Multigene analysis unveils distinctive expression profiles of helper T-cell-related genes in the intestinal mucosa that discriminate between ulcerative colitis and Crohn's disease

Inflammatory Bowel Diseases

Volumn 20, Issue 6, 2014, Pages 967-977

  Iboshi, Yoichiro ^a   Nakamura, Kazuhiko ^a   Ihara, Eikichi ^a   Iwasa, Tsutomu ^a   Akiho, Hirotada ^a   Harada, Naohiko ^b   Nakamuta, Makoto ^b   Takayanagi, Ryoichi ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b NATIONAL HOSPITAL ORGANIZATION   (Japan)

Author keywords

Cytokine; Discriminant analysis; Gene expression; Inflammatory bowel disease; Real time PCR

Indexed keywords

CYTOKINE; TRANSCRIPTION FACTOR; BIOLOGICAL MARKER;

ADULT; ARTICLE; COLON CROHN DISEASE; CONTROLLED STUDY; CROHN DISEASE; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIFFERENTIAL DIAGNOSIS; DISCRIMINANT ANALYSIS; DISEASE ACTIVITY; ENDOSCOPIC BIOPSY; FEMALE; GENE EXPRESSION; HELPER CELL; HUMAN; HUMAN TISSUE; INFLAMMATORY BOWEL DISEASE; INTESTINE MUCOSA; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RECEIVER OPERATING CHARACTERISTIC; REGULATORY T LYMPHOCYTE; TH1 CELL; TH17 CELL; TH2 CELL; ULCERATIVE COLITIS; UNIVARIATE ANALYSIS; AGED; CLINICAL TRIAL; COLITIS, ULCERATIVE; GASTROINTESTINAL ENDOSCOPY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; MIDDLE AGED; MULTICENTER STUDY; PROCEDURES; REPRODUCIBILITY; STANDARDS; YOUNG ADULT;

ADULT; AGED; BIOLOGICAL MARKERS; COLITIS, ULCERATIVE; CROHN DISEASE; CYTOKINES; DIAGNOSIS, DIFFERENTIAL; ENDOSCOPY, GASTROINTESTINAL; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INTESTINAL MUCOSA; MALE; MIDDLE AGED; REAL-TIME POLYMERASE CHAIN REACTION; REPRODUCIBILITY OF RESULTS; T-LYMPHOCYTES, HELPER-INDUCER; T-LYMPHOCYTES, REGULATORY; TRANSCRIPTION FACTORS; YOUNG ADULT;

EID: 84902162746     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1097/MIB.0000000000000028     Document Type: Article

References (32)

