Repopulation by endogenous hepatocytes does not reconstitute liver mass in rats treated with retrorsine

Cell Transplantation

Volumn 17, Issue 12, 2008, Pages 1415-1421

  Laconi, Sergio ^a   Doratiotto, Silvia ^a   Montisci, Stefania ^a   Pani, Paolo ^a   Laconi, Ezio ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Cell cycle block; Cyclin D1; Regenerative nodules; Retrorsine

Indexed keywords

RETRORSINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; LIVER CELL; LIVER HISTOLOGY; LIVER NODULE; LIVER RESECTION; LIVER WEIGHT; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; RAT; TREATMENT RESPONSE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL DIVISION; CYCLIN D1; DNA; HEPATOCYTES; LIVER; MALE; PROLIFERATING CELL NUCLEAR ANTIGEN; PYRROLIZIDINE ALKALOIDS; RATS; RATS, INBRED F344;

RATTUS;

EID: 62549083496     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368908787648128     Document Type: Article

References (21)

1. Bradford, M. M. A rapid and sensitive method for the quantitation of microgram quantities of proteins utilizing the principle of protein-dye binding. Anal. Biochem. 72: 246-256; 1976.
2. Burton, K. A study of the conditions and mechanisms of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem. J. 65:315-323; 1956.
3. Downing, D. T.; Peterson, J. E. Quantitative assessment of the persistent antimitotic effect of certain hepatoxic pyrrolizidine alkaloids on rat liver. Aust. J. Exp. Biol. Med. Sci. 46:493-502; 1968.
4. Fukami-Kobayashi, J.; Mitsui, Y. Cyclin D1 inhibits cell proliferation through binding to PCNA and cdk2. Exp. Cell Res. 246:338-347; 1999.
5. Gordon, G. J.; Coleman, W. B.; Hixson, D. C.; Grisham, J. W. Liver regeneration in rats with retrorsine-induced hepatocellular injury proceeds through a novel cellular response. Am. J. Pathol. 156:607-619; 2000.
6. Joseph, B.; Kumaran, V.; Berishvili, E.; Barghava, K. K.; Palestra, C. J.; Gupta, S. Monocrotaline promotes transplanted cell engraftment and advances liver repopulation in rats via liver conditioning. Hepatology 44:1411-1420; 2006.
7. Laconi, E.; Oren, R.; Mukhopadhyay, D. K.; Hurston, E.; Laconi, S.; Pani, P.; Dabeva, M. D.; Shafritz, D. A. Long term, near total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine. Am. J. Pathol. 153:319-329; 1998.
8. Laconi, S.; Pillai, S.; Porcu, P. P.; Shafritz, D. A.; Pani, P.; Laconi, E. Massive liver replacement by transplanted hepatocytes in the absence of exogenous growth stimuli in rats treated with retrorsine. Am. J. Pathol. 158:771-777; 2001.
9. Marongiu, F.; Doratiotto, S.; Montisci, S.; Pani, P.; Laconi, E. Liver repopulation and carcinogenesis: Two sides of the same coin? Am. J. Pathol. 172:857-864; 2008.
10. Mattocks, A. R.; White, I. N. H. Toxic effects and pyrrolic metabolites in the liver of young rats given the pyrrolizidine alkaloid retrorsine. Chem. Biol. Interact. 6:297-306; 1973.
11. Mattocks, A. R.; Driver, H. E.; Barbour, R. H.; Robins, D. J. Metabolism and toxicity of synthetic analogues of macrocyclic diester pyrrolizidine alkaloids. Chem. Biol. Interact. 58:95-108; 1986.
12. McLean, E. The toxic actions of pyrrolizidine (senecio) alkaloids. Pharmacol. Rev. 22:429-483; 1970.
13. Pagano, M.; Theodoras, A. M.; Tarn, S. W.; Draetta, G. F. Cyclin D1-mediated inhibition of repair and replica-tive DNA synthesis in human fibroblasts. Genes Dev. 8: 1627-1639; 1994.
14. Park, S. M.; Vo, K.; Lallier, M.; Cloutier, A. S.; Brochu, P.; Alvarez, F.; Martin, S. R. Hepatocyte transplantation in the Long Evans cinnamon rat model of Wilson's disease. Cell Transplant. 15:13-22; 2006.
15. Peterson, J. E. Effects of the pyrrolizidine alkaloid lasio-carpine-N-oxide on nuclear and cell division in the liver of rats. J. Pathol. Bacteriol. 89:153-171; 1965.
16. Picard, C.; Lambotte, L.; Starkel, P.; Sempoux, C.; Saliez, A.; Van Der Berge, V.; de Saeger, C.; Horsmans, Y. Retrorsine: A kinetic study of its influence on rat liver regeneration in the portal branch ligation model. J. Hepatol. 39: 99-105; 2003.
17. Pitzalis, S.; Doratiotto, S.; Greco, M.; Montisci, S.; Pasciu, D.; Porcu, G.; Pani, P.; Laconi, S.; Laconi, E. Cyclin Dl is up-regulated in hepatocytes in vivo following cell-cycle block induced by retrorsine. J. Hepatol. 43:485-490; 2005.
18. Samuel, A.; Jago, M. V. Localization in the cell cycle of the antimitotic action of the pyrrolizidine alkaloid, lasio-carpine and of its metabolite, dehydroheliotridine. Chem. Biol. Interact. 10:185-197; 1975.
19. Strom, S. C.; Bruzzone, P.; Cai, H.; Ellis, E.; Lehmann, T.; Mitamura, K.; Miki, T. Hepatocyte transplantation: Clinical experience and potential for future use. Cell Transplant. 15(Suppl. 1):S105-110; 2006.
20. Sumrejkanchanakij, P.; Tamamori-Adachi, M.; Matsun-aga, Y.; Eto, K.; Ikeda, M.-A. Role of cyclin Dl cytoplasmic sequestration in the survival of post-mitotic neurons. Oncogene 22:8723-8730; 2003.
21. Witek, R. P.; Fisher, S. H.; Petersen, B. E. Monocrotaline, an alternative to retrorsine-based hepatocyte transplantation in rodents. Cell Transplant. 14:41-47; 2005.