The flavonoid quercetin inhibits dimethylnitrosamine-induced liver damage in rats

Journal of Pharmacy and Pharmacology

Volumn 55, Issue 8, 2003, Pages 1169-1174

  Lee, Eun Sil ^a   Lee, Hye Eun ^a   Shin, Ji Young ^b   Yoon, Sik ^b   Moon, Jeon Ok ^a  

^a Pusan National University   (South Korea)

^b Pusan National University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALPHA ACTIN; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; COLLAGEN TYPE 1; DIMETHYLNITROSAMINE; FLAVONOID; GLUTATHIONE; HYDROXYPROLINE; MALONALDEHYDE; MESSENGER RNA; QUERCETIN; TRANSFORMING GROWTH FACTOR BETA1;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BODY WEIGHT; CELL ACTIVATION; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFECT; GENE SEQUENCE; HISTOPATHOLOGY; IN VIVO STUDY; LIVER; LIVER FIBROSIS; LIVER INJURY; LIVER PROTECTION; LIVER WEIGHT; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; RAT; STAINING; STELLATE CELL; TISSUE LEVEL; WEIGHT REDUCTION;

ANIMALS; DIMETHYLNITROSAMINE; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; QUERCETIN; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0043026951     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357021396     Document Type: Article

References (24)

1. Buege, J. A., Aust, S. D. (1978) Microsomal lipid peroxidation. Methods. Enzymol. 12: 302-310
2. Castilla, A., Prieto, J., Fausto, N. (1991) Transforming growth factors beta 1 and alpha in chronic liver disease. Effects of interferon alfa therapy. N. Engl. J. Med. 324: 933-940
3. Friedman, S. L. (2000) Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J. Biol. Chem. 275: 2247-2250
4. Gasso, M., Rubio, M., Varela, G., Cabre, M., Caballeria, J., Alonso, E., Deulofem, R., Camps, J., Gimenez, A., Piares, M., Pares, A., Mato, J. M., Rodes, J. (1996) Effects of S-adenosylmethionine on lipid peroxidation and liver fibrogenesis in carbon tetrachloride-induced cirrhosis. J. Hepatol. 25: 200-205
5. George, J., Roulot, D., Koteliansky, V. E., Bissel, D. M. (1999) In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: A potential new therapy for hepatic fibrosis. Proc. Natl. Acad. Sci. USA 96: 12719-12724
6. Gressner, A. M. (1996) Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: A key event in hepatic fibrogenesis. Kidney Int. 49: S39-S45
7. Higashi, T. (1988) Critical review on the determination of glutathione in biological preparations. Prot. Nucleic Enz. 33: 1370-1382
8. Jezequel, A. M., Mancini, R., Rinaldesi, M. L., Ballardini, G., Fallani, M., Bianch, F., Orlandi, F. (1989) Dimethylnitrosamine-induced cirrhosis. Evidence for an immunological mechanism. J. Hepatol. 8: 42-52
9. Junqueira, I. C., Bignolas, G., Brentani, R. R. (1979) Picrosirius staining plus polarization microscopy, a specific method for collagen detection in tissue sections. Histochem. J. 11: 447-455
10. 4 poisoning. Free Rad. Biol. Med. 28: 838-845
11. Kang, L. P., Qi, L. H., Zhang, J. P., Shi, N., Zhang, M., Wu, T. M., Chen, J. (2001) Effect of genistein and quercetin on proliferation, collagen synthesis, and type I procollagen mRNA levels of rat hepatic stellate cells. Acta Pharmacol. Sin. 22: 793-796
12. Kawada, N., Seki, S., Inoue, M., Kuroki, T. (1998) Effect of antioxidants, resveratrol, quercetin, and N-acetylcysteine, on the functions of cultured rat hepatic stellate cells and Kupffer cells. Hepatology 27: 1265-1274
13. Knekt, P., Kumpulainen, J., Jarvinen, R., Rissanen, H., Heliovaara, M., Reunanen, A., Hakulinen, T., Aromaa, A. (2002) Flavonoid intake and risk of chronic diseases. Am. J. Clin. Nutr. 76: 560-568
14. Lee, K. S., Buck, M., Houglum, K., Chojkier, M. (1995) Activation of hepatic stellate cells by TGF alpha and collagen IIS mediated by oxidative stress through c-myc expression. J. Clin. Invest. 96: 2461-2468
15. Li, D., Friedman, S. L. (1999) Liver fibrogenesis and the role of hepatic stellate cells: New insights and prospects for therapy. J. Gastroenterol. Hepatol. 14: 618-633
16. Lowry, O. H., Rosebrough, N. J., Farr, A. L., Randall, R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193: 265-275
17. Maher, J. J. (1999) Leukocytes as modulators of stellate cell activation. Alcohol Clin. Exp. Res. 23: 917-921
18. Parola, M., Pinzani, M., Casini, A., Albano, E., Poli, G., Gentilini, A., Gentilini, P., Dianzani, M. U. (1993) Stimulation of lipid peroxidation or 4-hydroxynonenal treatment increases procollagen alpha 1 (I) gene expression in human liver fat-storing cells. Biochem. Biophys. Res. Comm. 194: 1044-1050
19. Peres, W., Tunon, M. J., Collado, P. S., Herrmann, S., Marroni, N., Gonzalez-Gallego, J. (2000) The flavonoid quercetin ameliorates liver damage in rats with biliary obstruction. J. Hepatol. 33: 742-750
20. Reitman, E. J., Frankel, S. (1957) Colorimetric method for the determination of serum glutamic oxaloacetic acid and glutamic pyruvic transaminases. Am. Clin. Pathol. 38: 56-63
21. Tsukamoto, H., Rippe, R., Niemela, O., Lin, M. (1995) Role of oxidative stress in activation of Kupffer and Ito cells in liver fibrogenesis. J. Gastroenterol. Hepatol. 10: S50-S53
22. Vendemiale, G., Grattagliano, I., Caruso, M. L., Serviddio, G., Valentini, A. M., Pirrelli, M., Altomare, E. (2001) Increased oxidative stress in dimethylnitrosamine-induced liver fibrosis in the rat: Effect of N-acetylcysteine and interferon-α. Toxicol. Appl. Pharmacol. 175: 130-139
23. Woessner, J. F. (1961) The determination of hydroxyproline in tissue and protein samples containing small proportions of this amino acid. Arch. Biochem. Biophys. 93: 440-447
24. 4-induced acute liver injury of mice. Free Rad. Biol. Med. 29: 870-880