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Volumn 73, Issue , 2014, Pages 83-88

Delivery of inhalation drugs to children for asthma and other respiratory diseases

Author keywords

Aerosol; Airways; Deposition; Dry powder inhaler; Lungs; Metered dose inhaler; Nebuliser; Paediatric; Spacer; Throat

Indexed keywords

AEROSOLS; AIR TRANSPORTATION; DEPOSITION; DRUG PRODUCTS;

EID: 84902343133     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2013.11.007     Document Type: Review
Times cited : (38)

References (64)
  • 1
    • 35748964405 scopus 로고    scopus 로고
    • Not just small adults: the metaphors of paediatrics
    • Gillis J., Loughlan P. Not just small adults: the metaphors of paediatrics. Arch. Dis. Child. 2007, 92:946-947.
    • (2007) Arch. Dis. Child. , vol.92 , pp. 946-947
    • Gillis, J.1    Loughlan, P.2
  • 4
    • 84902325041 scopus 로고    scopus 로고
    • International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use, Clinical Investigation of Medicinal Products in the Pediatric Population E11
    • International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use, Clinical Investigation of Medicinal Products in the Pediatric Population E11. International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use, Geneva, Switzerland 2000.
    • (2000) International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use, Geneva, Switzerland
  • 9
    • 0019947563 scopus 로고
    • Mathematical model for the postnatal growth of the human lung
    • Hofmann W. Mathematical model for the postnatal growth of the human lung. Respir. Physiol. 1982, 49:115-129.
    • (1982) Respir. Physiol. , vol.49 , pp. 115-129
    • Hofmann, W.1
  • 10
    • 0001737928 scopus 로고
    • Effects of age on deposition of inhaled aerosols in the human lung
    • Xu G.B., Yu C.P. Effects of age on deposition of inhaled aerosols in the human lung. Aerosol Sci. Technol. 1986, 5:349-357.
    • (1986) Aerosol Sci. Technol. , vol.5 , pp. 349-357
    • Xu, G.B.1    Yu, C.P.2
  • 11
    • 0022397941 scopus 로고
    • Postnatal enlargement of human tracheobronchial airways and implications for particle deposition
    • Phalen R.F., Oldham M.J., Beaucage C.B., Crocker T.T., Mortensen J.D. Postnatal enlargement of human tracheobronchial airways and implications for particle deposition. Anat. Rec. 1985, 212:368-380.
    • (1985) Anat. Rec. , vol.212 , pp. 368-380
    • Phalen, R.F.1    Oldham, M.J.2    Beaucage, C.B.3    Crocker, T.T.4    Mortensen, J.D.5
  • 12
    • 85012487682 scopus 로고
    • Predicted deposition of nonhygroscopic aerosols in the human lung as a function of subject age
    • Hofmann W., Martonen T.B., Graham R.C. Predicted deposition of nonhygroscopic aerosols in the human lung as a function of subject age. J. Aerosol Med. 1989, 2:49-68.
    • (1989) J. Aerosol Med. , vol.2 , pp. 49-68
    • Hofmann, W.1    Martonen, T.B.2    Graham, R.C.3
  • 13
    • 0026679720 scopus 로고
    • Algebraic modeling of total and regional deposition of inhaled particles in the human lung of various ages
    • Yu C.P., Zhang L., Becquemin M.H., Roy M., Bouchikhi A. Algebraic modeling of total and regional deposition of inhaled particles in the human lung of various ages. J. Aerosol Sci. 1992, 23:73-79.
    • (1992) J. Aerosol Sci. , vol.23 , pp. 73-79
    • Yu, C.P.1    Zhang, L.2    Becquemin, M.H.3    Roy, M.4    Bouchikhi, A.5
  • 14
    • 0034587294 scopus 로고    scopus 로고
    • Mathematical model of airflow in the lungs of children I: effects of tumor sizes and locations
    • Segal R.A., Guan X., Shearer M., Martonen T.B. Mathematical model of airflow in the lungs of children I: effects of tumor sizes and locations. J. Theor. Med. 2000, 2:199-213.
    • (2000) J. Theor. Med. , vol.2 , pp. 199-213
    • Segal, R.A.1    Guan, X.2    Shearer, M.3    Martonen, T.B.4
  • 15
    • 0034582620 scopus 로고    scopus 로고
    • Mathematical model of a airflow in the lungs of children II: effects of ventilatory parameters
    • Guan X., Segal R.A., Shearer M., Martonen T.B. Mathematical model of a airflow in the lungs of children II: effects of ventilatory parameters. J. Theor. Med. 2000, 3:51-62.
