B cell subsets and dysfunction of regulatory B cells in IgG4-related diseases and primary Sjögren's syndrome: The similarities and differences

Arthritis Research and Therapy

Volumn 16, Issue 3, 2014, Pages

  Lin, Wei ^a   Jin, Lixia ^b   Chen, Hua ^a   Wu, Qingjun ^a   Fei, Yunyun ^a   Zheng, Wenjie ^a   Wang, Qian ^a   Li, Ping ^a   Li, Yongzhe ^a   Zhang, Wen ^a   Zhao, Yan ^a   Zeng, Xiaofeng ^a   Zhang, Fengchun ^a  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^b TSINGHUA UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

B CELL ACTIVATING FACTOR RECEPTOR; B CELL MATURATION ANTIGEN; B7 ANTIGEN; CD19 ANTIGEN; CD24 ANTIGEN; CD38 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G4; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 5; TRANSFORMING GROWTH FACTOR BETA; TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR; CYTOKINE; INTERLEUKIN 2 RECEPTOR ALPHA; TNFRSF13C PROTEIN, HUMAN;

ADULT; ARTICLE; B LYMPHOCYTE; CD4+ CD25+ T LYMPHOCYTE; CELL ACTIVITY; CELL ISOLATION; CELL SURFACE; CLINICAL STUDY; COCULTURE; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN G4 RELATED DISEASE; LABORATORY TEST; LYMPHOCYTE FUNCTION; LYMPHOCYTE SUBPOPULATION; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION; SJOEGREN SYNDROME; AGED; AUTOIMMUNE DISEASE; BLOOD; CD4+ T LYMPHOCYTE; CELL CULTURE; IMMUNOLOGY; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL;

ADULT; AGED; ANTIGENS, CD19; ANTIGENS, CD24; ANTIGENS, CD38; ANTIGENS, CD40; AUTOIMMUNE DISEASES; B-CELL ACTIVATION FACTOR RECEPTOR; B-LYMPHOCYTE SUBSETS; B-LYMPHOCYTES, REGULATORY; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOGLOBULIN G; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; SJOGREN'S SYNDROME;

EID: 84902375457     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar4571     Document Type: Article

References (37)

