Therapeutic applications of carbon nanotubes: Opportunities and challenges

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology

Volumn 6, Issue 4, 2014, Pages 327-337

  Rogers Nieman, Gabrielle M ^a   Dinu, Cerasela Zoica ^a  

^a West Virginia University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES;

CELLULAR MEMBRANES; FUNCTIONALIZATIONS; NEAR-INFRARED FLUORESCENCE IMAGING; PHARMACOLOGICAL PROFILES; PHYSICOCHEMICAL PROPERTY; POTENTIAL IMPACTS; THERAPEUTIC APPLICATION; TOXICOLOGICAL EFFECTS;

CARBON NANOTUBES;

ADENOSINE TRIPHOSPHATE; CARBON NANOTUBE; CYCLIN DEPENDENT KINASE 6; INTERFERON; MOLECULAR MOTOR; MULTI WALLED NANOTUBE; PROTEIN P53; SINGLE WALLED NANOTUBE; NANOMATERIAL;

ANEUPLOIDY; ARTICLE; CANCER CELL; CARCINOGENESIS; CELL CYCLE ARREST; CELL DIVISION; CHROMOSOME SEGREGATION; CYTOTOXICITY; DRUG DELIVERY SYSTEM; FLUORESCENCE IMAGING; GENOTOXICITY; HOST CELL; HUMAN; HYDROLYSIS; KINETOCHORE MICROTUBULE; MICROTUBULE ASSEMBLY; MITOSIS; MITOSIS SPINDLE; MOLECULAR RECOGNITION; NANOBIOTECHNOLOGY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; S PHASE CELL CYCLE CHECKPOINT; TOXICOLOGY; NANOTECHNOLOGY; NEOPLASMS; TRENDS;

HUMANS; NANOSTRUCTURES; NANOTECHNOLOGY; NANOTUBES, CARBON; NEOPLASMS;

EID: 84902381956     PISSN: 19395116     EISSN: 19390041     Source Type: Journal    
DOI: 10.1002/wnan.1268     Document Type: Article

References (84)

