Four structural subclasses of the antivirulence drug target disulfide oxidoreductase DsbA provide a platform for design of subclass-specific inhibitors

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1844, Issue 8, 2014, Pages 1391-1401

  McMahon, Róisín M ^a   Premkumar, Lakshmanane ^a   Martin, Jennifer L ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Antibiotic resistance; Antivirulence; Disulfide bond formation; DsbA; Structural classification

Indexed keywords

ENZYME; PROTEIN DISULFIDE REDUCTASE (GLUTATHIONE);

ANTIBIOTIC RESISTANCE; BIOINFORMATICS; CONFORMATION; DRUG TARGETING; ENTEROBACTERIACEAE; GRAM POSITIVE BACTERIUM; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN FOLDING; REVIEW; STATIC ELECTRICITY; SURFACE PROPERTY; VIRULENCE; WASTE;

BACTERIA (MICROORGANISMS); ENTEROBACTERIACEAE; NEGIBACTERIA; POSIBACTERIA;

ANTIBIOTIC RESISTANCE; ANTIVIRULENCE; DISULFIDE BOND FORMATION; DSBA; STRUCTURAL CLASSIFICATION;

DRUG DESIGN; ENZYME INHIBITORS; HUMANS; PROTEIN DISULFIDE-ISOMERASES; VIRULENCE; VIRULENCE FACTORS;

EID: 84902279694     PISSN: 15709639     EISSN: 18781454     Source Type: Journal    
DOI: 10.1016/j.bbapap.2014.01.013     Document Type: Review

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