Targeted metabolomic analysis of amino acid response to L-asparaginase in adherent cells

Metabolomics

Volumn 10, Issue 5, 2014, Pages 909-919

  Purwaha, Preeti ^a   Lorenzi, Philip L ^a   Silva, Leslie P ^a   Hawke, David H ^a   Weinstein, John N ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Amino acid; L Asparaginase; Mass spectrometry; Metabolism; Metabolomics; Ovarian cancer

Indexed keywords

ALANINE; AMINO ACID; ARGININE; ASPARAGINASE; ASPARAGINE; ASPARTIC ACID; CITRULLINE; CYSTEINE; CYSTINE; GLUTAMIC ACID; GLUTAMINE; GLYCINE; HISTIDINE; HYPOTAURINE; ISOLEUCINE; LEUCINE; LYSINE; METHIONINE; ORNITHINE; PHENYLALANINE; PROLINE; PUTRESCINE; SARCOSINE; SPERMIDINE; SPERMINE; TAURINE; TRYPTOPHAN; TYROSINE; VALINE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADHERENT CELL; AMINO ACID METABOLISM; ANALYTIC METHOD; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CELL LYSATE; CONTROLLED STUDY; CULTURE OPTIMIZATION; ELECTROSPRAY; ENZYME ACTIVITY; EXTRACTION; HUMAN; HUMAN CELL; INFORMATION PROCESSING; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITE; METABOLOMICS; OVARY CANCER; REPRODUCIBILITY; STANDARD; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION PROCESS;

EID: 84893197498     PISSN: 15733882     EISSN: 15733890     Source Type: Journal    
DOI: 10.1007/s11306-014-0634-1     Document Type: Article

References (26)