1. Orr GA, Verdier-Pinard P, McDaid H, Horwitz SB. Mechanisms of taxol resistance related to microtubules. Oncogene 2003, 22:7280-7295.
2. Eskey CJ, Wolmark N, McDowell CL, Domach MM, Jain RK. Residence time distributions of various tracers in tumors: implications for drug delivery and blood flow measurements. J Natl Cancer Inst 1994, 86:293-299.
3. Rios-Doria J, Carie A, Costich T, Burke B, Skaff H, Panicucci R, Sill K. A versatile polymer micelle drug delivery system for encapsulation and in vivo stabilization of hydrophobic anticancer drugs. J Drug Deliv 2012, 2012:951741.
4. Gharib MI, Burnett AK. Chemotherapy-induced cardiotoxicity: current practice and prospects of prophylaxis. Eur J Heart Fail 2002, 4:235-242.
5. Zhang W, Zhang Z, Zhang Y. The application of carbon nanotubes in target drug delivery systems for cancer therapies. Nanoscale Res Lett 2011, 6:1-22.
6. Iijima S. Helical microtubules of graphitic carbon. Nature 1991, 354:56-58.
7. Zhu HW, Xu CL, Wu DH, Wei BQ, Vajtai R, Ajayan PM. Direct synthesis of long single-walled carbon nanotube strands. Science 2002, 296:884-886. doi: 10.1126/science.1066996.
8. Hamada N, Sawada S, Oshiyama A. New one-dimensional conductors: graphitic microtubules. Phys Rev Lett 1992, 68:1579-1581.
9. Pampaloni F, Florin EL. Microtubule architecture: inspiration for novel carbon nanotube-based biomimetic materials. Trends Biotechnol 2008, 26:302-310.
10. Flavo MR, Clary GJ, Taylor RM, Chi V, Brooks FP, Washburn S, Superfine R. Bending and buckling of carbon nanotubes under large strain. Nature 1997, 389:582-584.
11. Salvetat JP, Briggs A, Bonard JM, Bacsa RR, Kulik AJ, Stockli T, Burnham NA, Forro L. Elastic and shear moduli of single-walled carbon nanotube ropes. Phys Rev Lett 1999, 82:944-947.
12. Ruoff R. Mechanical and thermal properties of carbon nanotubes. Carbon 1995, 33:925-930.
13. Graham AP, Duesberg G, Seidel R, Liebau M, Unger E, Krepul UF, Honlein W. Towards the integration of carbon nanotubes in microelectronics. Diamond Relat Mater 2004, 13:1296-1300.
14. Fuhrer MS, Kim B, Durkop T, Brintlinger T. High-mobility nanotube transistor memory. Nano Lett 2002, 2:755-759.
15. Shimoda H, Gao B, Tang XP, Kleinhammes A, Fleming L, Wu Y, Zhou O. Lithium intercalation into opened single-wall carbon nanotubes: storage capacity and electronic properties. Phys Rev Lett 2002, 88:015502.
16. Fan Z, Luo G, Zhang Z, Zhou L, Wei F. Electromagnetic and microwave absorbing properties of multi-walled carbon nanotubes/polymer composites. Mater Sci Eng B 2006, 132:85-89.
17. Suhr J, Zjang W, Ajayan PM, Koratkar NA. Temperature-activated interfacial friction damping in carbon nanotube polymer composites. Nano Lett 2006, 6:219-223.
18. Endo M, Koyama S, Matsuda Y, Hayashi T, Kim YA. Thrombogenicity and blood coagulation of a micro-catheter prepared from carbon nanotube-nylon based composite. Nano Lett 2005, 5:101-106.
19. Li X, Peng Y, Qu X. Carbon nanotubes selective destabilization of duplex and triplex DNA and inducing B-A transition in solution. Nucleic Acids Res 2006, 34:3670-3676.
20. Lacerda L. Carbon nanotube cell translocation and delivery of nucleic acids in vitro and in vivo. J Mater Chem 2008, 18:17-22.
21. Dinu CZ, Borkar I, Bale SS, Campbell AS, Kane RS, Dordick JS. Perhydrolase-nanotube-paint sporicidal composites stabilized by intramolecular crosslinking. J Mol Catal B: Enzym 2012, 75:20-26.
22. Dinu CZ, Bale S, Zhu G, Dordick JS. Tubulin encapsulation of carbon nanotubes into functional hybrid assemblies. Small 2009, 5:1-6.
23. Robinson JT, Hong G, Liang Y, Zhang B, Yaghi OK, Dai H. In vivo fluorescence imaging in the second near-infrared window with long circulating carbon nanotubes capable of ultrahigh tumor uptake. J Am Chem Soc 2012, 134:10664-10669.
24. Ramachandran S, Ernst K, Bachand GD, Vogel V, Hess H. Selective loading of kinesin-powered molecular shuttles with protein cargo and its application to biosensing. Small 2006, 2:330-334.
