Is there a role for proton therapy in the treatment of hepatocellular carcinoma? A systematic review

Radiotherapy and Oncology

Volumn 111, Issue 1, 2014, Pages 1-10

  Dionisi, Francesco ^a,b   Widesott, Lamberto ^a,b,c   Lorentini, Stefano ^a,b   Amichetti, Maurizio ^a,b  

^a ATreP Agenzia Provinciale per la Protonterapia   (Italy)

^b Proton Therapy Unit (APSS)   (Italy)

^c ETH ZURICH   (Switzerland)

Author keywords

Hepatocellular carcinoma; Proton therapy; Systematic review

Indexed keywords

IODINATED POPPYSEED OIL; PROTON; CONTRAST MEDIUM;

BIBLIOGRAPHIC DATABASE; BILIARY TRACT DISEASE; CANCER PATIENT; CANCER SURGERY; CHEMOEMBOLIZATION; COMPUTER ASSISTED TOMOGRAPHY; DISEASE FREE SURVIVAL; DISEASE SEVERITY; DISEASE SPECIFIC SURVIVAL; GASTROINTESTINAL TOXICITY; HUMAN; IMAGE GUIDED RADIOTHERAPY; LIVER; LIVER CELL CARCINOMA; LIVER TOXICITY; MEDLINE; OVERALL SURVIVAL; PATIENT SAFETY; PRACTICE GUIDELINE; PREDICTIVE VALUE; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; PROSPECTIVE STUDY; PROTON THERAPY; QUALITY OF LIFE; RADIATION DOSE; RADIATION DOSE DISTRIBUTION; RADIATION DOSE FRACTIONATION; RADIOTHERAPY PLANNING SYSTEM; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SCIENTIST; SYSTEMATIC REVIEW; TREATMENT OUTCOME; TREATMENT PLANNING; CARCINOMA, HEPATOCELLULAR; LIVER NEOPLASMS; PROCEDURES; ACUTE TOXICITY; ARTICLE; CHILD PUGH SCORE; LIVER FAILURE; LIVER FUNCTION; LIVER TRANSPLANTATION; LIVER WEIGHT; PROTON RADIATION; SKIN TOXICITY;

CARCINOMA, HEPATOCELLULAR; DOSE FRACTIONATION; HUMANS; LIVER NEOPLASMS; PROSPECTIVE STUDIES; PROTON THERAPY; PROTONS;

EID: 84902196263     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2014.02.001     Document Type: Review

References (71)

