Fcγ Receptor Polymorphisms and Susceptibility to Infection

Antibody Fc: Linking Adaptive and Innate Immunity

Volumn , Issue , 2013, Pages 217-237

  Clatworthy, Menna R ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Fc receptors; Malaria; Polymorphisms; Selection pressure; Sepsis; Streptococcus pneumoniae

Indexed keywords

EID: 84902432252     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-394802-1.00012-1     Document Type: Chapter

References (135)

1. Ballow M Primary immunodeficiency disorders: antibody deficiency. J Allergy Clin Immunol 2002, 109(4):581-591.
2. Guevara Patino JA, Holder AA, McBride JS, Blackman MJ Antibodies that inhibit malaria merozoite surface protein-1 processing and erythrocyte invasion are blocked by naturally acquired human antibodies. J Exp Med 1997, 186(10):1689-1699.
3. Ravetch JV, Clynes RA Divergent roles for Fc receptors and complement in vivo. Annu Rev Immunol 1998, 16:421-432.
4. Ravetch JV, Bolland S IgG Fc receptors. Annu Rev Immunol 2001, 19:275-290.
5. Smith KG, Clatworthy MR FcγRIIB in autoimmunity and infection: evolutionary and therapeutic implications. Nat Rev Immunol 2010, 10(5):328-343.
6. Nimmerjahn F, Ravetch JV Fcγ receptors: old friends and new family members. Immunity 2006, 24(1):19-28.
7. Warmerdam PA, Nabben NM, van de Graaf SA, van de Winkel JG, Capel PJ The human low affinity immunoglobulin G Fc receptor IIC gene is a result of an unequal crossover event. J Biol Chem 1993, 268(10):7346-7349.
8. Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination. Science 1990, 248(4956):732-735.
9. Hughes AL Gene duplication and recombination in the evolution of mammalian Fc receptors. J Mol Evol 1996, 43(1):4-10.
10. Traherne JA, Martin M, Ward R, Ohashi M, Pellett F, Gladman D, et al. Mechanisms of copy number variation and hybrid gene formation in the KIR immune gene complex. Hum Mol Genet 2009, 19(5):737-751.
11. Ravetch JV, Kinet JP Fc receptors. Annu Rev Immunol 1991, 9:457-492.
12. Galon J, Gauchat JF, Mazieres N, Spagnoli R, Storkus W, Lotze M, et al. Soluble Fcgamma receptor type III (FcgammaRIII, CD16) triggers cell activation through interaction with complement receptors. J Immunol 1996, 157(3):1184-1192.
13. Chuang FY, Sassaroli M, Unkeless JC Convergence of Fcγ receptor IIA and Fcγ receptor IIIB signaling pathways in human neutrophils. J Immunol 2000, 164(1):350-360.
14. Fernandes MJ, Rollet-Labelle E, Pare G, Marois S, Tremblay ML, Teillaud JL, et al. CD16b associates with high-density, detergent-resistant membranes in human neutrophils. Biochem J 2006, 393(Pt. 1):351-359.
15. Nimmerjahn F, Ravetch JV Fcgamma receptors as regulators of immune responses. Nat Rev Immunol 2008, 8(1):34-47.
16. Radaev S, Motyka S, Fridman WH, Sautes-Fridman C, Sun PD The structure of a human type III Fcgamma receptor in complex with Fc. J Biol Chem 2001, 276(19):16469-16477.
17. Ferrara C, Stuart F, Sondermann P, Brunker P, Umana P The carbohydrate at FcgammaRIIIa Asn-162. An element required for high affinity binding to non-fucosylated IgG glycoforms. J Biol Chem 2006, 281(8):5032-5036.
18. Lux A, Nimmerjahn F. Impact of differential glycosylation on IgG activity. Adv Exp Med Biol. 780: 113-124.
19. Bharadwaj D, Mold C, Markham E, Du Clos TW Serum amyloid P component binds to Fc gamma receptors and opsonizes particles for phagocytosis. J Immunol 2001, 166(11):6735-6741.
