Human duodenal epithelial cells constitutively express molecular components of antigen presentation but not costimulatory molecules

Human Immunology

Volumn 63, Issue 11, 2002, Pages 977-986

  Byrne, Brendan ^a   Madrigal Estebas, Laura ^a,b   McEvoy, Alice ^a   Carton, Janet ^a   Doherty, Derek G ^b   Whelan, Alex ^c   Feighery, Conleth ^c   O'Donoghue, Diarmuid P ^a   O'Farrelly, Cliona ^a,d  

^a ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

^b NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^c ST JAMES S HOSPITAL   (Ireland)

^d UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Antigen presentation; Epithelial; Human; Intestine

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; HLA DM ANTIGEN; HLA DR ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; TUBERCULIN;

ANTIGEN DETECTION; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CLONAL ANERGY; CONTROLLED STUDY; DUODENUM; DUODENUM BIOPSY; FLOW CYTOMETRY; HELPER CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; INTESTINE EPITHELIUM CELL; LYMPHOCYTE PROLIFERATION; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; RNA ANALYSIS; T LYMPHOCYTE ACTIVATION;

ANTIGEN PRESENTATION; ANTIGENS, CD; ANTIGENS, CD40; ANTIGENS, CD80; ANTIGENS, CD86; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; DUODENUM; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-D ANTIGENS; HLA-DR ANTIGENS; HUMANS; INTESTINAL MUCOSA; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; RNA, MESSENGER; T-LYMPHOCYTES; TUMOR CELLS, CULTURED;

EID: 0036830186     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0198-8859(02)00436-6     Document Type: Article

References (39)

