Fingerprinting breast cancer vs. normal mammary cells by mass spectrometric analysis of volatiles

Scientific Reports

Volumn 4, Issue , 2014, Pages

  He, Jingjing ^a,b   Sinues, Pablo Martinez Lozano ^b   Hollmén, Maija ^b   Li, Xue ^b   Detmar, Michael ^b   Zenobi, Renato ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

VOLATILE ORGANIC COMPOUND;

BREAST; BREAST NEOPLASMS; CELL CULTURE; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; HUMAN; METABOLISM; PRINCIPAL COMPONENT ANALYSIS; PROCEDURES;

BREAST; BREAST NEOPLASMS; CELLS, CULTURED; FEMALE; HUMANS; PRINCIPAL COMPONENT ANALYSIS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; VOLATILE ORGANIC COMPOUNDS;

EID: 84902143802     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep05196     Document Type: Article

References (53)

1. Jemal, A. et al. Cancer statistics, 2009. CA Cancer J. Clin. 59, 225-249 (2009).
2. Denkert, C. et al. Metabolomics of human breast cancer: New approaches for tumor typing and biomarker discovery. Genome Medicine 4, 37-46 (2012).
3. Odunsi, K. et al. Detection of peithelial ovarian cancer using 1H-NMR-based metabonomics. Int. J. Cancer 113, 782-788 (2005).
4. Asiago, V. et al. Early Detection of recurrent breast cancer using metabolite profiling. Cancer Res. 70, 8309-8318 (2010).
5. Griffin, J. L. & Shockcor, J. P. Metabolic profiles of cancer cells. Nat. Rev. 4, 551-561 (2004).
6. Catherine, O. Uncovering the metabolomic fingerprint of breast cancer. Int. J. Biochem Cell Biol. 43, 1010-1020 (2011).
7. Williams, H. & Pembroke, A. Sniffer dogs in the melanoma clinic. Lancet 1, 734 (1989).
8. Church, J. & Williams, H. Another sniffer dog for the clinic. Lancet. 358, 930 (2001).
9. McCulloch, M. et al. Diagnostic accuracy of canine scent detection in early-and late-stage lung and breast cancers. Integr. Cancer Ther. 5, 1-10 (2006).
10. Filipiak, W. et al. TD-GC-MS Analysis of volatile metabolites of human lung cancer and normal cells in vitro. Cancer Epidemiol. Biomarkers Prev. 19, 182-195 (2010).
11. Smith, D., Wang, T., Sulé-Suso, J., Spanel, P. & El Haj, A. Quantification of acetaldehyde released by lung cancer cells in vitro using selected ion flow tube mass spectrometry. Rapid Commun. Mass Spectrom. 17, 845-850 (2003).
12. Bullinger, D. et al. Metabolic signature of breast cancer cell line MCF-7: Profiling of modified nucleosides via LC-IT MS coupling. BMC Biochem. 8, 25-39 (2007).
13. Wu, C., Siems, W. F. & Hill, H. H. Secondary electrospray ionization ion mobility spectrometry/mass spectrometry of illicit drugs. Anal. Chem. 72, 396-403 (2000).
14. Chen, Y. H., Hill, H. H. & Wittmer, D. P. Analytical merit of electrospray ion mobility spectrometry as a chromatographic detector. J. Microcolumn Sep. 6, 515-24 (1994).
15. Kiselev, P. & Fenn, J. B. ESIMS Analysis of Vapors at Trace Levels. Proceedings of the 49th ASMS Conference on Mass Spectrometry and Allied Topics, Chicago, Illinois, May 27-31, 2001.
16. Fuerstenau, S., Kiselev, P. & Fenn, J. B. ESIMS in the Analysis of Trace Species in Gases. Proceedings of the 47th ASMS Conference on Mass Spectrometry, Dallas (TX), 1999.
17. Fuerstenau, S.Aggregation and Fragmentation in an electrospray ion source. New Haven (CT): Yale University, 1994.