20. Bharadwaj D, Stein MP, Volzer M, Mold C, Du Clos TW The major receptor for C-reactive protein on leukocytes is Fcgamma receptor II. J Exp Med 1999, 190(4):585-590.
21. Lu J, Marnell LL, Marjon KD, Mold C, Du Clos TW, Sun PD Structural recognition and functional activation of FcgammaR by innate pentraxins. Nature 2008, 456(7224):989-992.
22. Nimmerjahn F, Ravetch JV Divergent immunoglobulin g subclass activity through selective Fc receptor binding. Science 2005, 310(5753):1510-1512.
23. Pricop L, Redecha P, Teillaud JL, Frey J, Fridman WH, Sautes-Fridman C, et al. Differential modulation of stimulatory and inhibitory Fcγ receptors on human monocytes by Th1 and Th2 cytokines. J Immunol 2001, 166(1):531-537.
24. Grattage LP, McKenzie IF, Hogarth PM Effects of PMA, cytokines and dexamethasone on the expression of cell surface Fc receptors and mRNA in U937 cells. Immunol Cell Biol 1992, 70(Pt. 2):97-105.
25. van de Winkel JG, Capel PJ Human IgG Fc receptor heterogeneity: molecular aspects and clinical implications. Immunol Today 1993, 14(5):215-221.
26. Parren PW, Warmerdam PA, Boeije LC, Arts J, Westerdaal NA, Vlug A, et al. On the interaction of IgG subclasses with the low affinity Fc gamma RIIa (CD32) on human monocytes, neutrophils, and platelets. Analysis of a functional polymorphism to human IgG2. J Clin Invest 1992, 90(4):1537-1546.
27. Stein MP, Edberg JC, Kimberly RP, Mangan EK, Bharadwaj D, Mold C, et al. C-reactive protein binding to FcgammaRIIa on human monocytes and neutrophils is allele-specific. J Clin Invest 2000, 105(3):369-376.
28. Lehrnbecher T, Foster CB, Zhu S, Leitman SF, Goldin LR, Huppi K, et al. Variant genotypes of the low-affinity Fcγ receptors in two control populations and a review of low-affinity Fcγ receptor polymorphisms in control and disease populations. Blood 1999, 94(12):4220-4232.
29. Kuwano ST, Bordin JO, Chiba AK, Mello AB, Figueiredo MS, Vieira-Filho JP, et al. Allelic polymorphisms of human Fcgamma receptor IIa and Fcgamma receptor IIIB among distinct groups in Brazil. Transfusion 2000, 40(11):1388-1392.
30. Ravetch JV, Perussia B Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions. J Exp Med 1989, 170(2):481-497.
31. Wu J, Edberg JC, Redecha PB, Bansal V, Guyre PM, Coleman K, et al. A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease. J Clin Invest 1997, 100(5):1059-1070.
32. Chu ZT, Tsuchiya N, Kyogoku C, Ohashi J, Qian YP, Xu SB, et al. Association of Fcgamma receptor IIB polymorphism with susceptibility to systemic lupus erythematosus in Chinese: a common susceptibility gene in the Asian populations. Tissue Antigens 2004, 63(1):21-27.
33. Huizinga TW, de Haas M, van Oers MH, Kleijer M, Vile H, van der Wouw PA, et al. The plasma concentration of soluble Fc-gamma RIII is related to production of neutrophils. Br J Haematol 1994, 87(3):459-463.
34. Bux J, Stein EL, Bierling P, Fromont P, Clay M, Stroncek D, et al. Characterization of a new alloantigen (SH) on the human neutrophil Fcγ receptor IIIB. Blood 1997, 89(3):1027-1034.
35. Salmon JE, Millard SS, Brogle NL, Kimberly RP Fc gamma receptor IIIB enhances Fc gamma receptor IIa function in an oxidant-dependent and allele-sensitive manner. J Clin Invest 1995, 95(6):2877-2885.
36. Kyogoku C, Dijstelbloem HM, Tsuchiya N, Hatta Y, Kato H, Yamaguchi A, et al. Fcgamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibility. Arthritis Rheum 2002, 46(5):1242-1254.
