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Volumn 49, Issue , 2012, Pages 21-31

Deposition of inhaled micrometer-sized particles in oropharyngeal airway replicas of children at constant flow rates

Author keywords

Children; Deposition; Drug delivery; Inhalation; Micrometer sized particles; Oropharyngeal airways

Indexed keywords

AEROSOLS; ATMOSPHERIC MOVEMENTS; ATOMIZERS; CONTROLLED DRUG DELIVERY; DEPOSITION; DRUG DELIVERY; FLOW RATE; MICROMETERS; REYNOLDS NUMBER; TARGETED DRUG DELIVERY;

EID: 84859601531     PISSN: 00218502     EISSN: 18791964     Source Type: Journal    
DOI: 10.1016/j.jaerosci.2012.03.001     Document Type: Article
Times cited : (54)

References (46)
  • 1
    • 0026322169 scopus 로고
    • Total deposition of inhaled particles related to age: comparison with age dependent model calculations
    • Becquemin M.H., Yu C.P., Roy M., Bouchikhi A. Total deposition of inhaled particles related to age: comparison with age dependent model calculations. Radiation Protection Dosimetry 1991, 38:23-28.
    • (1991) Radiation Protection Dosimetry , vol.38 , pp. 23-28
    • Becquemin, M.H.1    Yu, C.P.2    Roy, M.3    Bouchikhi, A.4
  • 2
    • 0031691969 scopus 로고    scopus 로고
    • Deposition of fine particles in children spontaneously breathing at rest
    • Bennett W.D., Zeman K.L. Deposition of fine particles in children spontaneously breathing at rest. Inhalation Toxicology 1998, 10:831-842.
    • (1998) Inhalation Toxicology , vol.10 , pp. 831-842
    • Bennett, W.D.1    Zeman, K.L.2
  • 3
    • 4344696619 scopus 로고    scopus 로고
    • Effect of body size on breathing pattern and fine-particle deposition in children
    • Bennett W.D., Zeman K.L. Effect of body size on breathing pattern and fine-particle deposition in children. Journal of Applied Physiology 2004, 97:821-826.
    • (2004) Journal of Applied Physiology , vol.97 , pp. 821-826
    • Bennett, W.D.1    Zeman, K.L.2
  • 4
    • 0033011153 scopus 로고    scopus 로고
    • In vitro, ex vivo, in vivo veritas
    • Borgstrom L. In vitro, ex vivo, in vivo veritas. Allergy 1999, 54:88-92.
    • (1999) Allergy , vol.54 , pp. 88-92
    • Borgstrom, L.1
  • 5
    • 33846076698 scopus 로고    scopus 로고
    • Degree of throat deposition can explain the variability in lung deposition of inhaled drugs
    • Borgstrom L., Olsson B., Thorsson L. Degree of throat deposition can explain the variability in lung deposition of inhaled drugs. Journal of Aerosol Medicine 2006, 19(4):473-483.
    • (2006) Journal of Aerosol Medicine , vol.19 , Issue.4 , pp. 473-483
    • Borgstrom, L.1    Olsson, B.2    Thorsson, L.3
  • 6
    • 0024749908 scopus 로고
    • Deposition of inhaled particles in the oral airway during oronasal breathing
    • Bowes S.M., Swift D.L. Deposition of inhaled particles in the oral airway during oronasal breathing. Aerosol Science and Technology 1989, 11:157-167.
    • (1989) Aerosol Science and Technology , vol.11 , pp. 157-167
    • Bowes, S.M.1    Swift, D.L.2
  • 8
    • 0018823886 scopus 로고
    • Experimental measurements and empirical modeling of the regional deposition of inhaled particles in humans
    • Chan T.L., Lippmann M. Experimental measurements and empirical modeling of the regional deposition of inhaled particles in humans. American Industrial Hygiene Association Journal 1980, 41:399-409.
    • (1980) American Industrial Hygiene Association Journal , vol.41 , pp. 399-409
    • Chan, T.L.1    Lippmann, M.2
  • 10
    • 0034885367 scopus 로고    scopus 로고
    • Respiratory deposition patterns of salbutamol pMDI with CFC and HFA-134a formulations in a human airway replica
    • Cheng Y.S., Yazzie D., Zhou Y. Respiratory deposition patterns of salbutamol pMDI with CFC and HFA-134a formulations in a human airway replica. Journal of Aerosol Medicine 2001, 14(2):255-266.