18. Whitehouse, C. M., Levin, F. & Meng, C. K. Further Adventures With An Electrospray Ion Source. Proceedings of the 34th ASMS Conference, Cincinnati, OH, 1986.
19. Currie, E., Schulze, A., Zechner, R., Walther, T. C. & Farese, R. V. Jr. Cellular fatty acid metabolism and cancer. Cell Metab. 18, http://dx.doi.org/10.1016/j.cmet. 2013.05.017 (2013).
20. Barrera, G. Oxidative stress and lipid peroxidation products in cancer progression and therapy. ISRN Oncol. 2012, 137289 (2012).
21. Hakim, M. et al. Volatile organic compounds of lung cancer and possible biochemical pathways. Chem. Rev. 112, 5949-5966 (2012).
22. Forman, H. J. Reactive oxygen species and a, b-unsaturated aldehydes as second messengers in signal transduction. Ann. N. Y. Acad. Sci. 1203, 35-44 (2010).
23. Boonstra, J. & Post, J. A. Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells. Gene 337, 1-13 (2004).
24. Schafer, F. Q. & Buettner, G. R. Redox environment of the cell as viewed through the tedox state of the glutathione disulfide/glutathione couple. Free Radical Biol. Med. 30, 1191-1212 (2001)
25. Fazio, V. M. et al. 4-Hydroxynonenal, a product of cellular lipid peroxidation, which modulates c-myc and globin gene expression in K562 erythroleukemic cells. Cancer Res. 52, 4866-4871 (1992).
26. Barrera, G. et al. Inhibition of c-myc expression induced by 4-hydroxynonenal, a product of lipid peroxidation, in the HL-60 human leukemic cell line. Biochem. Biophys. Res. Commun. 203, 553-561 (1994).
27. Liu, R., Wang, X., Aihara, K. & Chen, L. Early diagnosis of complex diseases by molecular biomarkers, network biomarkers, and dynamical network biomarkers. Med. res. rev. DOI: 10.1002/med.21293 (2013).
28. Martinez-Lozano Sinues, P. & Fernández de la Mora, J. Direct analysis of fatty acid vapors in breath by electrospray ionization and atmospheric pressure ionization-mass spectrometry. Anal. Chem. 80, 8210-8215 (2008).
29. Martinez-Lozano Sinues, P., Zingaro, L., Finiguerra, A. & Cristoni, S. Secondary electrospray ionization-mass spectrometry: Breath study on a control group. J. Breath Res. 5, 016002 (2011).
30. Martinez-Lozano Sinues, P. et al. Mass spectrometry fingerprinting coupled to national institute of standards and technology mass spectral search algorithm for pattern recognition. Anal. Chim. Acta. 755, 28-36 (2012).
31. Fernandez de la Mora, J. Ionization of vapor molecules by an electrospray cloud. Int. J. Mass Spectrom. 300, 182-93 (2011).
32. Vidal-de-Miguel, G., Maćia, M., Pinacho, P. & Blanco, J. Low-Sample Flow Secondary Electrospray Ionization: Improving Vapor Ionization Efficiency. Anal. Chem. 84, 8475-9 (2012).
33. Vidal-de-Miguel, G. & Herrero, A.Secondary Electro Spray Ionization of complex vapor mixtures. Theoretical and experimental approach. J. Am. Soc. Mass Spectrom. 23, 1085-1096 (2012).
34. Martinez-Lozano Sinues, P., Criado, E. & Vidal, G. Mechanistic study on the ionization of trace gases by an electrospray plume. Int. J. Mass Spectrom. 313, 21-29 (2012).
35. Martinez-Lozano Sinues, P., Rus, J., Fernández de la Mora, G., Hernández, M. & Fernández de la Mora, J. Secondary Electrospray Ionization (SESI) of Ambient Vapors for Explosive Detection at Concentrations Below Parts Per Trillion. J. Am. Soc. Mass Spectrom. 20, 287-294 (2009).