37. Willcocks LC, Carr EJ, Niederer HA, Rayner TF, Williams TN, Yang W, et al. A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus. Proc Natl Acad Sci USA 2010, 107(17):7881-7885.
38. Floto RA, Clatworthy MR, Heilbronn KR, Rosner DR, MacAry PA, Rankin A, et al. Loss of function of a lupus-associated FcgammaRIIB polymorphism through exclusion from lipid rafts. Nat Med 2005, 11(10):1056-1058.
39. Kono H, Kyogoku C, Suzuki T, Tsuchiya N, Honda H, Yamamoto K, et al. FcγRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling. Hum Mol Genet 2005, 14(19):2881-2892.
40. Clatworthy MR, Willcocks L, Urban B, Langhorne J, Williams TN, Peshu N, et al. Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIB reduce susceptibility to malaria. Proc Natl Acad Sci USA 2007, 104(17):7169-7174.
41. Chen JY, Wang CM, Ma CC, Luo SF, Edberg JC, Kimberly RP, et al. Association of a transmembrane polymorphism of Fcgamma receptor IIB (FCGR2B) with systemic lupus erythematosus in Taiwanese patients. Arthritis Rheum 2006, 54(12):3908-3917.
42. Siriboonrit U, Tsuchiya N, Sirikong M, Kyogoku C, Bejrachandra S, Suthipinittharm P, et al. Association of Fcgamma receptor IIB and IIIB polymorphisms with susceptibility to systemic lupus erythematosus in Thais. Tissue Antigens 2003, 61(5):374-383.
43. Su K, Wu J, Edberg JC, Li X, Ferguson P, Cooper GS, et al. A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIB alters receptor expression and associates with autoimmunity. I. Regulatory FCGR2B polymorphisms and their association with systemic lupus erythematosus. J Immunol 2004, 172(11):7186-7191.
44. Su K, Yang H, Li X, Gibson AW, Cafardi JM, Zhou T, et al. Expression profile of FcgammaRIIB on leukocytes and its dysregulation in systemic lupus erythematosus. J Immunol 2007, 178(5):3272-3280.
45. Blank MC, Stefanescu RN, Masuda E, Marti F, King PD, Redecha PB, et al. Decreased transcription of the human FCGR2B gene mediated by the 343 G/C promoter polymorphism and association with systemic lupus erythematosus. Hum Genet 2005, 117(2-3):220-227.
46. Estivill X, Armengol L Copy number variants and common disorders: filling the gaps and exploring complexity in genome-wide association studies. PLoS Genet 2007, 3(10):1787-1799.
47. Briles DE, Nahm M, Schroer K, Davie J, Baker P, Kearney J, et al. Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 Streptococcus pneumoniae. J Exp Med 1981, 153(3):694-705.
48. Mold C, Rodic-Polic B, Du Clos TW Protection from Streptococcus pneumoniae infection by C-reactive protein and natural antibody requires complement but not Fc gamma receptors. J Immunol 2002, 168(12):6375-6381.
49. Rodriguez ME, van der Pol WL, Sanders LA, van de Winkel JG Crucial role of FcgammaRIIa (CD32) in assessment of functional anti-Streptococcus pneumoniae antibody activity in human sera. J Infect Dis 1999, 179(2):423-433.
50. Yee AM, Ng SC, Sobel RE, Salmon JE Fc gammaRIIA polymorphism as a risk factor for invasive pneumococcal infections in systemic lupus erythematosus. Arthritis Rheum 1997, 40(6):1180-1182.
51. Yee AM, Phan HM, Zuniga R, Salmon JE, Musher DM Association between FcgammaRIIa-R131 allotype and bacteremic pneumococcal pneumonia. Clin Infect Dis 2000, 30(1):25-28.
52. Yuan FF, Wong M, Pererva N, Keating J, Davis AR, Bryant JA, et al. FcgammaRIIA polymorphisms in Streptococcus pneumoniae infection. Immunol Cell Biol 2003, 81(3):192-195.
