Dose-volume histogram analysis of the safety of proton beam therapy for unresectable hepatocellular carcinoma

International Journal of Radiation Oncology Biology Physics

Volumn 79, Issue 5, 2011, Pages 1479-1486

  Kawashima, Mitsuhiko ^a   Kohno, Ryosuke ^a   Nakachi, Kohei ^a   Nishio, Teiji ^a   Mitsunaga, Shuichi ^a   Ikeda, Masafumi ^a   Konishi, Masaru ^a   Takahashi, Shinichiro ^a   Gotohda, Naoto ^a   Arahira, Satoko ^a   Zenda, Sadamoto ^a   Ogino, Takashi ^a   Kinoshita, Taira ^a  

^a NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

Author keywords

Dose volume histogram; Hepatocellular carcinoma; Proton beam radiotherapy; Radiation tolerance of the liver

Indexed keywords

CONFIDENCE INTERVAL; DOSE-VOLUME HISTOGRAM ANALYSIS; DOSE-VOLUME HISTOGRAMS; GASTROINTESTINAL TOXICITIES; GRAY EQUIVALENT; HEPATOCELLULAR CARCINOMA; INDOCYANINE; MEDIAN DIAMETERS; OVERALL SURVIVAL RATES; PROTON BEAM RADIOTHERAPY; PROTON BEAM THERAPY; RADIATION TOLERANCE OF THE LIVER; RETENTION RATE; TREATMENT PLANS;

COBALT; GRAPHIC METHODS; LIVER; PROTON BEAMS; RADIOTHERAPY; RISK PERCEPTION; STATISTICAL METHODS;

PROTONS;

COBALT 76; INDOCYANINE GREEN; RADIOISOTOPE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER RADIOTHERAPY; CANCER SURVIVAL; CLINICAL EFFECTIVENESS; FEMALE; GASTROINTESTINAL TOXICITY; HISTOGRAM; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; LIVER FAILURE; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PATIENT SAFETY; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; PROTON THERAPY; RADIATION DOSE FRACTIONATION; SURVIVAL RATE; SURVIVAL TIME;

AGED; AGED, 80 AND OVER; CARCINOMA, HEPATOCELLULAR; DISEASE-FREE SURVIVAL; FEMALE; HEPATIC INSUFFICIENCY; HUMANS; LIVER; LIVER NEOPLASMS; MALE; MIDDLE AGED; PROTONS; RADIATION TOLERANCE; RADIOTHERAPY DOSAGE; SURVIVAL RATE; TUMOR BURDEN;

EID: 79952699828     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.12.048     Document Type: Article

References (22)

1. Krishnan S, Dawson LA, Seong J, et al. Radiotherapy for hepatocellular carcinoma: An overview. Ann Surg Oncol 2008;15:1015-1024.
2. Bush DA, Hillebrand DJ, Slater JM, et al. High-dose proton beam radiotherapy of hepatocellular carcinoma: Preliminary results of a phase II trial. Gastroenterology 2004;127:S189-S193. (Pubitemid 39423387)
3. Kawashima M, Furuse J, Nishio T, et al. Phase II trial of radiotherapy employing proton beam for hepatocellular carcinoma. J Clin Oncol 2005;23:1839-1846. (Pubitemid 46211361)
4. Chiba T, Tokuuye K, Matsuzaki Y, et al. Proton beam therapy for hepatocellular carcinoma: A retrospective review of 162 patients. Clin Cancer Res 2005;11:3799-3805. (Pubitemid 40685599)
5. Kosuge T, Makuuchi M, Takayama T, et al. Long term results after resection of hepatocellular carcinoma: experience of 480 cases. Hepato-Gastroenterol 1993;40:328-332. (Pubitemid 23258549)
6. The Liver Cancer Study Group of Japan. Predictive factors for long term prognosis after partial hepatectomy for patients with hepatocellular carcinoma in Japan. Cancer 1994;74:2772-2780.
7. Makuuchi M, Sano K. The surgical approach to HCC: Our progress and results in Japan. Liver Transpl 2004;10:S46-S52. (Pubitemid 38240100)
8. Tsai TJ, Chau GY, Lui WY, et al. Clinical significance of microscopic tumor venous invasion in patients with resectable hepatocellular carcinoma. Surgery 2000;127:603-608.
9. Vauthey JN, Lauwers GY, Esnaola NF, et al. Simplified staging for hepatocellular carcinoma. J Clin Oncol 2002;20:1527-1536. (Pubitemid 34260532)
10. Imamura H, Sano K, Sugawara Y, Kokudo N, Makuuchi M. Assessment of hepatic reserve for indication of hepatic resection: Decision tree incorporating indocyanine green test. J Hepatobiliary Pancreat Surg 2005;12:16-22. (Pubitemid 40378835)
11. Esnaola NF, Lauwers GY, Mirza NQ, et al. Predictors of microvascular invasion in patients with hepatocellular carcinoma who are candidates for orthotopic liver transplantation. J Gastrointest Surg 2002;6:224-232. (Pubitemid 40433575)
12. Cammà C, Schepis F, Orlando A, et al. Transarterial chemoembolization for unresectable hepatocellular carcinoma: Metaanalysis of randomized controlled trials. Radiology 2002;224:47-54. (Pubitemid 34680374)
13. Takayasu K, Arii S, Ikai I, et al. Prospective cohort study of transarterial chemoembolization for unresectable hepatocellular carcinoma in 8510 patients. Gastroenterology 2006;131:461-469. (Pubitemid 44142456)
14. Lawrence TS, Tesser RJ, Ten Haken RK. An application of dose volume histograms to the treatment of intrahepatic malignancies with radiation therapy. Int J Radiat Oncol Biol Phys 1990;19:1041-1047. (Pubitemid 20345178)
15. Tsujii H, Tsuji H, Inada T, et al. Clinical results of fractionated proton therapy. Int J Radiat Oncol Biol Phys 1993;25:49-60. (Pubitemid 23029773)
16. Ando K, Furusawa Y, Suzuki M, et al. Relative biological effectiveness of the 235 MeV proton beams at the National Cancer Center Hospital East. J Radiat Res 2001;42:79-89. (Pubitemid 33658573)
17. Schwartz JD, Schwartz M, Mandeli J, Sung M. Neoadjuvant and adjuvant therapy for resectable hepatocellular carcinoma: review of the randomised clinical trials. Lancet Oncol 2002;3:593-603. (Pubitemid 35174678)
18. Méndez Romero A, Wunderink W, Hussain SM, et al. Stereotactic body radiation therapy for primary and metastatic liver tumors: A single institution phase I-II study. Acta Oncol 2006;45:831-837. (Pubitemid 44423129)
19. Choi BO, Jang HS, Kang KM, et al. Fractionated stereotactic body radiotherapy in patients with primary hepatocellular carcinoma. Jpn J Clin Oncol 2006;36:154-158.
20. Liang SX, Zhu XD, Lu HJ, et al. Hypofractionated three-dimensional conformal radiation therapy for primary liver carcinoma. Cancer 2005;103:2181-2188.
21. Avila MA, Berasain C, Sangro B, Prieto J. New therapies for hepatocellular carcinoma. Oncogene 2006;25:3866-3884. (Pubitemid 43980482)
22. Thames HD, Withers HR, Peters LJ, et al. Changes in early and late radiation responses with altered dose fractionation: Implications for dose-survival relationships. Int J Radiat Oncol Biol Phys 1982;8:219-226. (Pubitemid 12139897)