Inhibition of bacterial disulfide bond formation by the anticoagulant warfarin

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 1, 2010, Pages 297-301

  Dutton, Rachel J ^a   Wayman, April ^a   Wei, Jun Rong ^b   Rubin, Eric J ^b   Beckwith, Jon ^a   Boyd, Dana ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

DsbA; DsbB; Mycobacterium tuberculosis; Vitamin K epoxide reductase

Indexed keywords

BETA GALACTOSIDASE; DNA; MENADIONE EPOXIDE; OXIDOREDUCTASE; PHENINDIONE; UNCLASSIFIED DRUG; VITAMIN K EPOXIDE REDUCTASE; WARFARIN;

AMINO ACID SEQUENCE; ANTIBACTERIAL ACTIVITY; ANTICOAGULATION; ARTICLE; BACTERIAL GROWTH; BACTERIAL MUTATION; BINDING SITE; BLOOD CLOTTING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISULFIDE BOND; DNA SEQUENCE; DRUG EFFECT; DRUG EFFICACY; ESCHERICHIA COLI; EXPERIMENTAL MODEL; GENETIC ANALYSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; TUBERCULOSIS;

AMINO ACID SEQUENCE; ANIMALS; ANTICOAGULANTS; BACTERIAL PROTEINS; DISULFIDES; ESCHERICHIA COLI; HUMANS; MIXED FUNCTION OXYGENASES; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTATION; MYCOBACTERIUM TUBERCULOSIS; OXIDATION-REDUCTION; SEQUENCE ALIGNMENT; WARFARIN;

BACTERIA (MICROORGANISMS); CORYNEBACTERINEAE; ESCHERICHIA COLI; MYCOBACTERIUM TUBERCULOSIS;

EID: 76249133943     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0912952107     Document Type: Article

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