53. Moens L, Van Hoeyveld E, Verhaegen J, De Boeck K, Peetermans WE, Bossuyt X Fcgamma-receptor IIA genotype and invasive pneumococcal infection. Clin Immunol 2006, 118(1):20-23.
54. Yuan FF, Marks K, Wong M, Watson S, de Leon E, McIntyre PB, et al. Clinical relevance of TLR2, TLR4, CD14 and FcgammaRIIA gene polymorphisms in Streptococcus pneumoniae infection. Immunol Cell Biol 2008, 86(3):268-270.
55. Endeman H, Cornips MC, Grutters JC, van den Bosch JM, Ruven HJ, van Velzen-Blad H, et al. The Fcγ receptor IIA-R/R131 genotype is associated with severe sepsis in community-acquired pneumonia. Clin Vaccine Immunol 2009, 16(7):1087-1090.
56. Sole-Violan J, Garcia-Laorden MI, Marcos-Ramos JA, de Castro FR, Rajas O, Borderias L, et al. The Fcγ receptor IIA-H/H131 genotype is associated with bacteremia in pneumococcal community-acquired pneumonia. Crit Care Med 2011, 39(6):1388-1393.
57. Eklund C, Huttunen R, Syrjanen J, Laine J, Vuento R, Hurme M Polymorphism of the C-reactive protein gene is associated with mortality in bacteraemia. Scand J Infect Dis 2006, 38(11-12):1069-1073.
58. Clatworthy MR, Smith KG FcγRIIB balances efficient pathogen clearance and the cytokine-mediated consequences of sepsis. J Exp Med 2004, 199(5):717-723.
59. Brownlie RJ, Lawlor KE, Niederer HA, Cutler AJ, Xiang Z, Clatworthy MR, et al. Distinct cell-specific control of autoimmunity and infection by FcgammaRIIB. J Exp Med 2008, 205(4):883-895.
60. Gjertsson I, Kleinau S, Tarkowski A The impact of Fcgamma receptors on Staphylococcus aureus infection. Microb Pathog 2002, 33(4):145-152.
61. Bredius RG, de Vries CE, Troelstra A, van Alphen L, Weening RS, van de Winkel JG, et al. Phagocytosis of Staphylococcus aureus and Haemophilus influenzae type B opsonized with polyclonal human IgG1 and IgG2 antibodies. Functional hFc gamma RIIa polymorphism to IgG2. J Immunol 1993, 151(3):1463-1472.
62. Bredius RG, Fijen CA, De Haas M, Kuijper EJ, Weening RS, Van de Winkel JG, et al. Role of neutrophil Fc gamma RIIa (CD32) and Fc gamma RIIIB (CD16) polymorphic forms in phagocytosis of human IgG1- and IgG3-opsonized bacteria and erythrocytes. Immunology 1994, 83(4):624-630.
63. Pathan N, Faust SN, Levin M Pathophysiology of meningococcal meningitis and septicaemia. Arch Dis Child 2003, 88(7):601-607.
64. Bredius RG, Derkx BH, Fijen CA, de Wit TP, de Haas M, Weening RS, et al. Fc gamma receptor IIa (CD32) polymorphism in fulminant meningococcal septic shock in children. J Infect Dis 1994, 170(4):848-853.
65. Fijen CA, Bredius RG, Kuijper EJ, Out TA, De Haas M, De Wit AP, et al. The role of Fcγ receptor polymorphisms and C3 in the immune defence against Neisseria meningitidis in complement-deficient individuals. Clin Exp Immunol 2000, 120(2):338-345.
66. van der Pol WL, Huizinga TW, Vidarsson G, van der Linden MW, Jansen MD, Keijsers V, et al. Relevance of Fcγ receptor and interleukin-10 polymorphisms for meningococcal disease. J Infect Dis 2001, 184(12):1548-1555.
67. Smith I, Vedeler C, Halstensen A FcγRIIa and FcγRIIIB polymorphisms were not associated with meningococcal disease in Western Norway. Epidemiol Infect 2003, 130(2):193-199.
