Effects of quercetin on polychlorinated biphenyls-induced liver injury in rats;Efecto de la quercetina sobre la lesión hepática inducida por bifenilos policlorados en ratas

Nutricion Hospitalaria

Volumn 29, Issue 5, 2014, Pages 1141-1148

  de Oliveira, Cléia Rocha ^a,f   Ceolin, Juliana ^a   De Oliveira, Renata Rocha ^a   Schemitt, Elizângela Gonçalves ^d,e,f   Colares, Josieli Raskopf ^d,e,f   Bauermann, Liliane de Freitas ^c   Costabeber, Ijoni Hilda ^b   Morgan Martins, Maria Isabel ^d,e   Mauriz, José L ^g   Da Silva, Juliana ^f   Reyes, Juliana Moysés ^f   Marroni, Norma Possa ^d,e,f  

^a Universidade Federal de Santa Maria   (Spain)

^b Laboratório de Pesticidas Persistentes LAPP UFSM   (Spain)

^c Laboratório de Fisiologia UFSM   (Spain)

^d Laboratório de Hepatologia e Gastroenterologia Experimental HCPA   (Spain)

^e Laboratório de Estresse Oxidativo e Antioxidantes ULBRA   (Spain)

^f PPG Fisiologia/UFRGS ^*  (Spain)

^g UNIVERSITY OF LEÓN   (Spain)

Author keywords

Antioxidants; Hepatic toxicity; Pesticides

Indexed keywords

ANTIOXIDANT; POLLUTANT; POLYCHLORINATED BIPHENYL; QUERCETIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL; DRUG-INDUCED LIVER INJURY; LIVER FUNCTION TEST; MALE; METABOLISM; POLLUTANT; RAT; TOXICITY; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; DRUG-INDUCED LIVER INJURY; ENVIRONMENTAL POLLUTANTS; LIVER FUNCTION TESTS; MALE; POLYCHLORINATED BIPHENYLS; QUERCETIN; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 84902316904     PISSN: 02121611     EISSN: 16995198     Source Type: Journal    
DOI: 10.3305/nh.2014.29.5.7362     Document Type: Article

References (37)

