Human Breath Analysis May Support the Existence of Individual Metabolic Phenotypes

PLoS ONE

Volumn 8, Issue 4, 2013, Pages

  Martinez Lozano Sinues, Pablo ^a   Kohler, Malcolm ^b,c   Zenobi, Renato ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BODY FLUID; BREATH ANALYSIS; DIET; FEMALE; HUMAN; HUMAN EXPERIMENT; INTESTINE FLORA; MALE; MASS SPECTROMETRY; METABOLISM; METABOLITE; METABOLOMICS; NON INVASIVE MEASUREMENT; PHENOTYPE;

ACETONE; ADULT; BREATH TESTS; EXHALATION; FEMALE; HUMANS; MALE; MASS SPECTROMETRY; METABOLOME; PHENOTYPE; PRINCIPAL COMPONENT ANALYSIS;

EID: 84875736794     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0059909     Document Type: Article

References (23)

1. Nicholson JK, (2006) Global systems biology, personalized medicine and molecular epidemiology. Mol Syst Biol 2.
2. van 't Veer LJ, Bernards R, (2008) Enabling personalized cancer medicine through analysis of gene-expression patterns. Nature 452: 564-570.
3. Clayton TA, Baker D, Lindon JC, Everett JR, Nicholson JK, (2009) Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism. Proceedings of the National Academy of Sciences 106: 14728-14733.
4. Dallmann R, Viola AU, Tarokh L, Cajochen C, Brown SA, (2012) The human circadian metabolome. Proceedings of the National Academy of Sciences.
5. Eckel-Mahan KL, Patel VR, Mohney RP, Vignola KS, Baldi P, et al. (2012) Coordination of the transcriptome and metabolome by the circadian clock. Proceedings of the National Academy of Sciences 109: 5541-5546.
6. Kasukawa T, Sugimoto M, Hida A, Minami Y, Mori M, et al. (2012) Human blood metabolite timetable indicates internal body time. Proceedings of the National Academy of Sciences.
7. Andrew Clayton T, Lindon JC, Cloarec O, Antti H, Charuel C, et al. (2006) Pharmaco-metabonomic phenotyping and personalized drug treatment. Nature 440: 1073-1077.
8. Assfalg M, Bertini I, Colangiuli D, Luchinat C, Schäfer H, et al. (2008) Evidence of different metabolic phenotypes in humans. Proceedings of the National Academy of Sciences 105: 1420-1424.
9. Bernini P, Bertini I, Luchinat C, Nepi S, Saccenti E, et al. (2009) Individual Human Phenotypes in Metabolic Space and Time. Journal of Proteome Research 8: 4264-4271.
10. Pauling L, Robinson AB, Teranishi R, Cary P, (1971) Quantitative Analysis of Urine Vapor and Breath by Gas-Liquid Partition Chromatography. Proceedings of the National Academy of Sciences 68: 2374-2376.
11. Wu C, Siems WF, Hill HH, (2000) Secondary Electrospray Ionization Ion Mobility Spectrometry/Mass Spectrometry of Illicit Drugs. Analytical Chemistry 72: 396-403.
12. Vidakovic B, (2011) Statistics for Bioengineering Sciences: With MATLAB and WinBUGS Support. Springer.
13. Napoli C, Sperandio N, Lawlor RT, Scarpa A, Molinari H, et al. (2011) Urine Metabolic Signature of Pancreatic Ductal Adenocarcinoma by 1H Nuclear Magnetic Resonance: Identification, Mapping, and Evolution. Journal of Proteome Research 11: 1274-1283.
14. Rencher A, (2002) Methods of Multivariate Analysis. John Wiley & Sons.
15. Martínez-Lozano P, de la Mora JF, (2007) Electrospray ionization of volatiles in breath. International Journal of Mass Spectrometry 265: 68-72.
16. Martínez-Lozano P, Zingaro L, Finiguerra A, Cristoni S, (2011) Secondary electrospray ionization-mass spectrometry: breath study on a control group. Journal of Breath Research 5: 016002.
17. Chen H, Wortmann A, Zhang W, Zenobi R, (2007) Rapid In Vivo Fingerprinting of Nonvolatile Compounds in Breath by Extractive Electrospray Ionization Quadrupole Time-of-Flight Mass Spectrometry. Angewandte Chemie International Edition 46: 580-583.
18. Gamez G, Zhu L, Disko A, Chen H, Azov V, et al. (2011) Real-time, in vivo monitoring and pharmacokinetics of valproic acid via a novel biomarker in exhaled breath. Chemical Communications 47: 4884-4886.
19. Martínez-Lozano P, Fernández de la Mora J, (2008) Direct Analysis of Fatty Acid Vapors in Breath by Electrospray Ionization and Atmospheric Pressure Ionization-Mass Spectrometry. Analytical Chemistry 80: 8210-8215.
20. Spanel P, Dryahina K, Rejskova A, Chippendale TWE, Smith D, (2011) Breath acetone concentration; biological variability and the influence of diet. Physiological Measurement 32: N23-N31.
21. Bajtarevic A, Ager C, Pienz M, Klieber M, Schwarz K, et al. (2009) Noninvasive detection of lung cancer by analysis of exhaled breath. BMC Cancer 9: 348.
22. Turner C, Španěl P, Smith D, (2006) A longitudinal study of ethanol and acetaldehyde in the exhaled breath of healthy volunteers using selected-ion flow-tube mass spectrometry. Rapid Communications in Mass Spectrometry 20: 61-68.
23. Sinues PM-L, Kohler M, Zenobi R, (2013) Monitoring Diurnal Changes in Exhaled Human Breath. Analytical Chemistry 85: 369-373.