    • (2000) J. Theor. Med. , vol.3 , pp. 51-62
    • Guan, X.1    Segal, R.A.2    Shearer, M.3    Martonen, T.B.4
  • 16
    • 33745227332 scopus 로고    scopus 로고
    • Transport and deposition of respiratory aerosols in models of childhood asthma
    • Longest P.W., Vinchurkar S., Martonen T. Transport and deposition of respiratory aerosols in models of childhood asthma. J. Aerosol Sci. 2006, 37:1234-1257.
    • (2006) J. Aerosol Sci. , vol.37 , pp. 1234-1257
    • Longest, P.W.1    Vinchurkar, S.2    Martonen, T.3
  • 17
    • 61349171849 scopus 로고    scopus 로고
    • Inertial deposition of aerosols in bifurcating models during steady expiratory flow
    • Longest P.W., Vinchurkar S. Inertial deposition of aerosols in bifurcating models during steady expiratory flow. J. Aerosol Sci. 2009, 40:370-378.
    • (2009) J. Aerosol Sci. , vol.40 , pp. 370-378
    • Longest, P.W.1    Vinchurkar, S.2
  • 18
    • 0028244020 scopus 로고
    • Experimental data for total deposition in the respiratory tract of children
    • Schiller-Scotland C.F., Hlawa R., Gebhart J. Experimental data for total deposition in the respiratory tract of children. Toxicol. Lett. 1994, 72:137-144.
    • (1994) Toxicol. Lett. , vol.72 , pp. 137-144
    • Schiller-Scotland, C.F.1    Hlawa, R.2    Gebhart, J.3
  • 19
    • 0037637609 scopus 로고    scopus 로고
    • Distribution of technetium-99m-labelled QVAR™ delivered using an Autohaler™ device in children
    • Devadason S.G., Huang T., Walker S., Troedson R., Le Souëf P.N. Distribution of technetium-99m-labelled QVAR™ delivered using an Autohaler™ device in children. Eur. Respir. J. 2003, 21:1007-1011.
    • (2003) Eur. Respir. J. , vol.21 , pp. 1007-1011
    • Devadason, S.G.1    Huang, T.2    Walker, S.3    Troedson, R.4    Le Souëf, P.N.5
  • 20
    • 33846934467 scopus 로고    scopus 로고
    • Spacer inhalation technique and deposition of extrafine aerosol in asthmatic children
    • Roller C.M., Zhang G., Troedson R.G., Leach C.L., Le Souëf P.N. Spacer inhalation technique and deposition of extrafine aerosol in asthmatic children. Eur. Respir. J. 2007, 29:299-306.
    • (2007) Eur. Respir. J. , vol.29 , pp. 299-306
    • Roller, C.M.1    Zhang, G.2    Troedson, R.G.3    Leach, C.L.4    Le Souëf, P.N.5
  • 22
    • 0033497527 scopus 로고    scopus 로고
    • Inhalation therapy in asthma: nebulizer or pressurized metered-dose inhaler with holding chamber? In vivo comparison of lung deposition in children
    • Wildhaber J.H., Dore N.D., Wilson J.M., Devadason S.G., Le Souef P.N. Inhalation therapy in asthma: nebulizer or pressurized metered-dose inhaler with holding chamber? In vivo comparison of lung deposition in children. J. Pediatr. 1999, 135:28-33.
    • (1999) J. Pediatr. , vol.135 , pp. 28-33
    • Wildhaber, J.H.1    Dore, N.D.2    Wilson, J.M.3    Devadason, S.G.4    Le Souef, P.N.5
  • 23
    • 0033007647 scopus 로고    scopus 로고
    • Anatomy and physiology in delivery: can we define our targets?
    • Chrystyn H. Anatomy and physiology in delivery: can we define our targets?. Allergy 1999, 49:82-87.
    • (1999) Allergy , vol.49 , pp. 82-87
    • Chrystyn, H.1
  • 24
    • 0032613139 scopus 로고    scopus 로고
    • Aerosol delivery to children: what to use, how to choose
    • Dolovich M. Aerosol delivery to children: what to use, how to choose. Pediatr. Pulmonol. 1999, 27(Supplement 18):79-82.
