Outliers affecting cardiac troponin I measurement: Comparison of a new high sensitivity assay with a contemporary assay on the Abbott ARCHITECT analyser

Annals of Clinical Biochemistry

Volumn 51, Issue 4, 2014, Pages 476-484

  Sawyer, Nicola ^a   Blennerhassett, John ^a   Lambert, Ramon ^a   Sheehan, Paul ^a   Vasikaran, Samuel D ^a  

^a ROYAL PERTH HOSPITAL   (Australia)

Author keywords

analytes; Troponin

Indexed keywords

TROPONIN I;

ARTICLE; CONTEMPORARY TROPONIN I ASSAY; CONTROLLED STUDY; FEMALE; FOLLOW UP; HIGH SENSITIVITY TROPONIN I ASSAY; HUMAN; IMMUNOASSAY; IMMUNOASSAY ANALYZER; INTERMETHOD COMPARISON; LIMIT OF DETECTION; MAJOR CLINICAL STUDY; MALE; MEASUREMENT ACCURACY; PRIORITY JOURNAL; PROBABILITY; QUALITY CONTROL; BLOOD; BLOOD ANALYSIS; COMPARATIVE STUDY; DEVICES; SENSITIVITY AND SPECIFICITY;

BLOOD CHEMICAL ANALYSIS; FEMALE; HUMANS; MALE; SENSITIVITY AND SPECIFICITY; TROPONIN I;

EID: 84902173163     PISSN: 00045632     EISSN: 17581001     Source Type: Journal    
DOI: 10.1177/0004563213499737     Document Type: Article

References (22)

1. Morrow DA,Cannon CP,Jesse RLet al.National Academy of Clinical Biochemistry Laboratory Medicine practice guidelines: clinical characteristics and utilization of biochemical markers in acute coronary syndromes.Clin Chem. 2007;53:552-574.
2. Apple FS,Jesse RL,Newby KLet al.National Academy of Clinical Biochemistry and IFCC Committee for standardization of markers of cardiac damage laboratory medicine practice guidelines: analytical issues for biochemical markers of acute coronary syndromes.Clin Chem. 2007;53:547-551.
3. Antman E,Bassand JP,Klein Wet al.Myocardial infarction redefined - a consensus document of the Joint European Society of Cardiology/American College of Cardiology committee for the redefinition of myocardial infarction.JACC. 2000;36:959-969.
4. Thygesen K,Alpert JS,Jaffe ASet al.Third universal definition of myocardial infarction.Eur Heart J. 2012;33:2551-2567.
5. Chew DP,Aroney CN,Aylward PEet al.Addendum to the National Heart Foundation of Australia/Cardiac Society of Australia and New Zealand guidelines for the management of acute coronary syndromes (ACS) 2006.Heart Lung Circ. 2011;20:487-502.
6. Apple FS.A new season for cardiac troponin assays: it's time to keep a scorecard.Clin Chem. 2009;55:1303-1306.
7. Apple FS,Collinson PO.Analytical characteristics of high-sensitivity cardiac troponin assays.Clin Chem. 2012;58:54-61.
8. Aldous SJ,Florkowski CM,Crozier IGet al.Comparison of high sensitivity and contemporary troponin assays for the early detection of acute myocardial infarction in the emergency department.Ann Clin Biochem. 2011;48:241-248.
9. Aldous SJ,Florkowski CM,Crozier IGet al.High sensitivity troponin outperforms contemporary assays in predicting major adverse cardiac events up to two years in patients with chest pain.Ann Clin Biochem. 2011;48:249-255.
10. Ungerer JP,Pretorius CJ,Dimeski Get al.Falsely elevated troponin I results due to outliers indicate a lack of analytical robustness.Ann Clin Biochem. 2010;47:242-247.
11. Pretorius CJ,Dimeski G,O'Rourke PKet al.Outliers as a cause of false cardiac troponin results: investigating the robustness of 4 contemporary assays.Clin Chem. 2011;57:710-718.
12. Sheehan P,Blennerhassett J,Vasikaran S.Decision limit for troponin I and assay performance.Ann Clin Biochem. 2002;39:231-236.
13. Koerbin G,Tate J,Potter JMet al.Characterisation of a highly sensitive troponin I assay and its application to a cardio-healthy population.Clin Chem Lab Med. 2012;50:871-878.
14. Fleming SM,O'Byrne L,Finn Jet al.False-positive cardiac troponin I in a routine clinical population.Am J Cardiol. 2002;89:1212-1215.
15. Saenger AK,Beyrau R,Braun Set al.Multicenter analytical evaluation of a high-sensitivity troponin T assay.Clin Chim Acta. 2011;412:748-754.
16. Apple FS,Simpson PA,Merakami MM.Defining the serum 99th percentile in a normal reference population measured by a high-sensitivity cardiac troponin I assay.Clin Biochem. 2010;43:1034-1036.
17. Jones GRD,Panteghini MThe Clinical Biochemist Monograph: laboratory and clinical issues affecting the measurement and reporting of cardiac troponins. Tate JJohnson RJaffe A, ed. Alexandria, NSW: Australasian Association of Clinical Biochemists Inc; 2012:63-68.
18. Fitzmaurice TF,Brown C,Rifai Net al.False increase of cardiac troponin I with heterophilic antibodies.Clin Chem. 1998;44:2212-2214.
19. Erikson S,Ilva T,Becker Cet al.Comparison of cardiac troponin I immunoassays variably affected by circulating autoantibodies.Clin Chem. 2005;51:848-855.
20. Michielsen EC,Bisschops PG,Janssen MJ.False positive troponin result caused by a true macrotroponin.Clin Chem Lab Med. 2011;49:923-925.
21. Kazmierczak SC,Sekhon H,Richards C.False-positive troponin I measured with Abbott AxSYM attributed to fibrin interferences.Int J Card. 2005;101:27-31.
22. Reichlin T,Hochholzer W,Bassetti Set al.Early diagnosis of myocardial infarction with sensitive cardiac troponin assays.N Engl J Med. 2009;361:858-867.