Clinical effects of Diskus(TM) dry-powder inhaler at low and high inspiratory flow-rates in asthmatic children

European Respiratory Journal

Volumn 11, Issue 2, 1998, Pages 350-354

  Nielsen, K G ^a   Auk, I L ^a   Bojsen, K ^a   Ifversen, M ^a   Klug, B ^a   Bisgaard, H ^a  

^a Rigshospitalet   (Denmark)

Author keywords

Clinical trial; Diskus(TM) inhaler; Exercise induced bronchoconstriction; Inspiratory flow; Placebo controlled; Salmeterol

Indexed keywords

ANTIASTHMATIC AGENT; PLACEBO; SALMETEROL; BRONCHODILATING AGENT; DRUG DERIVATIVE; SALBUTAMOL;

ADOLESCENT; ARTICLE; ASTHMA; BRONCHOSPASM; CHILD; CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; EXERCISE INDUCED ASTHMA; FORCED EXPIRATORY VOLUME; HUMAN; IN VITRO STUDY; INHALATION; INHALATIONAL DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; POWDER INHALER; PRIORITY JOURNAL; VITAL CAPACITY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; EXERCISE; FEMALE; LUNG VENTILATION; MALE; NEBULIZER; PATHOPHYSIOLOGY; PHYSIOLOGY; POWDER; RANDOMIZED CONTROLLED TRIAL;

ADOLESCENT; ALBUTEROL; ASTHMA, EXERCISE-INDUCED; BRONCHOCONSTRICTION; BRONCHODILATOR AGENTS; CHILD; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; EXERCISE; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; MALE; NEBULIZERS AND VAPORIZERS; POWDERS; PULMONARY VENTILATION;

EID: 0031596530     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.98.11020350     Document Type: Article

References (20)

1. Olsson B, Asking L. Critical aspects of the function of inspiratory flow driven inhalers. J Aerosol Med 1994; (Suppl. 1): 43-47.
2. Malton A, Sumby BS, Smith IJ. A comparison of in vitro drug delivery from two multidose powder inhalation devices. Eur J Clin Res 1995; 7: 177-193.
3. Polgar G, Promadhat V. Pulmonary function testing in children: techniques and standards. London, WB Saunders, 1971.
4. Koch GG. The use of non-parametric methods in the statistical analysis of two-period change-over design. Biometrics 1972; 28: 577-584.
5. Nielsen KG, Skov M, Klug B, Ifversen M, Bisgaard H. Flow dependent effect of formoterol dry-powder inhaled from the Aerolizer™. Eur Respir J 1997; 10: 2105-2109.
6. Bisgaard H, Andersen JB, Bach-Mortensen N, et al. A clinical comparison of aerosol and powder administration of beclomethasone dipropionate in childhood asthma. Allergy 1984; 39: 365-369.
7. Richards R, Dickson CR, Renwick AG, Lewis RA, Holgate ST. Absorption and disposition kinetics of cromolyn sodium and the influence of inhalation technique. J Pharmacol Exp Ther 1987; 241: 1028-1032.
8. Newman SP, Morén F, Trofast H, Talaee N, Clarke SW. Terbutaline sulphate Turbuhaler: effect of inhaled flow rate on drug deposition and efficacy. Int J Pharm 1991; 74: 209-213.
9. Newman SP, Hollingworth A, Clark AR. Effect of different modes of inhalation on drug delivery from a dry powder inhaler. Int J Pharm 1994; 102: 127-132.
10. Borgström L, Bondesson E, Moren F, Newman SP. Lung deposition of budesonide inhaled via Turbuhaler. A comparison with terbutaline sulphate. Eur Respir J 1994; 7: 69-73.
11. Bisgaard H, Klug B, Burnell PKP, Sumby BS. Use of inhalation profiles from paediatric asthmatics using the diskus and turbuhaler inhalers to evaluate product performance in vitro. Am J Respir Crit Care Med 1996; 153: (4): A75.
12. de Benedictis FM, Tuteri G, Pazzelli P, Niccoli A, Mezzetti D, Vaccaro R. Salmeterol in exercise-induced bronchoconstriction in asthmatic children: comparison of two doses. Eur Respir J 1996; 9: 2099-2103.
13. Simons FE, Reeni Soni N, Watson WT, Becker AB. Bronchodilator and bronchoprotective effects of salmeterol in young patients with asthma. J Allergy Clin Immunol 1992; 90: 840-846.
14. Francis PWJ, Krastins IRB, Levison H. Oral and inhaled salbutamol in the prevention of exercise-induced bronchospasm. Pediatrics 1980; 86: 103-108.
15. Salome CM, Schoeffel RE, Yan K, Woolcock AJ. Effect of aerosol fenorterol on the severity of bronchial hyperreactivity in patients with asthma. Thorax 1983; 38: 854-858.
16. Verberne A, Hop WCJ, Bos AB, Kerrebijn K. Effect of a single dose of inhaled salmeterol on baseline airway caliber and methacholine-induced airway obstruction in asthmatic children. J Allergy Clin Immunol 1993; 91: 127-134.
17. 2-adrenergic agonist, has longer blocking effect than albuterol on hyperventilation induced bronchoconstriction. Am Rev Respir Dis 1990; 142: 1147-1152.
18. Sichletidis E, Daskalopoulou E, Kyriazis G, et al. Comparative efficacy of salbutamol and salmeterol in exercise-induced asthma. J Int Med Res 1993; 21: 81-88.
19. Anderson SD, Rodwell LT, Du Toit J, Young IH. Duration of protection by inhaled salmeterol in exercise-induced asthma. Chest 1991; 100: 1254-1260.
20. Bisgaard H. Delivery of inhaled medication to children. J Asthma 1997; 34: 443-468.