1. J. Ferlay, H.-R. Shin, F. Bray, D. Forman, C. Mathers, and D.M. Parkin Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 Int J Cancer 127 2010 2893 2917
2. S.F. Altekruse, K.A. McGlynn, and M.E. Reichman Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005 J Clin Oncol 27 2009 1485 1491
3. F. Trevisani, M.C. Cantarini, J.R. Wands, and M. Bernardi Recent advances in the natural history of hepatocellular carcinoma Carcinogenesis 29 2008 1299 1305
4. J.M. Llovet, J. Bustamante, and A. Castells et al. Natural history of untreated nonsurgical hepatocellular carcinoma: rationale for the design and evaluation of therapeutic trials Hepatology 29 1999 62 67
5. W.R. Jarnagin Management of small hepatocellular carcinoma: a review of transplantation, resection, and ablation Ann Surg Oncol 17 2010 1226 1233
6. R. Lencioni, D. Cioni, and L. Crocetti et al. Early-stage hepatocellular carcinoma in patients with cirrhosis: long-term results of percutaneous image-guided radiofrequency ablation Radiology 234 2005 961 967
7. L. Tiong, and G.J. Maddern Systematic review and meta-analysis of survival and disease recurrence after radiofrequency ablation for hepatocellular carcinoma Br J Surg 98 2011 1210 1224
8. J.M. Llovet, and J. Bruix Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival Hepatology 37 2003 429 442
9. J.M. Llovet, C. Brú, and J. Bruix Prognosis of hepatocellular carcinoma: the BCLC staging classification Semin Liver Dis 19 1999 329 338
10. C.C. Pan, B.D. Kavanagh, and L.A. Dawson et al. Radiation-associated liver injury Int J Radiat Oncol Biol Phys 76 2010 S94 S100
11. E. Ben-Josef, D. Normolle, and W.D. Ensminger et al. Phase II trial of high-dose conformal radiation therapy with concurrent hepatic artery floxuridine for unresectable intrahepatic malignancies J Clin Oncol 23 2005 8739 8747
12. R.V. Tse, M. Hawkins, and G. Lockwood et al. Phase I study of individualized stereotactic body radiotherapy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma J Clin Oncol 26 2008 657 664
13. EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma Eur J Cancer 2012 1990 599 641
14. NCCN clinical practice guidelines in oncology hepatobiliary cancers version 2.2012 available at < www.nccn.org/professionals/physician-gls/f- guidelines.asp#site >.
15. D.R. Olsen, O.S. Bruland, G. Frykholm, and I.N. Norderhaug Proton therapy - a systematic review of clinical effectiveness Radiother Oncol 83 2007 123 132
16. D. De Ruysscher, M. Mark Lodge, and B. Jones et al. Charged particles in radiotherapy: a 5-year update of a systematic review Radiother Oncol 103 2012 5 7
17. A. Liberati, D.G. Altman, and J. Tetzlaff et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration BMJ 339 2009 b2700
18. D.A. Bush, Z. Kayali, R. Grove, and J.D. Slater The safety and efficacy of high-dose proton beam radiotherapy for hepatocellular carcinoma: a phase 2 prospective trial Cancer 117 2011 3053 3059
19. T. Chiba, K. Tokuuye, and Y. Matsuzaki et al. Proton beam therapy for hepatocellular carcinoma: a retrospective review of 162 patients Clin Cancer Res 11 2005 3799 3805
20. H. Nakayama, S. Sugahara, and M. Tokita et al. Proton beam therapy for hepatocellular carcinoma: the University of Tsukuba experience Cancer 115 2009 5499 5506
21. S. Komatsu, T. Fukumoto, and Y. Demizu et al. Clinical results and risk factors of proton and carbon ion therapy for hepatocellular carcinoma Cancer 117 2011 4890 4904
22. T.S. Hong, T.F. DeLaney, and H.J. Mamon et al. Pilot study of respiratory gated proton beam therapy for liver tumors Int J Radiat Oncol Biol Phys 75 2009 S166
23. Kim T. Clinical applications and preliminary results of proton beam therapy (PBT) for hapatocellular carcinoma in NCC, Korea, presented at PTCOG 51, available at http://ptcog.web.psi.ch/archive-talks.html.
24. Lee J. Proton therapy for hepatocellular carcinoma, presented at PTCOG 46, WPTC, China, avalaible at http://ptcog.web.psi.ch/ptcog46-talks.html.
25. N. Fukumitsu, T. Hashimoto, and T. Okumura et al. Investigation of the geometric accuracy of proton beam irradiation in the liver Int J Radiat Oncol Biol Phys 82 2012 826 833
26. Y. Oshiro, T. Okumura, and M. Ishida et al. Displacement of hepatic tumor at time to exposure in end-expiratory-triggered-pulse proton therapy Radiother Oncol 99 2011 124 130