68. Platonov AE, Shipulin GA, Vershinina IV, Dankert J, van de Winkel JG, Kuijper EJ Association of human Fc gamma RIIa (CD32) polymorphism with susceptibility to and severity of meningococcal disease. Clin Infect Dis 1998, 27(4):746-750.
69. Domingo P, Muniz-Diaz E, Baraldes MA, Arilla M, Barquet N, Pericas R, et al. Associations between Fc gamma receptor IIA polymorphisms and the risk and prognosis of meningococcal disease. Am J Med 2002, 112(1):19-25.
70. Domingo P, Muniz-Diaz E, Baraldes MA, Arilla M, Barquet N, Pericas R, et al. Relevance of genetically determined host factors to the prognosis of meningococcal disease. Eur J Clin Microbiol Infect Dis 2004, 23(8):634-637.
71. Rodriguez ME, Hellwig SM, Hozbor DF, Leusen J, van der Pol WL, van de Winkel JG Fc receptor-mediated immunity against Bordetella pertussis. J Immunol 2001, 167(11):6545-6551.
72. Hellwig SM, van Oirschot HF, Hazenbos WL, van Spriel AB, Mooi FR, van De Winkel JG Targeting to Fcγ receptors, but not CR3 (CD11b/CD18), increases clearance of Bordetella pertussis. J Infect Dis 2001, 183(6):871-879.
73. Ioan-Facsinay A, de Kimpe SJ, Hellwig SM, van Lent PL, Hofhuis FM, van Ojik HH, et al. FcγRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection. Immunity 2002, 16(3):391-402.
74. Schenkein H.A., Barbour S.E., Tew J.G. Cytokines and inflammatory factors regulating immunoglobulin production in aggressive periodontitis. Periodontol 2000. 2007; 45: 113-127.
75. Loos BG, Leppers-Van de Straat FG, Van de Winkel JG, Van der Velden U Fcγ receptor polymorphisms in relation to periodontitis. J Clin Periodontol 2003, 30(7):595-602.
76. Chung HY, Lu HC, Chen WL, Lu CT, Yang YH, Tsai CC Gm (23) allotypes and Fcγ receptor genotypes as risk factors for various forms of periodontitis. J Clin Periodontol 2003, 30(11):954-960.
77. Kobayashi T, van der Pol WL, van de Winkel JG, Hara K, Sugita N, Westerdaal NA, et al. Relevance of IgG receptor IIIB (CD16) polymorphism to handling of Porphyromonas gingivalis: implications for the pathogenesis of adult periodontitis. J Periodontal Res 2000, 35(2):65-73.
78. Yasuda K, Sugita N, Kobayashi T, Yamamoto K, Yoshie H FcgammaRIIB gene polymorphisms in Japanese periodontitis patients. Genes Immun 2003, 4(8):541-546.
79. Wolf DL, Neiderud AM, Hinckley K, Dahlen G, van de Winkel JG, Papapanou PN Fcgamma receptor polymorphisms and periodontal status: a prospective follow-up study. J Clin Periodontol 2006, 33(10):691-698.
80. Dimou NL, Nikolopoulos GK, Hamodrakas SJ, Bagos PG Fcgamma receptor polymorphisms and their association with periodontal disease: a meta-analysis. J Clin Periodontol 2010, 37(3):255-265.
81. Halstead SB Pathogenesis of dengue: challenges to molecular biology. Science 1988, 239(4839):476-481.
82. Burke DS, Nisalak A, Johnson DE, Scott RM A prospective study of dengue infections in Bangkok. Am J Trop Med Hyg 1988, 38(1):172-180.
83. Kliks SC, Nimmanitya S, Nisalak A, Burke DS Evidence that maternal dengue antibodies are important in the development of dengue hemorrhagic fever in infants. Am J Trop Med Hyg 1988, 38(2):411-419.
84. Thein S, Aung MM, Shwe TN, Aye M, Zaw A, Aye K, et al. Risk factors in dengue shock syndrome. Am J Trop Med Hyg 1997, 56(5):566-572.
