Regulation of immunity and autoimmunity by B cells

Current Opinion in Immunology

Volumn 22, Issue 6, 2010, Pages 761-767

  Mauri, Claudia ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CD40 ANTIGEN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 10; RITUXIMAB; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN;

ALLERGIC ENCEPHALOMYELITIS; AUTOIMMUNE DISEASE; AUTOIMMUNITY; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; BRUGIAN FILARIASIS; CELL INTERACTION; CYTOKINE PRODUCTION; DISEASE COURSE; DISEASE EXACERBATION; ENZOOTIC ABORTION OF EWES; HUMAN; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; IMMUNOREGULATION; IMMUNOSTIMULATION; IMMUNOSUPPRESSIVE TREATMENT; INFECTION SENSITIVITY; LEISHMANIASIS; LYMPHOCYTE DEPLETION; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MALIGNANT NEOPLASTIC DISEASE; MULTIPLE SCLEROSIS; NONHUMAN; PHENOTYPE; REGULATORY B LYMPHOCYTE; REGULATORY T LYMPHOCYTE; REVIEW; RHEUMATOID ARTHRITIS; SCHISTOSOMIASIS MANSONI; SYSTEMIC LUPUS ERYTHEMATOSUS;

AUTOIMMUNE DISEASES; B-LYMPHOCYTES; HUMANS; IMMUNITY;

EID: 78649894129     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2010.10.009     Document Type: Review

References (56)