    • (1999) Pediatr. Pulmonol. , vol.27 , Issue.SUPPL. 18 , pp. 79-82
    • Dolovich, M.1
  • 26
    • 0029863731 scopus 로고    scopus 로고
    • Deposition pattern of radiolabeled salbutamol inhaled from a metered-dose inhaler by means of a spacer with mask in young children with airway obstruction
    • Tal A., Golan H., Grauer N., Aviram M., Albin D., Quastel M.R. Deposition pattern of radiolabeled salbutamol inhaled from a metered-dose inhaler by means of a spacer with mask in young children with airway obstruction. J. Pediatr. 1996, 128:479-484.
    • (1996) J. Pediatr. , vol.128 , pp. 479-484
    • Tal, A.1    Golan, H.2    Grauer, N.3    Aviram, M.4    Albin, D.5    Quastel, M.R.6
  • 27
    • 1942531311 scopus 로고    scopus 로고
    • A complementary combination of delivery device and drug formulation for inhalation therapy in preschool children
    • Schüepp K.G., Devadason S., Roller C., Wildhaber J.H. A complementary combination of delivery device and drug formulation for inhalation therapy in preschool children. Swiss Med. Wkly. 2004, 134:198-200.
    • (2004) Swiss Med. Wkly. , vol.134 , pp. 198-200
    • Schüepp, K.G.1    Devadason, S.2    Roller, C.3    Wildhaber, J.H.4
  • 28
  • 31
    • 0036839662 scopus 로고    scopus 로고
    • Inhalation and deposition of nebulized sodium cromoglycate in two different particle size distributions in children with asthma
    • Nerbrink O.L., Lindström M., Meurling L., Svartengren M. Inhalation and deposition of nebulized sodium cromoglycate in two different particle size distributions in children with asthma. Pediatr. Pulmonol. 2002, 34:351-360.
    • (2002) Pediatr. Pulmonol. , vol.34 , pp. 351-360
    • Nerbrink, O.L.1    Lindström, M.2    Meurling, L.3    Svartengren, M.4
  • 32
    • 0033509872 scopus 로고    scopus 로고
    • Comparison of albuterol delivered by a metered dose inhaler with spacer versus a nebulizer in children with mild acute asthma
    • Schuh S., Johnson D.W., Stephens D., Callahan S., Winders P., Canny G.J. Comparison of albuterol delivered by a metered dose inhaler with spacer versus a nebulizer in children with mild acute asthma. J. Pediatr. 1999, 135:22-27.
    • (1999) J. Pediatr. , vol.135 , pp. 22-27
    • Schuh, S.1    Johnson, D.W.2    Stephens, D.3    Callahan, S.4    Winders, P.5    Canny, G.J.6
  • 33
    • 0025234591 scopus 로고
    • How much aerosol reaches the lungs in wheezy infants and toddlers?
    • Salmon B., Wilson N.M., Silverman M. How much aerosol reaches the lungs in wheezy infants and toddlers?. Arch. Dis. Child. 1990, 65:401-403.
    • (1990) Arch. Dis. Child. , vol.65 , pp. 401-403
    • Salmon, B.1    Wilson, N.M.2    Silverman, M.3
  • 34
    • 0037998152 scopus 로고    scopus 로고
    • Efficiency of aerosol medication delivery from a metered dose inhaler versus jet nebulizer in infants with bronchopulmonary dysplasia
    • Fok T.F., Monkman S., Dolovich M., Gray S., Coates G., Paes B., Rashid F., Newhouse M., Kirpalani H. Efficiency of aerosol medication delivery from a metered dose inhaler versus jet nebulizer in infants with bronchopulmonary dysplasia. Pediatr. Pulmonol. 1996, 21:301-309.
    • (1996) Pediatr. Pulmonol. , vol.21 , pp. 301-309
    • Fok, T.F.1    Monkman, S.2    Dolovich, M.3    Gray, S.4    Coates, G.5    Paes, B.6    Rashid, F.7    Newhouse, M.8    Kirpalani, H.9
  • 35
    • 0038771127 scopus 로고    scopus 로고
    • Inhalation therapy in infants
    • Everard M.L. Inhalation therapy in infants. Adv. Drug Deliv. Rev. 2003, 55:869-878.
    • (2003) Adv. Drug Deliv. Rev. , vol.55 , pp. 869-878
    • Everard, M.L.1
  • 36
    • 84869038523 scopus 로고    scopus 로고
    • Delivery of inhaled drugs for infants and small children: a commentary on present and future needs
    • Fink J.B. Delivery of inhaled drugs for infants and small children: a commentary on present and future needs. Clin. Ther. 2012, 34:S36-S45.
