Diethyl maleate inhibits MCA+TPA transformed cell growth via modulation of GSH, MAPK, and cancer pathways

Chemico-Biological Interactions

Volumn 219, Issue , 2014, Pages 37-47

  Priya, Shivam ^a,b   Nigam, Akanksha ^a,b   Bajpai, Preeti ^b   Kumar, Sushil ^a  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

^b INTEGRAL UNIVERSITY   (India)

Author keywords

BALB c; C3H10T1 2; DEM; MAPK; Microarray

Indexed keywords

GLUTATHIONE; GLUTATHIONE ETHYL ESTER; MALEIC ACID DIETHYL ESTER; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; DIETHYL MALATE; MALIC ACID DERIVATIVE; MESSENGER RNA;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG CYTOTOXICITY; GENE EXPRESSION; GROWTH INHIBITION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; TRANSFORMED CELL; 3T3 CELL LINE; ANIMAL; BAGG ALBINO MOUSE; C3H MOUSE; CELL CYCLE CHECKPOINT; CELL PROLIFERATION; CELL TRANSFORMATION; CHEMISTRY; ENZYME ACTIVATION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TUNEL ASSAY;

3T3 CELLS; ANIMALS; APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; ENZYME ACTIVATION; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTATHIONE; IN SITU NICK-END LABELING; MALATES; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; MITOGEN-ACTIVATED PROTEIN KINASES; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84902209231     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2014.04.018     Document Type: Article

References (58)