27. D. Shin, T.H. Kim, and S.Y. Park et al. Influence of lipiodol agent on proton beam range in radiotherapy planning using computed tomography for hepatocellular carcinoma Int J Radiat Oncol Biol Phys 72 2008 687 694
28. M. Hata, K. Tokuuye, and S. Sugahara et al. Proton irradiation in a single fraction for hepatocellular carcinoma patients with uncontrollable ascites: technical considerations and results Strahlenther Onkol 183 2007 411 416
29. J.A. Wolfgang, E.M. Crowley, A. Rubinstein, G.T.Y. Chen, J.Y. Wo, and T.S. Hong Motion management for proton SBRT liver treatment: use of serial 4DCT to determine optimal localization strategy Int J Radiat Oncol Biol Phys 81 2011 S884 S885
30. M. Mizumoto, T. Okumura, and T. Hashimoto et al. Evaluation of liver function after proton beam therapy for hepatocellular carcinoma Int J Radiat Oncol Biol Phys 82 2012 e529 e535
31. A. Kanemoto, M. Mizumoto, and T. Okumura et al. Dose-volume histogram analysis for risk factors of radiation-induced rib fracture after hypofractionated proton beam therapy for hepatocellular carcinoma Acta Oncol 52 2013 538 544
32. K. Ohara, T. Okumura, and H. Tsuji et al. Radiation tolerance of cirrhotic livers in relation to the preserved functional capacity: analysis of patients with hepatocellular carcinoma treated by focused proton beam radiotherapy Int J Radiat Oncol Biol Phys 38 1997 367 372
33. M. Kawashima, R. Kohno, and K. Nakachi et al. Dose-volume histogram analysis of the safety of proton beam therapy for unresectable hepatocellular carcinoma Int J Radiat Oncol Biol Phys 79 2011 1479 1486
34. M. Kawashima, J. Furuse, and T. Nishio et al. Phase II study of radiotherapy employing proton beam for hepatocellular carcinoma J Clin Oncol 23 2005 1839 1846
35. V. Mazzaferro, E. Regalia, and R. Doci et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis N Engl J Med 334 1996 693 699
36. N. Yamanaka, E. Okamoto, K. Kuwata, and N. Tanaka A multiple regression equation for prediction of posthepatectomy liver failure Ann Surg 200 1984 658 663
37. X. Wang, S. Krishnan, and X. Zhang et al. Proton radiotherapy for liver tumors: dosimetric advantages over photon plans Med Dosim 33 2008 259 267
38. Particle therapy cooperative group (PTCOG) website available at http://ptcog.web.psi.ch/ptcentres.html.
39. M.A. Hawkins, and L.A. Dawson Radiation therapy for hepatocellular carcinoma: from palliation to cure Cancer 106 2006 1653 1663
40. C. Tao, and L.-X. Yang Improved radiotherapy for primary and secondary liver cancer: stereotactic body radiation therapy Anticancer Res 32 2012 649 655
41. T. Hashimoto, K. Tokuuye, and N. Fukumitsu et al. Repeated proton beam therapy for hepatocellular carcinoma Int J Radiat Oncol Biol Phys 65 2006 196 202
42. J.M. Llovet, S. Ricci, and V. Mazzaferro et al. Sorafenib in advanced hepatocellular carcinoma N Engl J Med 359 2008 378 390
43. M.-B. Meng, Y.-L. Cui, and Y. Lu et al. Transcatheter arterial chemoembolization in combination with radiotherapy for unresectable hepatocellular carcinoma: a systematic review and meta-analysis Radiother Oncol 92 2009 184 194
44. D.L. Andolino, C.S. Johnson, and M. Maluccio et al. Stereotactic body radiotherapy for primary hepatocellular carcinoma Int J Radiat Oncol Biol Phys 81 2011 e447 e453
45. A. Bujold, C.A. Massey, and J.J. Kim et al. Sequential phase I and II trials of stereotactic body radiotherapy for locally advanced hepatocellular carcinoma J Clin Oncol 31 2013 1631 1639
46. H. Nakayama, S. Sugahara, and K. Fukuda et al. Proton beam therapy for hepatocellular carcinoma located adjacent to the alimentary tract Int J Radiat Oncol Biol Phys 80 2011 992 995
47. S. Komatsu, M. Murakami, T. Fukumoto, Y. Hori, Y. Hishikawa, and Y. Ku Risk factors for survival and local recurrence after particle radiotherapy for single small hepatocellular carcinoma Br J Surg 98 2011 558 564
48. M. Mizumoto, K. Tokuuye, and S. Sugahara et al. Proton beam therapy for hepatocellular carcinoma adjacent to the porta hepatis Int J Radiat Oncol Biol Phys 71 2008 462 467
49. T. Eriguchi, A. Takeda, and N. Sanuki et al. Acceptable toxicity after stereotactic body radiation therapy for liver tumors adjacent to the central biliary system Int J Radiat Oncol Biol Phys 85 2013 1006 1011