85. Littaua R, Kurane I, Ennis FA Human IgG Fc receptor II mediates antibody-dependent enhancement of dengue virus infection. J Immunol 1990, 144(8):3183-3186.
86. Moi ML, Lim CK, Takasaki T, Kurane I Involvement of the Fc gamma receptor IIA cytoplasmic domain in antibody-dependent enhancement of dengue virus infection. J Gen Virol 2010, 91(Pt. 1):103-111.
87. Chan KR, Zhang SL, Tan HC, Chan YK, Chow A, Lim AP, et al. Ligation of Fc gamma receptor IIB inhibits antibody-dependent enhancement of dengue virus infection. Proc Natl Acad Sci USA 2011, 108(30):12479-12484.
88. Loke H, Bethell D, Phuong CX, Day N, White N, Farrar J, et al. Susceptibility to dengue hemorrhagic fever in Vietnam: evidence of an association with variation in the vitamin D receptor and Fc gamma receptor IIa genes. Am J Trop Med Hyg 2002, 67(1):102-106.
89. Garcia G, Sierra B, Perez AB, Aguirre E, Rosado I, Gonzalez N, et al. Asymptomatic dengue infection in a Cuban population confirms the protective role of the RR variant of the FcγRIIa polymorphism. Am J Trop Med Hyg 2010, 82(6):1153-1156.
90. Blondel B, Duncan G, Couderc T, Delpeyroux F, Pavio N, Colbere-Garapin F Molecular aspects of poliovirus biology with a special focus on the interactions with nerve cells. J Neurovirol 1998, 4(1):1-26.
91. Arita M, Horie H, Nomoto A Interaction of poliovirus with its receptor affords a high level of infectivity to the virion in poliovirus infections mediated by the Fc receptor. J Virol 1999, 73(2):1066-1074.
92. Ulvestad E, Williams K, Vedeler C, Antel J, Nyland H, Mork S, et al. Reactive microglia in multiple sclerosis lesions have an increased expression of receptors for the Fc part of IgG. J Neurol Sci 1994, 121(2):125-131.
93. Beck OE Distribution of virus antibody activity among human IgG subclasses. Clin Exp Immunol 1981, 43(3):626-632.
94. Rekand T, Langeland N, Aarli JA, Vedeler CA Fcγ receptor IIIA polymorphism as a risk factor for acute poliomyelitis. J Infect Dis 2002, 186(12):1840-1843.
95. Schalling M, Ekman M, Kaaya EE, Linde A, Biberfeld P A role for a new herpes virus (KSHV) in different forms of Kaposi's sarcoma. Nat Med 1995, 1(7):707-708.
96. Jawahar S, Moody C, Chan M, Finberg R, Geha R, Chatila T Natural killer (NK) cell deficiency associated with an epitope-deficient Fc receptor type IIIA (CD16-II). Clin Exp Immunol 1996, 103(3):408-413.
97. Forthal DN, Landucci G, Bream J, Jacobson LP, Phan TB, Montoya B FcγRIIa genotype predicts progression of HIV infection. J Immunol 2007, 179(11):7916-7923.
98. Bachmann MF, Zinkernagel RM Neutralizing antiviral B cell responses. Annu Rev Immunol 1997, 15:235-270.
99. Huber VC, Lynch JM, Bucher DJ, Le J, Metzger DW Fc receptor-mediated phagocytosis makes a significant contribution to clearance of influenza virus infections. J Immunol 2001, 166(12):7381-7388.
100. Scharf O, Golding H, King LR, Eller N, Frazier D, Golding B, et al. Immunoglobulin G3 from polyclonal human immunodeficiency virus (HIV) immune globulin is more potent than other subclasses in neutralizing HIV type 1. J Virol 2001, 75(14):6558-6565.
101. Takeda A, Tuazon CU, Ennis FA Antibody-enhanced infection by HIV-1 via Fc receptor-mediated entry. Science 1988, 242(4878):580-583.
102. Tsitsikov EN, Fuleihan R, McIntosh K, Scholl PR, Geha RS Cross-linking of Fc gamma receptors activates HIV-1 long terminal repeat-driven transcription in human monocytes. Int Immunol 1995, 7(10):1665-1670.
