Distinct cell cycle-dependent roles for dynactin and dynein at centrosomes

Journal of Cell Biology

Volumn 159, Issue 2, 2002, Pages 245-254

  Quintyne, Nicholas J ^a   Schroer, Trina A ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Cell cycle; Centrosome; Dynactin; Dynein; Microtubule

Indexed keywords

DYNACTIN; DYNEIN ADENOSINE TRIPHOSPHATASE; PROTEIN SUBUNIT;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL MOTILITY; CENTRIOLE; CENTROSOME; CONTROLLED STUDY; MICROTUBULE; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONTENT;

ANIMALS; CELL CYCLE; CENTRIOLES; COS CELLS; DYNEIN ATPASE; G1 PHASE; G2 PHASE; GENE EXPRESSION; INTERPHASE; MICROTUBULE-ASSOCIATED PROTEINS; MITOSIS; PROTEIN BINDING; S PHASE;

ANIMALIA;

EID: 0037191081     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200203089     Document Type: Article

References (55)

1. Allan, V. 2000. Dynactin. Curr. Biol. 10:R432.
2. Bornens, M. 2002. Centrosome composition and microtubule anchoring mechanisms. Curr. Opin. Cell Biol. 14:25-34.
3. Bouckson-Castaing, V., M. Moudjou, D.J. Ferguson, S. Mucklow, Y. Belkaid, G. Milon, and P.R. Crocker. 1996. Molecular characterisation of ninein, a new coiled-coil protein of the centrosome. J. Cell Sci. 109:179-190.
4. Bravo, R., and J.E. Celis. 1985. Changes in the nuclear distribution of cyclin (PCNA) during S-phase are not triggered by post-translational modifications that are expected to moderately affect its charge. FEBS Lett. 182:435-440.
5. Burkhardt, J.K., C.J. Echeverri, T. Nilsson, and R.B. Vallee. 1997. Overexpression of the dynamitin (p50) subunit of the dynactin complex disrupts dynein-dependent maintenance of membrane organelle distribution. J. Cell Biol. 139:469-484.
6. Chang, P., and T. Stearns. 2000. δ-Tubulin and ε-tubulin: Two new human centrosomal tubulins reveal new aspects of centrosome structure and function. Nat. Cell Biol. 2:30-35.
7. Clark, S.W., and D.I. Meyer. 1992. Centractin is an actin homologue associated with the centrosome. Nature. 359:246-250.
8. Compton, D.A. 1998. Focusing on spindle poles. J. Cell Sci. 111:1477-1481.
9. Compton, D.A. 2000. Spindle assembly in animal cells. Annu. Rev. Biochem. 69: 95-114.
10. Dictenberg, J.B., W. Zimmerman, C.A. Sparks, A. Young, C. Vidair, Y. Zheng, W. Carrington, F.S. Fay, and S.J. Doxsey. 1998. Pericentrin and γ-tubulin form a protein complex and are organized into a novel lattice at the centrosome. J. Cell Biol. 141:163-174.
11. Doxsey, S. 2001. Re-evaluating centrosome function. Nat. Rev. Mol. Cell Biol. 2:688-698.
12. Dujardin, D., U.I. Wacker, A. Moreau, T.A. Schroer, J.E. Rickard, and J.R. De Mey. 1998. Evidence for a role of CLIP-170 in the establishment of metaphase chromosome alignment. J. Cell Biol. 141:849-862.
13. Dujardin, D.L., and R.B. Vallee. 2002. Dynein at the cortex. Curr. Opin. Cell Biol. 14:44-49.
14. Echeverri, C.J., B.M. Paschal, K.T. Vaughan, and R.B. Vallee. 1996. Molecular characterization of 50-kD subunit of dynactin reveals function for the complex in chromosome alignment and spindle organization during mitosis. J. Cell Biol. 132:617-633.
15. Fry, A.M., T. Mayor, P. Meraldi, Y.D. Stierhof, K. Tanaka, and E.A. Nigg. 1998. C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2. J. Cell Biol. 141:1563-1574.
16. Gill, S.R., T.A. Schroer, I. Szilak, E.R. Steuer, M.P. Sheetz, and D.W. Cleveland. 1991. Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein. J. Cell Biol. 115: 1639-1650.
