Cell turnover in the repopulated rat liver: Distinct lineages for hepatocytes and the biliary epithelium

Cell and Tissue Research

Volumn 356, Issue 2, 2014, Pages 333-340

  Marongiu, Fabio ^a   Serra, Maria Paola ^a   Sini, Marcella ^a   Marongiu, Michela ^a   Contini, Antonella ^a   Laconi, Ezio ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Cell turnover; Hepatocyte transplantation; Liver repopulation; Progenitor cells; Rat; Streaming liver

Indexed keywords

ALPHA FETOPROTEIN; CELL MARKER; CLAUDIN 7; CYTOKERATIN 7; DIPEPTIDYL PEPTIDASE IV; EPITHELIAL CELL ADHESION MOLECULE; OV6 PROTEIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CELL ADHESION MOLECULE; CLAUDIN; CLDN7 PROTEIN, MOUSE; DIFFERENTIATION ANTIGEN; OVAL CELL MARKER OV-6; PYRROLIZIDINE ALKALOID; RETRORSINE; TUMOR ANTIGEN; TUMOR-ASSOCIATED ANTIGEN GA733;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; BILIARY EPITHELIUM; CELL DIFFERENTIATION; CELL FUSION; CELL LINEAGE; CELL POPULATION; CELL RENEWAL; CELL REPLACEMENT; CELL TRANSPLANTATION; CELL TURNOVER; CELLULAR PARAMETERS; CONTROLLED STUDY; EPITHELIUM; LIVER CELL; LIVER PARENCHYMA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; ANIMAL; BILE DUCT; BIOSYNTHESIS; CYTOLOGY; DRUG EFFECTS; EPITHELIUM CELL; FISCHER 344 RAT; GROWTH, DEVELOPMENT AND AGING; LIVER; LIVER REGENERATION; METABOLISM; TRANSPLANTATION;

ANIMALIA; RATTUS;

ALPHA-FETOPROTEINS; ANIMALS; ANTIGENS, DIFFERENTIATION; ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BILE DUCTS; CELL ADHESION MOLECULES; CELL LINEAGE; CLAUDINS; DIPEPTIDYL PEPTIDASE 4; EPITHELIAL CELLS; EPITHELIUM; HEPATOCYTES; KERATIN-7; LIVER; LIVER REGENERATION; PYRROLIZIDINE ALKALOIDS; RATS; RATS, INBRED F344;

EID: 84902291257     PISSN: 0302766X     EISSN: 14320878     Source Type: Journal    
DOI: 10.1007/s00441-014-1800-5     Document Type: Article

References (33)

