H
    • Daniels KA, Devora G, Lai WC, O'Donnell CL, Bennett M, Welsh RM (2001) Murine cytomegalovirus is regulated by a discrete subset of natural killer cells reactive with monoclonal antibody to Ly49H. J Exp Med 194:29-44
    • (2001) J Exp Med , vol.194 , pp. 29-44
    • Daniels, K.A.1    Devora, G.2    Lai, W.C.3    O'Donnell, C.L.4    Bennett, M.5    Welsh, R.M.6
  • 19
    • 42449116960 scopus 로고    scopus 로고
    • Natural killer cells: Diversity in search of a niche
    • Di Santo JP (2008) Natural killer cells: Diversity in search of a niche. Nat Immunol 9: 473-475
    • (2008) Nat Immunol , vol.9 , pp. 473-475
    • Di Santo, J.P.1
  • 21
    • 0037606040 scopus 로고    scopus 로고
    • bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: A potential new link between adaptive and innate immunity
    • bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: A potential new link between adaptive and innate immunity. Blood 101: 3052-3057
    • (2003) Blood , vol.101 , pp. 3052-3057
    • Fehniger, T.A.1    Cooper, M.A.2    Nuovo, G.J.3    Cella, M.4    Facchetti, F.5    Colonna, M.6    Caligiuri, M.A.7
  • 22
    • 1642444661 scopus 로고    scopus 로고
    • NK cell compartments and their activation by dendritic cells
    • Ferlazzo G, Munz C (2004) NK cell compartments and their activation by dendritic cells. J Immunol 172: 1333-1339
    • (2004) J Immunol , vol.172 , pp. 1333-1339
    • Ferlazzo, G.1    Munz, C.2
  • 23
    • 1642485249 scopus 로고    scopus 로고
    • The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic
    • Ferlazzo G, Thomas D, Lin SL, Goodman K, Morandi B, Muller WA, Moretta A, Munz C (2004) The abundant NK cells in human secondary lymphoid tissues require activation to express killer cell Ig-like receptors and become cytolytic. J Immunol 172: 1455-1462
    • (2004) J Immunol , vol.172 , pp. 1455-1462
    • Ferlazzo, G.1    Thomas, D.2    Lin, S.L.3    Goodman, K.4    Morandi, B.5    Muller, W.A.6    Moretta, A.7    Munz, C.8
  • 24
    • 20144371569 scopus 로고    scopus 로고
    • bright natural killer cells
    • bright natural killer cells. Immunity 22: 295-304
    • (2005) Immunity , vol.22 , pp. 295-304
    • Freud, A.G.1
  • 25
    • 33750686595 scopus 로고    scopus 로고
    • Human natural killer cell development
    • Freud AG, Caligiuri MA (2006) Human natural killer cell development. Immunol Rev 214: 56-72
    • (2006) Immunol Rev , vol.214 , pp. 56-72
    • Freud, A.G.1    Caligiuri, M.A.2
  • 28
    • 31144449386 scopus 로고    scopus 로고
    • CD27 dissects mature NK cells into two subsets with distinct responsiveness and migratory capacity
    • Hayakawa Y, Smyth MJ (2006) CD27 dissects mature NK cells into two subsets with distinct responsiveness and migratory capacity. J Immunol 176: 1517-1524
    • (2006) J Immunol , vol.176 , pp. 1517-1524
    • Hayakawa, Y.1    Smyth, M.J.2
  • 29
    • 63149141854 scopus 로고    scopus 로고
    • Stage 3 immature human natural killer cells found in secondary lymphoid tissue constitutively and selectively express the TH17 cytokine interleukin-22
    • Hughes T, Becknell B, McClory S, Briercheck E, Freud AG, Zhang X, Mao H, Nuovo G, Yu J, Caligiuri MA (2009) Stage 3 immature human natural killer cells found in secondary lymphoid tissue constitutively and selectively express the TH17 cytokine interleukin-22. Blood 113: 4008-4010