    • (2012) Clin. Ther. , vol.34
    • Fink, J.B.1
  • 38
    • 18844415115 scopus 로고    scopus 로고
    • Delivery of nebulized budesonide is affected by nebulizer type and breathing pattern
    • O'Callaghan C., White J., Jackson J., Barry P.W., Kantar A. Delivery of nebulized budesonide is affected by nebulizer type and breathing pattern. J. Pharm. Pharmacol. 2005, 57:787-790.
    • (2005) J. Pharm. Pharmacol. , vol.57 , pp. 787-790
    • O'Callaghan, C.1    White, J.2    Jackson, J.3    Barry, P.W.4    Kantar, A.5
  • 39
    • 0033406815 scopus 로고    scopus 로고
    • An in vitro analysis of the output of budesonide from different nebulizers
    • Barry P.W., O'Callaghan C. An in vitro analysis of the output of budesonide from different nebulizers. J. Allergy Clin. Immunol. 1999, 104:1168-1173.
    • (1999) J. Allergy Clin. Immunol. , vol.104 , pp. 1168-1173
    • Barry, P.W.1    O'Callaghan, C.2
  • 41
    • 0032239480 scopus 로고    scopus 로고
    • In vitro comparison of belomethasone and salbutamol metered-dose inhaler aerosol inhaled during pediatric tidal breathing from four valved holding chambers
    • Finlay W.H., Zuberbuhler P. In vitro comparison of belomethasone and salbutamol metered-dose inhaler aerosol inhaled during pediatric tidal breathing from four valved holding chambers. Chest 1998, 114:1676-1680.
    • (1998) Chest , vol.114 , pp. 1676-1680
    • Finlay, W.H.1    Zuberbuhler, P.2
  • 42
    • 0032526525 scopus 로고    scopus 로고
    • Inertial sizing of aerosol inhaled during pediatric tidal breathing from an MDI with attached holding chamber
    • Finlay W.H. Inertial sizing of aerosol inhaled during pediatric tidal breathing from an MDI with attached holding chamber. Int. J. Pharm. 1998, 168:147-152.
    • (1998) Int. J. Pharm. , vol.168 , pp. 147-152
    • Finlay, W.H.1
  • 43
    • 0028001316 scopus 로고
    • Reduction of morbidity in asthmatic children given a spacer device
    • Cunningham S.J., Crain E.F. Reduction of morbidity in asthmatic children given a spacer device. Chest 1994, 106:753-757.
    • (1994) Chest , vol.106 , pp. 753-757
    • Cunningham, S.J.1    Crain, E.F.2
  • 44
    • 0028905083 scopus 로고
    • Metered dose inhaler and nebuliser in acute asthma
    • Lin Y.-Z., Hsieh K.-H. Metered dose inhaler and nebuliser in acute asthma. Arch. Dis. Child. 1995, 72:214-218.
    • (1995) Arch. Dis. Child. , vol.72 , pp. 214-218
    • Lin, Y.-Z.1    Hsieh, K.-H.2
  • 47
    • 34247628328 scopus 로고    scopus 로고
    • Jet nebulizers versus pressurized metered dose inhalers with valved holding chambers: effects of the facemask on aerosol delivery
    • Nikander K., Berg E., Smaldone G.C. Jet nebulizers versus pressurized metered dose inhalers with valved holding chambers: effects of the facemask on aerosol delivery. J. Aerosol Med. 2007, 20:S46-S58.
    • (2007) J. Aerosol Med. , vol.20
    • Nikander, K.1    Berg, E.2    Smaldone, G.C.3
  • 48
    • 34247584997 scopus 로고    scopus 로고
    • Facemask design, facial deposition, and delivered dose of nebulized aerosols
    • Smaldone G.C., Sangwan S., Shah A. Facemask design, facial deposition, and delivered dose of nebulized aerosols. J. Aerosol Med. 2007, 20:S66-S77.
    • (2007) J. Aerosol Med. , vol.20
    • Smaldone, G.C.1    Sangwan, S.2    Shah, A.3
  • 49
    • 77956912575 scopus 로고    scopus 로고
    • Assessment of facial and ocular deposition of nebulized aerosol using a color-based method
    • Kundoor V., Dalby R.N. Assessment of facial and ocular deposition of nebulized aerosol using a color-based method. Drug Dev. Ind. Pharm. 2010, 36:1281-1285.