25. Yinghuai Z, Peng A, Carpenter K, Maguire JA, Hosmane NS, Takagaki M. Substituted caborane-appended water soluble single-walled carbon nanotubes: new approach to boron neutron capture therapy drug delivery. J Am Chem Soc 2005, 127:9875-9880.
26. Khandare JJ, Jalota-Badhwar A, Satavalekar SD, Bhansali SG, Aher ND, Kharas F, Banerjee SS. PEG-conjugated highly dispersive multifunctional magnetic multi-walled carbon nanotubes for cellular imaging. Nanoscale 2012, 4:837-844.
27. Cherukuri P, Bachilo S, Litovsky SH, Weisman RB. Near-infrared fluorescence microscopy of single-walled carbon nanotubes in phagocytic cells. J Am Chem Soc 2004, 126:15638-15639.
28. Pan D, Chen J, Yao S, Tao W, Nie L. An amperometric glucose biosensor based on glucose oxidase immobilized in electropolymerized poly(o-aminophenol) and carbon nanotubes composite film on a gold electrode. Anal Sci 2005, 21:367-371.
29. Kurkina T, Vlandes A, Ahmad A, Kern K, Balasubramanian K. Label-free detection of few copies of DNA with carbon nanotube impedance biosensors. Angew Chem Int Ed 2011, 50:3710-3714.
30. Wu W, Wieckowski S, Pastorin G, Benincasa M, Klumpp C, Briand JP, Gennaro R, Prato M, Bianco A. Targeted delivery of amphotericin B to cells by using functionalized carbon nanotubes. Angew Chem Int Ed Engl 2005, 44:6358-6362.
31. Liu Z, Chen K, Davis C, Sherlock S, Cao Q, Chen X, Dai H. Drug delivery with carbon nanotubes for in vivo cancer treatment. Cancer Res 2008, 68:6652.
32. Madani SY, Naderi N, Dissanayake O, Tan A, Seifalian AM. A new era of cancer treatment: carbon nanotubes as drug delivery tools. Int J Nanomedicine 2011, 6:2963-2979.
33. Wu HC, Chang X, Liu L, Zhao F, Zhao Y. Chemistry of carbon nanotubes in biomedical applications. J Mater Chem 2010, 20:1036-1052.
34. Jain S, Singh S, Pillai S. Toxicity issues related to biomedical applications of carbon nanotubes. J Nanomed Nanotechnol 2012, 3:1000140.
35. Doak SH, Griffiths S, Manshian B, Singh N, Williams PM, Brown AP, Jenkins GJ. Confounding experimental considerations in nanogenotoxicology. Mutagenesis 2009, 24:285-293.
36. Han JH, Lee E, So KP, Lee YH, Bae GN, Lee SB, Ji JH, Cho MN, Yu IJ. Monitoring multiwalled carbon nanotube exposure in carbon nanotube research facility. Inhal Toxicol 2008, 20:741-749.
37. Maynard AD, Baron P, Foley M, Shvedova AA, Kisin ER, Castranova V. Exposure to carbon nanotube material: aerosol release during the handling of unrefined single-walled carbon nanotube material. J Toxicol Environ Health A 2004, 67:87-107.
38. Pauluhn J. Subchronic 13-week inhalation exposure of rats to multiwalled carbon nanotubes: toxic effects are determined by density of agglomerate structures, not fibrillar structures. Toxicol Sci 2010, 113:226-242.
39. Shvedova AA, Kisin E, Murray AR, Johnson VJ, Gorelik O, Arapalli S, Hubbs AF, Mercer RR, Keohavong P, Sussman N, et al. Inhalation versus aspiration of single walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress and mutagenesis. Am J Physiol Lung Cell Mol Physiol 2008, 295:L552-L565.
40. OSHA. Occupational Safety and Health Administration, ed. Limits for Air Contaminates: Occupational Safety and Health Standards. Washington, DC: ; 2006.
41. National Institute for Occupational Safety and Health. Current Intelligence Bulletin: Occupational Exposure to Carbon Nanotubes and Nanofibers. Atlanta, GA: NIOSH; 2010.
42. Porter DW, Hubbs A, Chen BT, McKinney W, Mercer RR, Wolfarth MG, Battelli L, Wu N, Sriram K, Leonard S, et al. Acute pulmonary dose-response to inhaled multi-walled carbon nanotubes. Nanotoxicology 2013, 7:1179-1194. doi: 10.3109/17435390.2012.719649.
43. Mercer RR, Hubbs A, Scabilloni JF, Wang L, Battelli LA, Friend S, Castranova V, Porter DW. Pulmonary fibrotic response to aspiration of multi-walled carbon nanotubes. Part Fibre Toxicol 2011, 8:2-11.