    • (2009) Blood , vol.113 , pp. 4008-4010
    • Hughes, T.1    Becknell, B.2    McClory, S.3    Briercheck, E.4    Freud, A.G.5    Zhang, X.6    Mao, H.7    Nuovo, G.8    Yu, J.9    Caligiuri, M.A.10
  • 30
    • 34548201160 scopus 로고    scopus 로고
    • Developmental pathways that generate natural-killer-cell diversity in mice and humans
    • Huntington ND, Vosshenrich CA, Di Santo JP (2007) Developmental pathways that generate natural-killer-cell diversity in mice and humans. Nat Rev Immunol 7: 703-714
    • (2007) Nat Rev Immunol , vol.7 , pp. 703-714
    • Huntington, N.D.1    Vosshenrich, C.A.2    Di Santo, J.P.3
  • 31
    • 55149113836 scopus 로고    scopus 로고
    • The roles of IL-17A in inflammatory immune responses and host defense against pathogens
    • Iwakura Y, Nakae S, Saijo S, Ishigame H (2008) The roles of IL-17A in inflammatory immune responses and host defense against pathogens. Immunol Rev 226: 57-79
    • (2008) Immunol Rev , vol.226 , pp. 57-79
    • Iwakura, Y.1    Nakae, S.2    Saijo, S.3    Ishigame, H.4
  • 32
    • 1642577125 scopus 로고    scopus 로고
    • Turnover and proliferation of NK cells in steady state and lymphopenic conditions
    • Jamieson AM, Isnard P, Dorfman JR, Coles MC, Raulet DH (2004) Turnover and proliferation of NK cells in steady state and lymphopenic conditions. J Immunol 172: 864-870
    • (2004) J Immunol , vol.172 , pp. 864-870
    • Jamieson, A.M.1    Isnard, P.2    Dorfman, J.R.3    Coles, M.C.4    Raulet, D.H.5
  • 34
    • 60449110935 scopus 로고    scopus 로고
    • Natural killer cell tolerance licensing and other mechanisms
    • Jonsson AH, Yokoyama WM (2009) Natural killer cell tolerance licensing and other mechanisms. Adv Immunol 101: 27-79
    • (2009) Adv Immunol , vol.101 , pp. 27-79
    • Jonsson, A.H.1    Yokoyama, W.M.2
  • 35
    • 23644458333 scopus 로고    scopus 로고
    • Licensing of natural killer cells by host major histocompatibility complex class I molecules
    • Kim S et al (2005) Licensing of natural killer cells by host major histocompatibility complex class I molecules. Nature 436: 709-713
    • (2005) Nature , vol.436 , pp. 709-713
    • Kim, S.1
  • 36
    • 0037460058 scopus 로고    scopus 로고
    • Interleukin (IL)-15Rα-deficient natural killer cells survive in normal but not IL-15Rα-deficient mice
    • Koka R, Burkett PR, Chien M, Chai S, Chan F, Lodolce JP, Boone DL, Ma A (2003) Interleukin (IL)-15Rα-deficient natural killer cells survive in normal but not IL-15Rα-deficient mice. J Exp Med 197: 977-984
    • (2003) J Exp Med , vol.197 , pp. 977-984
    • Koka, R.1    Burkett, P.R.2    Chien, M.3    Chai, S.4    Chan, F.5    Lodolce, J.P.6    Boone, D.L.7    Ma, A.8
  • 37
    • 65649141586 scopus 로고    scopus 로고
    • Pathogen recognition in the innate immune response
    • Kumar H, Kawai T, Akira S (2009) Pathogen recognition in the innate immune response. Biochem J 420: 1-16
    • (2009) Biochem J , vol.420 , pp. 1-16
    • Kumar, H.1    Kawai, T.2    Akira, S.3
  • 38
    • 0042322879 scopus 로고    scopus 로고
    • Innate defence: Evidence for memory in invertebrate immunity
    • Kurtz J, Franz K (2003) Innate defence: Evidence for memory in invertebrate immunity. Nature 425: 37-38
    • (2003) Nature , vol.425 , pp. 37-38
