Glutamine supplementation in acute pancreatitis: A meta-analysis of randomized controlled trials

Pancreatology

Volumn 13, Issue 5, 2013, Pages 468-474

  Asrani, Varsha ^a,b   Chang, Wai Keat ^a   Dong, Zhiyong ^c   Hardy, Gil ^a   Windsor, John A ^a   Petrov, Maxim S ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b AUCKLAND CITY HOSPITAL   (New Zealand)

^c GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

Acute pancreatitis; Enteral nutrition; Glutamine; Parenteral nutrition; Pharmaconutrition

Indexed keywords

GLUTAMINE;

ACUTE PANCREATITIS; ARTICLE; DIET SUPPLEMENTATION; HUMAN; INFECTIOUS COMPLICATION; LENGTH OF STAY; META ANALYSIS; MORTALITY; NUTRIENT; OUTCOME ASSESSMENT; PARENTERAL NUTRITION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK ASSESSMENT; SYSTEMATIC REVIEW; TREATMENT OUTCOME;

ACUTE PANCREATITIS; ENTERAL NUTRITION; GLUTAMINE; PARENTERAL NUTRITION; PHARMACONUTRITION;

ENTERAL NUTRITION; GLUTAMINE; HUMANS; INFECTION CONTROL; LENGTH OF STAY; PANCREATITIS; PARENTERAL NUTRITION; PARENTERAL NUTRITION, TOTAL; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84892592313     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1016/j.pan.2013.07.282     Document Type: Article

References (40)

