Defining the serum 99th percentile in a normal reference population measured by a high-sensitivity cardiac troponin I assay

Clinical Biochemistry

Volumn 43, Issue 12, 2010, Pages 1034-1036

  Apple, Fred S ^a   Simpson, Peter A ^b   Murakami, MaryAnn M ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b SINGULEX INC   (United States)

Author keywords

99th percentile reference value; High sensitivity cardiac troponin; Myocardial infarction

Indexed keywords

BIOLOGICAL MARKER; TROPONIN I;

ACUTE CORONARY SYNDROME; ACUTE HEART INFARCTION; ADULT; ARTICLE; ASSAY; DIAGNOSTIC VALUE; FEMALE; HEART INFARCTION; HUMAN; MALE; MICROPARTICLE IMMUNOASSAY; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REFERENCE VALUE; RISK ASSESSMENT; SERUM; ADOLESCENT; AGED; BLOOD; MIDDLE AGED; MYOCARDIAL INFARCTION; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; TROPONIN I; YOUNG ADULT;

EID: 77954309778     PISSN: 00099120     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2010.05.014     Document Type: Article

References (16)

1. Thygesen K., Alpert J.S. White HD on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Universal definition of myocardial infarction. Circulation 2007, 116:2634-2653.
2. Morrow D.A., Cannon C.P., Jesse R.L., Newby L.K., Ravkilde J., Storrow A.B., et al. National Academy of Clinical Biochemistry practice guidelines: clinical characteristics and utilization of biomarkers in acute coronary syndromes. Clin Chem 2007, 53:552-574.
3. Apple F.S., Jesse R.L., Newby L.K., Wu A.H.B., Christenson R.H. for the NACB committee members and the IFCC Committee on Standardization of Markers of Cardiac Damage (C-SMCD). National Academy of Clinical Biochemistry and IFCC Committee on Standardization of Markers of Cardiac Damage Laboratory Medicine Practice Guidelines: analytical issues for biochemical markers of acute coronary syndromes. Clin Chem 2007, 53:547-551.
4. Apple F.S. Opinion: a new season for cardiac troponin assays: its time to keep a scorecard. Clin Chem 2009, 55:1303-1306.
5. Apple F.S., Parvin C.A., Buechler K.F., Christenson R.H., Wu A.H.B., Jaffe A.S. Validation of the 99th percentile cutoff independent of assay imprecision (%CV) for cardiac troponin monitoring for ruling out myocardial infarction. Clin Chem 2005, 51:2198-2200.
6. Kupchak P., Wu A.H.B., Ghani F., Newby L.K., Ohman E.M., Christenson R.H. Influence of Imprecision on ROC curve analysis for cardiac markers. Clin Chem 2006, 52:752-753.
7. Venge P., Johnston N., Lindahl B., James S. Normal plasma levels of cardiac troponin I measured by the high-sensitivity cardiac troponin I access prototype assay and the impact on the diagnosis of myocardial infarction. J Am Coll Cardiol 2009, 54:1165-1172.
8. Wilson S.R., Sabatine M.S., Braunwald E., Sloan S., Murphy S.A., Morrow D.A. Detection of myocardial injury in patients with unstable angina using a novel nanoparticle cardiac troponin I assay: observations from the PROTECT-TIMI 30 trial. Am Heart J 2009, 158:386-391.
9. Sabatine M.S., Morrow D.A., de Lemos J.A., Jarolim P., Braunwald E. Detection of acute changes in circulating troponin in the setting of transient stress test-induced myocardial ischaemia using an ultrasensitive assay: results from TIMI 35. Eur Heart J 2009, 30:162-169.
10. Mingels A., Jacobs L., Michielsen E., Swaanenburg J., Wodzig W., van Dieijin-Visser M. Reference population and marathon runner sera assessed by highly sensitive cardiac troponin T and commercial cardiac troponin T and I assays. Clin Chem 2009, 55:101-109.
11. Apple F.S., Murakami M.M. Serum and plasma cardiac troponin I 99th percentile reference values for 3 2nd-generation assays. Clin Chem 2007, 53:1558-1560.
12. Wu A.H.B., Jaffe A.S., Apple F.S., Jesse R.L., Francis G.L., Morrow D.A., et al. National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: use of cardiac troponin and B-type natriuretic peptide or N-terminal proB-type natriuretic peptide for etiologies other than acute coronary syndromes and heart failure. Clin Chem 2007, 53:2086-2096.
13. Wu A.H.B., Lu Q.A., Todd J., Moecks J., Wians F. Short- and long-term biological variation in cardiac troponin I measured with a high-sensitivity assay: implications for clinical practice. Clin Chem 2009, 55:52-58.
14. Apple F.S., Pearce L.A., Smith S.W., Kaczmarek J.M., Murakami M.M. Use of VITROS troponin I ES assay for early diagnosis of myocardial infarction and predicting of adverse events: role of following deltas. Clin Chem 2009, 55:930-938.
15. Keller T., Zeller T., Peetz D., Tzikas S., Roth A., Czyz E., et al. Sensitive troponin I assay in early diagnosis of acute myocardial infarction. N Eng J Med 2009, 361:868-877.
16. Storrow A.B., Zhou C., Gaddis G., Han J.H., Miller J., Klubert D., et al. Decreasing lab turnaround time improves emergency department throughput and decreases emergency medical services diversion: a simulation model. Acad Emerg Med 2008, 15:1130-1135.