    • Kurtz, J.1    Franz, K.2
  • 39
    • 0035031191 scopus 로고    scopus 로고
    • Susceptibility to mouse cytomegalovirus is associated with deletion of an activating natural killer cell receptor of the C-type lectin superfamily
    • Lee SH, Girard S, Macina D, Busa M, Zafer A, Belouchi A, Gros P, Vidal SM (2001) Susceptibility to mouse cytomegalovirus is associated with deletion of an activating natural killer cell receptor of the C-type lectin superfamily. Nat Genet 28: 42-45
    • (2001) Nat Genet , vol.28 , pp. 42-45
    • Lee, S.H.1    Girard, S.2    Macina, D.3    Busa, M.4    Zafer, A.5    Belouchi, A.6    Gros, P.7    Vidal, S.M.8
  • 40
    • 33749318470 scopus 로고    scopus 로고
    • Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
    • Liang SC, Tan XY, Luxenberg DP, Karim R, Dunussi-Joannopoulos K, Collins M, Fouser LA (2006) Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 203: 2271-2279
    • (2006) J Exp Med , vol.203 , pp. 2271-2279
    • Liang, S.C.1    Tan, X.Y.2    Luxenberg, D.P.3    Karim, R.4    Dunussi-Joannopoulos, K.5    Collins, M.6    Fouser, L.A.7
  • 41
    • 33745401218 scopus 로고    scopus 로고
    • Natural killer cells as an initial defense against pathogens
    • Lodoen MB, Lanier LL (2006) Natural killer cells as an initial defense against pathogens. Curr Opin Immunol 18: 391-398
    • (2006) Curr Opin Immunol , vol.18 , pp. 391-398
    • Lodoen, M.B.1    Lanier, L.L.2
  • 42
    • 57849145994 scopus 로고    scopus 로고
    • Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin
    • Luci C et al (2009) Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin. Nat Immunol 10: 75-82
    • (2009) Nat Immunol , vol.10 , pp. 75-82
    • Luci, C.1
  • 45
    • 33748865886 scopus 로고    scopus 로고
    • NK cells of human secondary lymphoid tissues enhance T cell polarization via IFN-gamma secretion
    • Morandi B, Bougras G, Muller WA, Ferlazzo G, Munz C (2006) NK cells of human secondary lymphoid tissues enhance T cell polarization via IFN-gamma secretion. Eur J Immunol 36: 2394-2400
    • (2006) Eur J Immunol , vol.36 , pp. 2394-2400
    • Morandi, B.1    Bougras, G.2    Muller, W.A.3    Ferlazzo, G.4    Munz, C.5
  • 49
    • 33645989497 scopus 로고    scopus 로고
    • T cell- and B cell-independent adaptive immunity mediated by natural killer cells
    • O'Leary JG, Goodarzi M, Drayton DL, von Andrian UH (2006) T cell- and B cell-independent adaptive immunity mediated by natural killer cells. Nat Immunol 7: 507-516
    • (2006) Nat Immunol , vol.7 , pp. 507-516
    • O'Leary, J.G.1    Goodarzi, M.2    Drayton, D.L.3    von Andrian, U.H.4
  • 50
    • 41549135632 scopus 로고    scopus 로고
    • The biological functions of T helper 17 cell effector cytokines in inflammation
    • Ouyang W, Kolls JK, Zheng Y (2008) The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 28: 454-467
    • (2008) Immunity , vol.28 , pp. 454-467
    • Ouyang, W.1    Kolls, J.K.2    Zheng, Y.3
  • 51
    • 2342462460 scopus 로고    scopus 로고
    • Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation
    • Radaeva S, Sun R, Pan HN, Hong F, Gao B (2004) Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology 39: 1332-1342
    • (2004) Hepatology , vol.39 , pp. 1332-1342
    • Radaeva, S.1    Sun, R.2    Pan, H.N.3    Hong, F.4    Gao, B.5