1. Lund F.E., Randall T.D. Effector and regulatory B cells: modulators of CD4(+) T cell immunity. Nat Rev Immunol 2010, 10:236-247.
2. Edwards J.C., Cambridge G., Abrahams V.M. Do self-perpetuating B lymphocytes drive human autoimmune disease?. Immunology 1999, 97:188-196.
3. Shimomura Y., Mizoguchi E., Sugimoto K., Kibe R., Benno Y., Mizoguchi A., Bhan A.K. Regulatory role of B-1 B cells in chronic colitis. Int Immunol 2008, 20:729-737.
4. Rodriguez-Pinto D., Moreno J. B cells can prime naive CD4+ T cells in vivo in the absence of other professional antigen-presenting cells in a CD154-CD40-dependent manner. Eur J Immunol 2005, 35:1097-1105.
5. Yan J., Harvey B.P., Gee R.J., Shlomchik M.J., Mamula M.J. B cells drive early T cell autoimmunity in vivo prior to dendritic cell-mediated autoantigen presentation. J Immunol 2006, 177:4481-4487.
6. Shlomchik M.J., Craft J.E., Mamula M.J. From T to B and back again: positive feedback in systemic autoimmune disease. Nat Rev Immunol 2001, 1:147-153.
7. Eynon E.E., Parker D.C. Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens. J Exp Med 1992, 175:131-138.
8. Fuchs E.J., Matzinger P. B cells turn off virgin but not memory T cells. Science 1992, 258:1156-1159.
9. Harris D.P., Haynes L., Sayles P.C., Duso D.K., Eaton S.M., Lepak N.M., Johnson L.L., Swain S.L., Lund F.E. Reciprocal regulation of polarized cytokine production by effector B and T cells. Nat Immunol 2000, 1:475-482.
10. Mauri C., Ehrenstein M.R. The 'short' history of regulatory B cells. Trends Immunol 2008, 29:34-40.
11. Fillatreau S., Gray D., Anderton S.M. Not always the bad guys: B cells as regulators of autoimmune pathology. Nat Rev Immunol 2008, 8:391-397.
12. Wolf S.D., Dittel B.N., Hardardottir F., Janeway C.A. Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice. J Exp Med 1996, 184:2271-2278.
13. Fillatreau S., Sweenie C.H., McGeachy M.J., Gray D., Anderton S.M. B cells regulate autoimmunity by provision of IL-10. Nat Immunol 2002, 3:944-950.
14. Mizoguchi A., Mizoguchi E., Smith R.N., Preffer F.I., Bhan A.K. Suppressive role of B cells in chronic colitis of T cell receptor alpha mutant mice. J Exp Med 1997, 186:1749-1756.
15. Evans J.G., Chavez-Rueda K.A., Eddaoudi A., Meyer-Bahlburg A., Rawlings D.J., Ehrenstein M.R., Mauri C. Novel suppressive function of transitional 2 B cells in experimental arthritis. J Immunol 2007, 178:7868-7878.
16. Hu C.Y., Rodriguez-Pinto D., Du W., Ahuja A., Henegariu O., Wong F.S., Shlomchik M.J., Wen L. Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice. J Clin Invest 2007, 117:3857-3867.
17. Mizoguchi A., Mizoguchi E., Takedatsu H., Blumberg R.S., Bhan A.K. Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation. Immunity 2002, 16:219-230.
18. Goetz M., Atreya R., Ghalibafian M., Galle P.R., Neurath M.F. Exacerbation of ulcerative colitis after rituximab salvage therapy. Inflamm Bowel Dis 2007, 13:1365-1368.
19. Yanaba K., Bouaziz J.-D., Haas K.M., Poe J.C., Fujimoto M., Tedder T.F. A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity 2008, 28:639-650.
20. Yanaba K., Bouaziz J.D., Matsushita T., Tsubata T., Tedder T.F. The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. J Immunol 2009, 182:7459-7472.
21. Watanabe R., Ishiura N., Nakashima H., Kuwano Y., Okochi H., Tamaki K., Sato S., Tedder T.F., Fujimoto M. Regulatory B cells (B10 cells) have a suppressive role in murine lupus: CD19 and B10 cell deficiency exacerbates systemic autoimmunity. J Immunol 2010, 184:4801-4809.
22. Blair P.A., Chavez-Rueda K.A., Evans J.G., Shlomchik M.J., Eddaoudi A., Isenberg D.A., Ehrenstein M.R., Mauri C. Selective targeting of B cells with agonistic anti-CD40 is an efficacious strategy for the generation of induced regulatory T2-like B cells and for the suppression of lupus in MRL/lpr mice. J Immunol 2009, 182:3492-3502.
23. Nylen S., Sacks D. Interleukin-10 and the pathogenesis of human visceral leishmaniasis. Trends Immunol 2007, 28:378-384.
24. Ronet C., Hauyon-La Torre Y., Revaz-Breton M., Mastelic B., Tacchini-Cottier F., Louis J., Launois P. Regulatory B cells shape the development of Th2 immune responses in BALB/c mice infected with Leishmania major through IL-10 production. J Immunol 2010, 184:886-894.
25. Hernandez H.J., Wang Y., Stadecker M.J. In infection with Schistosoma mansoni, B cells are required for T helper type 2 cell responses but not for granuloma formation. J Immunol 1997, 158:4832-4837.
26. Gillan V., Lawrence R.A., Devaney E. B cells play a regulatory role in mice infected with the L3 of Brugia pahangi. Int Immunol 2005, 17:373-382.
27. Paciorkowski N., Shultz L.D., Rajan T.V. Primed peritoneal B lymphocytes are sufficient to transfer protection against Brugia pahangi infection in mice. Infect Immun 2003, 71:1370-1378.
28. Madan R., Demircik F., Surianarayanan S., Allen J.L., Divanovic S., Trompette A., Yogev N., Gu Y., Khodoun M., Hildeman D., et al. Nonredundant roles for B cell-derived IL-10 in immune counter-regulation. J Immunol 2009, 183:2312-2320.
29. Buendia A.J., Del Rio L., Ortega N., Sanchez J., Gallego M.C., Caro M.R., Navarro J.A., Cuello F., Salinas J. B-cell-deficient mice show an exacerbated inflammatory response in a model of Chlamydophila abortus infection. Infect Immun 2002, 70:6911-6918.
