Uncovering effects of ex vivo protease activity during proteomics and peptidomics sample extraction in rat brain tissue by oxygen-18 labeling

Journal of Proteome Research

Volumn 13, Issue 6, 2014, Pages 2807-2817

  Stingl, Christoph ^a   Söderquist, Marcus ^b   Karlsson, Oskar ^c   Borén, Mats ^b   Luider, Theo M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b Denator AB   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

neuropeptides; oxygen 18; peptidomics; quality control; sample stabilization

Indexed keywords

NEUROPEPTIDE; OXYGEN 18; PROTEINASE; UREA; OXYGEN; PEPTIDE FRAGMENT; PEPTIDE HYDROLASE; PROTEOME;

ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; DATA BASE; ENZYME DEGRADATION; ENZYME STABILITY; EX VIVO STUDY; EXTRACTION; FEMALE; HEAT; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PEPTIDE ANALYSIS; PEPTIDE SYNTHESIS; PEPTIDOMICS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MOTIF; PROTEOMICS; QUALITY CONTROL; RAT; TANDEM MASS SPECTROMETRY; TEMPERATURE; ANIMAL; ARTIFACT; BRAIN; CHEMISTRY; METABOLISM; PEPTIDE MAPPING; WISTAR RAT;

ANIMALS; ARTIFACTS; BRAIN; FEMALE; ISOTOPE LABELING; NEUROPEPTIDES; OXYGEN ISOTOPES; PEPTIDE FRAGMENTS; PEPTIDE HYDROLASES; PEPTIDE MAPPING; PROTEOLYSIS; PROTEOME; PROTEOMICS; RATS, WISTAR; TANDEM MASS SPECTROMETRY;

EID: 84902106529     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr401232e     Document Type: Article

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