  • 52
    • 64349091538 scopus 로고    scopus 로고
    • Natural killer cells: Remembrances of things past
    • Raulet DH (2009) Natural killer cells: Remembrances of things past. Curr Biol 19: R294-296
    • (2009) Curr Biol , vol.19
    • Raulet, D.H.1
  • 53
    • 33745567831 scopus 로고    scopus 로고
    • Self-tolerance of natural killer cells
    • Raulet DH, Vance RE (2006) Self-tolerance of natural killer cells. Nat Rev Immunol 6: 520-531
    • (2006) Nat Rev Immunol , vol.6 , pp. 520-531
    • Raulet, D.H.1    Vance, R.E.2
  • 54
    • 42149101137 scopus 로고    scopus 로고
    • NK cell tolerance and the maternal-fetal interface
    • Riley JK, Yokoyama WM (2008) NK cell tolerance and the maternal-fetal interface. Am J Reprod Immunol 59: 371-387
    • (2008) Am J Reprod Immunol , vol.59 , pp. 371-387
    • Riley, J.K.1    Yokoyama, W.M.2
  • 55
    • 34247150402 scopus 로고    scopus 로고
    • dim NK cells upon activation
    • dim NK cells upon activation. J Immunol 178: 4947-4955
    • (2007) J Immunol , vol.178 , pp. 4947-4955
    • Romagnani, C.1
  • 56
  • 57
    • 57849117363 scopus 로고    scopus 로고
    • RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells
    • Sanos SL, Bui VL, Mortha A, Oberle K, Heners C, Johner C, Diefenbach A (2009) RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells. Nat Immunol 10: 83-91
    • (2009) Nat Immunol , vol.10 , pp. 83-91
    • Sanos, S.L.1    Bui, V.L.2    Mortha, A.3    Oberle, K.4    Heners, C.5    Johner, C.6    Diefenbach, A.7
  • 58
    • 57449118239 scopus 로고    scopus 로고
    • Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense
    • Satoh-Takayama N et al (2008) Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. Immunity 29: 958-970
    • (2008) Immunity , vol.29 , pp. 958-970
    • Satoh-Takayama, N.1
  • 59
    • 0037172968 scopus 로고    scopus 로고
    • Recognition of a virus-encoded ligand by a natural killer cell activation receptor
    • Smith HR et al (2002) Recognition of a virus-encoded ligand by a natural killer cell activation receptor. Proc Natl Acad Sci USA 99: 8826-8831
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 8826-8831
    • Smith, H.R.1
  • 60
    • 0029024613 scopus 로고
    • Development of human T and natural killer cells
    • Spits H, Lanier LL, Phillips JH (1995) Development of human T and natural killer cells. Blood 85: 2654-2670
    • (1995) Blood , vol.85 , pp. 2654-2670
    • Spits, H.1    Lanier, L.L.2    Phillips, J.H.3
  • 61
    • 34250654922 scopus 로고    scopus 로고
    • Germ-line and rearranged Tcrd transcription distinguish bona fide NK cells and NK-like gammadelta T cells
    • Stewart CA, Walzer T, Robbins SH, Malissen B, Vivier E, Prinz I (2007) Germ-line and rearranged Tcrd transcription distinguish bona fide NK cells and NK-like gammadelta T cells. Eur J Immunol 37: 1442-1452
    • (2007) Eur J Immunol , vol.37 , pp. 1442-1452
    • Stewart, C.A.1    Walzer, T.2    Robbins, S.H.3    Malissen, B.4    Vivier, E.5    Prinz, I.6
  • 63
    • 46849090674 scopus 로고    scopus 로고
    • Noncytotoxic functions of NK cells: Direct pathogen restriction and assistance to adaptive immunity
    • Strowig T, Brilot F, Munz C (2008b) Noncytotoxic functions of NK cells: direct pathogen restriction and assistance to adaptive immunity. J Immunol 180: 7785-7791