1. M.Y. Abdalla Glutathione as potential target for cancer therapy; more or less is good? (Mini-Review) Jordan J. Biol. Sci. 4 2011 119 124
2. M.P. Gamcsik, M.S. Kasibhatla, S.D. Teeter, and O.M. Colvin Glutathione levels in human tumors Biomarkers 17 8 2012 671 691
3. A. Meister Glutathione deficiency produced by inhibition of its synthesis, and its reversal; applications in research and therapy Pharmacol. Ther. 51 1991 155 194
4. M.M. Gottesman, T. Fojo, and S.E. Bates Multidrug resistance in cancer: role of ATP-dependent transporters Nat. Rev. Cancer 2 2002 48 58 (Pubitemid 37328807)
5. J.I. Chuang, T.Y. Chang, and H.S. Liu Glutathione depletion-induced apoptosis of Ha-ras-transformed NIH3T3 cells can be prevented by melatonin Oncogene 22 9 2003 1349 1357 (Pubitemid 36384596)
6. G.K. Balendiran, R. Dabur, and D. Fraser The role of glutathione in cancer Cell Biochem. Funct. 22 6 2004 343 352 (Pubitemid 39518098)
7. J.J. Mieyal, M.M. Gallogly, S. Qanungo, E.A. Sabens, and M.D. Shelton Molecular mechanisms and clinical implications of reversible protein S-glutathionylation Antioxid. Redox Signaling 10 11 2008 1941 1988
8. N. Ballatori, S.M. Krance, S. Notenboom, S. Shi, K. Tieu, and C.L. Hammond Glutathione dysregulation and the etiology and progression of human diseases Biol. Chem. 390 3 2009 191 214
9. A.L. Ortega, S. Mena, and J.M. Estrela Glutathione in cancer cell death Cancer 3 1 2011 1285 1310
10. D.M. Townsend, K.D. Tew, and H. Tapiero The importance of glutathione in human disease Biomed. Pharmacother. 57 3-4 2003 145 155 (Pubitemid 36740460)
11. J.M. Estrela, A. Ortega, and E. Obrador Glutathione in cancer biology and therapy Crit. Rev. Clin. Lab. Sci. 43 2006 143 181 (Pubitemid 43860449)
12. O.W. Griffith, M.E. Anderson, and A. Meister Inhibition of glutathione biosynthesis by prothionine sulfoximine (S-n-propyl homocysteine sulfoximine), a selective inhibitor of gamma-glutamylcysteine synthetase J. Biol. Chem. 254 4 1979 1205 1210
13. G. Rappa, A. Lorico, R.A. Flavell, and A.C. Sartorelli Evidence that the multidrug resistance protein (mrp) functions as a co-transporter of glutathione and natural product toxins Cancer Res. 57 1997 5232 5237 (Pubitemid 27516354)
14. P. Mistry, and K.R. Harrap Historical aspects of glutathione and cancer chemotherapy Pharmacol. Ther. 49 1991 125 132
15. E.A. Bump, and J.M. Brown Role of glutathione in the radiation response of mammalian cells in vitro and in vivo Pharmacol. Ther. 47 1990 117 136 (Pubitemid 20183311)
16. A.L. Simons, I.M. Ahmad, D.M. Mattson, K.J. Dornfeld, and D.R. Spitz 2-deoxy-d-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells Cancer Res. 67 7 2007 3364 3370 (Pubitemid 46724876)
17. C.J. Weydert, Y. Zhang, W. Sun, T.A. Waugh, M.L. Teoh, K.K. Andringa, N. Aykin-Burns, D.R. Spitz, B.J. Smith, and L.W. Oberley Increased oxidative stress created by adenoviral MnSOD or CuZnSOD plus BCNU (1,3-bis(2-chloroethyl)-1- nitrosourea) inhibits breast cancer cell growth Free Radical Biol. Med. 44 5 2008 856 867
18. A. Parkinson Biotransformation of xenobiotics C.D. Klaassen, Casarett and Doull's Toxicology 2001 McGraw-Hill 133 224
19. E. Boyland, and L.F. Chasseaud Enzyme-catalysed conjugations of glutathione with unsaturated compounds Biochem. J. 104 1967 95 102
20. J. Markovic, N.J. Mora, A.M. Broseta, A. Gimeno, N. de-la- Concepción, J. Viña, and F.V. Pallardó The depletion of nuclear Glutathione impairs cell proliferation in 3t3 fibroblasts PLoS ONE 4 7 2009 e6413
21. S. Priya, A. Nigam, P. Bajpai, and S. Kumar Dysregulation of pathways involved in the processing of cancer and microenvironment information in MCA+TPA transformed C3H/10T1/2 cells In Vitro Cell. Dev. Biol. Anim. 49 2013 295 305
22. D. Krahn The use: of cultured mammalian cell transformation systems to identify potential carcinogens B. Butterworth, L. Goldberg, Strategies for Short Term Testing for Mutagens/Carcinogens 1979 CRC Press West Palm Beach 55 66
23. R. Combes, M. Balls, and M. Fischbach et al. The report and recommendations of cell transformation assays as predictors of human carcinogenicity ECVAM Workshop 39 Altern. Lab. Anim. 27 1999 745 767 (Pubitemid 29503028)
24. R.A. LeBoeuf, G.A. Kerckaert, M.J. Aardema, and R.J. Isfort Use of Syrian hamster embryo and BALB/c 3T3 cell transformation for assessing the carcinogenic potential of chemicals D.B. McGregor, J.M. Rice, S. Venitt, The Use of Short- and Medium-Term Tests for Carcinogens and Data on Genetic Effects in Carcinogenic Hazard Evaluation vol. 146 1999 IARC Lyon, France 409 425
25. K. Aoshiba, S. Yasui, K. Nishimura, and A. Nagai Thiol depletion induces apoptosis in cultured lung fibroblasts Am. J. Respir. Cell Mol. Biol. 21 1999 54 64 (Pubitemid 129508628)
26. I. Rahman, A. Kode, and S.K. Biswas Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method Nat. Protoc. 1 6 2006 3159 3165
27. D.W. Voehringer, D.J. McConkey, T.J. McDonnell, S. Brisbay, and R.E. Meyn Bcl-2 expression causes redistribution of glutathione to the nucleus PNAS 95 6 1998 2956 2960 (Pubitemid 28135836)
28. J. Markovic, C. Borrás, A. Ortega, J. Sastre, J. Viña, and F.V. Pallardó Glutathione is recruited into the nucleus in early phases of cell proliferation J. Biol. Chem. 282 28 2007 20416 20424 (Pubitemid 47099986)
29. L.U. Ling, K.B. Tan, H. Lin, and G.N. Chiu The role of reactive oxygen species and autophagy in safingol-induced cell death Cell Death Dis. 2 2011 e129