1. Yoshizaki A, Miyagaki T, DiLillo DJ, Matsushita T, Horikawa M, Kountikov EI, Spolski R, Poe JC, Leonard WJ, Tedder TF. Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions. Nature 2012, 491:264-268. 10.1038/nature11501, 3493692, 23064231.
2. Mauri C, Ehrenstein MR. The 'short' history of regulatory B cells. Trends Immunol 2008, 29:34-40. 10.1016/j.it.2007.10.004, 18289504.
3. Mann MK, Ray A, Basu S, Karp CL, Dittel BN. Pathogenic and regulatory roles for B cells in experimental autoimmune encephalomyelitis. Autoimmunity 2012, 45:388-399. 10.3109/08916934.2012.665523, 3639139, 22443691.
4. Mauri C, Bosma A. Immune regulatory function of B cells. Annu Rev Immunol 2012, 30:221-241. 10.1146/annurev-immunol-020711-074934, 22224776.
5. Takahashi H, Yamamoto M, Suzuki C, Naishiro Y, Shinomura Y, Imai K. The birthday of a new syndrome: IgG4-related diseases constitute a clinical entity. Autoimmun Rev 2010, 9:591-594. 10.1016/j.autrev.2010.05.003, 20457280.
6. Tanaka A, Moriyama M, Nakashima H, Miyake K, Hayashida JN, Maehara T, Shinozaki S, Kubo Y, Nakamura S. Th2 and regulatory immune reactions contribute to IgG4 production and the initiation of Mikulicz disease. Arthritis Rheum 2012, 64:254-263. 10.1002/art.33320, 21898360.
7. Kanari H, Kagami S, Kashiwakuma D, Oya Y, Furuta S, Ikeda K, Suto A, Suzuki K, Hirose K, Watanabe N, Okamoto Y, Yamamoto S, Iwamoto I, Nakajima H. Role of Th2 cells in IgG4-related lacrimal gland enlargement. Int Arch Allergy Immunol 2010, 152:47-53. 10.1159/000312125, 20523063.
8. Malladi AS, Sack KE, Shiboski SC, Shiboski CH, Baer AN, Banushree R, Dong Y, Helin P, Kirkham BW, Li M, Sugai S, Umehara H, Vivino FB, Vollenweider CF, Zhang W, Zhao Y, Greenspan JS, Daniels TE, Criswell LA. Primary Sjogren's syndrome as a systemic disease: a study of participants enrolled in an international Sjogren's syndrome registry. Arthritis Care Res (Hoboken) 2012, 64:911-918. 10.1002/acr.21610, 3595164, 22238244.
9. Morgan WS, Castleman B. A clinicopathologic study of Mikulicz's disease. Am J Pathol 1953, 29:471-503. 1937437, 13040489.
10. Wilde B, Thewissen M, Damoiseaux J, Knippenberg S, Hilhorst M, van Paassen P, Witzke O, Cohen TJ. Regulatory B cells in ANCA-associated vasculitis. Ann Rheum Dis 2013, 72:1416-1419. 10.1136/annrheumdis-2012-202986, 23666929.
11. Blair PA, Norena LY, Flores-Borja F, Rawlings DJ, Isenberg DA, Ehrenstein MR, Mauri C. CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic lupus erythematosus patients. Immunity 2010, 32:129-140. 10.1016/j.immuni.2009.11.009, 20079667.
12. Watanabe R, Ishiura N, Nakashima H, Kuwano Y, Okochi H, Tamaki K, Sato S, Tedder TF, Fujimoto M. Regulatory B cells (B10 cells) have a suppressive role in murine lupus: CD19 and B10 cell deficiency exacerbates systemic autoimmunity. J Immunol 2010, 184:4801-4809. 10.4049/jimmunol.0902385, 3734559, 20368271.
13. Majlessi L, Lo-Man R, Leclerc C. Regulatory B and T cells in infections. Microbes Infect 2008, 10:1030-1035. 10.1016/j.micinf.2008.07.017, 18672084.
14. Biragyn A, Lee-Chang C. A new paradigm for an old story: the role of regulatory B cells in cancer. Front Immunol 2012, 3:206. 3401824, 22837759.
15. Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, Matsui S, Yoshino T, Nakamura S, Kawa S, Hamano H, Kamisawa T, Shimosegawa T, Shimatsu A, Nakamura S, Ito T, Notohara K, Sumida T, Tanaka Y, Mimori T, Chiba T, Mishima M, Hibi T, Tsubouchi H, Inui K, Ohara H. Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011. Mod Rheumatol 2012, 22:21-30. 10.3109/s10165-011-0571-z, 22218969.
16. Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, Daniels TE, Fox PC, Fox RI, Kassan SS, Pillemer SR, Talal N, Weisman MH. Classification criteria for Sjogren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002, 61:554-558. 10.1136/ard.61.6.554, 1754137, 12006334.
17. Carsetti R, Rosado MM, Wardmann H. Peripheral development of B cells in mouse and man. Immunol Rev 2004, 197:179-191. 10.1111/j.0105-2896.2004.0109.x, 14962195.
18. Sims GP, Ettinger R, Shirota Y, Yarboro CH, Illei GG, Lipsky PE. Identification and characterization of circulating human transitional B cells. Blood 2005, 105:4390-4398. 10.1182/blood-2004-11-4284, 1895038, 15701725.
19. Palanichamy A, Barnard J, Zheng B, Owen T, Quach T, Wei C, Looney RJ, Sanz I, Anolik JH. Novel human transitional B cell populations revealed by B cell depletion therapy. J Immunol 2009, 182:5982-5993. 10.4049/jimmunol.0801859, 2746373, 19414749.