    • (2008) J Immunol , vol.180 , pp. 7785-7791
    • Strowig, T.1    Brilot, F.2    Munz, C.3
  • 64
    • 59049094662 scopus 로고    scopus 로고
    • Adaptive immune features of natural killer cells
    • Sun JC, Beilke JN, Lanier LL (2009) Adaptive immune features of natural killer cells. Nature 457: 557-561
    • (2009) Nature , vol.457 , pp. 557-561
    • Sun, J.C.1    Beilke, J.N.2    Lanier, L.L.3
  • 65
    • 60549102720 scopus 로고    scopus 로고
    • Takatori H, Kanno Y, Watford WT, Tato CM, Weiss G, Ivanov II, Littman DR, O'Shea JJ (2009) Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J Exp Med 206: 35-41
    • Takatori H, Kanno Y, Watford WT, Tato CM, Weiss G, Ivanov II, Littman DR, O'Shea JJ (2009) Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J Exp Med 206: 35-41
  • 66
    • 0035894946 scopus 로고    scopus 로고
    • Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-gamma-dependent suppression of subcutaneous tumor growth
    • Takeda K, Smyth MJ, Cretney E, Hayakawa Y, Yamaguchi N, Yagita H, Okumura K (2001) Involvement of tumor necrosis factor-related apoptosis-inducing ligand in NK cell-mediated and IFN-gamma-dependent suppression of subcutaneous tumor growth. Cell Immunol 214: 194-200
    • (2001) Cell Immunol , vol.214 , pp. 194-200
    • Takeda, K.1    Smyth, M.J.2    Cretney, E.3    Hayakawa, Y.4    Yamaguchi, N.5    Yagita, H.6    Okumura, K.7
  • 67
    • 33750121077 scopus 로고    scopus 로고
    • A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127
    • Vosshenrich CA et al (2006) A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127. Nat Immunol 7: 1217-1224
    • (2006) Nat Immunol , vol.7 , pp. 1217-1224
    • Vosshenrich, C.A.1
  • 69
    • 33645990656 scopus 로고    scopus 로고
    • Contact hypersensitivity: Not just T cells!
    • Yokoyama WM (2006) Contact hypersensitivity: Not just T cells! Nat Immunol 7: 437-439
    • (2006) Nat Immunol , vol.7 , pp. 437-439
    • Yokoyama, W.M.1
  • 70
    • 42449106480 scopus 로고    scopus 로고
    • Mistaken notions about natural killer cells
    • Yokoyama WM (2008) Mistaken notions about natural killer cells. Nat Immunol 9: 481-485
    • (2008) Nat Immunol , vol.9 , pp. 481-485
    • Yokoyama, W.M.1
  • 71
    • 35348983341 scopus 로고    scopus 로고
    • Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation
    • Zenewicz LA, Yancopoulos GD, Valenzuela DM, Murphy AJ, Karow M, Flavell RA (2007) Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity 27: 647-659
    • (2007) Immunity , vol.27 , pp. 647-659
    • Zenewicz, L.A.1    Yancopoulos, G.D.2    Valenzuela, D.M.3    Murphy, A.J.4    Karow, M.5    Flavell, R.A.6
  • 72
    • 59749095603 scopus 로고    scopus 로고
    • IL-22 and inflammation: Leukin' through a glass onion
    • Zenewicz LA, Flavell RA (2008) IL-22 and inflammation: Leukin' through a glass onion. Eur J Immunol 38: 3265-3268
    • (2008) Eur J Immunol , vol.38 , pp. 3265-3268
    • Zenewicz, L.A.1    Flavell, R.A.2
  • 74
    • 40049083827 scopus 로고    scopus 로고
    • Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
    • Zheng Y et al (2008) Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med 14 282-289
    • (2008) Nat Med , vol.14 , pp. 282-289
    • Zheng, Y.1


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