Silymarin improves vascular function of aged ovariectomized rats

Phytotherapy Research

Volumn 28, Issue 6, 2014, Pages 868-872

  Demirci, Buket ^a   Dost, Turhan ^a   Gokalp, Filiz ^a   Birincioglu, Mustafa ^a  

^a ADNAN MENDERES UNIVERSITY   (Turkey)

Author keywords

endothelium; menopause; oophorectomy; silymarin; vascular reactivity

Indexed keywords

ESTRADIOL; FULVESTRANT; SILYMARIN;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL STIFFNESS; ARTICLE; BLOOD VESSEL FUNCTION; BLOOD VESSEL TONE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; ESTROGEN ACTIVITY; ESTROGEN THERAPY; FEMALE; FOLLOW UP; NONHUMAN; OUTCOME ASSESSMENT; POSTMENOPAUSE; RAT; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE RELAXATION; VASCULAR ENDOTHELIUM; VASODILATATION;

RATTUS;

ENDOTHELIUM; MENOPAUSE; OOPHORECTOMY; SILYMARIN; VASCULAR REACTIVITY;

ACETYLCHOLINE; ANIMALS; ELASTICITY; ENDOTHELIUM, VASCULAR; ESTRADIOL; ESTROGENS; FEMALE; NITROPRUSSIDE; OVARIECTOMY; PHENYLEPHRINE; PHYTOESTROGENS; RATS; RATS, WISTAR; SILYMARIN; VASOCONSTRICTION; VASODILATION;

EID: 84902251186     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5067     Document Type: Article

References (27)

1. Ahmadi-Ashtiani H, Allameh A, Rastegar H, Soleimani M, Barkhordari E,. 2012. Inhibition of cyclooxygenase-2 and inducible nitric oxide synthase by silymarin in proliferating mesenchymal stem cells: comparison with glutathione modifiers. J Nat Med 66: 85-94.
2. Baluchnejadmojarad T, Roghani M, Mafakheri M,. 2010. Neuroprotective effect of silymarin in 6-hydroxydopamine hemi-parkinsonian rat: involvement of estrogen receptors and oxidative stress. Neurosci Lett 480: 206-210.
3. Cau SB, Carneiro FS, Tostes RC,. 2012. Differential modulation of nitric oxide synthases in aging: therapeutic opportunities. Front Physiol 3: 218.
4. Chlopcikova S, Psotova J, Miketova P, Simanek V,. 2004. Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part I. Silymarin and its flavonolignans. Phytother Res 18: 107-110.
5. Demirci B, McKeown PP, Bayraktutan UB,. 2008. The bimodal regulation of vascular function by superoxide anion: role of endothelium. BMB Rep 41: 223-229.
6. El-Shitany NA, Hegazy S, El-desoky K,. 2010. Evidences for antiosteoporotic and selective estrogen receptor modulator activity of silymarin compared with ethinylestradiol in ovariectomized rats. Phytomedicine 17: 116-125.
7. Gabrielova E, Jaburek M, Gazak R, Vostalova J, Jezek J, Kren V, Modriansky M,. 2010. Dehydrosilybin attenuates the production of ROS in rat cardiomyocyte mitochondria with an uncoupler-like mechanism. J Bioenerg Biomembr 42: 499-509.
8. Gencel VB, Benjamin MM, Bahou SN, Khalil RA,. 2012. Vascular effects of phytoestrogens and alternative menopausal hormone therapy in cardiovascular disease. Mini Rev Med Chem 12: 149-174.
9. Kafkas S, Dost T, Ozkayran H, Yenisey C, Tuncyurek P, Birincioglu M,. 2012. Effect of estrogen therapy on adipocytokines in ovariectomized-aged rats. J Obstet Gynaecol Res 38: 231-238.
10. Karaki H, Ozaki H, Hori M, et al,. 1997. Calcium movements, distribution, and functions in smooth muscle. Pharmacol Rev 49: 157-230.
11. Kim KH, Moriarty K, Bender JR,. 2008. Vascular cell signaling by membrane estrogen receptors. Steroids 73: 864-869.
12. Klabunde RE, Ryan KM, Paxson CE,. 2007. Acute hyperglycaemia does not alter coronary vascular function in isolated, perfused rat hearts. Diabetes Obes Metab 9: 697-705.
13. Ko EA, Han J, Jung ID, Park WS,. 2008. Physiological roles of K+ channels in vascular smooth muscle cells. J Smooth Muscle Res 44: 65-81.
14. Kroll DJ, Shaw HS, Oberlies NH,. 2007. Milk thistle nomenclature: why it matters in cancer research and pharmacokinetic studies. Integr Cancer Ther 6: 110-119.
15. Miller AP, Xing D, Feng W, Fintel M, Chen YF, Oparil S,. 2007. Aged rats lose vasoprotective and anti-inflammatory actions of estrogen in injured arteries. Menopause 14: 251-260.
16. Moncada S, Higgs EA,. 2006. The discovery of nitric oxide and its role in vascular biology. Br J Pharmacol 147 (Suppl 1): S193-S201.
17. Novella S, Heras M, Hermenegildo C, Dantas AP,. 2012. Arterioscler Thromb Vasc Biol 32: 2035-2042.
18. Parlar A, Can C, Erol A, Ulker S,. 2010. Posttransplantation therapeutic rapamycin concentration protects nitric oxide-related vascular endothelial function: comparative effects in rat thoracic aorta and coronary endothelial cell culture. Transplant Proc 42: 1923-1930.
19. Pechenino AS, Lin L, Mbai FN, et al, 2011. Impact of aging vs estrogen loss on cardiac gene expression: estrogen replacement and inflammation. Physiol Genomics 43: 1065-1073.
20. Pliskova M, Vondracek J, Kren V, et al,. 2005. Effects of silymarin flavonolignans and synthetic silybin derivatives on estrogen and aryl hydrocarbon receptor activation. Toxicology 215: 80-89.
21. Rao PR, Viswanath RK,. 2007. Cardioprotective activity of silymarin in ischemia-reperfusion-induced myocardial infarction in albino rats. Exp Clin Cardiol 12: 179-187.
22. Rossouw JE, Anderson GL, Prentice RL, et al,. 2002. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 288: 321-333.
23. Seidlova-Wuttke D, Becker T, Christoffel V, Jarry H, Wuttke W,. 2003. Silymarin is a selective estrogen receptor beta (ERbeta) agonist and has estrogenic effects in the metaphysis of the femur but no or antiestrogenic effects in the uterus of ovariectomized (ovx) rats. J Steroid Biochem Mol Biol 86: 179-188.
24. Stice JP, Eiserich JP, Knowlton AA,. 2009. Role of aging versus the loss of estrogens in the reduction in vascular function in female rats. Endocrinology 150: 212-219.
25. Teoh H, Quan A, Leung SW, Man RY,. 2009. Vascular effects of estrone and diethylstilbestrol in porcine coronary arteries. Menopause 16: 104-109.
26. Tyagi A, Agarwal C, Dwyer-Nield LD, Singh RP, Malkinson AM, Agarwal R,. 2012. Silibinin modulates TNF-alpha and IFN-gamma mediated signaling to regulate COX2 and iNOS expression in tumorigenic mouse lung epithelial LM2 cells. Mol Carcinog 51: 832-842.
27. Zhao J, Lahiri-Chatterjee M, Sharma Y, Agarwal R,. 2000. Inhibitory effect of a flavonoid antioxidant silymarin on benzoyl peroxide-induced tumor promotion, oxidative stress and inflammatory responses in SENCAR mouse skin. Carcinogenesis 21: 811-816.