False positive troponin result caused by a true macrotroponin

Clinical Chemistry and Laboratory Medicine

Volumn 49, Issue 5, 2011, Pages 923-925

  Michielsen, Etienne C H J ^a   Bisschops, Pieter G T ^a   Janssen, Marcel J W ^a  

^a VIECURI MEDICAL CENTER   (Netherlands)

Author keywords

gel filtration chromatography; interference; macrotroponin; polyethylene glycol; reference values; troponin

Indexed keywords

BRAIN NATRIURETIC PEPTIDE; CARDIAC TROPONIN I; D DIMER; IMMUNOGLOBULIN G; MACROGOL; MACROTROPONIN; PROLACTIN; PROTEIN A; TROPONIN I; UNCLASSIFIED DRUG;

ACUTE HEART INFARCTION; ADULT; ANGIOCARDIOGRAPHY; ARTICLE; CASE REPORT; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; CYANOCOBALAMIN DEFICIENCY; DILUTION; DYSPNEA; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAM; FALSE POSITIVE RESULT; FEMALE; GEL FILTRATION CHROMATOGRAPHY; HUMAN; IMMUNOASSAY; IMMUNOREACTIVITY; LIMIT OF DETECTION; LUNG EMBOLISM; MYOCARDITIS; PHYSICAL EXAMINATION; PRECIPITATION; PRIORITY JOURNAL;

ADULT; ANIMALS; CHEMICAL PRECIPITATION; CHROMATOGRAPHY, GEL; FALSE POSITIVE REACTIONS; FEMALE; HUMANS; IMMUNOASSAY; IMMUNOGLOBULIN G; MALE; MICE; MIDDLE AGED; TROPONIN;

EID: 79954499008     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2011.147     Document Type: Article

References (11)

1. Wells PS, Ginsberg JS, Anderson DR, Kearon C, Gent M, Tur-pie AG, et al. Use of a clinical model for safe management of patients with suspected pulmonary embolism. Ann Intern Med 1998;129:997-1005. (Pubitemid 29005822)
2. Mingels A, Jacobs L, Michielsen E, Swaanenburg J, Wodzig W, van Dieijen-Visser M. Reference population and marathon runner sera assessed by highly sensitive cardiac troponin T and commercial cardiac troponin T and I assays. Clin Chem 2009;55:101-8.
3. Beltran L, Fahie-Wilson MN, McKenna TJ, Kavanagh L, Smith TP. Serum total prolactin and monomeric prolactin reference intervals determined by precipitation with polyethylene glycol: evaluation and validation on common immunoassay platforms. Clin Chem 2008;54:1673-81.
4. Kavanagh L, McKenna TJ, Fahie-Wilson MN, Gibney J, Smith TP. Specificity and clinical utility of methods for the detection of macroprolactin. Clin Chem 2006;52:1366-72. (Pubitemid 43956029)
5. Suliman AM, Smith TP, Gibney J, McKenna TJ. Frequent mis-diagnosis and mismanagement of hyperprolactinemic patients before the introduction of macroprolactin screening: application of a new strict laboratory definition of macroprolactinemia. Clin Chem 2003;49:1504-9. (Pubitemid 37011739)
6. Michielsen EC, Diris JH, Kleijnen VW, Wodzig WK, Van Diei-jen-Visser MP. Interpretation of cardiac troponin T behaviour in size-exclusion chromatography Clin Chem Lab Med 2006; 44:1422-7. (Pubitemid 44967690)
7. Labugger R, Organ L, Collier C, Atar D, Van Eyk JE. Extensive troponin I and T modification detected in serum from patients with acute myocardial infarction. Circulation 2000;102:1221-6.
8. Legendre-Bazydlo LA, Haverstick DM, Kennedy JL, Dent JM, Bruns DE. Persistent increase of cardiac troponin I in plasma without evidence of cardiac injury Clin Chem 2010;56:702-5.
9. Plebani M, Mion M, Altinier S, Girotto MA, Baldo G, Zani-notto M. False-positive troponin I attributed to a macrocom-plex. Clin Chem 2002;48:677-9.
10. Mifflin TE, Bruns DE, Wrotnoski U, MacMillan RH, Stallings RG, Felder RA, et al. University of Virginia case conference. Macroamylase, macro creatine kinase, and other macroen-zymes. Clin Chem 1985;31:1743-8. (Pubitemid 16035437)
11. Panteghini M, Gerhardt W, Apple FS, Dati F, Ravkilde J, Wu AH. Quality specifications for cardiac troponin assays. Clin Chem Lab Med 2001;39:175-9. (Pubitemid 32318485)