20. Berthelot JM, Jamin C, Amrouche K, Le Goff B, Maugars Y, Youinou P. Regulatory B cells play a key role in immune system balance. Joint Bone Spine 2013, 80:18-22. 10.1016/j.jbspin.2012.04.010, 22858147.
21. Li X, Zhong H, Bao W, Boulad N, Evangelista J, Haider MA, Bussel J, Yazdanbakhsh K. Defective regulatory B-cell compartment in patients with immune thrombocytopenia. Blood 2012, 120:3318-3325. 10.1182/blood-2012-05-432575, 3476542, 22859611.
22. Knippenberg S, Peelen E, Smolders J, Thewissen M, Menheere P, Cohen TJ, Hupperts R, Damoiseaux J. Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naive/memory Breg ratio during a relapse but not in remission. J Neuroimmunol 2011, 239:80-86. 10.1016/j.jneuroim.2011.08.019, 21940055.
23. Lemoine S, Morva A, Youinou P, Jamin C. Regulatory B cells in autoimmune diseases: how do they work?. Ann NY Acad Sci 2009, 1173:260-267. 10.1111/j.1749-6632.2009.04651.x, 19758160.
24. Umehara H, Okazaki K, Masaki Y, Kawano M, Yamamoto M, Saeki T, Matsui S, Sumida T, Mimori T, Tanaka Y, Tsubota K, Yoshino T, Kawa S, Suzuki R, Takegami T, Tomosugi N, Kurose N, Ishigaki Y, Azumi A, Kojima M, Nakamura S, Inoue D. A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details. Mod Rheumatol 2012, 22:1-14. 10.3109/s10165-011-0508-6, 3278618, 21881964.
25. Ebbo M, Daniel L, Pavic M, Seve P, Hamidou M, Andres E, Burtey S, Chiche L, Serratrice J, Longy-Boursier M, Ruivard M, Haroche J, Godeau B, Beucher AB, Berthelot JM, Papo T, Pennaforte JL, Benyamine A, Jourde N, Landron C, Roblot P, Moranne O, Silvain C, Granel B, Bernard F, Veit V, Mazodier K, Bernit E, Rousset H, Boucraut J. IgG4-related systemic disease: features and treatment response in a French cohort: results of a multicenter registry. Medicine (Baltimore) 2012, 91:49-56. 10.1097/MD.0b013e3182433d77, 22198501.
26. Boneparth A, Davidson A. B-cell activating factor targeted therapy and lupus. Arthritis Res Ther 2012, 14:S2. 10.1186/ar3920, 3535720, 23281926.
27. Fairfax K, Mackay IR, Mackay F. BAFF/BLyS inhibitors: A new prospect for treatment of systemic lupus erythematosus. Iubmb Life 2012, 64:595-602. 10.1002/iub.1046, 22641424.
28. Varin MM, Le Pottier L, Youinou P, Saulep D, Mackay F, Pers JO. B-cell tolerance breakdown in Sjogren's syndrome: focus on BAFF. Autoimmun Rev 2010, 9:604-608. 10.1016/j.autrev.2010.05.006, 20457281.
29. Vadacca M, Margiotta D, Sambataro D, Buzzulini F, Lo VM, Rigon A, Afeltra A. BAFF/APRIL pathway in Sjogren syndrome and systemic lupus erythematosus: relationship with chronic inflammation and disease activity. Reumatismo 2010, 62:259-265.
30. Sellam J, Miceli-Richard C, Gottenberg JE, Ittah M, Lavie F, Lacabaratz C, Gestermann N, Proust A, Lambotte O, Mariette X. Decreased B cell activating factor receptor expression on peripheral lymphocytes associated with increased disease activity in primary Sjogren's syndrome and systemic lupus erythematosus. Ann Rheum Dis 2007, 66:790-797. 10.1136/ard.2006.065656, 1954659, 17185325.
31. Karimi MH, Pourfathollah AA. CD40 and tolerance induction. Iran J Allergy Asthma Immunol 2012, 11:1-13.
32. Ping L, Ogawa N, Sugai S. Novel role of CD40 in Fas-dependent apoptosis of cultured salivary epithelial cells from patients with Sjogren's syndrome. Arthritis Rheum 2005, 52:573-581. 10.1002/art.20789, 15692983.
33. Zhang W, Shi Q, Xu X, Chen H, Lin W, Zhang F, Zeng X, Zhang X, Ba D, He W. Aberrant CD40-induced NF-kappaB activation in human lupus B lymphocytes. PLoS One 2012, 7:e41644. 10.1371/journal.pone.0041644, 3428310, 22952582.
34. Mauri C. Regulation of immunity and autoimmunity by B cells. Curr Opin Immunol 2010, 22:761-767. 10.1016/j.coi.2010.10.009, 21087847.
35. Kuchroo VK, Das MP, Brown JA, Ranger AM, Zamvil SS, Sobel RA, Weiner HL, Nabavi N, Glimcher LH. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 1995, 80:707-718. 10.1016/0092-8674(95)90349-6, 7534215.
36. Bijl M, Horst G, Limburg PC, Kallenberg CG. Expression of costimulatory molecules on peripheral blood lymphocytes of patients with systemic lupus erythematosus. Ann Rheum Dis 2001, 60:523-526. 10.1136/ard.60.5.523, 1753642, 11302879.
37. Jeannin P, Delneste Y, Lecoanet-Henchoz S, Gauchat JF, Ellis J, Bonnefoy JY. CD86 (B7-2) on human B cells. A functional role in proliferation and selective differentiation into IgE- and IgG4-producing cells. J Biol Chem 1997, 272:15613-15619. 10.1074/jbc.272.25.15613, 9188449.