Assessment of facial and ocular deposition of nebulized aerosol using a color-based method

Drug Development and Industrial Pharmacy

Volumn 36, Issue 11, 2010, Pages 1281-1285

  Kundoor, Vipra ^a   Dalby, Richard N ^a  

^a UNIVERSITY OF MARYLAND   (United States)

Author keywords

Breathing pattern; Face model; Facemask; Nebulizer; Pediatric

Indexed keywords

AEROSOL; AIRFLOW; ARTICLE; BREATHING PATTERN; FACE MASK; IN VITRO STUDY; NEBULIZER; QUANTITATIVE ANALYSIS; THREE DIMENSIONAL IMAGING;

AEROSOLS; CHILD, PRESCHOOL; COLOR; EQUIPMENT DESIGN; EYE; FACE; HUMANS; MASKS; MODELS, ANATOMIC; NEBULIZERS AND VAPORIZERS; RESPIRATION;

EID: 77956912575     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639041003753854     Document Type: Article

References (18)

1. Sangwan S, Gurses BK, Smaldone GC. (2004). Facemask and facial deposition of aerosols. Pediatr Pulmonol, 37:447-452
2. Everard ML, Clark AR, Milner AD. (1992). Drug delivery from holding chambers with attached facemask. Arch Dis Child, 67:580-585
3. Salmon B, Wilson NM, Silverman M. (1990). How much aerosol reaches the lungs of wheezy infants and toddlers? Arch Dis Child, 65(4):401-403
4. Newhouse MT. (1993). Pulmonary drug targeting with aerosols: Principles and clinical applications in adults and children. Am J Asthma Allergy Pediatr, 7(1):23-25
5. Hayden JT, Smith N, Woolf DA, Barry PW, OCallaghan C. (2004). A randomized crossover trial of facemask efficacy. Arch Dis Child, 89:72-73
6. Anhoj J, Thorsson L, Bisgaard H. (2000). Lung deposition of inhaled drug increases with age. Am J Respir Crit Care Med, 162(5):1819-1822
7. Fok TF, Monkman S, Dolovich M, Gray S, Coates G, Paes B. (1996). Effeciency of aerosol medication delivery from a metered dose inhaler versus jet nebulizer in infants with bronchopulmonary dysplasia. Pediatr Pulmonol, 21(5):301-309
8. Everard ML, Clark AR, Milner AD. (1992). Drug delivery from jet nebulizers. Arch Dis Child, 67:586-591
9. Erzinger S, Schueepp KG, Wildhaber JB, Devadason SG, Wildhaber JH. (2007). Facemasks and aerosol delivery in vivo. J Aerosol Med, 20(1):S78-84.
10. Kundoor V, Dalby R. (2010). Assessment of nasal spray deposition pattern in a silicone human nose model using a color based method. Pharm Res, 27(1):30-36
11. Janssens HM, Devadason SG, Hop WC, LeSouf PN, De Jongste JC, Tiddens HA. (1999). Variability of aerosol delivery via spacer devices in young asthmatic children in daily life. Eur Respir J, 13:787-791
12. Janssens H. (2000). Aerosol delivery from spacers in wheezy infants: A daily life study. Eur Respir J, 16:850-856
13. Hayden J. (2000). Choice of a facemask attached to a spacer may markedly affect drug delivery to young children. Thorax, 55(Suppl. 3):A62.
14. Amirav I, Newhouse MT. (2001). Aerosol therapy with valved holding chambers in young children: Importance of the facemask seal. Pediatrics, 108:389-394
15. Smaldone GC, Berg E, Morra L, et al. (2001). Drug delivery from inhalation devices is dependent on facemask seal and the childs breathing pattern. Am J Cri Care Med, 63:A847.
16. Smaldone GC, Sangwan S, Shah A. (2007). Facemask design, facial deposition, and delivered dose of nebulized aerosols. J Aerosol Med, 20(1):S66-77.
17. Harris KW, Smaldone GC. (2008). Facial and ocular deposition of nebulized budesonide. Chest, 133:482-488
18. Smaldone GC, Berg E, Nikander K. (2005). Variation in pediatric aerosol delivery: Importance of facemask. J Aerosol Med, 18(3):354-363