1. Nikolaus S, Schreiber S. Diagnostics of inflammatory bowel disease. Gastroenterology. 2007; 133: 1670-1689. (Pubitemid 350029755)
2. Xavier RJ, Podolsky DK Unravelling the pathogenesis of inflammatory bowel disease. Nature. 2007; 448: 427-434. (Pubitemid 47123518)
3. Nakamura K, Kitani A, Strober W. Cell contact-dependent immunosup-pression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med. 2001; 194: 629-644. (Pubitemid 32844773)
4. Nakamura K, Kitani A, Fuss I., et al TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice. J Immunol. 2004; 172: 834-842. (Pubitemid 38113739)
5. Strober W, Fuss IJ Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology. 2011; 140: 1756-1767.
6. Feldmann M. Many cytokines are very useful therapeutic targets in disease. J Clin Invest. 2008; 118: 3533-3536.
7. Fuss IJ, Neurath M, Boirivant M., et al Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol. 1996; 157: 1261-1270. (Pubitemid 126449643)
8. Strober W, Fuss IJ, Blumberg RS The immunology of mucosal models of inflammation. Annu Rev Immunol. 2002; 20: 495-549. (Pubitemid 34293433)
9. Fuss IJ, Heller F, Boirivant M., et al Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcer-ative colitis. J Clin Invest. 2004; 113: 1490-1497. (Pubitemid 39071705)
10. Heller F, Florian P, Bojarski C., et al Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology. 2005; 129: 550-564. (Pubitemid 41096643)
11. Harrington LE, Hatton RD, Mangan P.R., et al Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 2005; 6: 1123-1132. (Pubitemid 41541790)
12. Park H, Li Z, Yang X.O., et al A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol. 2005; 6: 1133-1141. (Pubitemid 41541791)
13. Harrington LE, Mangan PR, Weaver CT Expanding the effector CD4 T-cell repertoire: the Th17 lineage. Curr Opin Immunol. 2006; 18: 349-356.
14. Holtta V, Klemetti P, Sipponen T., et al IL-23/IL-17 immunity as a hallmark of Crohn's disease. Inflamm Bowel Dis. 2008; 14: 1175-1184.
15. Fujino S, Andoh A, Bamba S., et al Increased expression of interleukin 17 in inflammatory bowel disease. Gut. 2003; 52: 65-70. (Pubitemid 36020767)
16. Reimund JM, Wittersheim C, Dumont S., et al Mucosal inflammatory cytokine production by intestinal biopsies in patients with ulcerative colitis and Crohn's disease. J Clin Immunol. 1996; 16: 144-150. (Pubitemid 26166392)
17. Olsen T, Rismo R, Cui G., et al TH1 and TH17 interactions in untreated inflamed mucosa of inflammatory bowel disease, and their potential to mediate the inflammation. Cytokine. 2011; 56: 633-640.
18. Olsen T, Goll R, Cui G., et al Tissue levels of tumor necrosis factor-alpha correlates with grade of inflammation in untreated ulcerative colitis. Scand J Gastroenterol. 2007; 42: 1312-1320. (Pubitemid 47537070)
19. Nielsen OH, Kirman I, Rudiger N., et al Upregulation of interleukin-12 and -17 in active inflammatory bowel disease. Scand J Gastroenterol. 2003; 38: 180-185. (Pubitemid 36349930)
20. Leon AJ, Gomez E, Garrote J.A., et al High levels of proinflammatory cytokines, but not markers of tissue injury, in unaffected intestinal areas from patients with IBD. Mediators Inflamm. 2009; 2009: 580450.
21. Kobayashi T, Okamoto S, Hisamatsu T., et al IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease. Gut. 2008; 57: 1682-1689.
22. Christophi GP, Rong R, Holtzapple P.G., et al Immune markers and differential signaling networks in ulcerative colitis and Crohn's disease. Inflamm Bowel Dis. 2012; 18: 2342-2356.
23. Bogaert S, Laukens D, Peeters H., et al Differential mucosal expression of Th17-related genes between the inflamed colon and ileum of patients with inflammatory bowel disease. BMC Immunol. 2010; 11: 61.
24. Kobori A, Yagi Y, Imaeda H., et al Interleukin-33 expression is specifically enhanced in inflamed mucosa of ulcerative colitis. J Gastroenterol. 2010; 45: 999-1007.
25. Rachmilewitz D. Coated mesalazine (5-aminosalicylic acid) versus sul-phasalazine in the treatment of active ulcerative colitis: a randomised trial. BMJ. 1989; 298: 82-86. (Pubitemid 19032930)
26. Daperno M, D'Haens G, Van Assche G, et al Development and validation of a new, simplified endoscopic activity score for Crohn's disease: the SES-CD. Gastrointest Endosc. 2004; 60: 505-512. (Pubitemid 39311530)
27. Matsuoka K, Inoue N, Sato T., et al T-bet upregulation and subsequent interleukin 12 stimulation are essential for induction of Th1 mediated immunopathology in Crohn's disease. Gut. 2004; 53: 1303-1308. (Pubitemid 39120117)
28. Yamamoto-Furusho J.K., Miranda-Perez E, Fonseca-Camarillo G, et al Interleukin 21 expression is increased in rectal biopsies from patients with ulcerative colitis. Inflamm Bowel Dis. 2010; 16: 1090.
29. von Stein P., Lofberg R, Kuznetsov N.V., et al Multigene analysis can discriminate between ulcerative colitis, Crohn's disease, and irritable bowel syndrome. Gastroenterology. 2008; 134: 1869-1881. (Pubitemid 351790741)
30. Bjerrum JT, Nyberg C, Olsen J., et al Assessment of the validity of a multigene analysis in the diagnostics of inflammatory bowel disease. J Intern Med. 2014; 275: 484-493.
31. Granlund A, Flatberg A, Ostvik A.E., et al Whole genome gene expression meta-analysis of inflammatory bowel disease colon mucosa demonstrates lack of major differences between Crohn's disease and ulcerative colitis. PLoS One. 2013; 8:e56818.
32. Sakai T, Kusugami K, Nishimura H., et al Interleukin 15 activity in the rectal mucosa of inflammatory bowel disease. Gastroenterology. 1998; 114: 1237-1243. (Pubitemid 28243910)