    • (2010) Drug Dev. Ind. Pharm. , vol.36 , pp. 1281-1285
    • Kundoor, V.1    Dalby, R.N.2
  • 50
    • 34247573853 scopus 로고    scopus 로고
    • Facemasks and aerosol delivery by metered dose inhaler-valved holding chamber in young children: a tight seal makes the difference
    • Janssens H.M., Tiddens H.A.W.M. Facemasks and aerosol delivery by metered dose inhaler-valved holding chamber in young children: a tight seal makes the difference. J. Aerosol Med. 2007, 20:S59-S65.
    • (2007) J. Aerosol Med. , vol.20
    • Janssens, H.M.1    Tiddens, H.A.W.M.2
  • 51
    • 34247595354 scopus 로고    scopus 로고
    • Design of facemasks for delivery of aerosol-based medication via pressurized metered dose inhaler with valved holding chamber: key issues that affect performance
    • Morton R.W., Mitchell J.P. Design of facemasks for delivery of aerosol-based medication via pressurized metered dose inhaler with valved holding chamber: key issues that affect performance. J. Aerosol Med. 2007, 20:S29-S45.
    • (2007) J. Aerosol Med. , vol.20
    • Morton, R.W.1    Mitchell, J.P.2
  • 52
    • 0027290024 scopus 로고
    • Importance of the inhalation device on the effect of budesonide
    • Agertoft L., Pedersen S. Importance of the inhalation device on the effect of budesonide. Arch. Dis. Child. 1993, 69:130-133.
    • (1993) Arch. Dis. Child. , vol.69 , pp. 130-133
    • Agertoft, L.1    Pedersen, S.2
  • 53
    • 0031596530 scopus 로고    scopus 로고
    • Clinical effect of Diskus™ dry-powder inhaler at low and high inspiratory flow-rates in asthmatic children
    • Nielsen K.G., Auk I.L., Bojsen K., Ifversen M., Klug B., Bisgaard H. Clinical effect of Diskus™ dry-powder inhaler at low and high inspiratory flow-rates in asthmatic children. Eur. Respir. J. 1998, 11:350-354.
    • (1998) Eur. Respir. J. , vol.11 , pp. 350-354
    • Nielsen, K.G.1    Auk, I.L.2    Bojsen, K.3    Ifversen, M.4    Klug, B.5    Bisgaard, H.6
  • 54
    • 1542373594 scopus 로고    scopus 로고
    • Efficacy and safety of ipratropium bromide plus fenoterol inhaled via Respimat® Soft Mist™ inhaler vs. a conventional metered dose inhaler plus spacer in children with asthma
    • von Berg A., Jeena P.M., Soemantri P.A., Vertruyen A., Schmidt P., Gerken F., Razzouk H. Efficacy and safety of ipratropium bromide plus fenoterol inhaled via Respimat® Soft Mist™ inhaler vs. a conventional metered dose inhaler plus spacer in children with asthma. Pediatr. Pulmonol. 2004, 37:264-272.
    • (2004) Pediatr. Pulmonol. , vol.37 , pp. 264-272
    • von Berg, A.1    Jeena, P.M.2    Soemantri, P.A.3    Vertruyen, A.4    Schmidt, P.5    Gerken, F.6    Razzouk, H.7
  • 55
    • 56049107464 scopus 로고    scopus 로고
    • Deposition ofmicrometer-sized aerosol particles in infant nasal airway replicas
    • Storey-Bishoff J., Noga M., Finlay W.H. Deposition ofmicrometer-sized aerosol particles in infant nasal airway replicas. J. Aerosol Sci. 2008, 39:1055-1065.
    • (2008) J. Aerosol Sci. , vol.39 , pp. 1055-1065
    • Storey-Bishoff, J.1    Noga, M.2    Finlay, W.H.3
  • 56
    • 79955974555 scopus 로고    scopus 로고
    • In vitro deposition measurement of inhaled micrometer-sized particles in extrathoracic airways of children and adolescents during nose breathing
    • Golshani L., Noga M.L., Thompson R.B., Finlay W.H. In vitro deposition measurement of inhaled micrometer-sized particles in extrathoracic airways of children and adolescents during nose breathing. J. Aerosol Sci. 2011, 42:474-488.
