Neuroglobin gene therapy prevents optic atrophy and preserves durably visual function in harlequin mice

Molecular Therapy

Volumn 22, Issue 6, 2014, Pages 1096-1109

  Lechauve, Christophe ^a,b,c   Augustin, Sébastien ^a,b,c   Cwerman Thibault, Hélène ^a,b,c   Reboussin, Élodie ^a,b,c   Roussel, Delphine ^a,b,c   Lai Kuen, René ^a   Saubamea, Bruno ^a   Sahel, José Alain ^a,b,c   Debeir, Thomas ^d   Corral Debrinski, Marisol ^a,b,c  

^a INSERM   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c CNRS   (France)

^d SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS ASSOCIATED VIRUS SEROTPE 2 2 NEUROGLOBIN VECTOR; ADENOVIRUS VECTOR; MESSENGER RNA; NEUROGLOBIN; UNCLASSIFIED DRUG; GLOBIN; NERVE PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LOSS; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENE THERAPY; MALE; MOUSE; NGB GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; OPTIC NERVE; OPTIC NERVE ATROPHY; RESPIRATORY CHAIN; RETINA; RETINA GANGLION CELL; RNA STABILITY; RNA TRANSLATION; SINGLE DRUG DOSE; VISION; ADMINISTRATION AND DOSAGE; ANIMAL; DEFICIENCY; DEPENDOPARVOVIRUS; DISEASE MODEL; GENE VECTOR; GENETICS; GLIOSIS; METABOLISM; NERVE FIBER; OPTIC ATROPHY; PATHOLOGY; ADULT; DRUG EFFICACY; EYE PROTECTION; GENE OVEREXPRESSION; GENETIC TRANSDUCTION; MOUSE STRAIN; NEUROPROTECTION; OUTCOME ASSESSMENT; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RETINA INJURY; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ADENO-ASSOCIATED VIRUS; MUS;

ANIMALS; AXONS; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; ELECTRON TRANSPORT COMPLEX I; GENETIC THERAPY; GENETIC VECTORS; GLIOSIS; GLOBINS; MICE; NERVE TISSUE PROTEINS; OPTIC ATROPHY; RETINAL GANGLION CELLS;

EID: 84902156582     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2014.44     Document Type: Article

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