    • (2001) Journal of Aerosol Medicine , vol.14 , Issue.2 , pp. 255-266
    • Cheng, Y.S.1    Yazzie, D.2    Zhou, Y.3
  • 11
    • 4644324201 scopus 로고    scopus 로고
    • Aerosol deposition in the extrathoracic region
    • Cheng Y.S. Aerosol deposition in the extrathoracic region. Aerosol Science and Technology 2003, 37:659-671.
    • (2003) Aerosol Science and Technology , vol.37 , pp. 659-671
    • Cheng, Y.S.1
  • 12
    • 0020365288 scopus 로고
    • Modifications of the ICRP task group lung model to reflect age-dependence
    • Crawford D.J., Eckerman K.F. Modifications of the ICRP task group lung model to reflect age-dependence. Radiation Protection Dosimetry 1982, 2(4):209-220.
    • (1982) Radiation Protection Dosimetry , vol.2 , Issue.4 , pp. 209-220
    • Crawford, D.J.1    Eckerman, K.F.2
  • 13
    • 0034864345 scopus 로고    scopus 로고
    • In vitro monodisperse aerosol deposition in a mouth and throat with six different inhalation devices
    • DeHaan W.H., Finlay W.H. In vitro monodisperse aerosol deposition in a mouth and throat with six different inhalation devices. Journal of Aerosol Medicine 2001, 14(3):361-367.
    • (2001) Journal of Aerosol Medicine , vol.14 , Issue.3 , pp. 361-367
    • DeHaan, W.H.1    Finlay, W.H.2
  • 14
    • 1542291134 scopus 로고    scopus 로고
    • Predicting extrathoracic deposition from dry powder inhalers
    • DeHaan W.H., Finlay W.H. Predicting extrathoracic deposition from dry powder inhalers. Journal of Aerosol Science 2004, 35(3):309-331.
    • (2004) Journal of Aerosol Science , vol.35 , Issue.3 , pp. 309-331
    • DeHaan, W.H.1    Finlay, W.H.2
  • 17
    • 17644387588 scopus 로고    scopus 로고
    • Suitability of the upper airway models obtained from MRI studies in simulating drug lung deposition from inhalers
    • Ehtezazi T., Southern K.W., Allanson D., Jenkinson I., O'Callaghan C. Suitability of the upper airway models obtained from MRI studies in simulating drug lung deposition from inhalers. Pharmaceutical Research 2005, 22:166-170.
    • (2005) Pharmaceutical Research , vol.22 , pp. 166-170
    • Ehtezazi, T.1    Southern, K.W.2    Allanson, D.3    Jenkinson, I.4    O'Callaghan, C.5
  • 18
    • 0020273631 scopus 로고
    • Measurements of the total and regional deposition of inhaled particles in the human respiratory tract
    • Emmett P.C., Aitken R.J., Hannan W.J. Measurements of the total and regional deposition of inhaled particles in the human respiratory tract. Journal of Aerosol Science 1982, 13(6):549-560.
    • (1982) Journal of Aerosol Science , vol.13 , Issue.6 , pp. 549-560
    • Emmett, P.C.1    Aitken, R.J.2    Hannan, W.J.3
  • 19
    • 48249139478 scopus 로고    scopus 로고
    • Recent advances in predictive understanding of respiratory tract deposition
    • Finlay W.H., Martin A.R. Recent advances in predictive understanding of respiratory tract deposition. Journal of Aerosol Medicine 2008, 21(2):1-17.
    • (2008) Journal of Aerosol Medicine , vol.21 , Issue.2 , pp. 1-17
    • Finlay, W.H.1    Martin, A.R.2
  • 20
    • 0018002742 scopus 로고
    • Regional deposition of 2.5-7.5μm diameter inhaled particles in healthy male non-smokers
    • Foord N., Black A., Walsh M. Regional deposition of 2.5-7.5μm diameter inhaled particles in healthy male non-smokers. Journal of Aerosol Science 1978, 9:343-357.