30. E. Hanon, A. Vanderplasschen, and P.P. Pastoret The use of flow cytometry for concomitant detection of apoptosis and cell cycle analysis Biochemica 2 1996 25 27
31. F. Belloc, M.R. Boisseau, C. Jalloustre, J. Reiffers, P. Bernard, and F. Lacombe A flow cytometric method using Hoechst 33342 and propidium iodide for simultaneous cell cycle analysis and apoptosis determination in unfixed cells Cytometry 17 1994 59 65
32. S. Bandyopadhyay, D.M. Hartley, C.M. Cahill, D.K. Lahiri, N. Chattopadhyay, and T. Rogers Interleukin-1alpha stimulates non-amyloidogenic pathway by alpha-secretase (ADAM-10 and ADAM-17) cleavage of APP in human astrocytic cells involving p38 MAP kinase J. Neurosci. Res. 84 2006 106 118 (Pubitemid 44023067)
33. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 254
34. S.R. Patierno, D. Banh, and J.R. Landolph Transformation of C3H/10T1/2 mouse embryo cells to focus formation and anchorage independence by insoluble lead chromate but not soluble calcium chromate: relationship to mutagenesis and internalization of lead chromate particles Cancer Res. 48 18 1988 5280 5288
35. O. Toussaint, A. Houbion, and J. Remacle Relationship between the critical level of oxidative stresses and the glutathione peroxidase activity Toxicology 81 2 1993 89 101
36. A. Sakai BALB/c 3T3 cell transformation assays for the assessment of chemical carcinogenicity AATEX 14 2007 367 373
37. R. Kalluri, and M. Zeisberg Fibroblasts in cancer Nat. Rev. Cancer 6 2006 392 401
38. M.E. Anderson Glutathione: an overview of biosynthesis and modulation Chem. Biol. Interact. 111-112 1998 1 14 (Pubitemid 28271929)
39. R.A. Britten, J.A. Green, C. Broughton, P.G. Browning, R. White, and H.M. Warenius The relationship between nuclear glutathione levels and resistance to melphalan in human ovarian tumour cells Biochem. Pharmacol. 41 1991 647 649
40. D. Trachootham, W. Lu, M.A. Ogasawara, R.D. Nilsa, and P. Huang Redox regulation of cell survival Antioxid. Redox Signal. 10 8 2008 1343 1374
41. H.J. Forman, J.M. Fukuto, and M. Torres Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers Am. J. Physiol. Cell Physiol. 287 2 2004 246 256
42. T. Honda, S. Coppola, L. Ghibelli, S.H. Cho, S. Kagawa, K.B. Spurgers, S.M. Brisbay, J.A. Roth, R.E. Meyn, B. Fang, and T.J. McDonnell GSH depletion enhances adenoviral bax-induced apoptosis in lung cancer cells Cancer Gene Ther. 11 4 2004 249 255 (Pubitemid 41184343)
43. T. Schnelldorfer, S. Gansauge, F. Gansauge, S. Schlosser, H.G. Beger, and A.K. Nussler Glutathione depletion causes cell growth inhibition and enhanced apoptosis in pancreatic cancer cells Cancer 89 2000 1440 1447
44. N. Sato, S. Iwata, K. Nakamura, T. Hori, T. Mori, and J. Yodoi Thiol-mediated redox regulation of apoptosis: possible roles of cellular thiols other than glutathione in T cell apoptosis J. Immunol. 154 1995 3194 3203
45. R. Franco, M.I. Panayiotidis, and J.A. Cidlowski Glutathione depletion is necessary for apoptosis in lymphoid cells independent of reactive oxygen species formation J. Biol. Chem. 282 42 2007 30452 30465 (Pubitemid 350035221)
46. M.T. Vincenzini, P. Marraccini, T. Iantomasi, F. Favilli, S. Pacini, and M. Ruggiero Altered metabolism of glutathione in cells transformed by oncogenes which cause resistance to ionizing radiations FEBS Lett. 320 3 1993 219 223 (Pubitemid 23105113)
47. Y. Higuchi Glutathione depletion-induced chromosomal DNA fragmentation associated with apoptosis and necrosis J. Cell. Mol. Med. 8 4 2004 455 464 (Pubitemid 44145478)
48. Y. Gotoh, T. Noda, R. Iwakiri, K. Fujimoto, C.A. Rhoads, and T.Y. Aw Lipid peroxide-induced redox imbalance differentially mediates CaCo-2 cell proliferation and growth arrest Cell Prolif. 35 2002 221 235 (Pubitemid 34985157)
49. S.G. Menon, E.H. Sarsour, D.R. Spitz, R. Higashikubo, M. Sturm, H. Zhang, and P.C. Goswami Redox regulation of the G1 to S phase transition in the mouse embryo fibroblast cell cycle Cancer Res. 63 2003 2109 2117 (Pubitemid 36538614)
50. P.D. Vivancos, T. Wolf, J. Markovic, F.V. Pallardo, and C.H. Foyer A nuclear glutathione cycle within the cell cycle Biochem. J. 431 2010 169 178
51. D. Wu, and A. Cederbaum Glutathione depletion in CYP2E1-expressing liver cells induces toxicity due to the activation of p38 mitogen-activated protein kinase and reduction of nuclear factor-B DNA binding activity Mol. Pharmacol. 66 2004 749 760 (Pubitemid 39329275)
52. R.J. Davis Signal transduction by the JNK group of MAP kinases Cell 103 2 2000 239 252
53. R.P. Sahu, R. Zhang, S. Batra, Y. Shi, and S.K. Srivastava Benzyl isothiocyanate-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of MAPK in human pancreatic cancer cells Carcinogenesis 30 10 2009 1744 1753
54. S.M. Deneke, and B.L. Fanburg Regulation of cellular glutathione Am. J. Physiol. 257 1989 163 173
55. D.W. Jung, Z.M. Che, J. Kim, K. Kim, K.Y. Kim, D. Williams, and J. Kim Tumor-stromal crosstalk in invasion of oral squamous cell carcinoma: a pivotal role of CCL7 Int. J. Cancer 127 2010 332 344
56. S. Kumar, M. Antony, and N.K. Mehrotra Role of cutaneous GSH in 12-O-tetradecanoyl-phorbol 13-acetate-induced mouse skin tumor promotion Arch. Dermatol. Res. 280 6 1988 371 374
57. M.A. Shibata, M. Hirose, A. Masuda, T. Kato, M. Mutai, and N. Ito Modification of BHA forestomach carcinogenesis in rats: inhibition by diethylmaleate or indomethacin and enhancement by a retinoid Carcinogenesis 14 7 1993 1265 1269 (Pubitemid 23229666)
58. D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 5 2011 646 674