17. Gill, S.R., D.W. Cleveland, and T.A. Schroer. 1994. Characterization of DLC-A and DLC-B, two families of cytoplasmic dynein light chain subunits. Mol. Biol. Cell. 5:645-654.
18. Gopalan, G., C.S. Chan, and P.J. Donovan. 1997. A novel mammalian, mitotic spindle-associated kinase is related to yeast and fly chromosome segregation regulators. J. Cell Biol. 138:643-656.
19. Habermann, A., T.A. Schroer, G. Griffiths, and J.K. Burkhardt. 2001. Immunolocalization of cytoplasmic dynein and dynactin subunits in cultured macrophages: Enrichment on early endocytic organelles. J. Cell Sci. 114:229-240.
20. Heald, R. 2000. Motor function in the mitotic spindle. Cell. 102:399-402.
21. Helps, N.R., X. Luo, H.M. Barker, and P.T. Cohen. 2000. NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1. Biochem. J. 349:509-518.
22. Hinchcliffe, E.H., and G. Sluder. 2001. "It takes two to tango:" understanding how centrosome duplication is regulated throughout the cell cycle. Genes Dev. 15:1167-1181.
23. 1 into S phase. Science. 291:1547-1550.
24. Jean, C., Y. Tollon, B. Raynaud-Messina, and M. Wright. 1999. The mammalian interphase centrosome: Two independent units maintained together by the dynamics of the microtubule cytoskeleton. Eur. J. Cell Biol. 78:549-560.
25. Karki, S., and E.L. Holzbaur. 1999. Cytoplasmic dynein and dynactin in cell division and intracellular transport. Curr. Opin. Cell Biol. 11:45-53.
26. Karki, S., and E.L.F. Holzbaur. 1995. Affinity chromatography demonstrates a direct binding between cytoplasmic dynein and the dynactin complex. J. Biol. Chem. 270:28806-28811.
27. Karki, S., B. LaMonte, and E.L.F. Holzbaur. 1998. Characterization of the p22 subunit of dynactin reveals the localization of cytoplasmic dynein and dynactin to the midbody of dividing cells. J. Cell Biol. 142:1023-1034.
28. Khodjakov, A., and C.L. Rieder. 2001. Centrosomes enhance the fidelity of cytokinesis in vertebrates and are required for cell cycle progression. J. Cell Biol. 153:237-242.
29. King, S.J., and T.A. Schroer. 2000. Dynactin increases the processivity of the cytoplasmic dynein motor. Nat. Cell Biol. 2:20-24.
30. Lange, B.M. 2002. Integration of the centrosome in cell cycle control, stress response and signal transduction pathways. Curr. Opin. Cell Biol. 14:35-43.
31. Mayor, T., Y.D. Stierhof, K. Tanaka, A.M. Fry, and E.A. Nigg. 2000. The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion. J. Cell Biol. 151:837-846.
32. Meraldi, P., and E.A. Nigg. 2001. Centrosome cohesion is regulated by a balance of kinase and phosphatase activities. J. Cell Sci. 114:3749-3757.
33. Mogensen, M.M., A. Malik, M. Piel, V. Bouckson-Castaing, and M. Bornens. 2000. Microtubule minus-end anchorage at centrosomal and non-centrosomal sites: The role of ninein. J. Cell Sci. 113:3013-3023.
34. Muresan, V., M.C. Stankewich, W. Steffen, J.S. Morrow, E.L. Holzbaur, and B.J. Schnapp. 2001. Dynactin-dependent, dynein-driven vesicle transport in the absence of membrane proteins: A role for spectrin and acidic phospholipids. Mol. Cell. 7:173-183.
35. Nakagawa, Y., Y. Yaman, T. Okanoue, S. Tsukita, and S. Tsukita. 2001. Outer dense fiber 2 is a widespread centrosome scaffold component preferentially associated with mother centrioles: Its identification from mother centrioles. Mol. Biol. Cell. 12:1687-1697.