    • (1978) Journal of Aerosol Science , vol.9 , pp. 343-357
    • Foord, N.1    Black, A.2    Walsh, M.3
  • 21
    • 79955974555 scopus 로고    scopus 로고
    • In vitro deposition measurement of inhaled micrometer-sized particles in extrathoracic airways of children and adolescents during nose breathing
    • Golshahi L., Noga M.L., Thompson R.B., Finlay W.H. In vitro deposition measurement of inhaled micrometer-sized particles in extrathoracic airways of children and adolescents during nose breathing. Journal of Aerosol Science 2011, 42(7):474-488.
    • (2011) Journal of Aerosol Science , vol.42 , Issue.7 , pp. 474-488
    • Golshahi, L.1    Noga, M.L.2    Thompson, R.B.3    Finlay, W.H.4
  • 22
    • 3242722612 scopus 로고    scopus 로고
    • In vitro intersubject and intrasubject deposition measurements in realistic mouth-throat geometries
    • Grgic B., Finlay W.H., Burnell P.K.P., Heenan A.F. In vitro intersubject and intrasubject deposition measurements in realistic mouth-throat geometries. Journal of Aerosol Science 2004, 35:1025-1040.
    • (2004) Journal of Aerosol Science , vol.35 , pp. 1025-1040
    • Grgic, B.1    Finlay, W.H.2    Burnell, P.K.P.3    Heenan, A.F.4
  • 23
    • 0345256446 scopus 로고    scopus 로고
    • Regional aerosol deposition and flow measurements in an idealized mouth and throat
    • Grgic B., Finlay W.H., Heenan A.F. Regional aerosol deposition and flow measurements in an idealized mouth and throat. Journal of Aerosol Science 2004, 35:21-32.
    • (2004) Journal of Aerosol Science , vol.35 , pp. 21-32
    • Grgic, B.1    Finlay, W.H.2    Heenan, A.F.3
  • 24
    • 33748971376 scopus 로고    scopus 로고
    • The effect of unsteady flow rate increase on in vitro mouth-throat deposition of inhaled boluses
    • Grgic B., Martin A.R., Finlay W.H. The effect of unsteady flow rate increase on in vitro mouth-throat deposition of inhaled boluses. Journal of Aerosol Science 2006, 37:1222-1233.
    • (2006) Journal of Aerosol Science , vol.37 , pp. 1222-1233
    • Grgic, B.1    Martin, A.R.2    Finlay, W.H.3
  • 25
    • 0001575722 scopus 로고
    • The deposition of aerosol particles in the nasopharyngeal region of the human respiratory tract
    • Hounam R.F., Black A., Walsh M. The deposition of aerosol particles in the nasopharyngeal region of the human respiratory tract. Journal of Aerosol Science 1971, 2:47-61.
    • (1971) Journal of Aerosol Science , vol.2 , pp. 47-61
    • Hounam, R.F.1    Black, A.2    Walsh, M.3
  • 26
    • 0014515304 scopus 로고
    • The effect of particle size on the regional deposition of inhaled aerosols in the human respiratory tract
    • Lippmann M., Albert R.E. The effect of particle size on the regional deposition of inhaled aerosols in the human respiratory tract. American Industrial Hygiene Association Journal 1969, 30:257-275.
    • (1969) American Industrial Hygiene Association Journal , vol.30 , pp. 257-275
    • Lippmann, M.1    Albert, R.E.2
  • 27
    • 0020548616 scopus 로고
    • Assessment of aerosol deposition patterns in human respiratory tract casts
    • Ann Arbor Science Publishers, Ann Arbor, V.A. Marple, B.Y.H. Liu (Eds.)
    • Martonen T.B., Lowe J. Assessment of aerosol deposition patterns in human respiratory tract casts. Aerosols in the Mining and Industrial Work Environments 1983, 151-164. Ann Arbor Science Publishers, Ann Arbor. V.A. Marple, B.Y.H. Liu (Eds.).
    • (1983) Aerosols in the Mining and Industrial Work Environments , pp. 151-164
    • Martonen, T.B.1    Lowe, J.2
  • 28
    • 1642515060 scopus 로고    scopus 로고
    • Studies of the human oropharyngeal airspaces using magnetic resonance imaging. I. Validation of a three-dimensional MRI method for producing ex vivo virtual and physical casts of the oropharyngeal airways during inspiration
    • McRobbie D.W., Pritchard S., Quest R.A. Studies of the human oropharyngeal airspaces using magnetic resonance imaging. I. Validation of a three-dimensional MRI method for producing ex vivo virtual and physical casts of the oropharyngeal airways during inspiration. Journal of Aerosol Medicine 2003, 16(4):401-415.
