Neuroglobin: Enzymatic reduction and oxygen affinity

Biochemical and Biophysical Research Communications

Volumn 367, Issue 4, 2008, Pages 893-898

  Giuffrè, Alessandro ^a   Moschetti, Tommaso ^a   Vallone, Beatrice ^a   Brunori, Maurizio ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Enzymatic reduction; Hexacoordinate globin; Mutagenesis; Neuroprotection; Oxygen affinity; Rapid kinetics

Indexed keywords

FLAVORUBREDOXIN OXIDOREDUCTASE; NEUROGLOBIN; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; ENZYME ACTIVITY; ESCHERICHIA COLI; KINETICS; NEUROPROTECTION; NONHUMAN; OXYGEN AFFINITY; PRIORITY JOURNAL; REDUCTION;

ANIMALS; BINDING SITES; ENZYMES; GLOBINS; MICE; NERVE TISSUE PROTEINS; OXIDATION-REDUCTION; OXYGEN; PROTEIN BINDING;

ESCHERICHIA COLI; VERTEBRATA;

EID: 38649142814     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.01.021     Document Type: Article

References (33)

1. Burmester T., Weich B., Reinhardt S., and Hankeln T. A vertebrate globin expressed in the brain. Nature 407 (2000) 520-523
2. Sun Y., Jin K., Mao X.O., Zhu Y., and Greenberg D.A. Neuroglobin is up-regulated by and protects neurons from hypoxic-ischemic injury. Proc. Natl. Acad. Sci. USA 98 (2001) 15306-15311
3. Sun Y., Jin K., Peel A., Mao X.O., Xie L., and Greenberg D.A. Neuroglobin protects the brain from experimental stroke in vivo. Proc. Natl. Acad. Sci. USA 100 (2003) 3497-3500
4. Khan A.A., Wang Y., Sun Y., Mao X.O., Xie L., Miles E., Graboski J., Chen S., Ellerby L.M., Jin K., and Greenberg D.A. Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia. Proc. Natl. Acad. Sci. USA 103 (2006) 17944-17948
5. Pesce A., Bolognesi M., Bocedi A., Ascenzi P., Dewilde S., Moens L., Hankeln T., and Burmester T. Neuroglobin and cytoglobin. Fresh blood for the vertebrate globin family. EMBO Rep. 3 (2002) 1146-1151
6. Hankeln T., Wystub S., Laufs T., Schmidt M., Gerlach F., Saaler-Reinhardt S., Reuss S., and Burmester T. The cellular and subcellular localization of neuroglobin and cytoglobin-a clue to their function?. IUBMB Life 56 (2004) 671-679
7. Fago A., Hundahl C., Malte H., and Weber R.E. Functional properties of neuroglobin and cytoglobin. Insights into the ancestral physiological roles of globins. IUBMB Life 56 (2004) 689-696
8. Hankeln T., Ebner B., Fuchs C., Gerlach F., Haberkamp M., Laufs T.L., Roesner A., Schmidt M., Weich B., Wystub S., Saaler-Reinhardt S., Reuss S., Bolognesi M., De Sanctis D., Marden M.C., Kiger L., Moens L., Dewilde S., Nevo E., Avivi A., Weber R.E., Fago A., and Burmester T. Neuroglobin and cytoglobin in search of their role in the vertebrate globin family. J. Inorg. Biochem. 99 (2005) 110-119
9. Wakasugi K., Kitatsuji C., and Morishima I. Possible neuroprotective mechanism of human neuroglobin. Ann. N. Y. Acad. Sci. 1053 (2005) 220-230
10. Brunori M., and Vallone B. A globin for the brain. FASEB J. 20 (2006) 2192-2197
11. Nienhaus K., and Nienhaus G.U. Searching for neuroglobin's role in the brain. IUBMB Life 59 (2007) 490-497
12. Brunori M., and Vallone B. Neuroglobin, seven years after. Cell. Mol. Life Sci. 64 (2007) 1259-1268
13. Greenberg D.A., Jin K., and Khan A.A. Neuroglobin: an endogenous neuroprotectant. Curr. Opin. Pharmacol. 1 (2007) 10.1016/j.coph.2007.1009.1003
14. Wakasugi K., Nakano T., and Morishima I. Oxidized human neuroglobin acts as a heterotrimeric Galpha protein guanine nucleotide dissociation inhibitor. J. Biol. Chem. 278 (2003) 36505-36512
15. Wakasugi K., and Morishima I. Identification of residues in human neuroglobin crucial for Guanine nucleotide dissociation inhibitor activity. Biochemistry 44 (2005) 2943-2948
