Structure-based mutational studies of substrate inhibition of betaine aldehyde dehydrogenase BetB from staphylococcus aureus

Applied and Environmental Microbiology

Volumn 80, Issue 13, 2014, Pages 3992-4002

  Chen, Chao ^a   Joo, Jeong Chan ^a   Brown, Greg ^a   Stolnikova, Ekaterina ^a,b   Halavaty, Andrei S ^c   Savchenko, Alexei ^a   Anderson, Wayne F ^c   Yakunin, Alexander F ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b INSTITUTE OF PHYSICOCHEMICAL AND BIOLOGICAL PROBLEMS IN SOIL SCIENCE   (Russian Federation)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDES; BACTERIA; BETAINES; BINDING ENERGY; BINDING SITES; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; PROTEINS;

ALDEHYDE DEHYDROGENASE; MOLECULAR MECHANISM; MUTATIONAL ANALYSIS; STAPHYLOCOCCUS AUREUS; SUBSTRATE BINDING; SUBSTRATE DOCKING; SUBSTRATE INHIBITION; SUBSTRATE-BINDING SITES;

SUBSTRATES;

ALDEHYDE; BACTERIUM; ENZYME ACTIVITY; INHIBITION; MUTATION; SUBSTRATE;

BETAINE; BETAINE ALDEHYDE; BETAINE ALDEHYDE DEHYDROGENASE; ENZYME INHIBITOR; MUTANT PROTEIN; PROTEIN BINDING;

AMINO ACID SUBSTITUTION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS; STAPHYLOCOCCUS AUREUS;

AMINO ACID SUBSTITUTION; BETAINE; BETAINE-ALDEHYDE DEHYDROGENASE; BINDING SITES; DNA MUTATIONAL ANALYSIS; ENZYME INHIBITORS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; PROTEIN BINDING; PROTEIN CONFORMATION; STAPHYLOCOCCUS AUREUS;

EID: 84902132974     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.00215-14     Document Type: Article

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