    • (2003) Journal of Aerosol Medicine , vol.16 , Issue.4 , pp. 401-415
    • McRobbie, D.W.1    Pritchard, S.2    Quest, R.A.3
  • 29
    • 1642537925 scopus 로고    scopus 로고
    • Development and preliminary validation studies with an ex-vivo oropharyngeal model
    • Interpharm Press Inc., Buffalo Grove, Illinois, P.R. Byron, R.N. Dalby, S.J. Farr (Eds.)
    • Newhouse M.T., Dobranowski J.A., Chambers C., Dobranowski J., Dobranowski M. Development and preliminary validation studies with an ex-vivo oropharyngeal model. Respiratory Drug Delivery VI 1998, 389-391. Interpharm Press Inc., Buffalo Grove, Illinois. P.R. Byron, R.N. Dalby, S.J. Farr (Eds.).
    • (1998) Respiratory Drug Delivery VI , pp. 389-391
    • Newhouse, M.T.1    Dobranowski, J.A.2    Chambers, C.3    Dobranowski, J.4    Dobranowski, M.5
  • 30
    • 0002578732 scopus 로고
    • The retention of gases and particles in the human nose
    • Pergamon Press, Oxford, C.N. Davies (Ed.)
    • Pattle R.E. The retention of gases and particles in the human nose. Inhaled Particles and Vapors 1961, 302-309. Pergamon Press, Oxford. C.N. Davies (Ed.).
    • (1961) Inhaled Particles and Vapors , pp. 302-309
    • Pattle, R.E.1
  • 31
    • 84859623781 scopus 로고
    • A comparison of the regional deposition of monodisperse polystyrene aerosols in the respiratory tracts of healthy male smokers and non-smokers
    • Pritchard J.N., Black A., Foord N., Walsh M. A comparison of the regional deposition of monodisperse polystyrene aerosols in the respiratory tracts of healthy male smokers and non-smokers. Journal of Aerosol Science 1981, 12(3):214.
    • (1981) Journal of Aerosol Science , vol.12 , Issue.3 , pp. 214
    • Pritchard, J.N.1    Black, A.2    Foord, N.3    Walsh, M.4
  • 32
    • 12244285288 scopus 로고    scopus 로고
    • Studies of the human oropharyngeal airspaces using magnetic resonance imaging. II. The use of three-dimensional gated MRI to determine the influence of mouthpiece diameter and resistance of inhalation devices on the oropharyngeal airspace geometry
    • Pritchard S.E., McRobbie D.W. Studies of the human oropharyngeal airspaces using magnetic resonance imaging. II. The use of three-dimensional gated MRI to determine the influence of mouthpiece diameter and resistance of inhalation devices on the oropharyngeal airspace geometry. Journal of Aerosol Medicine 2004, 17(4):310-324.
    • (2004) Journal of Aerosol Medicine , vol.17 , Issue.4 , pp. 310-324
    • Pritchard, S.E.1    McRobbie, D.W.2
  • 34
    • 0026973474 scopus 로고
    • Total deposition of aerosol particles in the respiratory tract of children during spontaneous and controlled mouth breathing
    • Schiller-Scotland C.H.F., Hlawa R., Gebhart J., Wonne R., Heyder J. Total deposition of aerosol particles in the respiratory tract of children during spontaneous and controlled mouth breathing. Journal of Aerosol Science 1992, 23(Suppl. 1):S457-S460.
    • (1992) Journal of Aerosol Science , vol.23 , Issue.SUPPL. 1
    • Schiller-Scotland, C.H.F.1    Hlawa, R.2    Gebhart, J.3    Wonne, R.4    Heyder, J.5
  • 35
    • 0018887470 scopus 로고
    • Experimental determination of the regional deposition of aerosol particles in the human respiratory tract
    • Stahlhofen W., Gebhart J., Heyder J. Experimental determination of the regional deposition of aerosol particles in the human respiratory tract. American Industrial Hygiene Association Journal 1980, 41(6):385-398a.