1. Mayer L, Eisenhardt D, Salomon P, Bauer W, Plous R, Piccinini L: Expression of class II molecules on intestinal epithelial cells in humans: Differences between normal and inflammatory bowel disease. Gastroenterology 100:3, 1991.
2. Kelly J, Weir DG, Feighery C: Differential expression of HLA-D gene products in the normal and coeliac small bowel. Tissue Antigens 30:151, 1988.
3. Powrie F: T cells in inflammatory bowel disease: Protective and pathogenic roles. Immunity 3:171, 1995.
4. Chen Y, Inobe J, Weiner HL: Induction of oral tolerance to myelin basic protein in CDS-depleted mice: Both CD4+ and CD8+ cells mediate active suppression. J Immunol 155:910, 1995.
5. Hershberg RM, Mayer LF: Antigen processing and presentation by intestinal epithelial cells - Polarity and complexity. Immunol Today 21:123, 2000.
6. Blumberg RS, Lencer WI, Zhu X, Kim HS, Claypool S, Balk SP, Saubermann LJ, Colgan SP: Antigen presentation by intestinal epithelial cells. Immunol Letts 69:7, 1999.
7. Wolf PR, Ploegh HL: How MHC class II molecules acquire peptide cargo: biosynthesis and trafficking through the endocytic pathway. Annu Rev Cell Dev Biol 11:267, 1995.
8. Ghosh P, Amaya M, Mellins E, Wiley DC: The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3. Nature 378:457, 1995.
9. Riberdy JM, Cresswell P: The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentationl. J Immunol 148:2586, 1992.
10. Denzin LK, Robbins NF, Carboy-Newcomb C, Cresswell P: Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells. Immunity 1:595, 1994.
11. Vogt AB, Kropshofer H, Hammerling GJ: How HLA-DM affects the peptide repertoire bound to HLA-DR molecules. Hum Immunol 54:170, 1997.
12. Lamb CA, Yewdell JW, Bennink JR, Cresswell P: Invariant chain targets HLA class II molecules to acidic endosomes containing internalized influenza virus. Proc Natl Acad Sci USA 88:5998, 1991.
13. Peterson M, Miller J: Invariant chain influences the immunological recognition of MHC class II molecules. Nature 345:172, 1990.
14. Linsley PS, Brady W, Grosmaire L, Aruffo A, Damle NK, Ledbetter JA: Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J Exp Med 173:721, 1991.
15. Freeman GJ, Gribben JG, Boussiotis VA, Ng JW, Restivo VAJ, Lombard LA, Gray GS, Nadler LM: Cloning of B7-2: A CTLA-4 counter-receptor that costimulates human T cell proliferation. Science 262:909, 1993.
16. Yang Y, Wilson JM: CD40 ligand-dependent T cell activation: Requirement of B7-CD28 signaling through CD40. Science 273:1862, 1996.
17. Madrigal L, Lynch S, Feighery C, Weir D, Kelleher D, O'Farrelly C: Flow cytometric analysis of surface major histocompatibility complex class II expression on human epithelial cells prepared from small intestinal biopsies. J Immunol Methods 158:207, 1993.
18. Bland PW, Warren LG: Antigen presentation by epithelial cells of the rat small intestine. I. Kinetics, antigen specificity and blocking by anti-Ia antisera. Immunol Letts 58:9, 1986.
19. Mayer L, Shlien R: Evidence for function of Ia molecules on gut epithelial cells in man. J Exp Med 166:1471, 1987.
20. Kaiserlian D, Vidal K, Revillard JP: Murine enterocytes can present soluble antigen to specific class II-restricted CD4+ T cells. Eur J Immunol 19:1513, 1989.
21. Hershberg RM, Framson PE, Cho DH, Lee LY, Kovats S, Beitz J, Blum JS, Nepom GT: Intestinal epithelial cells use two distinct pathways for HLA class II antigen processing. J Clin Invest 100:204, 1997.
22. Hershberg RM, Cho DH, Youakim A, Bradley MB, Lee JS, Framson PE, Nepom GT: Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells. J Clin Invest 102:792, 1998.
23. Nakazawa A, Watanabe M, Kanai T, Yajima T, Yamazaki M, Ogata H, Ishii H, Azuma M, Hibi T: Functional expression of costimulatory molecule CD86 on epithelial cells in the inflamed colonic mucosa. Gastroenterology 117:536, 1999.
24. Sanderson IR, Ouellette AJ, Carter EA, Harmatz PR: Ontogeny of class II MHC mRNA in the mouse small intestinal epithelium. Mol Immunol 29:1257, 1992.
25. Momburg F, Koretz K, Von Herbay A, Moller P: Nonimmune human cells can express MHC class II antigens in the absence of invariant chain - An immunohistological study on normal and chronically inflamed small intestine. Clin Exp Immunol 72:367, 1988.
26. Vidal K, Samarut C, Magaud JP, Revillard JP, Kaiserlian D: Unexpected lack of reactivity of allogeneic anti-Ia monoclonal antibodies with MHC class II molecules expressed by mouse intestinal epithelial cells. J Immunol 151:4642, 1993.
27. Abuzakouk M, Feighery C, Kelleher D, O'Briain DS, Jones E, Weir D, Casey E, O'Farrelly C: Increased HLA-DR and CD44 antigen expression in the gut: Evidence of extraarticular immunological activity in rheumatoid arthritis. J Rheumatol 26:1869, 1999.
28. Collins C, Norris S, McEntee G, Traynor O, Bruno L, von Boehmer H, Hegarty J, O'Farrelly C: RAG1, RAG2 and pre-T cell receptor alpha chain expression by adult human hepatic T cells: Evidence for extrathymic T cell maturation. Eur J Immunol 26:3114, 1996.
29. Carol M, Lambrechts A, Van Gossum A, Libin M, Goldman M, Mascart-Lemone F: Spontaneous secretion of interferon gamma and interleukin 4 by human intraepithelial and lamina propria gut lymphocytes. Gut 42:643, 1998.
30. Whitacre CC, Gienapp IE, Orosz CG, Bitar DM: Oral tolerance in experimental autoimmune encephalomyelitis. III. Evidence for clonal anergy. J Immunol 147:2155, 1991.
31. Van Houten N, Blake SF: Direct measurement of anergy of antigen-specific T cells following oral tolerance induction. J Immunol 157:1337, 1996.
32. Swallow MM, Wallin JJ, Sha WC: B7h, a novel costimulatory homolog of B7.1 and B7.2 is induced by TNF-a. Immunity 11:423, 1999.
33. Gonzalo JA, Tian J, Delaney T, Corcoran J, Rottmann JB, Lora J, Al-garawi A, Kroczek R, Gutierrez-Ramos JC, Coyle AJ: ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses. Nat Immun 2:597, 2001.
34. Madrigal-Estebas L, McManus R, Byrne B, Lynch S, Doherty DG, Kelleher D, O'Donoghue DP, Feighery C, O'Farrelly C: Human small intestinal epithelial cells secrete interleukin-7 and differentially express two different interleukin-7 mRNA transcripts: Implications for extrathymic T-cell differentiation. Hum Immunol 58:83, 1997.
35. Reinecker H-C, MacDermott RP, Mirau S, Dignass A, Podolsky DK: Intestinal epithelial cells both express and respond to interleukin 15. Gastroenterology 111:1706, 1996.
36. Jung HC, Eckmann L, Yang SK, Panja A, Fierer J, Morzycka-Wroblewska E, Kagnoff MF: A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion. J Clin Invest 95:55, 1995.
37. Autschbach F, Braunstein J, Helmke B, Zuna I, Schurmann G, Niemir ZI, Wallich R, Otto HF, Meuer SC: In situ expression of interleukin-10 in noninflamed human gut and in inflammatory bowel disease. Am J Pathol 153:121, 1998.
38. Blumberg RS, Terhorst C, Bleicher P, McDermott FV, Allan CH, Landau SB, Trier JS, Balk SP: Expression of a nonpolymorphic MHC class I-like molecule, CD1d, by human intestinal epithelial cells. J Immunol 147:2518, 1991.
39. Groh V, Steinle A, Bauer S, Spies T: Recognition of stress-induced MHC molecules by intestinal epithelial gd T cells. Science 279:1737, 1998.