1. Alison MR (1986) Regulation of hepatic growth. Physiol Rev 66:499-541
2. Alison MR, Marongiu F, Laconi E (2012) Transplanted hepatocytes: wiped out or washed out? J Hepatol 56:996-997
3. Berry MN, Friend DS (1969) High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. J Cell Biol 43:506-520
4. Best DH, Coleman WB (2007) Treatment with 2-AAF blocks the small hepatocyte-like progenitor cell response in retrorsine-exposed rats. J Hepatol 46:1055-1063 (Pubitemid 46680361)
5. Bralet MP, Branchereau S, Brechot C, Ferry N (1994) Cell lineage study in the liver using retroviralmediated gene transfer. Evidence against the streaming of hepatocytes in normal liver. Am J Pathol 144:896-905 (Pubitemid 24160631)
6. Chen YH, Chang MH, Chien CS, Wu SH, Yu CH, Chen HL (2013) Contribution of mature hepatocytes to small hepatocyte-like progenitor cells in retrorsine-exposed rats with chimeric livers. Hepatology 57:1215-1224
7. Duncan AW, Dorrell C, Grompe M (2009) Stem cells and liver regeneration. Gastroenterology 137:466-481
8. Español-Suñer R, Carpentier R, Van Hul N, Legry V, Achouri Y, Cordi S, Jacquemin P, Lemaigre F, Leclercq IA (2012) Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice. Gastroenterology 143:1564-1575
9. Faggioli F, Sacco MG, Susani L, Montagna C, Vezzoni P (2008) Cell fusion is a physiological process in mouse liver. Hepatology 48:1655-1664
10. Fellous TG, Islam S, Tadrous PJ, Elia G, Kocher HM, Bhattacharya S (2009) Locating the stem cell niche and tracing hepatocyte lineages in human liver. Hepatology 49:1655-1663
11. Furuyama K, Kawaguchi Y, Akiyama H, Horiguchi M, Kodama S, Kuhara T, Hosokawa S, Elbahrawy A, Soeda T, Koizumi M, Masui T, Kawaguchi M, Takaori K, Doi R, Nishi E, Kakinoki R, Deng JM, Behringer RR, Nakamura T, Uemoto S (2011) Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nat Genet 43:34-41
12. Imai T, Jiang M, Kastner P, Chambon P, Metzger D (2001) Selective ablation of retinoid X receptor alpha in hepatocytes impairs their lifespan and regenerative capacity. Proc Natl Acad Sci U S A 98:4581-4586 (Pubitemid 32295019)
13. Kennedy S, Rettinger S, Flye MW, Ponder KP (1995) Experiments in transgenic mice show that hepatocytes are the source for postnatal liver growth and do not stream. Hepatology 22:160-168
14. Laconi S, Pillai S, Porcu PP, Shafritz DA, Pani P, Laconi E (2001) Massive liver replacement by transplanted hepatocytes in the absence of exogenous growth stimuli in rats treated with retrorsine. Am J Pathol 158:771-777 (Pubitemid 32158638)
15. Laconi S, Montisci S, Doratiotto S, Greco M, Pasciu D, Pillai S, Pani P, Laconi E (2006) Liver repopulation by transplanted hepatocytes and risk of hepatocellular carcinoma. Transplantation 82:1319-1323 (Pubitemid 44832915)
16. Laconi S, Doratiotto S, Montisci S, Pani P, Laconi E (2008) Repopulation by endogenous hepatocytes does not reconstitute liver mass in rats treated with retrorsine. Cell Transplant 17:1415-1421
17. MacDonald RA (1961) "Lifespan" of liver cells. Autoradio-graphic study using tritiated thymidine in normal, cirrhotic, and partially hepatectomized rats. Arch Int Med 107:335-343
18. Malato Y, Naqvi S, Schürmann N, Ng R, Wang B, Zape J, Kay MA, Grimm D, Willenbring H (2011) Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration. J Clin Invest 121:4850-4860
19. McLean E (1970) The toxic actions of pyrrolizidine (senecio) alkaloids. Pharmacol Rev 22:429-483
20. Michalopoulos GK (2010) Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas. Am J Pathol 176:2-13
21. Michalopoulos GK, Barua L, Bowen WC (2005) Transdifferentiation of rat hepatocytes into biliary cells after bile duct ligation and toxic biliary injury. Hepatology 41:535-544 (Pubitemid 40289500)
22. Overturf K, Al-Dhalimy M, Tanguay R, Brantly M, Ou CN, Finegold M, Grompe M (1996) Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tryosinaemia type I. Nat Genet 12:266-273 (Pubitemid 26080085)
23. Pichard V, Aubert D, Ferry N (2009) Direct in vivo cell lineage analysis in the retrorsine and 2AAF models of liver injury after genetic labeling in adult and newborn rats. PLoS One 4:e7267
24. Ponder KP (1996) Analysis of liver development, regeneration, and carcinogenesis by genetic marking studies. FASEB J 106:73-82
25. Quintana-Bustamante O, Alvarez-Barrientos A, Kofman AV, Fabregat I, Bueren JA, Theise ND, Segovia JC (2006) Hematopoietic mobilization in mice increases the presence of bone marrow-derived hepatocytes via in vivo cell fusion. Hepatology 43:108-116 (Pubitemid 43733597)
26. Rhim JA, Sandgren EP, Degen JL, Palmiter RD, Brinster RL (1994) Replacement of diseased mouse liver by hepatic cell transplantation. Science 263:1149-1152 (Pubitemid 24105963)
27. Schmelzer E, Zhang L, Bruce A, Wauthier E, Ludlow J, Yao HL, Moss N, Melhem A, McClelland R, Turner W, Kulik M, Sherwood S, Tallheden T, Cheng N, Furth ME, Reid LM (2007) Human hepatic stem cells from fetal and postnatal donors. J Exp Med 204:1973-1987 (Pubitemid 47236331)
28. Schoental R, Magee PN (1959) Evolution of liver lesions in the rat after a single dose of pyrrolizidine alkaloids. Acta Unio Int Contra Cancrum 15:212-215
29. Seglen PO (1976) Preparation of isolated rat liver cells. Methods Cell Biol 13:29-83
30. Semeraro R, Carpino G, Cardinale V, Onori P, Gentile R, Cantafora A, Franchitto A, Napoli C, Anceschi M, Brunelli R, Bosco D, Torrice A, Reid L, Gaudio E, Alvaro D (2012) Multipotent stem/progenitor cells in the human foetal biliary tree. J Hepatol 57:987-994
31. Thompson NL, Hixson DC, Callanan H, Panzica M, Flanagan D, Faris RA, Hong WJ, Hartel-Schenk S, Doyle D (1991) A Fischer rat substrain deficient in dipeptidyl peptidase IVactivity makes normal steady-state RNA levels and an altered protein. Use as a liver-cell transplantation model. Biochem J 273:497-502
32. Wang X, Willenbring H, Akkari Y, Torimaru Y, Foster M, Al-Dhalimy M, Lagasse E, Finegold M, Olson S, Grompe M (2003) Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 422:897-901 (Pubitemid 36520042)
33. Zajicek G, Oren R, Weinreb M Jr (1985) The streaming liver. Liver 5: 293-300 (Pubitemid 16162133)