Role of interferon regulatory factor 3-mediated apoptosis in the establishment and maintenance of persistent infection by Sendai virus

Journal of Virology

Volumn 87, Issue 1, 2013, Pages 16-24

  Chattopadhyay, Saurabh ^a   Fensterl, Volker ^a   Zhang, Ying ^a   Veleeparambil, Manoj ^a   Yamashita, Michifumi ^a   Sen, Ganes C ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; DOXYCYCLINE; INTERFERON REGULATORY FACTOR 3; MANGANESE SUPEROXIDE DISMUTASE; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; RANTES; RETINOIC ACID INDUCIBLE PROTEIN I; STAT1 PROTEIN; TOLL LIKE RECEPTOR 3; TYROSINE;

3' UNTRANSLATED REGION; APOPTOSIS; ARTICLE; CCL5 GENE; CONTROLLED STUDY; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IFI44 GENE; IFIT1 GENE; IFIT2 GENE; IFIT3 GENE; INNATE IMMUNITY; INTERFERON REGULATORY FACTOR 3 GENE; INTRACELLULAR SIGNALING; ISG15 GENE; MICROARRAY ANALYSIS; NATURAL SELECTION; NONHUMAN; PERSISTENT INFECTION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SENDAI VIRUS INFECTION; SOD2 GENE; VIRUS GENE; VIRUS PARTICLE;

ANIMALS; APOPTOSIS; CELL LINE; FIBROBLASTS; HOST-PATHOGEN INTERACTIONS; HUMANS; INTERFERON REGULATORY FACTOR-3; MICE; SENDAI VIRUS; VIRUS REPLICATION;

SENDAI VIRUS;

EID: 84871942583     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01853-12     Document Type: Article

References (27)

1. Griffin DE, Hardwick JM. 1997. Regulators of apoptosis on the road to persistent alphavirus infection. Annu. Rev. Microbiol. 51:565-592.
2. Sarkar SN, Sen GC. 2004. Novel functions of proteins encoded by viral stress-inducible genes. Pharmacol. Ther. 103:245-259.
3. Jensen S, Thomsen AR. 2012. Sensing of RNA viruses: a review of innate immune receptors involved in recognizing RNA virus invasion. J. Virol. 86:2900-2910.
4. Yu M, Levine SJ. 2011. Toll-like receptor, RIG-I-like receptors and the NLRP3 inflammasome: key modulators of innate immune responses to double-stranded RNA viruses. Cytokine Growth Factor Rev. 22:63-72.
5. Colonna M. 2007. TLR pathways and IFN-regulatory factors: to each its own. Eur. J. Immunol. 37:306-309.
6. Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K, Uematsu S, Jung A, Kawai T, Ishii KJ, Yamaguchi O, Otsu K, Tsujimura T, Koh CS, Reis e Sousa C, Matsuura Y, Fujita T, Akira S. 2006.0 Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441:101-105.0000000
7. Loo YM, Fornek J, Crochet N, Bajwa G, Perwitasari O, Martinez- Sobrido L, Akira S, Gill MA, Garcia-Sastre A, Katze MG, Gale M, Jr. 2008. Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. J. Virol. 82:335-345.
8. Seth RB, Sun L, Chen ZJ. 2006. Antiviral innate immunity pathways. Cell Res. 16:141-147.
9. Yatim N, Albert ML. 2011. Dying to replicate: the orchestration of the viral life cycle, cell death pathways, and immunity. Immunity 35:478-490.
10. Chattopadhyay S, Marques JT, Yamashita M, Peters KL, Smith K, Desai A, Williams BR, Sen GC. 2010. Viral apoptosis is induced by IRF-3- mediated activation of Bax. EMBO J. 29:1762-1773.
11. Chattopadhyay S, Sen GC. 2010. IRF-3 and Bax: a deadly affair. Cell Cycle 9:2479-2480.
12. Peters K, Chattopadhyay S, Sen GC. 2008. IRF-3 activation by Sendai virus infection is required for cellular apoptosis and avoidance of persistence. J. Virol. 82:3500-3508.
13. Chattopadhyay S, Yamashita M, Zhang Y, Sen GC. 2011. The IRF-3/ Bax-mediated apoptotic pathway, activated by viral cytoplasmic RNA and DNA, inhibits virus replication. J. Virol. 85:3708-3716.
14. Hiscott J. 2007. Triggering the innate antiviral response through IRF-3 activation. J. Biol. Chem. 282:15325-15329.
15. White CL, Chattopadhyay S, Sen GC. 2011. Phosphatidylinositol 3-kinase signaling delays Sendai virus-induced apoptosis by preventing XIAP degradation. J. Virol. 85:5224-5227.
16. Terenzi F, White C, Pal S, Williams BR, Sen GC. 2007. Tissue-specific and inducer-specific differential induction of ISG56 and ISG54 in mice. J. Virol. 81:8656-8665.
17. Fridovich I. 1995. Superoxide radical and superoxide dismutases. Annu. Rev. Biochem. 64:97-112.
18. Valyi-Nagy T, Dermody TS. 2005. Role of oxidative damage in the pathogenesis of viral infections of the nervous system. Histol. Histopathol. 20: 957-967.
19. Janicke RU, Sprengart ML, Wati MR, Porter AG. 1998. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J. Biol. Chem. 273:9357-9360.
20. Fensterl V, Wetzel JL, Ramachandran S, Ogino T, Stohlman SA, Bergmann CC, Diamond MS, Virgin HW, Sen GC. 2012. Interferon-induced Ifit2/ISG54 protects mice from lethal VSV neuropathogenesis. PLoS Pathog. 8:e1002712. doi:10.1371/journal.ppat.1002712.
21. Kato A, Kiyotani K, Kubota T, Yoshida T, Tashiro M, Nagai Y. 2007. Importance of the anti-interferon capacity of Sendai virus C protein for pathogenicity in mice. J. Virol. 81:3264-3271.
22. Komatsu T, Takeuchi K, Yokoo J, Gotoh B. 2002. Sendai virus C protein impairs both phosphorylation and dephosphorylation processes of Stat1. FEBS Lett. 511:139-144.
23. Andrejeva J, Childs KS, Young DF, Carlos TS, Stock N, Goodbourn S, Randall RE. 2004. The V proteins of paramyxoviruses bind the IFNinducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. Proc. Natl. Acad. Sci. U.S.A. 101:17264-17269.
24. Ramachandran A, Horvath CM. 2010. Dissociation of paramyxovirus interferon evasion activities: universal and virus-specific requirements for conserved V protein amino acids in MDA5 interference. J. Virol. 84: 11152-11163.
25. Lu LL, Puri M, Horvath CM, Sen GC. 2008. Select paramyxoviral V proteins inhibit IRF3 activation by acting as alternative substrates for inhibitor of kappaB kinase epsilon (IKKe)/TBK1. J. Biol. Chem. 283:14269-14276.
26. Sears N, Sen GC, Stark GR, Chattopadhyay S. 2011. caspase-8-mediated cleavage inhibits IRF-3 protein by facilitating its proteasome-mediated degradation. J. Biol. Chem. 286:33037-33044.
27. Ye J, Maniatis T. 2011. Negative regulation of interferon-beta gene expression during acute and persistent virus infections. PLoS One 6:e20681. doi:10.1371/journal.pone.0020681.