36. Dillon, L. A. et al. Optimisation of secondary electrospray ionisation (SESI) for the trace determination of gas-phase volatile organic compounds. Analyst 135, 306-314 (2010).
37. Martinez-Lozano Sinues, P. et al. Breath Analysis in Real Time by Mass Spectrometry in Chronic Obstructive Pulmonary Disease. Respiration. 87, 301-310 (2014).
38. Martinez-Lozano Sinues, P., Kohler, M. & Zenobi, R. Monitoring diurnal changes in exhaled human breath. Anal. Chem. 85, 369-373 (2013).
39. Martinez-Lozano Sinues, P., Kohler, M. & Zenobi, R. Human breath analysis may support the existence of individual metabolic phenotypes. PLoS ONE. 8, e59909 (2013).
40. Martinez-Lozano Sinues, P., Zenobi, R. & Kohler, M. Analysis of the exhalome: A diagnostic tool of the future. CHEST Journal. 144, 746-749 (2013).
41. Martinez-Lozano Sinues, P. Mass spectrometric study of cutaneous volatiles by secondary electrospray ionization. Int. J. Mass Spectrom. 282, 128-132 (2009).
42. Martinez-Lozano Sinues, P. & Fernández de la Mora, J. On-line Detection of Human Skin Vapors. J. Am. Soc. Mass Spectrom. 20, 1060-1063 (2009).
43. Martinez-Lozano Sinues, P. & de la Mora, J. F. Electrospray ionization of volatiles in breath. Int. J. Mass Spectrom. 265, 68-72 (2007).
44. Reynolds, J. C. et al. Detection of volatile organic compounds in breath using thermal desorption electrospray ionization-ion mobility-mass spectrometry. Anal Chem. 82, 2139-2144 (2010).
45. Berchtold, C., Meier, L., Steinhoff, R. & Zenobi, R. A new strategy based on realtime secondary electrospray ionization and high-resolution mass spectrometry to discriminate endogenous and exogenous compounds in exhaled breath. Metabolomics. 1-11 (2013).
46. Zhu, J., Bean, H. D., Wargo, M., Leclair, L. & Hill, J. E. Detecting bacterial lung infections: in vivo evaluation of in vitro volatile fingerprints. J. Breath Res. 7, 016003 (2013).
47. Zhu, J., Bean, H. D., Jiménez-D́iaz, J. & Hill, J. E. Secondary electrospray ionization-mass spectrometry (SESI-MS) breathprinting of multiple bacterial lung pathogens, a mouse model study. Journal of Applied Physiology 114, 1544-1549 (2013).
48. Zhu, J. et al. Robust detection of P. aeruginosa and S. aureus acute lung infections by secondary electrospray ionization-mass spectrometry (SESI-MS) breathprinting: from initial infection to clearance. J. Breath Res. 7, 037106 (2013).
49. Bean, H. D., Zhu, J. & Hill, J. E. Characterizing Bacterial Volatiles using Secondary Electrospray Ionization Mass Spectrometry (SESI-MS). J. Vis. Exp. e2664 (2011).
50. Zhu, J., Bean, H. D., Kuo, Y. M. & Hill, J. E. Fast Detection of Volatile Organic Compounds from Bacterial Cultures by Secondary Electrospray Ionization-Mass Spectrometry. J. Clin. Microbiol. 48, 4426-4431 (2010).
51. Borgaonkar, S. P., Hocker, H., Shin, H. & Markey, M. K. Comparison of normalization methods for the identification of biomarkers using MALDI-TOF and SELDI-TOF mass spectra. OMICS 1, 115-126 (2010).
52. Das, S. Filters, Wrappers and a Boosting-Based Hybrid for Feature Selection. ICML '01: Proceedings of the Eighteenth International Conference on Machine Learning. Morgan Kaufmann Publishers Inc. 74-81 (2001).
53. Kohavi, R. & John, G. H. Wrappers for feature subset selection. Artificial Intelligence. 97, 273-324 (1997).