103. Poonia B, Kijak GH, Pauza CD High affinity allele for the gene of FCGR3A is risk factor for HIV infection and progression. PLoS One 2010, 5(12):e15562.
104. Forthal DN, Gabriel EE, Wang A, Landucci G, Phan TB Association of Fcγ receptor IIIa genotype with the rate of HIV infection after gp120 vaccination. Blood 2012, 120(14):2836-2842.
105. Brouwer KC, Lal RB, Mirel LB, Yang C, van Eijk AM, Ayisi J, et al. Polymorphism of Fc receptor IIa for IgG in infants is associated with susceptibility to perinatal HIV-1 infection. AIDS 2004, 18(8):1187-1194.
106. Forthal DN, Gilbert PB, Landucci G, Phan T Recombinant gp120 vaccine-induced antibodies inhibit clinical strains of HIV-1 in the presence of Fc receptor-bearing effector cells and correlate inversely with HIV infection rate. J Immunol 2007, 178(10):6596-6603.
107. Haynes B.F. Case-control study of the RV144 trial for immune correlates: the analysis and way forward. AIDS Vaccine Conference, September 12-15, 2011, Bangkok, Thailand.
108. Breman JG, Alilio MS, Mills A Conquering the intolerable burden of malaria: what's new, what's needed: a summary. Am J Trop Med Hyg 2004, 71(2 Suppl.):1-15.
109. Stevenson MM, Riley EM Innate immunity to malaria. Nat Rev Immunol 2004, 4(3):169-180.
110. Malaguarnera L, Musumeci S The immune response to Plasmodium falciparum malaria. Lancet Infect Dis 2002, 2(8):472-478.
111. Hunt NH, Grau GE Cytokines: accelerators and brakes in the pathogenesis of cerebral malaria. Trends Immunol 2003, 24(9):491-499.
112. Majarian WR, Daly TM, Weidanz WP, Long CA Passive immunization against murine malaria with an IgG3 monoclonal antibody. J Immunol 1984, 132(6):3131-3137.
113. Fandeur T, Dubois P, Gysin J, Dedet JP, da Silva LP In vitro and in vivo studies on protective and inhibitory antibodies against Plasmodium falciparum in the Saimiri monkey. J Immunol 1984, 132(1):432-437.
114. McGregor IA The passive transfer of human malarial immunity. Am J Trop Med Hyg 1964, 13(Suppl):S237-S239.
115. Bouharoun-Tayoun H, Druilhe P Plasmodium falciparum malaria: evidence for an isotype imbalance which may be responsible for delayed acquisition of protective immunity. Infect Immun 1992, 60(4):1473-1481.
116. Taylor AM, Day NP, Sinh DX, Loc PP, Mai TT, Chau TT, et al. Reactive nitrogen intermediates and outcome in severe adult malaria. Trans R Soc Trop Med Hyg 1998, 92(2):170-175.
117. Taylor RR, Allen SJ, Greenwood BM, Riley EM IgG3 antibodies to Plasmodium falciparum merozoite surface protein 2 (MSP2): increasing prevalence with age and association with clinical immunity to malaria. Am J Trop Med Hyg 1998, 58(4):406-413.
118. Ndungu FM, Bull PC, Ross A, Lowe BS, Kabiru E, Marsh K Naturally acquired immunoglobulin (Ig)G subclass antibodies to crude asexual Plasmodium falciparum lysates: evidence for association with protection for IgG1 and disease for IgG2. Parasite Immunol 2002, 24(2):77-82.
119. Yoneto T, Waki S, Takai T, Tagawa Y, Iwakura Y, Mizuguchi J, et al. A critical role of Fc receptor-mediated antibody-dependent phagocytosis in the host resistance to blood-stage Plasmodium berghei XAT infection. J Immunol 2001, 166(10):6236-6241.
120. Shi YP, Nahlen BL, Kariuki S, Urdahl KB, McElroy PD, Roberts JM, et al. Fcγ receptor IIa (CD32) polymorphism is associated with protection of infants against high-density Plasmodium falciparum infection. VII. Asembo Bay Cohort Project. J Infect Dis 2001, 184(1):107-111.