    • (1980) American Industrial Hygiene Association Journal , vol.41 , Issue.6
    • Stahlhofen, W.1    Gebhart, J.2    Heyder, J.3
  • 37
    • 0020762792 scopus 로고
    • Particle deposition in extrathoracic airways of healthy subjects and of patients with early stages of laryngeal carcinoma
    • Stahlhofen W., Gebhart J., Heyder J., Scheuch G., Juraske P. Particle deposition in extrathoracic airways of healthy subjects and of patients with early stages of laryngeal carcinoma. Journal of Aerosol Science 1984, 15(3):215-217.
    • (1984) Journal of Aerosol Science , vol.15 , Issue.3 , pp. 215-217
    • Stahlhofen, W.1    Gebhart, J.2    Heyder, J.3    Scheuch, G.4    Juraske, P.5
  • 38
    • 85010181389 scopus 로고
    • Intercomparison of experimental regional aerosol deposition data
    • Stahlhofen W., Rudolf G., James A.C. Intercomparison of experimental regional aerosol deposition data. Journal of Aerosol Medicine 1989, 2(3):285-308.
    • (1989) Journal of Aerosol Medicine , vol.2 , Issue.3 , pp. 285-308
    • Stahlhofen, W.1    Rudolf, G.2    James, A.C.3
  • 39
    • 0034019232 scopus 로고    scopus 로고
    • On the suitability of k-ε turbulence modeling for aerosol deposition in the mouth and throat: a comparison with experiment
    • Stapleton K.W., Guentsch E., Hoskinson M.K., Finlay W.H. On the suitability of k-ε turbulence modeling for aerosol deposition in the mouth and throat: a comparison with experiment. Journal of Aerosol Science 2000, 31:739-749.
    • (2000) Journal of Aerosol Science , vol.31 , pp. 739-749
    • Stapleton, K.W.1    Guentsch, E.2    Hoskinson, M.K.3    Finlay, W.H.4
  • 40
    • 56049107464 scopus 로고    scopus 로고
    • Deposition of micrometer-sized aerosol particles in infant nasal airway replicas
    • Storey-Bishoff J., Noga M., Finlay W.H. Deposition of micrometer-sized aerosol particles in infant nasal airway replicas. Journal of Aerosol Science 2008, 39:1055-1065.
    • (2008) Journal of Aerosol Science , vol.39 , pp. 1055-1065
    • Storey-Bishoff, J.1    Noga, M.2    Finlay, W.H.3
  • 44
    • 0026995555 scopus 로고
    • Apparatus and method for measuring regional distribution of therapeutic aerosols and comparing delivery systems
    • Swift D.L. Apparatus and method for measuring regional distribution of therapeutic aerosols and comparing delivery systems. Journal of Aerosol Science 1992, 23(Suppl. 1):S495-S498.
    • (1992) Journal of Aerosol Science , vol.23 , Issue.SUPPL. 1
    • Swift, D.L.1
  • 45
    • 34047221701 scopus 로고    scopus 로고
    • Peak inspiratory flow rates generated through the Novolizer and the Turbuhaler dry powder inhaler devices by children with stable asthma
    • Von Berg A., Kremer H., Ellers-lenz B., Conrad F., Erb K., Maus J., Hermann R. Peak inspiratory flow rates generated through the Novolizer and the Turbuhaler dry powder inhaler devices by children with stable asthma. Journal of Aerosol Medicine 2007, 20(1):50-58.
    • (2007) Journal of Aerosol Medicine , vol.20 , Issue.1 , pp. 50-58
    • Von Berg, A.1    Kremer, H.2    Ellers-lenz, B.3    Conrad, F.4    Erb, K.5    Maus, J.6    Hermann, R.7
  • 46
    • 82955188722 scopus 로고    scopus 로고
    • Comparison of deposition in the USP and physical mouth-throat models with solid and liquid particles
    • Zhou Y., Sun J., Cheng Y.S. Comparison of deposition in the USP and physical mouth-throat models with solid and liquid particles. Journal of Aerosol Medicine and Pulmonary Drug Delivery 2011, 24:1-8.
    • (2011) Journal of Aerosol Medicine and Pulmonary Drug Delivery , vol.24 , pp. 1-8
    • Zhou, Y.1    Sun, J.2    Cheng, Y.S.3


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