30. Mosser D.M., Zhang X. Interleukin-10: new perspectives on an old cytokine. Immunol Rev 2008, 226:205-218.
31. Shah S., Divekar A.A., Hilchey S.P., Cho H.M., Newman C.L., Shin S.U., Nechustan H., Challita-Eid P.M., Segal B.M., Yi K.H., et al. Increased rejection of primary tumors in mice lacking B cells: inhibition of anti-tumor CTL and TH1 cytokine responses by B cells. Int J Cancer 2005, 117:574-586.
32. Inoue S., Leitner W.W., Golding B., Scott D. Inhibitory effects of B cells on antitumor immunity. Cancer Res 2006, 66:7741-7747.
33. Mauri C., Gray D., Mushtaq N., Londei M. Prevention of arthritis by interleukin 10-producing B cells. J Exp Med 2003, 197:489-501.
34. Tian J., Zekzer D., Hanssen L., Lu Y., Olcott A., Kaufman D.L. Lipopolysaccharide-activated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice. J Immunol 2001, 167:1081-1089.
35. Brummel R., Lenert P. Activation of marginal zone B cells from lupus mice with type A(D) CpG-oligodeoxynucleotides. J Immunol 2005, 174:2429-2434.
36. Rafei M., Hsieh J., Zehntner S., Li M., Forner K., Birman E., Boivin M.N., Young Y.K., Perreault C., Galipeau J. A granulocyte-macrophage colony-stimulating factor and interleukin-15 fusokine induces a regulatory B cell population with immune suppressive properties. Nat Med 2009, 15:1038-1045.
37. Lampropoulou V., Hoehlig K., Roch T., Neves P., Calderon Gomez E., Sweenie C.H., Hao Y., Freitas A.A., Steinhoff U., Anderton S.M., et al. TLR-activated B cells suppress T cell-mediated autoimmunity. J Immunol 2008, 180:4763-4773.
38. Yang M., Sun L., Wang S., Ko K.H., Xu H., Zheng B.J., Cao X., Lu L. Novel function of B cell-activating factor in the induction of IL-10-producing regulatory B cells. J Immunol 2010, 184:3321-3325.
39. Gray M., Miles K., Salter D., Gray D., Savill J. Apoptotic cells protect mice from autoimmune inflammation by the induction of regulatory B cells. Proc Natl Acad Sci 2007, 104:14080-14085.
40. Amu S., Saunders S.P., Kronenberg M., Mangan N.E., Atzberger A., Fallon P.G. Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model. J Allergy Clin Immunol 2010, 125:1114-1124. e1118.
41. Matsushita T., Horikawa M., Iwata Y., Tedder T.F. Regulatory B cells (b10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis. J Immunol 2010, 185:2240-2252.
42. Sugimoto K., Ogawa A., Shimomura Y., Nagahama K., Mizoguchi A., Bhan A.K. Inducible IL-12-producing B cells regulate Th2-mediated intestinal inflammation. Gastroenterology 2007, 133:124-136.
43. Moritoki Y., Zhang W., Tsuneyama K., Yoshida K., Wakabayashi K., Yang G.X., Bowlus C., Ridgway W.M., Ueno Y., Ansari A.A., et al. B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis. Gastroenterology 2009, 136:1037-1047.
44. Mann M.K., Maresz K., Shriver L.P., Tan Y., Dittel B.N. B cell regulation of CD4+CD25+ T regulatory cells and IL-10 via B7 is essential for recovery from experimental autoimmune encephalomyelitis. J Immunol 2007, 178:3447-3456.
45. Lundy S.K., Fox D.A. Reduced Fas ligand-expressing splenic CD5+ B lymphocytes in severe collagen-induced arthritis. Arthritis Res Ther 2009, 11:R128.
46. Blair P.A., Norena L.Y., Flores-Borja F., Rawlings D.J., Isenberg D.A., Ehrenstein M.R., Mauri C. CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients. Immunity 2010, 32:129-140.
47. Sims G.P., Ettinger R., Shirota Y., Yarboro C.H., Illei G.G., Lipsky P.E. Identification and characterization of circulating human transitional B cells. Blood 2005, 105:4390-4398.
48. Newell K.A., Asare A., Kirk A.D., Gisler T.D., Bourcier K., Suthanthiran M., Burlingham W.J., Marks W.H., Sanz I., Lechler R.I., et al. Identification of a B cell signature associated with renal transplant tolerance in humans. J Clin Invest 2010, 120:1836-1847.
49. Anolik J.H., Barnard J., Owen T., Zheng B., Kemshetti S., Looney R.J., Sanz I. Delayed memory B cell recovery in peripheral blood and lymphoid tissue in systemic lupus erythematosus after B cell depletion therapy. Arthritis Rheum 2007, 56:3044-3056.
50. Palanichamy A., Barnard J., Zheng B., Owen T., Quach T., Wei C., Looney R.J., Sanz I., Anolik J.H. Novel human transitional B cell populations revealed by B cell depletion therapy. J Immunol 2009, 182:5982-5993.
51. Leandro M.J., Cambridge G., Ehrenstein M.R., Edwards J.C. Reconstitution of peripheral blood B cells after depletion with rituximab in patients with rheumatoid arthritis. Arthritis Rheum 2006, 54:613-620.
52. Correale J., Farez M., Razzitte G. Helminth infections associated with multiple sclerosis induce regulatory B cells. Ann Neurol 2008, 64:187-199.
53. Tretter T., Venigalla R.K., Eckstein V., Saffrich R., Sertel S., Ho A.D., Lorenz H.M. Induction of CD4+ T-cell anergy and apoptosis by activated human B cells. Blood 2008, 112:4555-4564.
54. Tu W., Lau Y.L., Zheng J., Liu Y., Chan P.L., Mao H., Dionis K., Schneider P., Lewis D.B. Efficient generation of human alloantigen-specific CD4+ regulatory T cells from naive precursors by CD40-activated B cells. Blood 2008, 112:2554-2562.
55. Zheng J., Liu Y., Lau Y.L., Tu W. CD40-activated B cells are more potent than immature dendritic cells to induce and expand CD4(+) regulatory T cells. Cell Mol Immunol 2010, 7:44-50.
56. Katz S.I., Parker D., Turk J.L. B-cell suppression of delayed hypersensitivity reactions. Nature 1974, 251:550-551.