50. S.H. Son, B.O. Choi, and M.R. Ryu et al. Stereotactic body radiotherapy for patients with unresectable primary hepatocellular carcinoma: dose-volumetric parameters predicting the hepatic complication Int J Radiat Oncol Biol Phys 78 2010 1073 1080
51. H.I. Yoon, W.S. Koom, and I.J. Lee et al. The significance of ICG-R15 in predicting hepatic toxicity in patients receiving radiotherapy for hepatocellular carcinoma Liver Int 32 2012 1165 1171
52. H. Kato, H. Tsujii, and T. Miyamoto et al. Results of the first prospective study of carbon ion radiotherapy for hepatocellular carcinoma with liver cirrhosis Int J Radiat Oncol Biol Phys 59 2004 1468 1476
53. H. Imada, H. Kato, and S. Yasuda et al. Comparison of efficacy and toxicity of short-course carbon ion radiotherapy for hepatocellular carcinoma depending on their proximity to the porta hepatis Radiother Oncol 96 2010 231 235
54. D. Habermehl, J. Debus, and T. Ganten et al. Hypofractionated carbon ion therapy delivered with scanned ion beams for patients with hepatocellular carcinoma - feasibility and clinical response Radiat Oncol 8 2013 59
55. J.C. Park, S.H. Park, and J.H. Kim et al. Liver motion during cone beam computed tomography guided stereotactic body radiation therapy Med Phys 39 2012 6431 6442
56. R.B. Jeffrey Jr., A.A. Moss, J.M. Quivey, M.P. Federle, and W.M. Wara CT of radiation-induced hepatic injury Am J Roentgenol 135 1980 445 448
57. H. Suit, and M. Urie Proton beams in radiation therapy J Natl Cancer Inst 84 1992 155 164
58. T. Ahmadi, Y. Itai, H. Onaya, H. Yoshioka, T. Okumura, and Y. Akine CT evaluation of hepatic injury following proton beam irradiation: appearance, enhancement, and 3D size reduction pattern J Comput Assist Tomogr 23 1999 655 663
59. T. Fukumoto, S. Komatsu, Y. Hori, M. Murakami, Y. Hishikawa, and Y. Ku Particle beam radiotherapy with a surgical spacer placement for advanced abdominal leiomyosarcoma results in a significant clinical benefit J Surg Oncol 101 2010 97 99
60. P.J. Taddei, R.M. Howell, S. Krishnan, S.B. Scarboro, D. Mirkovic, and W.D. Newhauser Risk of second malignant neoplasm following proton versus intensity-modulated photon radiotherapies for hepatocellular carcinoma Phys Med Biol 55 2010 7055 7065
61. A.J. Lomax, T. Boehringer, and A. Coray et al. Intensity modulated proton therapy: a clinical example Med Phys 28 2001 317 324
62. A. Smith, M. Gillin, and M. Bues et al. The M.D. Anderson proton therapy system Med Phys 36 2009 4068 4083
63. U. Schneider, A. Lomax, and P. Pemler et al. The impact of IMRT and proton radiotherapy on secondary cancer incidence Strahlenther Onkol 182 2006 647 652
64. A.J. Lomax, E. Pedroni, H. Rutz, and G. Goitein The clinical potential of intensity modulated proton therapy Z Med Phys 14 2004 147 152
65. R. Kaderka, D. Schardt, and M. Durante et al. Out-of-field dose measurements in a water phantom using different radiotherapy modalities Phys Med Biol 57 2012 5059 5074
66. G. Fava, L. Widesott, and F. Fellin et al. In-gantry or remote patient positioning? Monte Carlo simulations for proton therapy centers of different sizes Radiother Oncol 103 2012 18 24
67. A. Knopf, C. Bert, and E. Heath et al. Special report: workshop on 4D-treatment planning in actively scanned particle therapy - recommendations, technical challenges, and future research directions Med Phys 37 2010 4608 4614
68. P.C. Park, X.R. Zhu, and A.K. Lee et al. A beam-specific planning target volume (PTV) design for proton therapy to account for setup and range uncertainties Int J Radiat Oncol Biol Phys 82 2012 e329 e336
69. J. Unkelbach, T.C.Y. Chan, and T. Bortfeld Accounting for range uncertainties in the optimization of intensity modulated proton therapy Phys Med Biol 52 2007 2755 2773
70. A.-C. Knopf, T.S. Hong, and A. Lomax Scanned proton radiotherapy for mobile targets-the effectiveness of re-scanning in the context of different treatment planning approaches and for different motion characteristics Phys Med Biol 56 2011 7257 7271
71. M. Goitein, and M. Jermann The relative costs of proton and X-ray radiation therapy Clin Oncol (R Coll Radiol) 15 2003 S37 S50