Preserved bioactivity and tunable release of a SDF1-GPVI bi-specific protein using photo-crosslinked PEGda hydrogels

Biomaterials

Volumn 35, Issue 25, 2014, Pages 7180-7187

  Schesny, Marianne K ^a,b   Monaghan, Michael ^b   Bindermann, Andrea H ^a   Freund, Désirée ^c   Seifert, Martina ^d   Eble, Johannes A ^c   Vogel, Sebastian ^e   Gawaz, Meinrad P ^e   Hinderer, Svenja ^b   Schenke Layland, Katja ^a,b,f  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b FRAUNHOFER INSTITUTE FOR INTERFACIAL ENGINEERING AND BIOTECHNOLOGY IGB   (Germany)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e UNIVERSITY OF TÜBINGEN   (Germany)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bioactivity; Cardiac tissue engineering; Drug release; Hydrogel; Protein

Indexed keywords

BIOACTIVITY; DRUG DELIVERY; DRUG PRODUCTS; POLYETHYLENE GLYCOLS; PROTEINS; STEM CELLS; TISSUE ENGINEERING;

CARDIAC TISSUE ENGINEERING; CONTROLLABLE RELEASE; CROSS-LINKING DENSITY; DRUG DELIVERY SYSTEM; DRUG RELEASE; MYOCARDIAL FUNCTION; MYOCARDIAL INFARCTION; POLYETHYLENE GLYCOL DIACRYLATE;

HYDROGELS;

CHEMOKINE RECEPTOR CXCR4; GLYCOPROTEIN VI; POLY(ETHYLENE GLYCOL)DIACRYLATE; POLYMER; STROMAL CELL DERIVED FACTOR 1; STROMAL CELL DERIVED FACTOR 1 GLYCOPROTEIN VI BISPECIFIC PROTEIN; UNCLASSIFIED DRUG; BIOMATERIAL; COLLAGEN TYPE 1; CXCL12 PROTEIN, MOUSE; FIBRINOGEN RECEPTOR; HYDROGEL; MACROGOL DERIVATIVE; PLATELET MEMBRANE GLYCOPROTEIN VI;

ANIMAL CELL; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CROSS LINKING; DENSITY; DRUG DELIVERY SYSTEM; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HYDROGEL; IN VITRO STUDY; NONHUMAN; PHOTOCROSSLINKING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN SECRETION; SUSTAINED DRUG RELEASE; ANIMAL; CELL CULTURE; CHEMISTRY; ENDOTHELIAL PROGENITOR CELL; METABOLISM; MOUSE; MYOCARDIAL INFARCTION; PH; PROCEDURES;

ANIMALS; CELLS, CULTURED; CHEMOKINE CXCL12; COATED MATERIALS, BIOCOMPATIBLE; COLLAGEN TYPE I; DRUG DELIVERY SYSTEMS; ENDOTHELIAL PROGENITOR CELLS; HUMANS; HYDROGELS; HYDROGEN-ION CONCENTRATION; MICE; MYOCARDIAL INFARCTION; PLATELET MEMBRANE GLYCOPROTEINS; POLYETHYLENE GLYCOLS; RECEPTORS, CXCR4;

EID: 84902107406     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.04.116     Document Type: Article

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