Phosphorylation mediated structural and functional changes in pentameric ligand-gated ion channels: Implications for drug discovery

International Journal of Biochemistry and Cell Biology

Volumn 53, Issue , 2014, Pages 218-223

  Talwar, Sahil ^a   Lynch, Joseph W ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Conformational changes; Cys loop receptor; Drug discovery; Pentameric ligand gated ion channel; Phosphorylation

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BUNGAROTOXIN RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLYCINE RECEPTOR; LIGAND GATED ION CHANNEL; NEUROTRANSMITTER; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA4; SEROTONIN 3 RECEPTOR; CYSTEINE LOOP LIGAND GATED ION CHANNEL RECEPTOR;

ARTICLE; BINDING SITE; CHRONIC PAIN; CONFORMATIONAL TRANSITION; CYTOPLASM; HUMAN; INFLAMMATORY PAIN; NONHUMAN; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; TOBACCO DEPENDENCE; BRAIN; CHEMISTRY; DRUG DEVELOPMENT; METABOLISM; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; SYNAPTIC TRANSMISSION;

BRAIN; CYSTEINE LOOP LIGAND-GATED ION CHANNEL RECEPTORS; DRUG DISCOVERY; HUMANS; LIGAND-GATED ION CHANNELS; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GLYCINE; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP; SYNAPTIC TRANSMISSION;

EID: 84902161726     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2014.05.028     Document Type: Short Survey

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