Tissue is alive: New technologies are needed to address the problems of protein biomarker pre-analytical variability

Proteomics - Clinical Applications

Volumn 3, Issue 8, 2009, Pages 874-882

  Espina, Virginia ^a   Mueller, Claudius ^a   Edmiston, Kirsten ^b   Sciro, Manuela ^a,c   Petricoin, Emanuel F ^a   Liotta, Lance A ^a  

^a GEORGE MASON UNIVERSITY   (United States)

^b INOVA FAIRFAX HOSPITAL   (United States)

^c CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

Author keywords

Biomarker; Fixation; Histology; Phosphoprotein; Preservation

Indexed keywords

BIOLOGICAL MARKER; FORMALDEHYDE; INTERLEUKIN 1BETA; INTERLEUKIN 6; PHOSPHATASE; PHOSPHOPROTEIN; PHOSPHOTRANSFERASE; PROTEIN TYROSINE PHOSPHATASE; SERINE; THREONINE; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; TYROSINE;

APOPTOSIS; ARTICLE; BIOTECHNOLOGY; CLINICAL RESEARCH; CRYOSURGERY; DIAGNOSTIC PROCEDURE; ENZYME PHOSPHORYLATION; EX VIVO STUDY; EXCISION; GENE EXPRESSION PROFILING; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLIC STRESS; MICRODISSECTION; MOLECULAR BIOLOGY; MOLECULAR STABILITY; NEEDLE BIOPSY; NUCLEIC ACID ANALYSIS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN STABILITY; PROTEOMICS; QUANTITATIVE ANALYSIS; RNA EXTRACTION; RNA TRANSCRIPTION; SIGNAL TRANSDUCTION; TISSUE ENGINEERING; TISSUE PRESERVATION;

EID: 70350215650     PISSN: 18628346     EISSN: None     Source Type: Journal    
DOI: 10.1002/prca.200800001     Document Type: Article

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