1. Petrov MS, Whelan K. Comparison of complications attributable to enteral and parenteral nutrition in severe acute pancreatitis: a systematic review and meta-analysis. Br J Nutr 2010; 103: 1287e95.
2. Petrov MS, Loveday BP, Pylypchuk RD, McIlroy K, Phillips AR, Windsor JA. Systematic review and meta-analysis of enteral nutrition formulations in acute pancreatitis. Br J Surg 2009; 96: 1243e52.
3. Petrov MS, van Santvoort HC, Besselink MG, van der Heijden GJ, Windsor JA, Gooszen HG. Enteral nutrition and the risk of mortality and infectious complications in patients with severe acute pancreatitis e a meta-analysis of randomized trials. Arch Surg 2008; 143: 1111e7.
4. Meier R, Beglinger C, Layer P, Gullo L, Keim V, Laugier R, et al. ESPEN guidelines on nutrition in acute pancreatitis. Cin Nutr 2002; 21: 14e20.
5. Petrov MS, Pylypchuk RD, Emelyanov NV. Systematic review: nutritional support in acute pancreatitis. Alim Pharmacol Ther 2008; 28: 704e12.
6. Petrov MS, Atduev VA, Zagainov VE. Advanced enteral therapy in acute pancreatitis: is there a room for immunonutrition? A meta-analysis. Int J Surg 2008; 6: 119e24.
7. Hardy G, Manzanares W. Pharmaconutrition: how has this concept evolved in the last two decades? Nutrition 2011; 27: 1090e2.
8. Jones NE, Heyland DK. Pharmaconutrition: a new emerging paradigm. Curr Opin Gastroenterol 2008; 24: 215e22.
9. Dellinger EP, Forsmark CE, Layer P, Lévy P, Maraví-Poma E, Petrov MS, et al. Pancreatitis across Nations Clinical Research and Education Alliance (PANCREA). Determinant-based classification of acute pancreatitis severity: an international multidisciplinary consultation. Ann Surg 2012; 256: 875e80.
10. Calder PC. Immunonutrition in surgical and critically ill patients. Br J Nutr 2007; 98: S133e9.
11. Hardy G, Bovan SJ, McElroy B. Stability of glutamine in parenteral nutrition. Lancet 1993; 342: 186.
12. Ziegler TR, Szeszycki EE, Estivariz CF, Puckett AB, Leader LM. Glutamine: from basic science to clinical application. Nutrition 1996; 12: 68e70.
13. Hall JC, Heel K, McMauley R. Glutamine. Br J Surg 1996; 83: 305e12.
14. Fürst P, Pogan K, Stehle P. Glutamine dipeptides in clinical nutrition. Nutrition 1997; 13: 731e7.
15. Conejero R, Bonet A, Grau T, Esteban A, Mesejo A, Montejo JC, et al. Effect of a glutamine-enriched enteral diet on intestinal permeability and infectious morbidity at 28 days in critically ill patients with systemic inflammatory response syndrome: a randomized, single-blind, prospective, multicenter study. Nutrition 2002; 18: 716e21
16. Houdijk AP, Rijnsburger ER, Jansen J, Wesdorp RI, Weiss JK, McCamish MA, et al. Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma. Lancet 1998; 352: 772e6.
17. Zheng YM, Li F, Zhang MM, Wu XT. Glutamine dipeptide for parenteral nutrition in abdominal surgery: a meta-analysis of randomized controlled trials. World J Gastroenterol 2006; 12: 7537e41.
18. Lin JJ, Chung XJ, Yang CY, Lau HL. A meta-analysis of trials using the intention to treat principle for glutamine supplementation in critically ill patients with burn. Burns 2013; 39: 565e70.
19. Novak F, Heyland DK, Avenell A, Drover JW, Su X. Glutamine supplementation in serious illness: a systematic review of the evidence. CritCareMed 2002; 30: 2022e9.
20. Sandstrom P, Trulsson L, Gasslander T, Sundqvist T, von Dobeln U, Svanvik J. Serum amino acid in patients with acute pancreatitis. Amino Acids 2008; 35: 225e31.
21. Petrov MS. Moving beyond the 'pancreatic rest' in severe and critical acute pancreatitis. Critical Care 2013; 17: 161.
22. Petrov MS, Windsor JA. Nutritional management of acute pancreatitis: the concept of 'gut rousing'. Curr Opin Clin Nutr Metab Care 2013; 16: 557e63.
23. Moher D, Liberati A, Tetzlaff J, Altman DG. The PRISMA group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg 2010; 8: 336e41.
24. Higgins JP, Altman DG, Gotzsche PC, Juni P, Moher D, Oxman AD, et al. The Cochrane collaboration's tool for assessing risk of bias in randomised trials. BMJ 2011; 343: D5928.
25. Hozo SP, Djulbegovic B, Hozo I. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol 2005; 5: 13.
26. de Beaux AC, O'Riordain MG, Ross JA, Jodozi L, Carter DC, Fearon KC. Glutaminesupplemented total parenteral nutrition reduces blood mononuclear cell interleukin-8 release in severe acute pancreatitis. Nutrition 1998; 14: 261E5.
27. Fuentes-Orozco C, Cervantes-Guevara G, Mucino-Hernandez I, Lopez- Ortega A, Ambriz-Gonzalez G, Gutierrez-de-la-Rosa JL, et al. L-alanyl-Lglutamine- supplemented parenteral nutrition decreases infectious morbidity rate in patients with severe acute pancreatitis. JPEN J Parenter Enteral Nutr 2008; 32: 403E11.
28. Guo Y, Xiao M. Effect of glutamine on nutrition state in severe acute pancreatitis. Clin J Med Officer 2006: 01.
29. Hadju N, Belagyi T, Issekutz A, Bartek P, Gartner B, Olah A. A combination of intravenous glutamine and early naso-jejunal feeding in predicted severe pancreatitis e a prospective randomized double-blind clinical trial. Magyar Sebeszet 2012; 65: 44E51.
30. Han M, Liu T, Liu G, Wang PZ. Clinical observation of immune nutritional agent on the treatment effect in patients with severe pancreatitis. J Tianjin Med Univ 2011; 17: 227E9.
31. He XL, Ma QJ, Lu JG, Chu YK, Du XL. Effect of total parenteral nutrition (TPN) with and without glutamine dipeptide supplementation on outcome in severe acute pancreatitis (SAP). Clin Nutr Supplements 2004; 1: 43E7.
32. Huang XX, Wang XP, Ma JJ, Jing DD, Wang PW, Wu K. Effects of enteral nutrition supplemented with glutamine and arginine on gut barrier in patients with severe acute pancreatitis: a prospective randomized controlled trial. Zhonghua Yi Xue Za Zhi 2008; 88: 2407e9.
33. Huang XX, Wang XP, Wu K, Xu CF, Chen WC, Wang YD, et al. Effect of early continuous enteral nutrition combined with intestinal mucosal protective agents on gut barrier in patients with severe acute pancreatitis: A multicenter prospective randomized controlled trial. Chin J Dig 2008; 28: 225e32.
34. Ockenga J, Borchert K, Rifai K, Manns MP, Bischoff SC. Effect of glutamineenriched total parenteral nutrition in patients with acute pancreatitis. Clin Nutr 2002; 21: 409E16.
35. Pearce CB, Sadek SA, Walters AM, Goggin PM, Somers SS, Toh SK, et al. A double-blind, randomised, controlled trial to study the effects of an enteral feed supplemented with glutamine, arginine, and omega-3 fatty acid in predicted acute severe pancreatitis. JOP 2006; 7: 361E71.
36. Sahin H, Mercanligil SM, Inanc N, Ok E. Effects of glutamine-enriched total parenteral nutrition on acute pancreatitis. Eur J Clin Nutr 2007; 61: 1429E34.
37. Yang SQ, Xu JG. Effect of glutamine on serum interleukin-8 and tumor necrosis factor-alpha levels in patients with severe pancreatitis. Nan Fang Yi Ke Da Xue Xue Bao 2008; 28: 129E31.
38. Heyland D, Muscedere J, Wischmeyer PE, Cook D, Jones G, Albert M, et al., Canadian Critical Care Trials Group. A randomised trial of glutamine and antioxidants in critically ill patients. NEJM 2013; 368: 1489E97.
39. Haisch M, Fukagawa NK, Matthews DE. Oxidation of glutamine by sphlanic bed in humans. Am J Physiol Endocrinol Metab 2000; 278: 593E602.
40. Melis GC, Boelens PG, van der Sijp JR, Popovici T, De Bandt JP, Cynober L, et al. The feeding route (enteral or parenteral) affects the plasma response of the dipetide Ala-Gln and the amino acids glutamine, citrulline and arginine, with the administration of Ala-Gln in preoperative patients. Br J Nutr 2005; 94: 19E26.