44. Raja PMV, Connolley J, Ganesan GP, Lijie C, Ajayan PM, Nalamasu O, Thompson DM. Impact of carbon nanotube exposure, dosage and aggregation on smooth muscle cells. Toxicol Lett 2007, 169:51-63.
45. Sargent LM, Shvedova A, Hubbs AF, Salisbury JL, Benkovic SA, Kashon ML, Lowry DT, Murray AR, Kisin ER, Friend S, et al. Induction of aneuploidy by single-walled carbon nanotubes. Environ Mol Mutag 2009, 50:708-717.
46. Sargent LM, Hubbs A, Young SH, Kashon ML, Dinu CZ, Salisbury JL, Benkovic SA, Lowry DT, Murray AR, Kisin ER, et al. Single-walled carbon nanotube-induced mitotic disruption. Mutat Res 2012, 745:28-37.
47. Nam CW, Kang S, Kwak MK. Cell growth inhibition and apoptosis by SDS-solubilized single-walled carbon nanotubes in normal rat kidney epithelial cells. Arch Pharm Res 2011, 34:661-669.
48. Pacurari M, Yin X, Zhao H, Ding M, Leonard SS, Schwegler-Berry D, Ducatman BS, Sbarra D, Hoover MD, Castranova V, et al. Raw single-wall carbon nanotubes induce oxidative stress and activate MAPKs, AP-1, NF-kB, and Akt in normal and malignant human mesothelial cells. Environ Health Perspect 2008, 116:1211-1217.
49. Ursini CL, Cavallo D, Fresegna AM, Ciervo A, Maiello R, Buresti G, Casciardi S, Tombolini F, Bellucci S, Iavicoli S. Comparative cyto-genotoxicity assessment of functionalized and pristine multiwalled carbon nanotubes on human lung epithelial cells. Toxicol In Vitro 2012, 26:831-840.
50. Ding L, Stilwell J, Zhang T, Elboudwarej O, Jiang H, Selegue JP, Cooke PA, Gray JW, Chen FF. Molecular characterization of the cytotoxic mechanism of multiwall carbon nanotubes and nano-onions on human skin fibroblast. Nano Lett 2005, 5:2448-2464.
51. Guo N, Wan Y, Denvir J, Porter DW, Pacurari M, Wolfarth MG, Castranova V, Qian Y. Multi-walled carbon nanotube-induced gene signatures in the mouse lung: potential predictive value for human lung cancer risk and prognosis. J Toxicol Environ Health A 2012, 75:1129-1153.
52. Zhang Y, Yan B. Cell cycle regulation by carboxylated multiwalled carbon nanotubes through p53-independant induction of p21 under the control of the BMP signaling pathway. Chem Res Toxicol 2012, 26:1212-1221.
53. Vittorio O, Raffa V, Cuschieri A. Influence of purity and surface oxidation on cytotoxicity of multiwalled carbon nanotubes with human neuroblastoma cells. Nanomedicine 2009, 5:424-431.
54. Cavallo D, Fanizza C, Ursini CL, Casciardi S, Paba E, Ciervo A, Fresegna AM, Maiello R, Marcelloni AM, Buresti G, et al. Multi-walled carbon nanotube induce cytotoxicity and genotoxicity in human lung epithelial cells. J Appl Toxicol 2011, 32:454-464.
55. Muller J, Decordier I, Hoet PH, Lombaert N, Thomassen L, Huaux F, Lison D, Kirsh-Volders M. Clastogenic and aneugenic effects of multi-walled carbon nanotubes in epithelial cells. Carcinogenesis 2008, 29:427-433.
56. Rodriguez-Fernandez L, Valiente R, Gonzalez J, Villegas JC, Fanarraga ML. Multiwalled carbon nanotubes display microtubule biomimetic properties in vivo, enhancing microtubule assembly and stabilization. ACS Nano 2012, 6:6614-6625.
57. Kisin ER, Murray A, Sargent LM, Lowry DT, Chirila M, Siegrist KJ, Schwegler-Berry D, Leonard S, Castranova V, Fadeel B, et al. Genotoxicity of carbon nanofibers: are they potentially more or less dangerous than carbon nanotubes or asbestos? Toxicol Appl Pharmacol 2011, 252:1-10.
58. Bardi G, Tognini P, Ciofani G, Raffa V, Costa M, Pizzorusso T. Pluronic-coated carbon nanotubes do not induce degeneration of cortical neurons in vivo and in vitro. Nanomedicine 2009, 5:96-104.
59. Tong L, Zhang W, Hang H, Yu Z, Chu PK, Xu A. Toxicity of carbon nanotubes to p21 and hus1 gene deficient mammalian cells. J Nanosci Nanotechnol 2011, 11:11001-11005.
60. Burbank KS, Mitchison T. Quick guides: microtubule dynamic instability. Curr Biol 2006, 16:R516. doi: 10.1016/j.cub.2006.06.044.
61. Nogales E. Structural insight into microtubule function. Annu Rev Biophys Biomol Struct 2001, 30:397-420.