1. Asselin, B. L., et al. (1989). In vitro and in vivo killing of acute lymphoblastic leukemia cells by L-asparaginase. Cancer Research, 49, 4363-4368.
2. Balasubramanian, M. N., Butterworth, E. A., & Kilberg, M. S. (2013). Asparagine synthetase: Regulation by cell stress and involvement in tumor biology. American Journal of Physiology Endocrinology and Metabolism, 304, E789-E799.
3. Bi, H., Krausz, K. W., Manna, S. K., Li, F., Johnson, C. H., & Gonzalez, F. J. (2013). Optimization of harvesting, extraction, and analytical protocols for UPLC-ESI-MS-based metabolomic analysis of adherent mammalian cancer cells. Analytical and Bioanalytical Chemistry, 405, 5279-5289.
4. Bussey, K. J., et al. (2006). Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel. Molecular Cancer Therapeutics, 5, 853-867.
5. Danielsson, A. P., Moritz, T., Mulder, H., & Spegel, P. (2010). Development and optimization of a metabolomic method for analysis of adherent cell cultures. Analytical Biochemistry, 404, 30-39.
6. De Jonge, L. P., Douma, R. D., Heijnen, J. J., & van Gulik, W. M. (2012). Optimization of cold methanol quenching for quantitative metabolomics of Penicillium chrysogenum. Metabolomics, 8, 727-735.
7. Dietmair, S., Timmins, N. E., Gray, P. P., Nielsen, L. K., & Kromer, J. O. (2010). Towards quantitative metabolomics of mammalian cells: Development of a metabolite extraction protocol. Analytical Biochemistry, 404, 155-164.
8. Fine, B. M., Kaspers, G. J., Ho, M., Loonen, A. H., & Boxer, L. M. (2005). A genome-wide view of the in vitro response to l-asparaginase in acute lymphoblastic leukemia. Cancer Research, 65, 291-299.
9. Hutson, R. G., Kitoh, T., Moraga Amador, D. A., Cosic, S., Schuster, S. M., & Kilberg, M. S. (1997). Amino acid control of asparagine synthetase: Relation to asparaginase resistance in human leukemia cells. American Journal of Physiology, 272, C1691-C1699.
10. Kitoh, T., Asai, S., Akiyama, Y., Kubota, M., & Mikawa, H. (1992). The inhibition of lymphocyte blastogenesis by asparaginase: Critical role of glutamine in both T and B lymphocyte transformation. Acta Paediatrica Japonica, 34, 579-583.
11. Kronthaler, J., Gstraunthaler, G., & Heel, C. (2012). Optimizing high-throughput metabolomic biomarker screening: A study of quenching solutions to freeze intracellular metabolism in CHO cells. OMICS: A Journal of Integrative Biology, 16, 90-97.
12. La Spina, M., Catania, R., Lo Nigro, L., De Grandi, C., Palmucci, S., & Di Cataldo, A. (2010). Neurological complications during treatment of childhood cancer: Mind Wernicke encephalopathy. Pediatric Hematology and Oncology, 27, 320-323.
13. Leslie, M., Case, M. C., Hall, A. G., & Coulthard, S. A. (2006). Expression levels of asparagine synthetase in blasts from children and adults with acute lymphoblastic leukaemia. British Journal of Haematology, 132, 740-742.
14. Lorenz, M. A., Burant, C. F., & Kennedy, R. T. (2011). Reducing time and increasing sensitivity in sample preparation for adherent mammalian cell metabolomics. Analytical Chemistry, 83, 3406-3414.
15. Lorenzi, P. L., & Weinstein, J. N. (2009). Asparagine synthetase: A new potential biomarker in ovarian cancer. Drug News Perspect, 22, 61-64.
16. Lorenzi, P. L., et al. (2006). Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells. Molecular Cancer Therapeutics, 5, 2613-2623.
17. Lorenzi, P. L., et al. (2008). Asparagine synthetase is a predictive biomarker of L-asparaginase activity in ovarian cancer cell lines. Molecular Cancer Therapeutics, 7, 3123-3128.
18. Meinert, S., Rapp, S., Schmitz, K., Noack, S., Kornfeld, G., & Hardiman, T. (2013). Quantitative quenching evaluation and direct intracellular metabolite analysis in Penicillium chrysogenum. Analytical Biochemistry, 438, 47-52.
19. Scherf, U., et al. (2000). A gene expression database for the molecular pharmacology of cancer. Nature Genetics, 24, 236-244.
20. Sellick, C. A., Hansen, R., Stephens, G. M., Goodacre, R., & Dickson, A. J. (2011). Metabolite extraction from suspension-cultured mammalian cells for global metabolite profiling. Nature Protocols, 6, 1241-1249.
21. Sellick, C. A., et al. (2009). Effective quenching processes for physiologically valid metabolite profiling of suspension cultured Mammalian cells. Analytical Chemistry, 81, 174-183.
22. Silva, L. P., Lorenzi, P. L., Yong, V., Hawke, D. H., Weinstein, J. N., & Purwaha, P. (2013). Measurement of DNA concentration as a normalization strategy for metabolomic data from adherent cell lines. Analytical Chemistry. doi: 10. 1021/ac401559v.
23. Su, N., Pan, Y. X., Zhou, M., Harvey, R. C., Hunger, S. P., & Kilberg, M. S. (2008). Correlation between asparaginase sensitivity and asparagine synthetase protein content, but not mRNA, in acute lymphoblastic leukemia cell lines. Pediatric Blood & Cancer, 50, 274-279.
24. Sweeney, P. J., & Walker, J. M. (1993). Pronase (EC 3. 4. 24. 4). Methods in Molecular Biology, 16, 271-276.
25. Tran, T. T., Dietmair, S., Chan, L. C., Huynh, H. T., Nielsen, L. K., & Reid, S. (2012). Development of quenching and washing protocols for quantitative intracellular metabolite analysis of uninfected and baculovirus-infected insect cells. Methods, 56, 396-407.
26. Yu, M., et al. (2012). L-asparaginase inhibits invasive and angiogenic activity and induces autophagy in ovarian cancer. Journal of Cellular and Molecular Medicine, 16, 2369-2378.