1. Mohr S, Schwanz TG, Wagner R, Costabeber IH, Soldateli L. Determination of Polychlorinated Biphenyls in umbilical cord serum by extraction by acid hydrolysis followed by gas chro-matography coupled with an electron capture microdetector. Quím Nova 2011; 34: 444-9.
2. Costabeber I. Persistent organochlorine residues in mammary fat and its relationship with alientares habits: health repercussions. Universidad de Córdoba, España: Tesis doctoral, 1999.
3. Costabeber I, Angulo R, Jodral M. Organochlorine residues in mammary adipose tissue and its relationship with breast cancer. Medicine. RibeirãoPreto 2000; 33: 506-14.
4. Pastor A, Collado PS, Almar M, González-Gallego J. Micro-somal function in biliary obstructed rats: Effects of S-adenosyl-methionine. J Hepatol 1996; 24: 353-9.
5. Mauriz JL, Matilla B, Culebras JM, González P, González-Gallego J. Dietary glycine inhibits activation of nuclear factor kappa B and prevents liver injury in hemorrhagic shock in the rat. Free Rad Biol Med 2001; 31: 1236-44.
6. Marroni NP, Morgan-Martins MI, Porawski M. Free Radicals in the health disease: from bench to clinic. Curitiba: Editora CRV, 2012. p. 168.
7. Mauriz JL, Molpeceres V, Garcia-Mediavilla MV, González P, Barrio JP, González-Gallego J. Melatonin prevents oxidative stress and changes in antioxidant enzyme expression and activity in the liver of aging rats. J Pineal Res 2007; 42: 222-30.
8. Rice-Evans CA, Miller NJ. Antioxidant activities of flavonoids as bioactive components of food.BiochemSocTrans 1996; 24: 790-5.
9. Brasil. Ministério da Agricultura Pecuária e Abastecimento. Instrução Normativa No 24, De 9 de agosto de 2011.
10. Llesuy SF, Milei J, Molina H, Boveris A, Milei S. Comparision of lipid peroxidation and Myocardia Damage Induced by Adria -mycin and 4'-Epiadrimicin in Mice. Tumor 1985; 71: 241-9.
11. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical biochemistry 1976; 72: 248-54.
12. Buege JA, Aust SD. Microsomal Lipid Peroxidation. Methods Enzymol 1978; 52: 302-10.
13. McCord JM, Fridovich I.The utility of superoxide dismutase in studying free radical reactions. I: radicals generated by the interaction of sulfite, dimethyl sulfoxide, and oxygen. J BiolChem 1969; 244: 6056-63.
14. Boveris A, Chance B. The mitochondrial generation of hydrogen peroxide.General properties and effect of hyperbaric oxygen. J Biochem 1973; 134: 707-16.
15. Da Silva J, Erdtmann B, Henriques JAP. GeneticToxicology. Porto Alegre: Ed Alcance. 2003. p. 424.
16. Shan X, Aw TY, Jones DP. Glutathione-dependent protection against oxidative injury.PharmacolTher 1990; 47: 61-71.
17. Brandão ABM, Marroni CA. Testes de Função Hepática in Mattos A. eDantas, W. Compendio de Hepatologia. São Paulo: Ed Fundo Editorial BYK 2a edição. 2001.
18. De David C. Quercetin protects the liver in thioacetamide-induced liver injury (TAA) and its complications. Universidade Federal do Rio Grande do Sul, Brasil: Tesisdoctoral, 2011.
19. Bona S. Antioxidant protection of quercetin in cirrhotic rat livers. Universidade Federal do Rio Grande do Sul, Porto Alegre: TesisMestrad, 2010.
20. Lee ES, Lee HE, Snhin JY, Yoon S, Moon JO. The flavanoid-quercetin inhibits dimethylnitrosamine -induced demage in rats. J Pharmacol 2003; 55: 1169-74.
21. Kang JS, Wanibuchi H, Morimura K. Role of P4502E1 in thio -cetamide - induced mouse hepatotoxicity. Toxicol Appl Pharmacol 2008; 228: 295-300.
22. Afanas'Ev IB, Dorozhko AI, Brodskii AV, Kostyuk VA, Potapovitch AI. Chelating and free radical scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxi-dation.BiochemPharmacol 1989; 38: 1763-9.
23. Filippin LI, Marroni NP, Xavier RM. Redox signaling and the inflammatory response in rheumatoids arthritis. Clin Expim-munol 2008; 152: 415-22.
24. Halliwell B, Gutteridge J. Free radical and biology and medicine. Oxford: New York, 2007.
25. Prakasan A, Sethupathy S, Lalitha S. Plasma and RBCs antioxi-dant status in accupacional male pesticide sprayers. Clin Chim Acta 2001; 310: 107-12.
26. Goel A, Dani VDH, Dhawan DK. Protective effects of zinc on lipid peroxidation, antioxidant enzymes and hepatic histoarchi-tecture in chlorpyrifos-induced toxicity. Chem Biol interact 2005; 156: 131-40.
27. Spolarics Z, Wu JX. Role of glutathione and catalase in H2O2 detoxification in LPS- activated hepatic endothelial and Kupffer Cells. Gastroint Liver Physiol 1997; 273: 1304.
28. Mehmetçik G, Özdemirler G, Koçak-Toker N. Role of Carno-sine in preventing thioacetamide - induced liver injury in the rat. Peptides 2008; 29: 425-9.
29. Baskarana Y, Periyasamy BV, Venkatramana, AC. Investigation of oxidant, anti-inflamatory and DNA- protective properties of eugenol in thioacetamide-induced liver injury in rats. Toxicol 2010; 268: 204-12.
30. Tieppo J, Cuevas MJ, Vercelino R, Tunon MJ, Marroni NP, Gonzalez-Gallego J. Quercetin administration ameliorates pulmonary complications of cirrhosis in rats. J Nutr 2009; 139: 1339-46.
31. Vercelino R, Marroni NP. The effect of N-acetylcysteine on the hepatopulmonary syndrome induced secondary biliary cirrhosis in rats. Universidade Federal do Rio Grande do Sul, Porto Alegre: TesisMestrad, 2005.
32. Baladia E, Basulto J, Manera M, Martínez R, Calbet D. Efectodel consumo de té verde o extractos de té verde enel peso y enlacom-posición corporal;revisión sistemática y metaanálisis. Nutr Hosp 2014; 29 (3): 479-90.
33. López-Lázaro M. Flavonoids as anticancer agents: structure-activity relationship study. Curr Med Chem 2002; 2: 691-714.
34. Pou SA, Niclis C, Aballay LR, Tumas N, Román MD, Muñoz SE, Coquet JB, Díaz MP. Cáncer y suasociaciónconpatronesali-mentariosen Córdoba (Argentina). NutrHosp 2014; 29 (3): 618-28.
35. Larramendy ML, Molinari G, Gonzáles NV, Pilili JP, Candioti JV, Reigosa MA, Soloneski S. Agroquímicos en Argentina. Genotoxicidad y citotoxicidadinducida por principiosactivos y susformulacionescomerciales. J Basic Appl Genet 2010; 21.
36. Murota K, Terao J. Antioxidativeflavanoidquercetin:implication of itd intestinal absorption and metabolism. Arch Biochem Biophys 2003; 417: 12-7.
37. Min K, Ebeler SE. Quercetin inhibits hydrogen peroxide-induced DNA damage and enhances DNA repair in Caco-2 cells. FoodChemToxicol 2009; 47: 2716-22.