62. Cytrynbaum EN, Sommi P, Brust-Mascher I, Scholey JM, Mogilner A. Early spindle assembly in Drosophilia embryos: role of a force balance involving cytoskeletal dynamics and nuclear mechanics. Mol Biol Cell 2005, 16:4967-4981.
63. Howard J. Mechanical signaling in networks of motors and cytoskeletal proteins. Annu Rev Biophys 2009, 38:217-234.
64. Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. Molecular Biology of the Cell. New York: Garland Science; 2002.
65. Burakov A, Kovalenko O, Semenovva I, Zhaparova O, Nadezdina E, Rodionov V. Cytoplasmic dynein is involved in the retention of microtubules at the centrosome in interphase. Traffic 2008, 9:472-480.
66. Quintyne NJ, Schroer T. Distinct cell cycle-dependant roles for dynactin and dynein at centrosomes. J Cell Biol 2002, 159:245-254.
67. Salisbury JL, D'Assoro A, Lingle WL. Centrosome amplification and the origin of chromosomal instability in breast cancer. J Mammary Gland Biol Neoplasia 2004, 9:275-283.
68. Pecreaux J, Roper J, Kruse K, Julicher F, Hyman AA, Grill SW, Howard J. Spindle oscillations during asymmetric cell division require a threshold number of active cortical force generators. Curr Biol 2006, 16:2111-2122.
69. Tanenbaum ME, Macurek L, Galjart N, Medema RH. Dynein, Lis1 and CLIP-170 counteract Eg5-dependant centrosome separation during bipolar spindle assembly. EMBO J 2008, 27:3235-3245.
70. Ferenz NP, Paul R, Fagerstrom C, Mogilner A, Wadsworth P. Dynein antagonizes Eg5 by crosslinking and sliding antiparallel microtubules. Curr Biol 2009, 19:1833-1838.
71. Gable A, Qiu M, Titus H, Balchand S, Ferenz NP, Ma N, Collins ES, Fagerstron C, Ross JL, Yang G, et al. Dynamic reorganization of Eg5 in the mammalian spindle throughout mitosis requires dynein and TPX2. Mol Biol Cell 2012, 23:1254-1266.
72. Raajimakers JA, van Heesbeen R, Meaders JL, Geers EF, Fernandez-Garcia B, Medema RH, Tenebaum ME. Nuclear envelope-associated dynein drives prophase centrosome separation and enables Eg5-independent bipolar spindle formation. EMBO J 2012, 31:4179-4190.
73. Kapitein LC, Peterman E, Kwok BH, Kim JH, Kapoor TM, Schmidt CF. The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks. Nature 2005, 435:114-118.
74. Sawin KE, LeGuellec K, Philippe M, Mitchison TJ. Mitotic spindle organization by a plus-end-directed microtubule motor. Nature 1992, 359:540-543.
75. Glued. J Biol Chem 1997, 272:19418-19424.
76. cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential fo bipolar spindle formation in vivo. Cell 1995, 83:1159-1169.
77. Fink G, Hajdo L, Skowronek KJ, Reuther C, Kasprzak AA, Diez S. The mitotic kinesin-14 Ncd drives directional microtubule-microtubule sliding. Nat Cell Biol 2009, 11:717-723.
78. Dinz CZ, Bale S, Dordick JS. Kinesin 1 ATPase manipulates biohybrids formed from tubulin and carbon nanotubes. Methods Mol Biol 2011, 743:77-93.
79. Chen Y, Chow J, Poon RYC. Inhibition of Eg5 acts synergistically with checkpoint abrogatin in promoting mitotic catastrophe. Mol Cancer Res 2012, 10:626-635.
80. Nakai R, Iida S, Takahashi T, Tsujita T, Okamoto S, Takada C, Akasaka K, Ichikawa S, Ishida H, Kusaka H, et al. K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells. Cancer Res 2009, 69:3901-3909.
81. Cahu J, Olichon A, Hentrich C, Schek H, Drinjakovic J, Zhang C, Doherty-Kirby A, Lajoie G, Surrey T. Phosphorylation by Cdk1 increases the binding of Eg5 to microtubules in vitro and in Xenopus egg extract spindles. PLoS One 2008, 3:e3936.
82. Dong C, Kashon M, Lowry D, Dordick JS, Reynolds SH, Rojanasakul Y, Sargent LM, Dinu CZ. Exposure to carbon nanotubes leads to changes in cellular biomechanics. Adv Heathc Mater 2013, 2:1-7.
83. Tusher VG, Tibshirani R, Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc Natl Acad Sci U S A 2001, 98:5116-5121. doi: 10.1073/pnas.091062498.
84. Suresh S. Nanomedicine-elastic clues in cancer detection. Nat Nanotechnol 2007, 2:748-749. doi: 10.1038/nnano.2007.397.