16. Kitatsuji C., Kurogochi M., Nishimura S., Ishimori K., and Wakasugi K. Molecular basis of guanine nucleotide dissociation inhibitor activity of human neuroglobin by chemical cross-linking and mass spectrometry. J. Mol. Biol. 368 (2007) 150-160
17. Pesce A., Dewilde S., Nardini M., Moens L., Ascenzi P., Hankeln T., Burmester T., and Bolognesi M. Human brain neuroglobin structure reveals a distinct mode of controlling oxygen affinity. Structure 11 (2003) 1087-1095
18. Vallone B., Nienhaus K., Brunori M., and Nienhaus G.U. The structure of murine neuroglobin: novel pathways for ligand migration and binding. Proteins 56 (2004) 85-92
19. Vallone B., Nienhaus K., Matthes A., Brunori M., and Nienhaus G.U. The structure of carbonmonoxy neuroglobin reveals a heme-sliding mechanism for control of ligand affinity. Proc. Natl. Acad. Sci. USA 101 (2004) 17351-17356
20. Anselmi M., Brunori M., Vallone B., and Di Nola A. Molecular dynamics simulation of deoxy and carboxy murine neuroglobin in water. Biophys. J. 93 (2007) 434-441
21. Dewilde S., Kiger L., Burmester T., Hankeln T., Baudin-Creuza V., Aerts T., Marden M.C., Caubergs R., and Moens L. Biochemical characterization and ligand binding properties of neuroglobin, a novel member of the globin family. J. Biol. Chem. 276 (2001) 38949-38955
22. Trent III J.T., Watts R.A., and Hargrove M.S. Human neuroglobin, a hexacoordinate hemoglobin that reversibly binds oxygen. J. Biol. Chem. 276 (2001) 30106-30110
23. Kriegl J.M., Bhattacharyya A.J., Nienhaus K., Deng P., Minkow O., and Nienhaus G.U. Ligand binding and protein dynamics in neuroglobin. Proc. Natl. Acad. Sci. USA 99 (2002) 7992-7997
24. Hamdane D., Kiger L., Dewilde S., Green B.N., Pesce A., Uzan J., Burmester T., Hankeln T., Bolognesi M., Moens L., and Marden M.C. The redox state of the cell regulates the ligand binding affinity of human neuroglobin and cytoglobin. J. Biol. Chem. 278 (2003) 51713-51721
25. Van Doorslaer S., Dewilde S., Kiger L., Nistor S.V., Goovaerts E., Marden M.C., and Moens L. Nitric oxide binding properties of neuroglobin. A characterization by EPR and flash photolysis. J. Biol. Chem. 278 (2003) 4919-4925
26. Nienhaus K., Kriegl J.M., and Nienhaus G.U. Structural dynamics in the active site of murine neuroglobin and its effects on ligand binding. J. Biol. Chem. 279 (2004) 22944-22952
27. Brunori M., Giuffrè A., Nienhaus K., Nienhaus G.U., Scandurra F.M., and Vallone B. Neuroglobin, nitric oxide, and oxygen: functional pathways and conformational changes. Proc. Natl. Acad. Sci. USA 102 (2005) 8483-8488
28. Fago A., Hundahl C., Dewilde S., Gilany K., Moens L., and Weber R.E. Allosteric regulation and temperature dependence of oxygen binding in human neuroglobin and cytoglobin. Molecular mechanisms and physiological significance. J. Biol. Chem. 279 (2004) 44417-44426
29. Gomes C.M., Vicente J.B., Wasserfallen A., and Teixeira M. Spectroscopic studies and characterization of a novel electron-transfer chain from Escherichia coli involving a flavorubredoxin and its flavoprotein reductase partner. Biochemistry 39 (2000) 16230-16237
30. Trandafir F., Hoogewijs D., Altieri F., Rivetti di Val Cervo P., Ramser K., Van Doorslaer S., Vanfleteren J.R., Moens L., and Dewilde S. Neuroglobin and cytoglobin as potential enzyme or substrate. Gene 398 (2007) 103-113
31. Gardner A.M., Helmick R.A., and Gardner P.R. Flavorubredoxin, an inducible catalyst for nitric oxide reduction and detoxification in Escherichia coli. J. Biol. Chem. 277 (2002) 8172-8177
32. Gomes C.M., Giuffrè A., Forte E., Vicente J.B., Saraiva L.M., Brunori M., and Teixeira M. A novel type of nitric-oxide reductase. Escherichia coli flavorubredoxin. J. Biol. Chem. 277 (2002) 25273-25276
33. Modjtahedi N., Giordanetto F., Madeo F., and Kroemer G. Apoptosis-inducing factor: vital and lethal. Trends Cell Biol. 16 (2006) 264-272