36. Ou, Y.Y., G.J. Mack, M. Zhang, and J.B. Rattner. 2002. CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation. J. Cell Sci. 115:1825-1835.
37. Glued and a novel actin. J. Biol. Chem. 268:15318-15323.
38. Pfarr, C.M., M. Coue, P.M. Gtissom, T.S. Hays, M.E. Porter, and J.R. McIntosh. 1990. Cytoplasmic dynein localizes to kinetochores during mitosis. Nature. 345:263-265.
39. Piel, M., P. Meyer, A. Khodjakov, C.L. Rieder, and M. Bornens. 2000. The respective contributions of the mother and daughter centrioles to centrosome activity and behavior in vertebrate cells. J. Cell Biol. 149:317-330.
40. Piel, M., J. Nordberg, U. Euteneuer, and M. Bornens. 2001. Centrosome-dependent exit of cytokinesis in animal cells. Science. 291:1550-1553.
41. Purohit, A., S.H. Tynan, R. Vallee, and S.J. Doxsey. 1999. Direct interaction of pericentrin with cytoplasmic dynein light intermediate chain contributes to mitotic spindle organization. J. Cell Biol. 147:481-492.
42. Quintyne, N.J., S.R. Gill, D.M. Eckley, C.L. Crego, D.A. Compton, and T.A. Schroer. 1999. Dynactin is required for microtubule anchoring at fibroblast centrosomes. J. Cell Biol. 147:321-334.
43. Roghi, C., and V.J. Allan. 1999. Dynamic association of cytoplasmic dynein heavy chain 1a with the Golgi apparatus and intermediate compartment. J. Cell Sci. 112:4673-4685.
44. Sanders, M.A., and J.L. Salisbury. 1994. Centrin plays an essential role in microtubule severing during flagellar excision in Chlamydomonas reinhardtii. J. Cell Biol. 124:795-805.
45. Schafer, D.A., S.R. Gill, J.A. Cooper, J.E. Heuser, and T.A. Schroer. 1994. Ultrastructural analysis of the dynactin complex: An actin-related protein is a component ofa filament that resembles f-actin. J. Cell Biol. 126:403-412.
46. Schroer, T.A., and M.P. Sheetz. 1991. Two activators of microtubule-based vesicle transport. J. Cell Biol. 115:1309-1318.
47. Schultz, S.J., A.M. Fry, C. Sutterlin, T. Ried, and E.A. Nigg. 1994. Cell cycledependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans. Cell Growth Differ. 5:625-635.
48. Steuer, E.R., T.A. Schroer, L. Wordeman, and M.P. Sheetz. 1990. Localization of cytoplasmic dynein to mitotic spindles and kinetochores. Nature. 345:266-268.
49. Tynan, S.H., A. Purohit, S.J. Doxsey, and R.B. Vallee. 2000. Light intermediate chain 1 defines a functional subfraction of cytoplasmic dynein which binds to pericentrin. J. Biol. Chem. 275:32763-32768.
50. Uto, K., and N. Sagata. 2000. Nek2B, a novel maternal form of Nek2 kinase, is essential for the assembly or maintenance of centrosomes in early Xenopus embryos. EMBO J. 19:1816-1826.
51. Glued. J. Cell Biol. 131:1507-1516.
52. Vaughan, P.S., J.D. Leszyk, and K.T. Vaughan. 2001. Cytoplasmic dynein intermediate chain phosphorylation regulates binding to dynactin. J. Biol. Chem. 276:26171-26179.
53. Glued component of the dynactin complex binds to both microtubules and the actinrelated protein centractin (Arp-1). Proc. Natl. Acad. Sci. USA. 92:1634-1638.
54. Young, A., J.B. Dictenberg, A. Purohit, R. Tuft, and S.J. Doxsey. 2000. Cytoplasmic dynein-mediated assembly ofpericentrin and gamma tubulin onto centrosomes. Mol. Biol. Cell. 11:2047-2056.
55. Zimmerman, W., and S.J. Doxsey. 2000. Construction of centrosomes and spindle poles by molecular motor-driven assembly of protein particles. Traffic. 1:927-934.