121. Cooke GS, Aucan C, Walley AJ, Segal S, Greenwood BM, Kwiatkowski DP, et al. Association of Fcgamma receptor IIa (CD32) polymorphism with severe malaria in West Africa. Am J Trop Med Hyg 2003, 69(6):565-568.
122. Ouma C, Keller CC, Opondo DA, Were T, Otieno RO, Otieno MF, et al. Association of FC gamma receptor IIA (CD32) polymorphism with malarial anemia and high-density parasitemia in infants and young children. Am J Trop Med Hyg 2006, 74(4):573-577.
123. Nasr A, Iriemenam NC, Troye-Blomberg M, Giha HA, Balogun HA, Osman OF, et al. Fc gamma receptor IIa (CD32) polymorphism and antibody responses to asexual blood-stage antigens of Plasmodium falciparum malaria in Sudanese patients. Scand J Immunol 2007, 66(1):87-96.
124. Sinha S, Mishra SK, Sharma S, Patibandla PK, Mallick PK, Sharma SK, et al. Polymorphisms of TNF-enhancer and gene for FcγRIIa correlate with the severity of falciparum malaria in the ethnically diverse Indian population. Malar J 2008, 7:13.
125. Schuldt K, Esser C, Evans J, May J, Timmann C, Ehmen C, et al. FCGR2A functional genetic variant associated with susceptibility to severe malarial anaemia in Ghanaian children. J Med Genet 2010, 47(7):471-475.
126. Omi K, Ohashi J, Patarapotikul J, Hananantachai H, Naka I, Looareesuwan S, et al. Fcγ receptor IIA and IIIB polymorphisms are associated with susceptibility to cerebral malaria. Parasitol Int 2002, 51(4):361-366.
127. Ouma C, Davenport GC, Garcia S, Kempaiah P, Chaudhary A, Were T, et al. Functional haplotypes of Fc gamma (Fcγ) receptor (FcγRIIA and FcγRIIIB) predict risk to repeated episodes of severe malarial anemia and mortality in Kenyan children. Hum Genet 2012, 131(2):289-299.
128. Israelsson E, Ekstrom M, Nasr A, Dolo A, Kearsley S, Arambepola G, et al. Marked differences in CRP genotype frequencies between the Fulani and sympatric ethnic groups in Africa. Malar J 2009, 8:136.
129. Waisberg M, Tarasenko T, Vickers BK, Scott BL, Willcocks LC, Molina-Cruz A, et al. Genetic susceptibility to systemic lupus erythematosus protects against cerebral malaria in mice. Proc Natl Acad Sci USA 2011, 108(3):1122-1127.
130. Kumaratilake LM, Rathjen DA, Mack P, Widmer F, Prasertsiriroj V, Ferrante A A synthetic tumor necrosis factor-alpha agonist peptide enhances human polymorphonuclear leukocyte-mediated killing of Plasmodium falciparum in vitro and suppresses Plasmodium chabaudi infection in mice. J Clin Invest 1995, 95(5):2315-2323.
131. Muniz-Junqueira MI, dos Santos-Neto LL, Tosta CE Influence of tumor necrosis factor-alpha on the ability of monocytes and lymphocytes to destroy intraerythrocytic Plasmodium falciparum in vitro. Cell Immunol 2001, 208(2):73-79.
132. Kwiatkowski DP How malaria has affected the human genome and what human genetics can teach us about malaria. Am J Hum Genet 2005, 77(2):171-192.
133. Williams TN, Wambua S, Uyoga S, Macharia A, Mwacharo JK, Newton CR, et al. Both heterozygous and homozygous alpha+thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya. Blood 2005, 106(1):368-371.
134. Gray CA, Lawrence RA A role for antibody and Fc receptor in the clearance of Brugia malayi microfilariae. Eur J Immunol 2002, 32(4):1114-1120.
135. Karsten CM, et al. Anti-inflammatory actvity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1. Nat Med 2012, 18:1401-1406.