    • (2011) J. Aerosol Sci. , vol.42 , pp. 474-488
    • Golshani, L.1    Noga, M.L.2    Thompson, R.B.3    Finlay, W.H.4
  • 58
    • 77955472439 scopus 로고    scopus 로고
    • Deposition of albuterol aerosol generated by pneumatic nebulizer in the Sophia Anatomical Infant Nose-Throat (SAINT) model
    • Laube B.L., Sharpless G., Shermer C., Nasir O., Sullivan V., Powell K. Deposition of albuterol aerosol generated by pneumatic nebulizer in the Sophia Anatomical Infant Nose-Throat (SAINT) model. Pharm. Res. 2010, 27:1722-1729.
    • (2010) Pharm. Res. , vol.27 , pp. 1722-1729
    • Laube, B.L.1    Sharpless, G.2    Shermer, C.3    Nasir, O.4    Sullivan, V.5    Powell, K.6
  • 59
    • 0141763844 scopus 로고    scopus 로고
    • Aerosol drug delivery using heliox and nebulizer reservoirs: results from an MRI-based pediatric model
    • Corcoran T.E., Shortall B.P., Kim I.K., Meza M.P., Chigier N. Aerosol drug delivery using heliox and nebulizer reservoirs: results from an MRI-based pediatric model. J. Aerosol Med. 2003, 16:263-271.
    • (2003) J. Aerosol Med. , vol.16 , pp. 263-271
    • Corcoran, T.E.1    Shortall, B.P.2    Kim, I.K.3    Meza, M.P.4    Chigier, N.5
  • 60
    • 52649144278 scopus 로고    scopus 로고
    • Development of the Premature Infant Nose Throat-Model (PrINT-Model) - an upper airway replica of a premature neonate for the study of aerosol delivery
    • Minocchieri S., Burren J.M., Bachmann M.A., Stern G., Wildhaber J., Buob S., Schindel R., Kraemer R., Frey U.P., Nelle M. Development of the Premature Infant Nose Throat-Model (PrINT-Model) - an upper airway replica of a premature neonate for the study of aerosol delivery. Pediatr. Res. 2008, 64:141-146.
    • (2008) Pediatr. Res. , vol.64 , pp. 141-146
    • Minocchieri, S.1    Burren, J.M.2    Bachmann, M.A.3    Stern, G.4    Wildhaber, J.5    Buob, S.6    Schindel, R.7    Kraemer, R.8    Frey, U.P.9    Nelle, M.10
  • 61
    • 84859601531 scopus 로고    scopus 로고
    • Deposition of inhaled micrometer-sized particles in oropharyngeal airway replicas of children at constant flow rates
    • Golshani L., Noga M.L., Finlay W.H. Deposition of inhaled micrometer-sized particles in oropharyngeal airway replicas of children at constant flow rates. J. Aerosol Sci. 2012, 49:21-31.
    • (2012) J. Aerosol Sci. , vol.49 , pp. 21-31
    • Golshani, L.1    Noga, M.L.2    Finlay, W.H.3
  • 62
    • 0034019232 scopus 로고    scopus 로고
    • On the suitability of k-ε turbulence modeling for aerosol deposition in the mouth and throat: a comparison with experiment
    • Stapleton K.W., Guentsch E., Hoskinson M.K., Finlay W.H. On the suitability of k-ε turbulence modeling for aerosol deposition in the mouth and throat: a comparison with experiment. J. Aerosol Sci. 2000, 31:739-749.
    • (2000) J. Aerosol Sci. , vol.31 , pp. 739-749
    • Stapleton, K.W.1    Guentsch, E.2    Hoskinson, M.K.3    Finlay, W.H.4
  • 63
    • 84859180342 scopus 로고    scopus 로고
    • An idealized child throat that mimics average pediatric oropharyngeal deposition
    • Golshani L., Finlay W.H. An idealized child throat that mimics average pediatric oropharyngeal deposition. Aerosol Sci. Technol. 2012, 46:i-iv.
    • (2012) Aerosol Sci. Technol. , vol.46
    • Golshani, L.1    Finlay, W.H.2
  • 64
    • 84874321222 scopus 로고    scopus 로고
    • Assessing the performance of two dry powder inhalers in preschool children using an idealized pediatric upper airway model
    • Below A., Bickmann D., Breitkreutz J. Assessing the performance of two dry powder inhalers in preschool children using an idealized pediatric upper airway model. Int. J. Pharm. 2013, 444:169-174.
    • (2013) Int. J. Pharm. , vol.444 , pp. 169-174
    • Below, A.1    Bickmann, D.2    Breitkreutz, J.3


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