Identification of a novel inhibition site in translocase MraY based upon the site of interaction with lysis protein e from bacteriophage φx174

ChemBioChem

Volumn 15, Issue 9, 2014, Pages 1300-1308

  Rodolis, Maria T ^a   Mihalyi, Agnes ^a   O'Reilly, Amy ^a   Slikas, Justinas ^a   Roper, David I ^a   Hancock, Robert E W ^b   Bugg, Timothy D H ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

antibiotics; bacteriophage; biosynthesis; lysis protein E; MraY; peptidoglycans

Indexed keywords

BACTERIAL ENZYME; CARRIER PROTEIN; DIPEPTIDE; PENTAPEPTIDE; POLYPEPTIDE ANTIBIOTIC AGENT; PROTEIN; PROTEIN E; SYNTHETIC PEPTIDE; TRANSLOCASE MRAY; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; E PROTEIN, BACTERIOPHAGE X174; MRAY PROTEIN, BACTERIA; PEPTIDE; TRANSFERASE; VIRUS PROTEIN;

AMINO ACID SEQUENCE; ANTIMICROBIAL ACTIVITY; ARTICLE; ASSAY; BACILLUS SUBTILIS; BACTERIOPHAGE PHI X 174; CELL MEMBRANE; CONSENSUS SEQUENCE; ENZYME INHIBITION; ESCHERICHIA COLI; IC 50; LYSIS; MICROCOCCUS LUTEUS; MINIMUM INHIBITORY CONCENTRATION; MUTANT; MUTATION; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

BACILLUS SUBTILIS; MICROCOCCUS LUTEUS; PSEUDOMONAS AERUGINOSA;

BACTERIAL PROTEINS; BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; PEPTIDES; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFERASES; VIRAL PROTEINS;

EID: 84902372066     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201402064     Document Type: Article

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