Comparison of cardiac troponin I immunoassays variably affected by circulating autoantibodies

Clinical Chemistry

Volumn 51, Issue 5, 2005, Pages 848-855

  Eriksson, Susann ^a   Ilva, Tuomo ^a   Becker, Charlotte ^b   Lund, Juha ^a   Porela, Pekka ^a   Pulkki, Kari ^c   Voipio Pulkki, Liisa Maria ^c   Pettersson, Kim ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b Malmö University Hospital   (Sweden)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; TROPONIN I;

ANALYTIC METHOD; ANTIBODY DETECTION; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ARTICLE; BLOOD SAMPLING; COMPLEX FORMATION; HUMAN; HUMAN CELL; IMMUNOASSAY; PHENOMENOLOGY; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; ROC CURVE;

AUTOANTIBODIES; CALIBRATION; CHEST PAIN; EPITOPES; FALSE NEGATIVE REACTIONS; FLUOROIMMUNOASSAY; HUMANS; MYOCARDIAL INFARCTION; ROC CURVE; SENSITIVITY AND SPECIFICITY; TROPONIN I;

EID: 17744395505     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1373/clinchem.2004.040089     Document Type: Article

References (28)

1. Cummins B, Auckland ML, Cummins P. Cardiac-specific troponin-I radioimmunoassay in the diagnosis of acute myocardial infarction. Am Heart J 1987;113:1333-44.
2. Alpert JS, Thygesen K, Antman E, Bassand JP. Myocardial infarction redefined-a consensus document of the Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J Am Coll Cardiol 2000;36:959-69.
3. Wu AH, Apple FS, Gibler WB, Jesse RL, Warshaw MM, Valdes R Jr. National Academy of Clinical Biochemistry Standards of Laboratory Practice: recommendations for the use of cardiac markers in coronary artery diseases. Clin Chem 1999;45:1104-21.
4. Collinson PO, Boa FG, Gaze DC. Measurement of cardiac troponins [Review]. Ann Clin Biochem 2001;38:423-49.
5. Panteghini M, Pagani F, Yeo KT, Apple FS, Christenson RH, Dati F, et al. Evaluation of imprecision for cardiac troponin assays at low-range concentrations. Clin Chem 2004;50:327-32.
6. Katrukha AG, Bereznikova AV, Filatov VL, Esakova TV, Kolosova OV, Pettersson K, et al. Degradation of cardiac troponin I: implication for reliable immunodetection. Clin Chem 1998;44:2433-40.
7. Morjana NA. Degradation of human cardiac troponin I after myocardial infarction. Biotechnol Appl Biochem 1998;28:105-11.
8. Labugger R, Organ L, Collier C, Atar D, Van Eyk JE. Extensive troppnin I and T modification detected in serum from patients with acute myocardial infarction. Circulation 2000;102:1221-6.
9. Bereznikova A, Katrukha A, Filatov V, Pettersson K, Esakova T, Bulargina T, et al. Monoclonal antibodies affected by cardiac troponin I phosphorylation: is part of troponin in the blood of myocardial infarction patients phosphorylated? [Abstract]. Clin Chem Lab Med 1999;37:S448.
10. 2+ and subunit interactions on surface accessibility of cysteine residues in cardiac troponin. Biochemistry 1988;27:5891-8.
11. Wu AHB, Feng Y-J, Moore R, Apple FS, McPherson PH, Buechler KF, et al. Characterization of cardiac troponin subunit release into serum after acute myocardial infarction and comparison of assays for troponin T and I. Clin Chem 1998;44:1198-208.
12. Katrukha AG, Bereznikova AV, Esakova TV, Pettersson K, Lövgren T, Severina ME, et al. Troponin I is released in bloodstream of patients with acute myocardial infarction not in free form but as complex. Clin Chem 1997;43:1379-85.
13. Giuliani I, Bertinchant JP, Granier C, Laprade M, Chocron S, Toubin G, et al. Determination of cardiac troponin I forms in the blood of patients with acute myocardial infarction and patients receiving crystalloid or cold blood cardioplegia. Clin Chem 1999;45:213-22.
14. Eriksson S, Junikka M, Laitinen P, Majamaa-Voltti K, Alfthan H, Pettersson K. Negative interference in cardiac troponin I immunoassays from a frequently occurring serum and plasma component. Clin Chem 2003;49:1095-104.
15. Eriksson S, Junikka M, Pettersson K. An interfering component in cardiac troponin I immunoassays-its nature and inhibiting effect on the binding of antibodies against different epitopes. Clin Biochem 2004;37:472-80.
16. Panteghini M. The interfering component in cardiac troponin I immunoassays: need for further experimental evidence [Letter]. Clin Chem 2004;50:676-7.
17. Eriksson S, Halenius H, Pulkki K, Hellman J, Pettersson K. Negative interference in cardiac troponin I immunoassays by circulating troponin autoantibodies. Clin Chem 2005;51:839-47.
18. Panteghini M, Gerhardt W, Apple FS, Dati F, Ravkilde J, Wu AH. Quality specifications for cardiac troponin assays. Clin Chem Lab Med 2001;39:175-9.
19. Lövgren T, Meriö L, Mitrunen K, Mäkinen ML, Mäkelä M, Blomberg K, et al. One-step all-in-one dry reagent immunoassays with fluorescent europium chelate label and time-resolved fluorometry. Clin Chem 1996;42:1196-201.
20. von Lode P, Rosenberg J, Pettersson K, Takalo H. A europium chelate for quantitative point-of-care immunoassays using direct surface measurement. Anal Chem 2003;75:3193-201.
21. Pettersson K, von Lode P, Eriksson S, Lövgren J, Takalo H. Multi-assay point-of-care platform: highly sensitive time-resolved fluorometric detection in combination with a universal "all-in-one" assay format. Point of Care 2003;2:225-32.
22. Pettersson K, Katajamäki T, Irjala K, Leppänen V, Majamaa-Voltti K, Laitinen P. Time-resolved fluorometry (TRF)-based immunoassay concept for rapid and quantitative determination of biochemical myocardial infarction markers from whole blood, serum and plasma. Luminescence 2000;15:399-407.
23. Pagani F, Stefini F, Panteghini M. Innotrac Aio! Second-generation cardiac troponin I assay: imprecision profile and other key characteristics for clinical use. Clin Chem 2004;50:1271-2.
24. Uettwiller-Geiger D, Wu AH, Apple FS, Jevans AW, Venge P, Olson MD, et al. Multicenter evaluation of an automated assay for troponin I. Clin Chem 2002;48:869-76.
25. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986;i:307-10.
26. Pollock MA, Jefferson SG, Kane JW, Lomax K, MacKinnon G, Winnard CB. Method comparison - a different approach. Ann Clin Biochem 1992;29:556-60.
27. Apple FS, Quist HE, Doyle PJ, Otto AP, Murakami MM. Plasma 99th percentile reference limits for cardiac troponin and creatine kinase MB mass for use with European Society of Cardiology/ American College of Cardiology consensus recommendations. Clin Chem 2003;49:1331-6.
28. Venge P, Johnston N, Lagerqvist B, Wallentin L, Lindahl B. Clinical and analytical performance of the Liaison cardiac troponin I assay in unstable coronary artery disease, and the impact of age on the definition of reference limits. A FRISC-II substudy. Clin Chem 2003;49:880-6.